SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SAL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 1y7i SALICYLIC
ACID-BINDING PROTEIN
2
(Nicotiana
tabacum) 		4 / 4 GLY A  12
VAL A  10
TRP A  18
GLY A  17
 SAL  A 501 ( 3.9A)
None
None
None
 0.84A 1ng8A-1y7iA:
undetectable		 1ng8A-1y7iA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 1y7i SALICYLIC
ACID-BINDING PROTEIN
2
(Nicotiana
tabacum) 		4 / 4 GLY A  12
VAL A  10
TRP A  18
GLY A  17
 SAL  A 501 ( 3.9A)
None
None
None
 0.84A 1ng8B-1y7iA:
undetectable		 1ng8B-1y7iA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1y7i SALICYLIC
ACID-BINDING PROTEIN
2
(Nicotiana
tabacum) 		4 / 5 LEU A 160
PHE A 136
MET A 149
SER A 179
 None
None
SAL  A 501 ( 4.6A)
None
 1.22A 1wrlC-1y7iA:
undetectable		 1wrlC-1y7iA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 1m6e S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE
(Clarkia
breweri) 		4 / 6 PRO X 257
MET X 150
HIS X 188
ASP X 187
 None
SAL  X2000 ( 4.8A)
None
None
 1.43A 2lh8A-1m6eX:
0.0		 2lh8A-1m6eX:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1y7i SALICYLIC
ACID-BINDING PROTEIN
2
(Nicotiana
tabacum) 		5 / 12 MET A 149
PHE A 151
LEU A  89
GLY A  83
SER A  81
 SAL  A 501 ( 4.6A)
SAL  A 501 (-4.8A)
None
None
SAL  A 501 (-3.0A)
 1.15A 2ogyA-1y7iA:
undetectable		 2ogyA-1y7iA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12
(Arabidopsis
thaliana) 		5 / 9 THR A 324
ILE A 119
GLY A 333
GLY A 326
PHE A 356
 SAL  A 602 ( 3.7A)
None
None
SAL  A 602 ( 3.6A)
None
 1.46A 2y7wA-4l39A:
undetectable		 2y7wA-4l39A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12
(Arabidopsis
thaliana) 		4 / 5 TYR A 120
ILE A 188
TYR A 181
THR A 182
 SAL  A 602 (-4.3A)
None
None
None
 1.48A 3dgqA-4l39A:
undetectable		 3dgqA-4l39A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1jgs MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR
(Escherichia
coli) 		5 / 9 ALA A  41
LEU A  78
ILE A  49
LEU A 100
THR A  39
 SAL  A 257 (-3.2A)
None
None
None
SAL  A 257 (-3.5A)
 1.34A 3fl9H-1jgsA:
undetectable		 3fl9H-1jgsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1y7i SALICYLIC
ACID-BINDING PROTEIN
2
(Nicotiana
tabacum) 		3 / 3 HIS A 238
HIS A  80
MET A 239
 SAL  A 501 (-3.9A)
None
None
 0.85A 3mihA-1y7iA:
undetectable		 3mihA-1y7iA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1y7i SALICYLIC
ACID-BINDING PROTEIN
2
(Nicotiana
tabacum) 		5 / 12 LEU A  82
ALA A 106
LEU A 119
GLY A  88
LEU A  87
 SAL  A 501 (-3.9A)
None
None
None
None
 1.12A 3olsA-1y7iA:
undetectable		 3olsA-1y7iA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1y7i SALICYLIC
ACID-BINDING PROTEIN
2
(Nicotiana
tabacum) 		5 / 11 LEU A  82
ALA A 106
LEU A 119
GLY A  88
LEU A  87
 SAL  A 501 (-3.9A)
None
None
None
None
 1.13A 3uudA-1y7iA:
undetectable		 3uudA-1y7iA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EM0_B_KANB302_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4em2 UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349
(Staphylococcus
aureus) 		11 / 11 TYR A  52
TYR A  55
LEU A  56
THR A  59
TYR A  70
TRP A  73
LEU A  74
ARG A  77
ARG A  94
VAL A 145
GLN A 149
 SAL  A 501 (-4.6A)
SAL  A 502 (-4.2A)
SAL  A 501 (-4.4A)
SAL  A 502 (-3.2A)
SAL  A 501 (-4.8A)
SAL  A 502 (-3.6A)
SAL  A 504 ( 3.8A)
SAL  A 501 ( 3.0A)
SAL  A 504 (-4.0A)
SAL  A 502 (-4.6A)
SAL  A 502 (-4.5A)
 0.44A 4em0B-4em2A:
24.0		 4em0B-4em2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12
(Arabidopsis
thaliana) 		7 / 7 LEU A 116
TYR A 120
ARG A 123
THR A 161
ILE A 217
THR A 324
GLY A 326
 SAL  A 602 (-4.7A)
SAL  A 602 (-4.3A)
SAL  A 602 (-3.1A)
None
SAL  A 602 ( 4.4A)
SAL  A 602 ( 3.7A)
SAL  A 602 ( 3.6A)
 0.35A 4eq4A-4l39A:
63.1		 4eq4A-4l39A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12
(Arabidopsis
thaliana) 		8 / 8 LEU A 116
TYR A 120
ARG A 123
THR A 161
ILE A 217
VAL A 299
THR A 324
GLY A 326
 SAL  A 602 (-4.7A)
SAL  A 602 (-4.3A)
SAL  A 602 (-3.1A)
None
SAL  A 602 ( 4.4A)
APC  A 603 (-4.2A)
SAL  A 602 ( 3.7A)
SAL  A 602 ( 3.6A)
 0.33A 4eq4B-4l39A:
63.2		 4eq4B-4l39A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12
(Arabidopsis
thaliana) 		7 / 7 LEU A 116
TYR A 120
ARG A 123
THR A 161
ILE A 217
THR A 324
GLY A 326
 SAL  A 602 (-4.7A)
SAL  A 602 (-4.3A)
SAL  A 602 (-3.1A)
None
SAL  A 602 ( 4.4A)
SAL  A 602 ( 3.7A)
SAL  A 602 ( 3.6A)
 0.27A 4eqlA-4l39A:
53.3		 4eqlA-4l39A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12
(Arabidopsis
thaliana) 		7 / 7 LEU A 116
TYR A 120
ARG A 123
THR A 161
ILE A 217
THR A 324
GLY A 326
 SAL  A 602 (-4.7A)
SAL  A 602 (-4.3A)
SAL  A 602 (-3.1A)
None
SAL  A 602 ( 4.4A)
SAL  A 602 ( 3.7A)
SAL  A 602 ( 3.6A)
 0.26A 4eqlB-4l39A:
54.9		 4eqlB-4l39A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1jgs MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR
(Escherichia
coli) 		3 / 3 LEU A  60
LEU A  75
ARG A  94
 None
SAL  A 256 ( 4.6A)
None
 0.62A 5hnzB-1jgsA:
undetectable		 5hnzB-1jgsA:
14.57