SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SAC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2kwo ZINC FINGER PROTEIN
DPF3
(Homo
sapiens) 		5 / 12 GLY A 268
GLY A 291
SER A 290
LEU A 296
CYH A 265
 None
SAC  B   1 ( 4.9A)
None
SAC  B   1 ( 3.4A)
ZN  A 501 (-2.3A)
 1.09A 3e23A-2kwoA:
undetectable		 3e23A-2kwoA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 2kwo ZINC FINGER PROTEIN
DPF3
HISTONE PEPTIDE
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLU A 315
GLY B   4
ARG A 289
PHE A 264
 None
SAC  B   1 ( 4.8A)
SAC  B   1 ( 4.1A)
SAC  B   1 ( 3.8A)
 1.16A 5jcnB-2kwoA:
undetectable		 5jcnB-2kwoA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 VAL A  73
TYR A  79
GLU A 327
LEU A   3
 None
None
None
SAC  A   2 ( 4.1A)
 1.15A 5umwB-4ouaA:
undetectable
5umwE-4ouaA:
undetectable		 5umwB-4ouaA:
11.26
5umwE-4ouaA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 LEU B   3
VAL B  73
TYR B  79
GLU B 327
 SAC  B   2 ( 4.0A)
None
None
None
 1.16A 5umwA-4ouaB:
undetectable
5umwF-4ouaB:
undetectable		 5umwA-4ouaB:
9.07
5umwF-4ouaB:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 LEU A   3
VAL A  73
TYR A  79
GLU A 327
 SAC  A   2 ( 4.1A)
None
None
None
 1.09A 5umwA-4ouaA:
undetectable
5umwF-4ouaA:
undetectable		 5umwA-4ouaA:
11.26
5umwF-4ouaA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2kwo HISTONE PEPTIDE
ZINC FINGER PROTEIN
DPF3
(Homo
sapiens) 		4 / 5 HIS B  18
ASP A 263
TRP A 311
GLY A 291
 SAC  B   1 ( 4.9A)
SAC  B   1 ( 2.8A)
None
SAC  B   1 ( 4.9A)
 1.33A 5x7pB-2kwoB:
undetectable		 5x7pB-2kwoB:
1.26