SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'SA8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1RQP_A_SAMA500_0 (5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	10 / 10	ASP A 16 LEU A 17 ASP A 21 SER A 23 TRP A 50 THR A 76 TYR A 77 THR A 80 PHE A 156 SER A 158	SA8 A1299 (-2.9A) SA8 A1299 ( 4.8A) SA8 A1299 (-3.7A) SA8 A1299 (-3.1A) SA8 A1299 (-4.2A) SA8 A1299 ( 4.7A) None SA8 A1299 (-4.0A) SA8 A1299 (-3.5A) SA8 A1299 (-2.6A)	0.12A	1rqpA-2c4tA: 47.1	1rqpA-2c4tA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1RQP_B_SAMB500_0 (5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	10 / 10	ASP A 16 LEU A 17 ASP A 21 SER A 23 TRP A 50 THR A 76 TYR A 77 THR A 80 PHE A 156 SER A 158	SA8 A1299 (-2.9A) SA8 A1299 ( 4.8A) SA8 A1299 (-3.7A) SA8 A1299 (-3.1A) SA8 A1299 (-4.2A) SA8 A1299 ( 4.7A) None SA8 A1299 (-4.0A) SA8 A1299 (-3.5A) SA8 A1299 (-2.6A)	0.15A	1rqpB-2c4tA: 46.7	1rqpB-2c4tA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1RQP_C_SAMC500_1 (5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	10 / 10	ASP A 16 LEU A 17 ASP A 21 SER A 23 TRP A 50 THR A 76 TYR A 77 THR A 80 PHE A 156 SER A 158	SA8 A1299 (-2.9A) SA8 A1299 ( 4.8A) SA8 A1299 (-3.7A) SA8 A1299 (-3.1A) SA8 A1299 (-4.2A) SA8 A1299 ( 4.7A) None SA8 A1299 (-4.0A) SA8 A1299 (-3.5A) SA8 A1299 (-2.6A)	0.12A	1rqpC-2c4tA: 46.4	1rqpC-2c4tA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2Q6K_A_ADNA699_1 (CHLORINASE)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	4 / 7	ASP A 16 TYR A 77 PRO A 78 THR A 80	SA8 A1299 (-2.9A) None SA8 A1299 (-4.4A) SA8 A1299 (-4.0A)	0.46A	2q6kA-2c4tA: 31.5	2q6kA-2c4tA: 38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V7U_A_SAMA1299_1 (5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	9 / 9	ASP A 16 LEU A 17 ASP A 21 SER A 23 TRP A 50 THR A 76 TYR A 77 THR A 80 PHE A 156	SA8 A1299 (-2.9A) SA8 A1299 ( 4.8A) SA8 A1299 (-3.7A) SA8 A1299 (-3.1A) SA8 A1299 (-4.2A) SA8 A1299 ( 4.7A) None SA8 A1299 (-4.0A) SA8 A1299 (-3.5A)	0.18A	2v7uC-2c4tA: 46.9	2v7uC-2c4tA: 99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V7U_B_SAMB1299_0 (5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	9 / 9	ASP A 16 LEU A 17 ASP A 21 SER A 23 TRP A 50 THR A 76 TYR A 77 THR A 80 PHE A 156	SA8 A1299 (-2.9A) SA8 A1299 ( 4.8A) SA8 A1299 (-3.7A) SA8 A1299 (-3.1A) SA8 A1299 (-4.2A) SA8 A1299 ( 4.7A) None SA8 A1299 (-4.0A) SA8 A1299 (-3.5A)	0.16A	2v7uA-2c4tA: 47.1	2v7uA-2c4tA: 99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V7U_B_SAMB1300_0 (5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	9 / 9	ASP A 16 LEU A 17 ASP A 21 SER A 23 TRP A 50 THR A 76 TYR A 77 THR A 80 PHE A 156	SA8 A1299 (-2.9A) SA8 A1299 ( 4.8A) SA8 A1299 (-3.7A) SA8 A1299 (-3.1A) SA8 A1299 (-4.2A) SA8 A1299 ( 4.7A) None SA8 A1299 (-4.0A) SA8 A1299 (-3.5A)	0.19A	2v7uB-2c4tA: 46.7	2v7uB-2c4tA: 99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V95_A_HCYA1375_1 (CORTICOSTEROID-BINDI NG GLOBULIN)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	5 / 12	ALA A 121 PRO A 122 VAL A 162 ASP A 16 PHE A 13	None None None SA8 A1299 (-2.9A) None	1.30A	2v95A-2c4tA: undetectable	2v95A-2c4tA: 21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5B6I_A_ADNA302_1 (FLUORINASE)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	7 / 7	ASP A 16 TRP A 50 THR A 76 TYR A 77 PRO A 78 THR A 80 SER A 158	SA8 A1299 (-2.9A) SA8 A1299 (-4.2A) SA8 A1299 ( 4.7A) None SA8 A1299 (-4.4A) SA8 A1299 (-4.0A) SA8 A1299 (-2.6A)	0.15A	5b6iA-2c4tA: 45.5	5b6iA-2c4tA: 82.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5B6I_B_ADNB302_1 (FLUORINASE)	2c4t	5'-FLUORO-5'-DEOXYAD ENOSINE SYNTHASE (Streptomyces cattleya)	6 / 6	ASP A 16 TRP A 50 THR A 76 TYR A 77 THR A 80 SER A 158	SA8 A1299 (-2.9A) SA8 A1299 (-4.2A) SA8 A1299 ( 4.7A) None SA8 A1299 (-4.0A) SA8 A1299 (-2.6A)	0.15A	5b6iB-2c4tA: 43.3	5b6iB-2c4tA: 82.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RQP_A_SAMA500_0","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",10,"ASP A  16;LEU A  17;ASP A  21;SER A  23;TRP A  50;THR A  76;TYR A  77;THR A  80;PHE A 156;SER A 158","SA8 A1299 (-2.9A);SA8 A1299 ( 4.8A);SA8 A1299 (-3.7A);SA8 A1299 (-3.1A);SA8 A1299 (-4.2A);SA8 A1299 ( 4.7A);None;SA8 A1299 (-4.0A);SA8 A1299 (-3.5A);SA8 A1299 (-2.6A)","0.12A","1rqpA-2c4tA:47.1",null],["1RQP_B_SAMB500_0","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",10,"ASP A  16;LEU A  17;ASP A  21;SER A  23;TRP A  50;THR A  76;TYR A  77;THR A  80;PHE A 156;SER A 158","SA8 A1299 (-2.9A);SA8 A1299 ( 4.8A);SA8 A1299 (-3.7A);SA8 A1299 (-3.1A);SA8 A1299 (-4.2A);SA8 A1299 ( 4.7A);None;SA8 A1299 (-4.0A);SA8 A1299 (-3.5A);SA8 A1299 (-2.6A)","0.15A","1rqpB-2c4tA:46.7","1rqpA-2c4tA:100.00"],["1RQP_C_SAMC500_1","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",10,"ASP A  16;LEU A  17;ASP A  21;SER A  23;TRP A  50;THR A  76;TYR A  77;THR A  80;PHE A 156;SER A 158","SA8 A1299 (-2.9A);SA8 A1299 ( 4.8A);SA8 A1299 (-3.7A);SA8 A1299 (-3.1A);SA8 A1299 (-4.2A);SA8 A1299 ( 4.7A);None;SA8 A1299 (-4.0A);SA8 A1299 (-3.5A);SA8 A1299 (-2.6A)","0.12A","1rqpC-2c4tA:46.4","1rqpB-2c4tA:100.00"],["2Q6K_A_ADNA699_1","CHLORINASE","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",4,"ASP A  16;TYR A  77;PRO A  78;THR A  80","SA8 A1299 (-2.9A);None;SA8 A1299 (-4.4A);SA8 A1299 (-4.0A)","0.46A","2q6kA-2c4tA:31.5","1rqpC-2c4tA:100.00"],["2V7U_A_SAMA1299_1","5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",9,"ASP A  16;LEU A  17;ASP A  21;SER A  23;TRP A  50;THR A  76;TYR A  77;THR A  80;PHE A 156","SA8 A1299 (-2.9A);SA8 A1299 ( 4.8A);SA8 A1299 (-3.7A);SA8 A1299 (-3.1A);SA8 A1299 (-4.2A);SA8 A1299 ( 4.7A);None;SA8 A1299 (-4.0A);SA8 A1299 (-3.5A)","0.18A","2v7uC-2c4tA:46.9","2q6kA-2c4tA:38.49"],["2V7U_B_SAMB1299_0","5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",9,"ASP A  16;LEU A  17;ASP A  21;SER A  23;TRP A  50;THR A  76;TYR A  77;THR A  80;PHE A 156","SA8 A1299 (-2.9A);SA8 A1299 ( 4.8A);SA8 A1299 (-3.7A);SA8 A1299 (-3.1A);SA8 A1299 (-4.2A);SA8 A1299 ( 4.7A);None;SA8 A1299 (-4.0A);SA8 A1299 (-3.5A)","0.16A","2v7uA-2c4tA:47.1","2v7uC-2c4tA:99.67"],["2V7U_B_SAMB1300_0","5'-FLUORO-5'-DEOXY ADENOSINE SYNTHETASE","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",9,"ASP A  16;LEU A  17;ASP A  21;SER A  23;TRP A  50;THR A  76;TYR A  77;THR A  80;PHE A 156","SA8 A1299 (-2.9A);SA8 A1299 ( 4.8A);SA8 A1299 (-3.7A);SA8 A1299 (-3.1A);SA8 A1299 (-4.2A);SA8 A1299 ( 4.7A);None;SA8 A1299 (-4.0A);SA8 A1299 (-3.5A)","0.19A","2v7uB-2c4tA:46.7","2v7uA-2c4tA:99.67"],["2V95_A_HCYA1375_1","CORTICOSTEROID-BINDING GLOBULIN","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",5,"ALA A 121;PRO A 122;VAL A 162;ASP A  16;PHE A  13","None;None;None;SA8 A1299 (-2.9A);None","1.30A","2v95A-2c4tA:undetectable","2v7uB-2c4tA:99.67"],["5B6I_A_ADNA302_1","FLUORINASE","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",7,"ASP A  16;TRP A  50;THR A  76;TYR A  77;PRO A  78;THR A  80;SER A 158","SA8 A1299 (-2.9A);SA8 A1299 (-4.2A);SA8 A1299 ( 4.7A);None;SA8 A1299 (-4.4A);SA8 A1299 (-4.0A);SA8 A1299 (-2.6A)","0.15A","5b6iA-2c4tA:45.5","2v95A-2c4tA:21.59"],["5B6I_B_ADNB302_1","FLUORINASE","2c4t","5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE","Streptomyces cattleya",6,"ASP A  16;TRP A  50;THR A  76;TYR A  77;THR A  80;SER A 158","SA8 A1299 (-2.9A);SA8 A1299 (-4.2A);SA8 A1299 ( 4.7A);None;SA8 A1299 (-4.0A);SA8 A1299 (-2.6A)","0.15A","5b6iB-2c4tA:43.3","5b6iA-2c4tA:82.13"]]