SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'S6P'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BNN_B_FCNB1199_1 (EPOXIDASE)	2gc1	GLUCOSE-6-PHOSPHATE ISOMERASE (Pyrococcus furiosus)	4 / 8	HIS A 90 GLU A 97 HIS A 88 ALA A 150	ZN A 401 ( 3.4A) ZN A 401 ( 2.5A) ZN A 401 ( 3.4A) S6P A 502 ( 3.9A)	0.99A	2bnnA-2gc1A: 9.7 2bnnB-2gc1A: 9.1	2bnnA-2gc1A: 23.26 2bnnB-2gc1A: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BNN_B_FCNB1199_1 (EPOXIDASE)	2gc1	GLUCOSE-6-PHOSPHATE ISOMERASE (Pyrococcus furiosus)	4 / 8	HIS A 90 GLU A 97 HIS A 136 ALA A 150	ZN A 401 ( 3.4A) ZN A 401 ( 2.5A) ZN A 401 ( 3.3A) S6P A 502 ( 3.9A)	0.54A	2bnnA-2gc1A: 9.7 2bnnB-2gc1A: 9.1	2bnnA-2gc1A: 23.26 2bnnB-2gc1A: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DTT_D_H4BD1006_1 (HYPOTHETICAL PROTEIN PH0634)	2gc1	GLUCOSE-6-PHOSPHATE ISOMERASE (Pyrococcus furiosus)	5 / 10	HIS A 88 HIS A 90 HIS A 136 THR A 85 PHE A 148	ZN A 401 ( 3.4A) ZN A 401 ( 3.4A) ZN A 401 ( 3.3A) S6P A 502 (-3.1A) None	1.05A	2dttD-2gc1A: undetectable 2dttF-2gc1A: undetectable	2dttD-2gc1A: 22.40 2dttF-2gc1A: 22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG4_A_CUA517_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	2gc1	GLUCOSE-6-PHOSPHATE ISOMERASE (Pyrococcus furiosus)	3 / 3	HIS A 90 HIS A 88 HIS A 158	ZN A 401 ( 3.4A) ZN A 401 ( 3.4A) S6P A 502 (-4.2A)	0.74A	3ag4A-2gc1A: undetectable	3ag4A-2gc1A: 15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A3U_A_NCAA1359_0 (NADH:FLAVIN OXIDOREDUCTASE/NADH OXIDASE)	2gc1	GLUCOSE-6-PHOSPHATE ISOMERASE (Pyrococcus furiosus)	4 / 7	THR A 85 HIS A 136 TYR A 99 TYR A 52	S6P A 502 (-3.1A) ZN A 401 ( 3.3A) S6P A 502 (-4.8A) S6P A 502 (-4.3A)	1.45A	4a3uA-2gc1A: undetectable	4a3uA-2gc1A: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G5J_A_0WMA1102_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2gc1	GLUCOSE-6-PHOSPHATE ISOMERASE (Pyrococcus furiosus)	4 / 7	PHE A 148 TYR A 99 TYR A 152 HIS A 158	None S6P A 502 (-4.8A) S6P A 502 ( 3.9A) S6P A 502 (-4.2A)	1.17A	4g5jA-2gc1A: undetectable	4g5jA-2gc1A: 21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PAH_A_LNRA600_1 (PHENYLALANINE HYDROXYLASE)	2gc1	GLUCOSE-6-PHOSPHATE ISOMERASE (Pyrococcus furiosus)	4 / 6	HIS A 90 HIS A 136 TYR A 99 GLU A 97	ZN A 401 ( 3.4A) ZN A 401 ( 3.3A) S6P A 502 (-4.8A) ZN A 401 ( 2.5A)	0.98A	4pahA-2gc1A: undetectable	4pahA-2gc1A: 20.20

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2BNN_B_FCNB1199_1","EPOXIDASE;EPOXIDASE","2gc1","GLUCOSE-6-PHOSPHATE ISOMERASE","Pyrococcus furiosus",4,"HIS A  90;GLU A  97;HIS A  88;ALA A 150"," ZN A 401 ( 3.4A); ZN A 401 ( 2.5A); ZN A 401 ( 3.4A);S6P A 502 ( 3.9A)","0.99A","2bnnA-2gc1A:9.7;2bnnB-2gc1A:9.1",null],["2BNN_B_FCNB1199_1","EPOXIDASE;EPOXIDASE","2gc1","GLUCOSE-6-PHOSPHATE ISOMERASE","Pyrococcus furiosus",4,"HIS A  90;GLU A  97;HIS A 136;ALA A 150"," ZN A 401 ( 3.4A); ZN A 401 ( 2.5A); ZN A 401 ( 3.3A);S6P A 502 ( 3.9A)","0.54A","2bnnA-2gc1A:9.7;2bnnB-2gc1A:9.1","2bnnA-2gc1A:23.26;2bnnB-2gc1A:23.26"],["2DTT_D_H4BD1006_1","HYPOTHETICAL PROTEIN PH0634;HYPOTHETICAL PROTEIN PH0634","2gc1","GLUCOSE-6-PHOSPHATE ISOMERASE","Pyrococcus furiosus",5,"HIS A  88;HIS A  90;HIS A 136;THR A  85;PHE A 148"," ZN A 401 ( 3.4A); ZN A 401 ( 3.4A); ZN A 401 ( 3.3A);S6P A 502 (-3.1A);None","1.05A","2dttD-2gc1A:undetectable;2dttF-2gc1A:undetectable","2bnnA-2gc1A:23.26;2bnnB-2gc1A:23.26"],["3AG4_A_CUA517_0","CYTOCHROME C OXIDASE SUBUNIT 1","2gc1","GLUCOSE-6-PHOSPHATE ISOMERASE","Pyrococcus furiosus",3,"HIS A  90;HIS A  88;HIS A 158"," ZN A 401 ( 3.4A); ZN A 401 ( 3.4A);S6P A 502 (-4.2A)","0.74A","3ag4A-2gc1A:undetectable","2dttD-2gc1A:22.40;2dttF-2gc1A:22.40"],["4A3U_A_NCAA1359_0","NADH:FLAVIN OXIDOREDUCTASE\/NADH OXIDASE","2gc1","GLUCOSE-6-PHOSPHATE ISOMERASE","Pyrococcus furiosus",4,"THR A  85;HIS A 136;TYR A  99;TYR A  52","S6P A 502 (-3.1A); ZN A 401 ( 3.3A);S6P A 502 (-4.8A);S6P A 502 (-4.3A)","1.45A","4a3uA-2gc1A:undetectable","3ag4A-2gc1A:15.74"],["4G5J_A_0WMA1102_1","EPIDERMAL GROWTH FACTOR RECEPTOR","2gc1","GLUCOSE-6-PHOSPHATE ISOMERASE","Pyrococcus furiosus",4,"PHE A 148;TYR A  99;TYR A 152;HIS A 158","None;S6P A 502 (-4.8A);S6P A 502 ( 3.9A);S6P A 502 (-4.2A)","1.17A","4g5jA-2gc1A:undetectable","4a3uA-2gc1A:20.50"],["4PAH_A_LNRA600_1","PHENYLALANINE HYDROXYLASE","2gc1","GLUCOSE-6-PHOSPHATE ISOMERASE","Pyrococcus furiosus",4,"HIS A  90;HIS A 136;TYR A  99;GLU A  97"," ZN A 401 ( 3.4A); ZN A 401 ( 3.3A);S6P A 502 (-4.8A); ZN A 401 ( 2.5A)","0.98A","4pahA-2gc1A:undetectable","4g5jA-2gc1A:21.86"]]