SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'S4M'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 ASP A 118
ASP A 149
ASP A 168
 S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
S4M  A 301 (-3.1A)
 0.79A 1ej0A-4yv2A:
11.4		 1ej0A-4yv2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 VAL A 234
GLY A 243
GLN A 201
TYR A  73
 None
None
None
S4M  A 301 (-4.4A)
 1.25A 1ekjC-4yv2A:
undetectable
1ekjD-4yv2A:
undetectable		 1ekjC-4yv2A:
22.22
1ekjD-4yv2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
GLU A 147
ASP A 178
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-4.4A)
 0.86A 1jg2A-2pt6A:
7.9		 1jg2A-2pt6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLY A 126
GLU A 147
ASP A 178
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-4.4A)
 0.88A 1jg3A-2pt6A:
7.7		 1jg3A-2pt6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLY A 126
GLU A 147
ASP A 178
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-4.4A)
 0.89A 1jg3B-2pt6A:
3.1		 1jg3B-2pt6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLY A 126
GLY A 128
GLY A 129
HIS A 103
ASP A 149
VAL A 152
 S4M  A 501 ( 4.4A)
None
None
S4M  A 501 (-3.7A)
None
S4M  A 501 ( 4.2A)
 1.44A 1n2xB-2pt6A:
13.4		 1n2xB-2pt6A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLY A  97
GLY A  99
GLY A 100
ASP A 120
VAL A 123
 S4M  A 301 ( 4.5A)
None
None
None
S4M  A 301 (-4.3A)
 0.68A 1n2xB-4yv2A:
13.4		 1n2xB-4yv2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
ILE A 148
ASP A 149
ASP A 178
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
 0.66A 1qaoA-2pt6A:
9.0		 1qaoA-2pt6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLY A  95
GLY A  97
ILE A 119
ASP A 120
ASP A 149
 S4M  A 301 (-3.5A)
S4M  A 301 ( 4.5A)
S4M  A 301 (-3.9A)
None
S4M  A 301 (-3.9A)
 0.71A 1qaoA-4yv2A:
9.2		 1qaoA-4yv2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 125
GLY A 126
GLU A 147
ASP A 178
 S4M  A 501 (-3.4A)
S4M  A 501 (-4.2A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
 0.80A 1qzzA-2pt6A:
12.5		 1qzzA-2pt6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 8 ASP A 196
ILE A 145
ILE A 153
ILE A 163
 S4M  A 501 (-2.6A)
None
None
None
 0.64A 1sh9A-2pt6A:
undetectable		 1sh9A-2pt6A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 ASP A  98
GLY A  95
HIS A  74
LEU A 116
ILE A 167
 S4M  A 301 (-3.1A)
S4M  A 301 (-3.5A)
S4M  A 301 (-4.0A)
None
None
 1.24A 1sq5B-4yv2A:
1.0		 1sq5B-4yv2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 128
GLY A 129
ILE A 148
ASP A 149
ASP A 178
 None
None
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
 0.40A 1sqfA-2pt6A:
9.9		 1sqfA-2pt6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		6 / 12 GLY A  99
GLY A 100
ILE A 119
ASP A 120
ASP A 149
GLY A 150
 None
None
S4M  A 301 (-3.9A)
None
S4M  A 301 (-3.9A)
S4M  A 301 (-3.6A)
 0.47A 1sqfA-4yv2A:
9.5		 1sqfA-4yv2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 125
GLY A 126
GLU A 147
ASP A 178
 S4M  A 501 (-3.4A)
S4M  A 501 (-4.2A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
 0.82A 1xdsA-2pt6A:
11.2		 1xdsA-2pt6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 125
GLY A 126
GLU A 147
ASP A 178
 S4M  A 501 (-3.4A)
S4M  A 501 (-4.2A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
 0.80A 1xdsB-2pt6A:
7.0		 1xdsB-2pt6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 5 ALA A 101
TYR A 102
TYR A 264
GLN A  93
 None
S4M  A 501 (-4.9A)
None
S4M  A 501 (-4.1A)
 0.97A 1xl6A-2pt6A:
undetectable
1xl6B-2pt6A:
undetectable		 1xl6A-2pt6A:
18.31
1xl6B-2pt6A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		3 / 3 GLY A 124
GLU A 147
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-2.6A)
 0.63A 2b25B-2pt6A:
9.7		 2b25B-2pt6A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
GLU A 147
ILE A 148
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.5A)
 0.54A 2vdvE-2pt6A:
3.8		 2vdvE-2pt6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLY A 126
GLU A 147
ILE A 148
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.5A)
 0.54A 2vdvF-2pt6A:
3.8		 2vdvF-2pt6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 THR A 169
ILE A  94
GLY A  95
ILE A 119
 S4M  A 301 (-4.7A)
None
S4M  A 301 (-3.5A)
S4M  A 301 (-3.9A)
 0.70A 2y7wC-4yv2A:
undetectable		 2y7wC-4yv2A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
ILE A 130
ASP A 149
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
None
None
S4M  A 501 (-3.5A)
 0.82A 2yqzA-2pt6A:
12.0		 2yqzA-2pt6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
ILE A 130
ASP A 149
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
None
None
S4M  A 501 (-3.5A)
 0.80A 2yqzB-2pt6A:
12.0		 2yqzB-2pt6A:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLN A 229
HIS A 103
ASP A 196
TYR A 264
PRO A 265
ILE A 261
 None
S4M  A 501 (-3.7A)
S4M  A 501 (-2.6A)
None
None
None
 1.45A 3b7pA-2pt6A:
51.0		 3b7pA-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		11 / 12 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLN A 229
TYR A 264
PRO A 265
ILE A 269
 None
S4M  A 501 (-4.1A)
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
None
None
None
 0.26A 3b7pA-2pt6A:
51.0		 3b7pA-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 TYR A 102
HIS A 103
ASP A 127
ASP A 196
ILE A 259
 S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
 1.43A 3b7pA-2pt6A:
51.0		 3b7pA-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		8 / 12 GLN A  64
TYR A  73
HIS A  74
ASP A  98
ASP A 168
GLN A 201
TYR A 237
PRO A 238
 S4M  A 301 (-4.2A)
S4M  A 301 (-4.4A)
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
None
 0.76A 3b7pA-4yv2A:
38.0		 3b7pA-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		8 / 12 GLN A  64
TYR A  73
HIS A  74
ASP A  98
ASP A 168
TYR A 237
PRO A 238
ILE A 242
 S4M  A 301 (-4.2A)
S4M  A 301 (-4.4A)
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
None
 0.57A 3b7pA-4yv2A:
38.0		 3b7pA-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLN A 201
HIS A  74
ASP A 168
TYR A 237
PRO A 238
 None
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
None
None
 1.33A 3b7pA-4yv2A:
38.0		 3b7pA-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		11 / 12 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLN A 229
TYR A 264
PRO A 265
ILE A 269
 None
S4M  A 501 (-4.1A)
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
None
None
None
 0.28A 3b7pB-2pt6A:
49.6		 3b7pB-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 TYR A 102
HIS A 103
ASP A 127
ASP A 196
ILE A 259
 S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
 1.35A 3b7pB-2pt6A:
49.6		 3b7pB-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		8 / 12 GLN A  64
TYR A  73
HIS A  74
ASP A  98
ASP A 168
GLN A 201
TYR A 237
PRO A 238
 S4M  A 301 (-4.2A)
S4M  A 301 (-4.4A)
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
None
 0.76A 3b7pB-4yv2A:
38.4		 3b7pB-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		8 / 12 GLN A  64
TYR A  73
HIS A  74
ASP A  98
ASP A 168
TYR A 237
PRO A 238
ILE A 242
 S4M  A 301 (-4.2A)
S4M  A 301 (-4.4A)
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
None
 0.59A 3b7pB-4yv2A:
38.4		 3b7pB-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLN A 201
HIS A  74
ASP A 168
TYR A 237
PRO A 238
 None
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
None
None
 1.40A 3b7pB-4yv2A:
38.4		 3b7pB-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 HIS A 103
ASP A 196
TYR A 264
PRO A 265
ILE A 261
 S4M  A 501 (-3.7A)
S4M  A 501 (-2.6A)
None
None
None
 1.32A 3b7pC-2pt6A:
49.6		 3b7pC-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		12 / 12 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLU A 231
SER A 232
TYR A 264
PRO A 265
ILE A 269
 None
S4M  A 501 (-4.1A)
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
None
None
None
None
 0.27A 3b7pC-2pt6A:
49.6		 3b7pC-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 TYR A 102
HIS A 103
ASP A 127
ASP A 196
ILE A 259
 S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
 1.38A 3b7pC-2pt6A:
49.6		 3b7pC-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		10 / 12 GLN A  64
TYR A  73
HIS A  74
ASP A  98
ASP A 168
GLU A 203
SER A 204
TYR A 237
PRO A 238
ILE A 242
 S4M  A 301 (-4.2A)
S4M  A 301 (-4.4A)
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
None
None
None
 0.63A 3b7pC-4yv2A:
38.3		 3b7pC-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLN A 201
HIS A  74
ASP A 168
TYR A 237
PRO A 238
 None
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
None
None
 1.29A 3b7pC-4yv2A:
38.3		 3b7pC-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		9 / 12 GLN A  72
TYR A 102
HIS A 103
GLY A 124
ILE A 148
ASP A 149
VAL A 152
ASP A 178
GLN A 229
 S4M  A 501 (-3.5A)
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-3.3A)
None
 0.66A 3bwcA-2pt6A:
38.8		 3bwcA-2pt6A:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		6 / 12 GLN A  40
GLY A  96
ASP A 120
VAL A 123
THR A 169
GLN A 201
 S4M  A 301 (-3.4A)
S4M  A 301 ( 4.6A)
None
S4M  A 301 (-4.3A)
S4M  A 301 (-4.7A)
None
 1.09A 3bwcA-4yv2A:
46.7		 3bwcA-4yv2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		12 / 12 GLN A  40
TYR A  73
HIS A  74
ILE A  94
GLY A  95
ILE A 119
ASP A 120
VAL A 123
ASP A 149
GLY A 150
THR A 169
GLN A 201
 S4M  A 301 (-3.4A)
S4M  A 301 (-4.4A)
S4M  A 301 (-4.0A)
None
S4M  A 301 (-3.5A)
S4M  A 301 (-3.9A)
None
S4M  A 301 (-4.3A)
S4M  A 301 (-3.9A)
S4M  A 301 (-3.6A)
S4M  A 301 (-4.7A)
None
 0.49A 3bwcA-4yv2A:
46.7		 3bwcA-4yv2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 4 LEU A  59
GLN A  64
ASP A 118
ASP A 168
 None
S4M  A 301 (-4.2A)
S4M  A 301 (-3.0A)
S4M  A 301 (-3.1A)
 0.29A 3bwcA-4yv2A:
46.7		 3bwcA-4yv2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		9 / 12 LEU A  88
TYR A 102
HIS A 103
GLY A 124
ASP A 127
ILE A 148
ASP A 149
VAL A 152
ASP A 196
 None
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-3.4A)
S4M  A 501 (-2.9A)
S4M  A 501 (-3.9A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-2.6A)
 0.37A 3bwcB-2pt6A:
29.5		 3bwcB-2pt6A:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		7 / 12 TYR A 102
HIS A 103
GLY A 124
ASP A 127
ILE A 148
VAL A 152
GLN A 229
 S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-3.4A)
S4M  A 501 (-2.9A)
S4M  A 501 (-3.9A)
S4M  A 501 ( 4.2A)
None
 0.71A 3bwcB-2pt6A:
29.5		 3bwcB-2pt6A:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		6 / 12 LEU A  59
GLY A  96
ASP A 120
VAL A 123
ASP A 168
GLN A 201
 None
S4M  A 301 ( 4.6A)
None
S4M  A 301 (-4.3A)
S4M  A 301 (-3.1A)
None
 1.17A 3bwcB-4yv2A:
45.6		 3bwcB-4yv2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU A  59
HIS A  74
ILE A 167
ASP A  98
ASP A 168
 None
S4M  A 301 (-4.0A)
None
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
 0.94A 3bwcB-4yv2A:
45.6		 3bwcB-4yv2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		12 / 12 LEU A  59
TYR A  73
HIS A  74
ILE A  94
GLY A  95
ASP A  98
ILE A 119
ASP A 120
VAL A 123
GLY A 150
ASP A 168
GLN A 201
 None
S4M  A 301 (-4.4A)
S4M  A 301 (-4.0A)
None
S4M  A 301 (-3.5A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.9A)
None
S4M  A 301 (-4.3A)
S4M  A 301 (-3.6A)
S4M  A 301 (-3.1A)
None
 0.45A 3bwcB-4yv2A:
45.6		 3bwcB-4yv2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 GLN A  40
GLN A  64
ASP A 118
ASP A 149
 S4M  A 301 (-3.4A)
S4M  A 301 (-4.2A)
S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
 0.30A 3bwcB-4yv2A:
45.6		 3bwcB-4yv2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 GLN A  64
ASP A 118
ASP A 149
THR A 169
 S4M  A 301 (-4.2A)
S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
S4M  A 301 (-4.7A)
 0.86A 3bwcB-4yv2A:
45.6		 3bwcB-4yv2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 TYR A 102
ASP A 127
ASP A 196
GLN A 229
TYR A 264
 S4M  A 501 (-4.9A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
 0.74A 3c6mA-2pt6A:
25.5		 3c6mA-2pt6A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 11 TYR A  73
ASP A  98
ASP A 168
GLN A 201
TYR A 237
 S4M  A 301 (-4.4A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
 0.79A 3c6mA-4yv2A:
23.2		 3c6mA-4yv2A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_B_SPMB501_1
(SPERMINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 TYR A  73
ASP A  98
ASP A 168
GLN A 201
TYR A 237
 S4M  A 301 (-4.4A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
 0.77A 3c6mB-4yv2A:
23.1		 3c6mB-4yv2A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 TYR A  73
ASP A  98
ASP A 168
GLN A 201
TYR A 237
 S4M  A 301 (-4.4A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
 0.70A 3c6mC-4yv2A:
23.0		 3c6mC-4yv2A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_D_SPMD501_1
(SPERMINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 10 TYR A 102
ASP A 127
ASP A 196
GLN A 229
TYR A 264
 S4M  A 501 (-4.9A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
 0.75A 3c6mD-2pt6A:
25.4		 3c6mD-2pt6A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_D_SPMD501_1
(SPERMINE SYNTHASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 TYR A  73
ASP A  98
ASP A 168
GLN A 201
TYR A 237
 S4M  A 301 (-4.4A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
 0.76A 3c6mD-4yv2A:
23.2		 3c6mD-4yv2A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
ILE A 148
ASP A 149
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-4.4A)
 0.88A 3cjtO-2pt6A:
12.6		 3cjtO-2pt6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
GLU A 147
ILE A 148
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.5A)
 0.44A 3ckkA-2pt6A:
4.4		 3ckkA-2pt6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLN A 133
ASP A  98
GLY A  96
VAL A  65
LEU A 116
 None
S4M  A 301 (-3.1A)
S4M  A 301 ( 4.6A)
None
None
 1.24A 3d91B-4yv2A:
undetectable		 3d91B-4yv2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLY A 126
GLU A 147
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.54A 3dxyA-2pt6A:
11.1		 3dxyA-2pt6A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		7 / 12 VAL A 123
GLY A 124
GLY A 126
GLU A 147
ASP A 149
ASP A 178
ALA A 179
 None
S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.57A 3fuuA-2pt6A:
11.5		 3fuuA-2pt6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLY A 100
LEU A  77
LEU A 106
SER A 135
GLY A  95
 None
None
None
None
S4M  A 301 (-3.5A)
 1.02A 3g2oA-4yv2A:
12.8		 3g2oA-4yv2A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 11 GLY A 124
GLU A 147
ILE A 148
ASP A 149
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.37A 3grvA-2pt6A:
12.2		 3grvA-2pt6A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 11 GLY A 124
GLY A 126
ILE A 148
ASP A 149
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.90A 3grvA-2pt6A:
12.2		 3grvA-2pt6A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLY A 124
GLU A 147
ILE A 148
ASP A 149
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.43A 3gryA-2pt6A:
12.2		 3gryA-2pt6A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLY A 124
GLY A 126
ILE A 148
ASP A 149
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.97A 3gryA-2pt6A:
12.2		 3gryA-2pt6A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.73A 3id5B-2pt6A:
10.8		 3id5B-2pt6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.73A 3id5F-2pt6A:
10.7		 3id5F-2pt6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.70A 3id6C-2pt6A:
5.6		 3id6C-2pt6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 128
GLY A 129
ASP A 149
ASP A 196
LEU A 207
 None
None
None
S4M  A 501 (-2.6A)
S4M  A 501 (-4.4A)
 0.70A 3m6vA-2pt6A:
10.1		 3m6vA-2pt6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 128
GLY A 129
ASP A 149
ASP A 196
LEU A 207
 None
None
None
S4M  A 501 (-2.6A)
S4M  A 501 (-4.4A)
 0.68A 3m6vB-2pt6A:
9.2		 3m6vB-2pt6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 4 GLY A 124
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 0.75A 3mb5A-2pt6A:
12.8		 3mb5A-2pt6A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.70A 3nmuA-2pt6A:
undetectable
3nmuF-2pt6A:
10.1		 3nmuA-2pt6A:
22.14
3nmuF-2pt6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.76A 3nvkF-2pt6A:
undetectable
3nvkJ-2pt6A:
12.3		 3nvkF-2pt6A:
22.63
3nvkJ-2pt6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 THR A 151
GLN A  72
ILE A 176
SER A  69
 None
S4M  A 501 (-3.5A)
None
None
 1.30A 3peoG-2pt6A:
undetectable		 3peoG-2pt6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ASP A 118
GLY A 121
VAL A 123
ASP A 120
 S4M  A 301 (-3.0A)
None
S4M  A 301 (-4.3A)
None
 1.02A 3vqrB-4yv2A:
3.4		 3vqrB-4yv2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 HIS A 103
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 (-3.7A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 1.27A 3vywA-2pt6A:
7.1		 3vywA-2pt6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 HIS A 103
GLY A 124
GLY A 126
ALA A 179
LEU A 207
 S4M  A 501 (-3.7A)
S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 1.22A 3vywB-2pt6A:
14.6		 3vywB-2pt6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 GLY A 126
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 0.77A 3vywC-2pt6A:
13.4		 3vywC-2pt6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLY A  95
GLY A  99
GLY A 100
ASP A 118
ASP A 149
 S4M  A 301 (-3.5A)
None
None
S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
 0.76A 4b17A-4yv2A:
10.6		 4b17A-4yv2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 HIS A 103
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 (-3.7A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 1.37A 4blvA-2pt6A:
11.2		 4blvA-2pt6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		3 / 3 GLU A 147
ASP A 149
ASP A 178
 S4M  A 501 (-2.7A)
None
S4M  A 501 (-3.3A)
 0.33A 4gc9A-2pt6A:
9.8		 4gc9A-2pt6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 11 ASP A 168
TYR A  73
GLY A  99
GLY A  78
ASP A  69
 S4M  A 301 (-3.1A)
S4M  A 301 (-4.4A)
None
None
None
 1.30A 4mm9A-4yv2A:
undetectable		 4mm9A-4yv2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 TYR A 137
ASP A 127
HIS A 103
ASP A 196
GLY A 125
 None
S4M  A 501 (-2.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.6A)
S4M  A 501 (-4.2A)
 1.46A 4qa0B-2pt6A:
5.0		 4qa0B-2pt6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 4 ASP A 168
GLY A  97
ASP A 118
ASP A 149
 S4M  A 301 (-3.1A)
S4M  A 301 ( 4.5A)
S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
 1.17A 5e72A-4yv2A:
12.3		 5e72A-4yv2A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 7 GLY A 124
GLY A 126
ASP A 178
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 0.79A 5ergB-2pt6A:
9.5		 5ergB-2pt6A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 10 VAL A 123
GLY A 124
GLY A 126
ILE A 176
ALA A 179
 None
S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
None
S4M  A 501 (-3.5A)
 0.94A 5vm8B-2pt6A:
2.4		 5vm8B-2pt6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 11 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
 None
S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 0.93A 5x6yA-2pt6A:
4.5		 5x6yA-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 10 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
 None
S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 0.87A 5x6yB-2pt6A:
3.6		 5x6yB-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLU A 147
ASP A 178
ALA A 179
SER A 197
LEU A 207
 S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
None
S4M  A 501 (-4.4A)
 1.11A 5x6yC-2pt6A:
8.0		 5x6yC-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 11 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
 None
S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 0.79A 5x6yC-2pt6A:
8.0		 5x6yC-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLY A  95
GLY A 100
ASP A 118
ASP A 149
ASP A 168
 S4M  A 301 (-3.5A)
None
S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
S4M  A 301 (-3.1A)
 0.64A 5yniA-4yv2A:
8.4		 5yniA-4yv2A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLY A  95
GLY A 100
ASP A 118
ASP A 149
ASP A 168
 S4M  A 301 (-3.5A)
None
S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
S4M  A 301 (-3.1A)
 0.66A 5ynmA-4yv2A:
8.4		 5ynmA-4yv2A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		3 / 3 TYR A 264
HIS A 103
MET A 106
 None
S4M  A 501 (-3.7A)
None
 1.19A 6af6A-2pt6A:
undetectable		 6af6A-2pt6A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		7 / 12 GLN A  72
GLY A 124
ILE A 148
ASP A 149
VAL A 152
ASP A 178
ALA A 179
 S4M  A 501 (-3.5A)
S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.56A 6bq4A-2pt6A:
35.8		 6bq4A-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLN A  72
ILE A 148
ASP A 149
ALA A 179
LEU A 207
 S4M  A 501 (-3.5A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 1.00A 6bq4A-2pt6A:
35.8		 6bq4A-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLY A 124
ILE A 148
ASP A 149
ASP A 178
ALA A 179
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 0.62A 6bq4A-2pt6A:
35.8		 6bq4A-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		7 / 12 GLN A  40
GLY A  95
ASP A 118
ILE A 119
ASP A 120
VAL A 123
ASP A 149
 S4M  A 301 (-3.4A)
S4M  A 301 (-3.5A)
S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
None
S4M  A 301 (-4.3A)
S4M  A 301 (-3.9A)
 0.51A 6bq4A-4yv2A:
31.7		 6bq4A-4yv2A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLN A  72
GLY A 124
ASP A 149
VAL A 152
ALA A 204
 S4M  A 501 (-3.5A)
S4M  A 501 (-3.4A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-3.6A)
 1.03A 6bq4B-2pt6A:
35.9		 6bq4B-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		7 / 12 GLN A  72
GLY A 124
ILE A 148
ASP A 149
VAL A 152
ASP A 178
ALA A 179
 S4M  A 501 (-3.5A)
S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.47A 6bq4B-2pt6A:
35.9		 6bq4B-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
ILE A 148
ASP A 178
ALA A 179
PRO A 203
 S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.1A)
 0.54A 6bq4B-2pt6A:
35.9		 6bq4B-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		7 / 12 GLN A  40
GLY A  95
ASP A 118
ILE A 119
ASP A 120
VAL A 123
ASP A 149
 S4M  A 301 (-3.4A)
S4M  A 301 (-3.5A)
S4M  A 301 (-3.0A)
S4M  A 301 (-3.9A)
None
S4M  A 301 (-4.3A)
S4M  A 301 (-3.9A)
 0.41A 6bq4B-4yv2A:
31.8		 6bq4B-4yv2A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 GLN A  40
GLY A  96
ASP A 118
ASP A 120
VAL A 123
 S4M  A 301 (-3.4A)
S4M  A 301 ( 4.6A)
S4M  A 301 (-3.0A)
None
S4M  A 301 (-4.3A)
 1.05A 6bq4B-4yv2A:
31.8		 6bq4B-4yv2A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 125
SER A  69
GLN A  72
ILE A 148
ASP A 178
 S4M  A 501 (-4.2A)
None
S4M  A 501 (-3.5A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.3A)
 1.21A 6bxnB-2pt6A:
3.6		 6bxnB-2pt6A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4yv2 SPERMIDINE SYNTHASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 ILE A  94
GLY A  95
GLY A  97
ILE A 119
ASP A 120
 None
S4M  A 301 (-3.5A)
S4M  A 301 ( 4.5A)
S4M  A 301 (-3.9A)
None
 0.61A 6iftA-4yv2A:
9.3		 6iftA-4yv2A:
21.65