SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'S35'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
(Homo
sapiens) 		5 / 12 ASP B 300
GLY A  56
GLY A  57
SER A 150
HIS B 429
 None
S35  A1259 ( 3.7A)
S35  A1259 ( 3.6A)
S35  A1259 ( 3.8A)
S35  A1259 ( 3.9A)
 0.98A 1dx6A-4az3B:
undetectable		 1dx6A-4az3B:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
(Homo
sapiens) 		5 / 10 ASP B 300
GLY A  56
GLY A  57
SER A 150
HIS B 429
 None
S35  A1259 ( 3.7A)
S35  A1259 ( 3.6A)
S35  A1259 ( 3.8A)
S35  A1259 ( 3.9A)
 0.96A 1w76B-4az3B:
undetectable		 1w76B-4az3B:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
(Homo
sapiens) 		5 / 12 LEU A  74
ALA B 308
MET B 333
LEU B 313
THR B 433
 None
NAG  A3020 ( 4.0A)
S35  A1259 ( 3.9A)
None
None
 1.35A 1ya3A-4az3A:
undetectable		 1ya3A-4az3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
(Homo
sapiens) 		5 / 12 LEU A  74
ALA B 308
MET B 333
LEU B 313
THR B 433
 None
NAG  A3020 ( 4.0A)
S35  A1259 ( 3.9A)
None
None
 1.45A 1ya3B-4az3A:
undetectable		 1ya3B-4az3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
(Homo
sapiens) 		5 / 12 LEU A  74
ALA B 308
MET B 333
LEU B 313
THR B 433
 None
NAG  A3020 ( 4.0A)
S35  A1259 ( 3.9A)
None
None
 1.36A 2aa5B-4az3A:
undetectable		 2aa5B-4az3A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
(Homo
sapiens) 		5 / 12 THR B 306
ALA B 309
LEU A  67
LEU A  74
MET B 430
 None
None
None
None
S35  A1259 ( 4.6A)
 1.08A 2jfaA-4az3B:
undetectable		 2jfaA-4az3B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
(Homo
sapiens) 		5 / 12 LEU A  74
ALA B 308
MET B 333
LEU B 313
THR B 433
 None
NAG  A3020 ( 4.0A)
S35  A1259 ( 3.9A)
None
None
 1.37A 2oaxC-4az3A:
undetectable		 2oaxC-4az3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
(Homo
sapiens) 		5 / 12 THR B 306
ALA B 309
LEU A  67
LEU A  74
MET B 430
 None
None
None
None
S35  A1259 ( 4.6A)
 1.00A 3hm1A-4az3B:
undetectable		 3hm1A-4az3B:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLY A  56
GLY A  57
SER A 150
HIS B 429
 S35  A1259 ( 3.7A)
S35  A1259 ( 3.6A)
S35  A1259 ( 3.8A)
S35  A1259 ( 3.9A)
 0.82A 3o9mB-4az3A:
9.8		 3o9mB-4az3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 HIS B 429
GLU A  69
ASN A  55
 S35  A1259 ( 3.9A)
None
S35  A1259 ( 3.7A)
 0.99A 4bupB-4az3B:
undetectable		 4bupB-4az3B:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 HIS B 429
GLU A  69
ASN A  55
 S35  A1259 ( 3.9A)
None
S35  A1259 ( 3.7A)
 0.96A 5wbvA-4az3B:
undetectable		 5wbvA-4az3B:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 HIS B 429
GLU A  69
ASN A  55
 S35  A1259 ( 3.9A)
None
S35  A1259 ( 3.7A)
 0.97A 5wbvB-4az3B:
undetectable		 5wbvB-4az3B:
21.01