SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'S2C'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.48A 1v8bA-1p8rA:
2.3		 1v8bA-1p8rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.34A 1v8bA-4iu4A:
2.4		 1v8bA-4iu4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.48A 1v8bB-1p8rA:
undetectable		 1v8bB-1p8rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.34A 1v8bB-4iu4A:
2.4		 1v8bB-4iu4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.33A 1v8bD-4iu4A:
2.6		 1v8bD-4iu4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		4 / 6 LEU A 179
TYR A 176
ILE A 190
GLY A 142
 None
None
None
S2C  A 551 ( 3.9A)
 0.86A 2du8A-1p8rA:
3.1		 2du8A-1p8rA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		4 / 6 LEU A 179
TYR A 176
ILE A 190
GLY A 142
 None
None
None
S2C  A 551 ( 3.9A)
 0.79A 2du8B-1p8rA:
3.1		 2du8B-1p8rA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		3 / 3 SER A 137
GLU A 277
ASP A 274
 S2C  A 551 (-3.3A)
S2C  A 551 (-3.6A)
None
 0.75A 2zulA-1p8rA:
3.2		 2zulA-1p8rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		3 / 3 SER A 150
GLU A 288
ASP A 285
 S2C  A 405 (-2.5A)
S2C  A 405 (-3.6A)
None
 0.83A 2zulA-4iu4A:
undetectable		 2zulA-4iu4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		4 / 5 HIS A 141
ASP A 128
HIS A 126
ASP A 124
 S2C  A 551 (-3.7A)
MN  A 501 ( 2.6A)
MN  A 500 ( 3.2A)
MN  A 500 (-2.6A)
 1.25A 3c0zA-1p8rA:
13.3		 3c0zA-1p8rA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.47A 3ce6D-1p8rA:
2.6		 3ce6D-1p8rA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.32A 3ce6D-4iu4A:
2.3		 3ce6D-4iu4A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		3 / 3 SER A 137
GLU A 277
ASP A 274
 S2C  A 551 (-3.3A)
S2C  A 551 (-3.6A)
None
 0.72A 3dmhA-1p8rA:
undetectable		 3dmhA-1p8rA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		3 / 3 SER A 150
GLU A 288
ASP A 285
 S2C  A 405 (-2.5A)
S2C  A 405 (-3.6A)
None
 0.79A 3dmhA-4iu4A:
2.5		 3dmhA-4iu4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 ASP A 285
VAL A 244
GLY A 112
THR A 255
THR A 257
 None
None
None
None
S2C  A 405 (-3.4A)
 0.89A 3el5B-4iu4A:
undetectable		 3el5B-4iu4A:
16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 9 HIS A 126
ASN A 130
SER A 136
ASP A 183
GLU A 186
 MN  A 500 ( 3.2A)
S2C  A 551 (-3.9A)
S2C  A 551 ( 3.7A)
S2C  A 551 (-2.8A)
S2C  A 551 ( 4.2A)
 1.19A 3gn0A-1p8rA:
55.8		 3gn0A-1p8rA:
87.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		9 / 9 HIS A 126
ASP A 128
ASN A 130
SER A 137
HIS A 141
GLY A 142
ASP A 183
GLU A 186
THR A 246
 MN  A 500 ( 3.2A)
MN  A 501 ( 2.6A)
S2C  A 551 (-3.9A)
S2C  A 551 (-3.3A)
S2C  A 551 (-3.7A)
S2C  A 551 ( 3.9A)
S2C  A 551 (-2.8A)
S2C  A 551 ( 4.2A)
S2C  A 551 ( 4.3A)
 0.46A 3gn0A-1p8rA:
55.8		 3gn0A-1p8rA:
87.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4iu4 ARGINASE
(Leishmania
mexicana) 		9 / 9 HIS A 139
ASP A 141
ASN A 143
SER A 150
HIS A 154
GLY A 155
ASP A 194
GLU A 197
THR A 257
 MN  A 402 ( 3.4A)
MN  A 401 ( 2.5A)
S2C  A 405 (-3.8A)
S2C  A 405 (-2.5A)
S2C  A 405 (-3.2A)
S2C  A 405 ( 3.7A)
S2C  A 405 (-2.4A)
S2C  A 405 ( 4.2A)
S2C  A 405 (-3.4A)
 0.28A 3gn0A-4iu4A:
48.7		 3gn0A-4iu4A:
42.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 9 HIS A 126
ASN A 130
SER A 136
ASP A 183
GLU A 186
 MN  A 500 ( 3.2A)
S2C  A 551 (-3.9A)
S2C  A 551 ( 3.7A)
S2C  A 551 (-2.8A)
S2C  A 551 ( 4.2A)
 1.14A 3gn0B-1p8rA:
56.0		 3gn0B-1p8rA:
87.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		9 / 9 HIS A 126
ASP A 128
ASN A 130
SER A 137
HIS A 141
GLY A 142
ASP A 183
GLU A 186
THR A 246
 MN  A 500 ( 3.2A)
MN  A 501 ( 2.6A)
S2C  A 551 (-3.9A)
S2C  A 551 (-3.3A)
S2C  A 551 (-3.7A)
S2C  A 551 ( 3.9A)
S2C  A 551 (-2.8A)
S2C  A 551 ( 4.2A)
S2C  A 551 ( 4.3A)
 0.44A 3gn0B-1p8rA:
56.0		 3gn0B-1p8rA:
87.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4iu4 ARGINASE
(Leishmania
mexicana) 		9 / 9 HIS A 139
ASP A 141
ASN A 143
SER A 150
HIS A 154
GLY A 155
ASP A 194
GLU A 197
THR A 257
 MN  A 402 ( 3.4A)
MN  A 401 ( 2.5A)
S2C  A 405 (-3.8A)
S2C  A 405 (-2.5A)
S2C  A 405 (-3.2A)
S2C  A 405 ( 3.7A)
S2C  A 405 (-2.4A)
S2C  A 405 ( 4.2A)
S2C  A 405 (-3.4A)
 0.23A 3gn0B-4iu4A:
48.7		 3gn0B-4iu4A:
42.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.50A 3ondA-1p8rA:
undetectable		 3ondA-1p8rA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.35A 3ondA-4iu4A:
2.2		 3ondA-4iu4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.49A 3ondB-1p8rA:
undetectable		 3ondB-1p8rA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.35A 3ondB-4iu4A:
undetectable		 3ondB-4iu4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		4 / 6 ASP A 183
ASP A 232
ASP A 128
GLU A 186
 S2C  A 551 (-2.8A)
MN  A 500 (-3.1A)
MN  A 501 ( 2.6A)
S2C  A 551 ( 4.2A)
 1.32A 4gkhJ-1p8rA:
undetectable		 4gkhJ-1p8rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4iu4 ARGINASE
(Leishmania
mexicana) 		4 / 6 ASP A 194
ASP A 243
ASP A 141
GLU A 197
 S2C  A 405 (-2.4A)
MN  A 402 (-2.8A)
MN  A 401 ( 2.5A)
S2C  A 405 ( 4.2A)
 1.31A 4gkhJ-4iu4A:
undetectable		 4gkhJ-4iu4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.49A 5axdA-1p8rA:
2.2		 5axdA-1p8rA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.49A 5axdC-1p8rA:
2.5		 5axdC-1p8rA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.40A 5m5kB-1p8rA:
3.1		 5m5kB-1p8rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.30A 5m5kB-4iu4A:
2.1		 5m5kB-4iu4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.35A 5m66A-4iu4A:
2.3		 5m66A-4iu4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.47A 5m66C-1p8rA:
undetectable		 5m66C-1p8rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.33A 5m66C-4iu4A:
2.3		 5m66C-4iu4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		4 / 6 GLY A 185
PRO A 184
THR A 134
SER A 136
 None
None
None
S2C  A 551 ( 3.7A)
 1.01A 5ny7A-1p8rA:
1.9		 5ny7A-1p8rA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		4 / 8 ALA A 140
GLU A 197
ASP A 165
ILE A 160
 None
S2C  A 405 ( 4.2A)
None
None
 0.95A 5t8sA-4iu4A:
undetectable		 5t8sA-4iu4A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.32A 5utuF-4iu4A:
undetectable		 5utuF-4iu4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 PRO A 247
THR A 246
GLU A 277
HIS A 141
THR A 127
 None
S2C  A 551 ( 4.3A)
S2C  A 551 (-3.6A)
S2C  A 551 (-3.7A)
None
 1.31A 5xioB-1p8rA:
2.5		 5xioB-1p8rA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 1p8r ARGINASE 1
(Rattus
norvegicus) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 500 ( 3.2A)
MN  A 500 ( 2.1A)
None
S2C  A 551 ( 3.9A)
S2C  A 551 (-3.7A)
 1.45A 6f3nB-1p8rA:
2.2		 6f3nB-1p8rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 4iu4 ARGINASE
(Leishmania
mexicana) 		5 / 12 HIS A 139
ASP A 245
THR A 255
GLY A 155
HIS A 154
 MN  A 402 ( 3.4A)
MN  A 402 ( 2.0A)
None
S2C  A 405 ( 3.7A)
S2C  A 405 (-3.2A)
 1.31A 6f3nB-4iu4A:
undetectable		 6f3nB-4iu4A:
22.93