SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'S0N'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WD9_B_IBPB1570_1 (ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL)	5x8g	2-SUCCINYLBENZOATE-- COA LIGASE (Bacillus subtilis)	4 / 8	ILE A 197 GLY A 264 GLY A 287 THR A 289	CA A 505 ( 4.5A) S0N A 501 (-4.1A) S0N A 501 (-4.5A) CA A 505 (-3.3A)	0.53A	2wd9B-5x8gA: 42.3	2wd9B-5x8gA: 25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WD9_C_IBPC1570_1 (ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL)	5x8g	2-SUCCINYLBENZOATE-- COA LIGASE (Bacillus subtilis)	5 / 10	THR A 152 ILE A 197 GLY A 264 GLY A 287 THR A 289	None CA A 505 ( 4.5A) S0N A 501 (-4.1A) S0N A 501 (-4.5A) CA A 505 (-3.3A)	0.73A	2wd9C-5x8gA: 41.9	2wd9C-5x8gA: 25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZLC_A_VDXA500_1 (VITAMIN D3 RECEPTOR)	5x8g	2-SUCCINYLBENZOATE-- COA LIGASE (Bacillus subtilis)	5 / 12	LEU A 261 SER A 285 SER A 198 SER A 201 LEU A 247	S0N A 501 (-4.3A) S0N A 501 ( 4.4A) S0N A 501 (-2.8A) S0N A 501 ( 4.0A) None	1.18A	2zlcA-5x8gA: undetectable	2zlcA-5x8gA: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GN8_A_DEXA247_2 (GLUCOCORTICOID RECEPTOR 2)	5x8g	2-SUCCINYLBENZOATE-- COA LIGASE (Bacillus subtilis)	3 / 3	MET A 235 MET A 242 PHE A 283	None S0N A 501 ( 4.1A) None	1.13A	3gn8A-5x8gA: undetectable	3gn8A-5x8gA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	5x8g	2-SUCCINYLBENZOATE-- COA LIGASE (Bacillus subtilis)	5 / 12	LEU A 449 ALA A 450 GLU A 91 ILE A 388 GLY A 391	None None None None S0N A 501 (-4.0A)	1.05A	3q95B-5x8gA: undetectable	3q95B-5x8gA: 19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PAH_A_LNRA600_1 (PHENYLALANINE HYDROXYLASE)	5x8g	2-SUCCINYLBENZOATE-- COA LIGASE (Bacillus subtilis)	4 / 6	LEU A 386 HIS A 196 TYR A 452 GLU A 392	None S0N A 501 (-4.0A) None S0N A 501 (-4.0A)	0.84A	4pahA-5x8gA: undetectable	4pahA-5x8gA: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6PAH_A_DAHA600_1 (PHENYLALANINE 4-MONOOXYGENASE)	5x8g	2-SUCCINYLBENZOATE-- COA LIGASE (Bacillus subtilis)	4 / 6	LEU A 386 HIS A 196 TYR A 452 GLU A 392	None S0N A 501 (-4.0A) None S0N A 501 (-4.0A)	0.93A	6pahA-5x8gA: undetectable	6pahA-5x8gA: 22.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2WD9_B_IBPB1570_1","ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL","5x8g","2-SUCCINYLBENZOATE--COA LIGASE","Bacillus subtilis",4,"ILE A 197;GLY A 264;GLY A 287;THR A 289"," CA A 505 ( 4.5A);S0N A 501 (-4.1A);S0N A 501 (-4.5A); CA A 505 (-3.3A)","0.53A","2wd9B-5x8gA:42.3",null],["2WD9_C_IBPC1570_1","ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL","5x8g","2-SUCCINYLBENZOATE--COA LIGASE","Bacillus subtilis",5,"THR A 152;ILE A 197;GLY A 264;GLY A 287;THR A 289","None; CA A 505 ( 4.5A);S0N A 501 (-4.1A);S0N A 501 (-4.5A); CA A 505 (-3.3A)","0.73A","2wd9C-5x8gA:41.9","2wd9B-5x8gA:25.80"],["2ZLC_A_VDXA500_1","VITAMIN D3 RECEPTOR","5x8g","2-SUCCINYLBENZOATE--COA LIGASE","Bacillus subtilis",5,"LEU A 261;SER A 285;SER A 198;SER A 201;LEU A 247","S0N A 501 (-4.3A);S0N A 501 ( 4.4A);S0N A 501 (-2.8A);S0N A 501 ( 4.0A);None","1.18A","2zlcA-5x8gA:undetectable","2wd9C-5x8gA:25.80"],["3GN8_A_DEXA247_2","GLUCOCORTICOID RECEPTOR 2","5x8g","2-SUCCINYLBENZOATE--COA LIGASE","Bacillus subtilis",3,"MET A 235;MET A 242;PHE A 283","None;S0N A 501 ( 4.1A);None","1.13A","3gn8A-5x8gA:undetectable","2zlcA-5x8gA:19.47"],["3Q95_B_ESLB700_1","ESTROGEN RECEPTOR","5x8g","2-SUCCINYLBENZOATE--COA LIGASE","Bacillus subtilis",5,"LEU A 449;ALA A 450;GLU A  91;ILE A 388;GLY A 391","None;None;None;None;S0N A 501 (-4.0A)","1.05A","3q95B-5x8gA:undetectable","3gn8A-5x8gA:19.50"],["4PAH_A_LNRA600_1","PHENYLALANINE HYDROXYLASE","5x8g","2-SUCCINYLBENZOATE--COA LIGASE","Bacillus subtilis",4,"LEU A 386;HIS A 196;TYR A 452;GLU A 392","None;S0N A 501 (-4.0A);None;S0N A 501 (-4.0A)","0.84A","4pahA-5x8gA:undetectable","3q95B-5x8gA:19.40"],["6PAH_A_DAHA600_1","PHENYLALANINE 4-MONOOXYGENASE","5x8g","2-SUCCINYLBENZOATE--COA LIGASE","Bacillus subtilis",4,"LEU A 386;HIS A 196;TYR A 452;GLU A 392","None;S0N A 501 (-4.0A);None;S0N A 501 (-4.0A)","0.93A","6pahA-5x8gA:undetectable","4pahA-5x8gA:22.11"]]