SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RZX'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_A_BEZA11_0 (CES1 PROTEIN)	3pgl	CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 1 (Homo sapiens)	4 / 4	LEU A 150 SER A 154 LEU A 166 LEU A 101	None RZX A 257 ( 3.8A) None None	1.09A	1yajA-3pglA: 1.6	1yajA-3pglA: 16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_P_BEZP801_1 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	3pgl	CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 1 (Homo sapiens)	4 / 6	PHE A 151 SER A 154 ALA A 153 LEU A 97	None RZX A 257 ( 3.8A) RZX A 257 ( 4.9A) None	1.19A	5dzkB-3pglA: undetectable 5dzkP-3pglA: undetectable	5dzkB-3pglA: 21.93 5dzkP-3pglA: 2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_R_BEZR801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	3pgl	CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 1 (Homo sapiens)	4 / 7	PHE A 151 SER A 154 ALA A 153 LEU A 97	None RZX A 257 ( 3.8A) RZX A 257 ( 4.9A) None	1.10A	5dzkD-3pglA: undetectable 5dzkR-3pglA: undetectable	5dzkD-3pglA: 21.93 5dzkR-3pglA: 2.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YAJ_A_BEZA11_0","CES1 PROTEIN","3pgl","CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 1","Homo sapiens",4,"LEU A 150;SER A 154;LEU A 166;LEU A 101","None;RZX A 257 ( 3.8A);None;None","1.09A","1yajA-3pglA:1.6",null],["5DZK_P_BEZP801_1","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","3pgl","CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 1","Homo sapiens",4,"PHE A 151;SER A 154;ALA A 153;LEU A  97","None;RZX A 257 ( 3.8A);RZX A 257 ( 4.9A);None","1.19A","5dzkB-3pglA:undetectable;5dzkP-3pglA:undetectable","1yajA-3pglA:16.80"],["5DZK_R_BEZR801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","3pgl","CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 1","Homo sapiens",4,"PHE A 151;SER A 154;ALA A 153;LEU A  97","None;RZX A 257 ( 3.8A);RZX A 257 ( 4.9A);None","1.10A","5dzkD-3pglA:undetectable;5dzkR-3pglA:undetectable","5dzkB-3pglA:21.93;5dzkP-3pglA:2.22"]]