SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RXP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 8 THR A 204
ASP A 207
ASN A 208
LEU A 181
 None
None
None
RXP  A6001 (-3.9A)
 1.03A 1lhvA-1hv5A:
0.0		 1lhvA-1hv5A:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.44A 1os2A-1hv5A:
23.4		 1os2A-1hv5A:
49.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.41A 1os2D-1hv5A:
23.5		 1os2D-1hv5A:
49.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.29A 1uttA-1hv5A:
24.0		 1uttA-1hv5A:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.39A 1utzA-1hv5A:
24.1		 1utzA-1hv5A:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.39A 1utzB-1hv5A:
24.1		 1utzB-1hv5A:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		6 / 6 ILE A 180
HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 ( 3.8A)
ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.44A 1y93A-1hv5A:
24.2		 1y93A-1hv5A:
49.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		3 / 3 ASP A 194
ILE A 118
VAL A 216
 None
None
RXP  A6001 (-3.7A)
 0.71A 2avvD-1hv5A:
undetectable		 2avvD-1hv5A:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.37A 2hu6A-1hv5A:
24.6		 2hu6A-1hv5A:
49.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.40A 2jihA-1hv5A:
9.8		 2jihA-1hv5A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 8 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.44A 2jihB-1hv5A:
9.9		 2jihB-1hv5A:
18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.64A 2ow9A-1hv5A:
23.1		 2ow9A-1hv5A:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.42A 2ow9B-1hv5A:
22.9		 2ow9B-1hv5A:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.43A 2ozrC-1hv5A:
22.9		 2ozrC-1hv5A:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.50A 2ozrD-1hv5A:
23.1		 2ozrD-1hv5A:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.45A 2ozrE-1hv5A:
23.1		 2ozrE-1hv5A:
47.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		3 / 3 HIS A 183
GLU A 220
HIS A 223
 ZN  A5501 (-3.6A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
 0.62A 3ba0A-1hv5A:
22.0		 3ba0A-1hv5A:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.47A 3hy7A-1hv5A:
10.2		 3hy7A-1hv5A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 9 LEU A 181
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 (-3.9A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.43A 3hy7B-1hv5A:
10.2		 3hy7B-1hv5A:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 5 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.39A 3kecA-1hv5A:
23.1		 3kecA-1hv5A:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		3 / 3 HIS A 219
GLU A 220
HIS A 223
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
 0.20A 3kecB-1hv5A:
22.9		 3kecB-1hv5A:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.55A 3likA-1hv5A:
23.9		 3likA-1hv5A:
49.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.35A 3lilA-1hv5A:
24.0		 3lilA-1hv5A:
49.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 ILE A 180
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 ( 3.8A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.50A 3ljgA-1hv5A:
24.1		 3ljgA-1hv5A:
49.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.57A 3lkaA-1hv5A:
24.5		 3lkaA-1hv5A:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 6 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.63A 4a7bA-1hv5A:
22.9		 4a7bA-1hv5A:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
 ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
 0.32A 4a7bB-1hv5A:
23.1		 4a7bB-1hv5A:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		4 / 4 HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.38A 5n5jA-1hv5A:
24.5		 5n5jA-1hv5A:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1hv5 STROMELYSIN 3
(Mus
musculus) 		5 / 5 ILE A 180
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 ( 3.8A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.42A 5n5kA-1hv5A:
24.6		 5n5kA-1hv5A:
49.40