SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RWZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU A  67
PHE A 282
GLN A 287
ILE A 138
PHE A  63
 RWZ  A 502 ( 4.4A)
None
None
None
RWZ  A 502 (-3.8A)
 1.24A 1skxA-3wsbA:
2.0		 1skxA-3wsbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 VAL A 167
ALA A 168
GLY A 169
ALA A 260
TYR A 160
 RWZ  A 502 (-4.3A)
FPS  A 501 (-4.7A)
None
None
None
 1.14A 3qxyA-3wsbA:
undetectable		 3qxyA-3wsbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 11 VAL A 167
ALA A 168
GLY A 169
ALA A 260
TYR A 160
 RWZ  A 502 (-4.3A)
FPS  A 501 (-4.7A)
None
None
None
 1.15A 3rc0A-3wsbA:
undetectable		 3rc0A-3wsbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 VAL A 167
ALA A 168
GLY A 169
ALA A 260
TYR A 160
 RWZ  A 502 (-4.3A)
FPS  A 501 (-4.7A)
None
None
None
 1.13A 3rc0B-3wsbA:
undetectable		 3rc0B-3wsbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 ILE A 318
ALA A 290
LEU A 203
ILE A 285
THR A 293
 None
None
RWZ  A 502 (-4.6A)
None
None
 1.23A 3tq8A-3wsbA:
undetectable		 3tq8A-3wsbA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 ILE A 318
ALA A 290
LEU A 203
ILE A 285
THR A 293
 None
None
RWZ  A 502 (-4.6A)
None
None
 1.21A 4g8zX-3wsbA:
undetectable		 4g8zX-3wsbA:
20.86