SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RVA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 8 ILE A 365
GLY A 370
TYR A 119
SER A 304
GLU A 308
 RVA  A 454 (-4.0A)
None
None
None
None
 1.47A 1mrjA-3rv6A:
undetectable		 1mrjA-3rv6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 366
GLY A 370
TYR A 119
GLU A 372
 RVA  A 454 (-3.9A)
None
None
None
 1.10A 6gqiA-3rv6A:
undetectable		 6gqiA-3rv6A:
22.38