SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RS7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 7 HIS A 361
HIS A 541
HIS A 366
LEU A 597
 FE2  A 840 (-3.3A)
FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
RS7  A 841 (-3.4A)
 1.10A 1am6A-1loxA:
0.0		 1am6A-1loxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.07A 1kiaA-1loxA:
undetectable		 1kiaA-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.07A 1kiaB-1loxA:
undetectable		 1kiaB-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.08A 1kiaC-1loxA:
undetectable		 1kiaC-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.07A 1nbhB-1loxA:
undetectable		 1nbhB-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.14A 1nbiA-1loxA:
undetectable		 1nbiA-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		5 / 12 ILE A 290
GLY A 413
ALA A 404
TRP A 145
GLY A 423
 None
None
RS7  A 841 (-3.3A)
None
None
 1.12A 1nbiB-1loxA:
undetectable		 1nbiB-1loxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 PHE A 353
ARG A 364
ASN A 238
 RS7  A 841 (-4.7A)
None
None
 0.81A 1xzxX-1loxA:
undetectable		 1xzxX-1loxA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		4 / 8 MET A 419
PHE A 415
SER A 420
LEU A 358
 RS7  A 841 ( 4.1A)
RS7  A 841 ( 4.8A)
None
None
 1.05A 2o01A-1loxA:
0.0		 2o01A-1loxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1lox 15-LIPOXYGENASE
(Oryctolagus
cuniculus) 		3 / 3 LYS A 171
ILE A 414
PHE A 415
 None
None
RS7  A 841 ( 4.8A)
 0.86A 3j7zS-1loxA:
0.8
3j7za-1loxA:
undetectable		 3j7zS-1loxA:
9.37
3j7za-1loxA:
2.57