SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RPQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 125
GLY A 413
ALA A 410
ALA A 127
GLU A 461
 None
None
None
None
RPQ  A1204 (-3.9A)
 1.05A 2gluA-5mqmA:
undetectable		 2gluA-5mqmA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
(Bacteroides
thetaiotaomicron) 		5 / 12 THR A 411
HIS A 121
ILE A 646
HIS A 456
LEU A 128
 PG4  A1205 (-4.4A)
None
RPQ  A1204 ( 4.3A)
None
None
 1.29A 3gwxB-5mqmA:
undetectable		 3gwxB-5mqmA:
12.15