SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RMN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 HIS A 277
GLU A 212
ALA A 114
HIS A 238
 None
RMN  A 401 ( 4.4A)
None
RMN  A 401 ( 4.4A)
 1.29A 1errA-4p56A:
undetectable
1errB-4p56A:
undetectable		 1errA-4p56A:
21.90
1errB-4p56A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 8 PHE A  45
TRP A 274
LEU A 266
ASP A 236
 None
None
None
RMN  A 401 (-2.8A)
 0.89A 2bxkA-4p56A:
undetectable		 2bxkA-4p56A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		5 / 12 ASN A 312
ILE A 247
ILE A 236
PHE A 338
HIS A 261
 None
None
RMN  A1369 ( 4.8A)
None
CO  A1368 ( 3.3A)
 1.42A 2qmjA-3zgjA:
undetectable		 2qmjA-3zgjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 5 HIS A 146
VAL A  41
GLY A 271
ALA A 273
 RMN  A 401 (-4.2A)
None
None
None
 0.95A 5hwaA-4p56A:
undetectable		 5hwaA-4p56A:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IM2_A_BEZA401_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		4 / 4 TYR A  94
ARG A 170
PRO A 210
GLU A 212
 RMN  A 401 (-4.6A)
RMN  A 401 (-2.8A)
RMN  A 401 ( 4.4A)
RMN  A 401 ( 4.4A)
 0.95A 5im2A-4p56A:
40.9		 5im2A-4p56A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 8 LEU A 323
ILE A 236
THR A 234
GLN A 260
 None
RMN  A1369 ( 4.8A)
RMN  A1369 (-3.2A)
RMN  A1369 ( 4.7A)
 0.98A 5ljbA-3zgjA:
undetectable		 5ljbA-3zgjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 12 GLU A 212
ASP A 278
HIS A 146
ALA A 145
GLY A 231
 RMN  A 401 ( 4.4A)
None
RMN  A 401 (-4.2A)
None
None
 1.29A 5syeB-4p56A:
undetectable		 5syeB-4p56A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Streptomyces
coelicolor) 		4 / 8 LEU A 358
ILE A 236
PHE A 233
ALA A 263
 RMN  A1369 ( 4.1A)
RMN  A1369 ( 4.8A)
None
CO  A1368 ( 4.4A)
 0.85A 5y7pC-3zgjA:
undetectable		 5y7pC-3zgjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 4p56 PUTATIVE
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN
(Bordetella
bronchiseptica) 		5 / 10 PRO A 193
SER A 213
VAL A  41
PHE A  99
PHE A  89
 None
RMN  A 401 (-2.5A)
None
PGE  A 402 ( 4.5A)
None
 1.03A 6behA-4p56A:
undetectable
6behB-4p56A:
undetectable
6behC-4p56A:
undetectable		 6behA-4p56A:
20.95
6behB-4p56A:
20.95
6behC-4p56A:
20.95