SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RM4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2N27_A_4DYA205_1 (CALMODULIN)	2qlx	L-RHAMNOSE MUTAROTASE (Rhizobium leguminosarum)	5 / 11	LEU A 31 ILE A 27 MET A 82 MET A 86 LEU A 99	None None RM4 A 300 ( 4.9A) RM4 A 300 ( 3.6A) None	1.41A	2n27A-2qlxA: undetectable	2n27A-2qlxA: 19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NJZ_A_SALA370_1 (GENTISATE 1,2-DIOXYGENASE)	5u9e	HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAR (Bacteria Latreille et al. 1825)	5 / 12	HIS A 34 HIS A 36 HIS A 74 HIS A 51 ILE A 88	NI A 202 ( 3.4A) NI A 202 ( 3.3A) NI A 202 ( 3.3A) None RM4 A 201 (-4.2A)	1.25A	3njzA-5u9eA: 4.7	3njzA-5u9eA: 12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O94_A_NCAA192_0 (NICOTINAMIDASE)	2qlx	L-RHAMNOSE MUTAROTASE (Rhizobium leguminosarum)	5 / 11	PHE A 55 PHE A 8 TYR A 43 ILE A 45 SER A 44	None None RM4 A 300 (-4.6A) None None	1.41A	3o94A-2qlxA: undetectable	3o94A-2qlxA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O94_B_NCAB192_0 (NICOTINAMIDASE)	2qlx	L-RHAMNOSE MUTAROTASE (Rhizobium leguminosarum)	5 / 11	PHE A 55 PHE A 8 TYR A 43 ILE A 45 SER A 44	None None RM4 A 300 (-4.6A) None None	1.41A	3o94B-2qlxA: undetectable	3o94B-2qlxA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O94_C_NCAC192_0 (NICOTINAMIDASE)	2qlx	L-RHAMNOSE MUTAROTASE (Rhizobium leguminosarum)	5 / 11	PHE A 55 PHE A 8 TYR A 43 ILE A 45 SER A 44	None None RM4 A 300 (-4.6A) None None	1.41A	3o94C-2qlxA: undetectable	3o94C-2qlxA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O94_D_NCAD192_0 (NICOTINAMIDASE)	2qlx	L-RHAMNOSE MUTAROTASE (Rhizobium leguminosarum)	5 / 11	PHE A 55 PHE A 8 TYR A 43 ILE A 45 SER A 44	None None RM4 A 300 (-4.6A) None None	1.41A	3o94D-2qlxA: undetectable	3o94D-2qlxA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZMD_A_SALA201_1 (PUTATIVE TRANSCRIPTIONAL REGULATOR)	2qlx	L-RHAMNOSE MUTAROTASE (Rhizobium leguminosarum)	4 / 8	TRP A 78 TYR A 20 GLU A 19 HIS A 24	RM4 A 300 (-4.5A) RM4 A 300 (-4.3A) None RM4 A 300 (-4.1A)	1.43A	3zmdA-2qlxA: undetectable 3zmdB-2qlxA: undetectable	3zmdA-2qlxA: 23.46 3zmdB-2qlxA: 23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U14_A_0HKA2000_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M3,ENDOLYSIN,MUSCARI NIC ACETYLCHOLINE RECEPTOR M3)	5u9e	HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAR (Bacteria Latreille et al. 1825)	4 / 4	ASN A 86 LEU A 155 PHE A 66 TYR A 67	RM4 A 201 (-2.4A) None None None	1.39A	4u14A-5u9eA: undetectable	4u14A-5u9eA: 10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CI6_A_NBOA607_1 (SERUM ALBUMIN)	5u9e	HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAR (Bacteria Latreille et al. 1825)	4 / 7	ASP A 37 ALA A 70 LYS A 6 LEU A 7	None None None RM4 A 201 (-4.5A)	1.04A	6ci6A-5u9eA: undetectable	6ci6A-5u9eA: 17.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2N27_A_4DYA205_1","CALMODULIN","2qlx","L-RHAMNOSE MUTAROTASE","Rhizobium leguminosarum",5,"LEU A  31;ILE A  27;MET A  82;MET A  86;LEU A  99","None;None;RM4 A 300 ( 4.9A);RM4 A 300 ( 3.6A);None","1.41A","2n27A-2qlxA:undetectable",null],["3NJZ_A_SALA370_1","GENTISATE 1,2-DIOXYGENASE","5u9e","HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAR","Bacteria Latreille et al. 1825",5,"HIS A  34;HIS A  36;HIS A  74;HIS A  51;ILE A  88"," NI A 202 ( 3.4A); NI A 202 ( 3.3A); NI A 202 ( 3.3A);None;RM4 A 201 (-4.2A)","1.25A","3njzA-5u9eA:4.7","2n27A-2qlxA:19.61"],["3O94_A_NCAA192_0","NICOTINAMIDASE","2qlx","L-RHAMNOSE MUTAROTASE","Rhizobium leguminosarum",5,"PHE A  55;PHE A   8;TYR A  43;ILE A  45;SER A  44","None;None;RM4 A 300 (-4.6A);None;None","1.41A","3o94A-2qlxA:undetectable","3njzA-5u9eA:12.07"],["3O94_B_NCAB192_0","NICOTINAMIDASE","2qlx","L-RHAMNOSE MUTAROTASE","Rhizobium leguminosarum",5,"PHE A  55;PHE A   8;TYR A  43;ILE A  45;SER A  44","None;None;RM4 A 300 (-4.6A);None;None","1.41A","3o94B-2qlxA:undetectable","3o94A-2qlxA:21.43"],["3O94_C_NCAC192_0","NICOTINAMIDASE","2qlx","L-RHAMNOSE MUTAROTASE","Rhizobium leguminosarum",5,"PHE A  55;PHE A   8;TYR A  43;ILE A  45;SER A  44","None;None;RM4 A 300 (-4.6A);None;None","1.41A","3o94C-2qlxA:undetectable","3o94B-2qlxA:21.43"],["3O94_D_NCAD192_0","NICOTINAMIDASE","2qlx","L-RHAMNOSE MUTAROTASE","Rhizobium leguminosarum",5,"PHE A  55;PHE A   8;TYR A  43;ILE A  45;SER A  44","None;None;RM4 A 300 (-4.6A);None;None","1.41A","3o94D-2qlxA:undetectable","3o94C-2qlxA:21.43"],["3ZMD_A_SALA201_1","PUTATIVE TRANSCRIPTIONAL REGULATOR;PUTATIVE TRANSCRIPTIONAL REGULATOR","2qlx","L-RHAMNOSE MUTAROTASE","Rhizobium leguminosarum",4,"TRP A  78;TYR A  20;GLU A  19;HIS A  24","RM4 A 300 (-4.5A);RM4 A 300 (-4.3A);None;RM4 A 300 (-4.1A)","1.43A","3zmdA-2qlxA:undetectable;3zmdB-2qlxA:undetectable","3o94D-2qlxA:21.43"],["4U14_A_0HKA2000_2","MUSCARINIC ACETYLCHOLINE RECEPTOR M3,ENDOLYSIN,MUSCARINIC ACETYLCHOLINE RECEPTOR M3","5u9e","HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAR","Bacteria Latreille et al. 1825",4,"ASN A  86;LEU A 155;PHE A  66;TYR A  67","RM4 A 201 (-2.4A);None;None;None","1.39A","4u14A-5u9eA:undetectable","3zmdA-2qlxA:23.46;3zmdB-2qlxA:23.46"],["6CI6_A_NBOA607_1","SERUM ALBUMIN","5u9e","HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAR","Bacteria Latreille et al. 1825",4,"ASP A  37;ALA A  70;LYS A   6;LEU A   7","None;None;None;RM4 A 201 (-4.5A)","1.04A","6ci6A-5u9eA:undetectable","4u14A-5u9eA:10.80"]]