SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RLT'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L2U_A_ELVA397_1 (INTEGRASE)	4mda	MARINER MOS1 TRANSPOSASE (Drosophila mauritiana)	4 / 5	ASP A 156 ASP A 249 TYR A 276 PRO A 278	MN A 401 (-2.6A) MN A 401 ( 2.7A) RLT A 403 (-3.6A) RLT A 403 ( 4.9A)	0.73A	3l2uA-4mdaA: 9.6	3l2uA-4mdaA: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L2W_A_ELVA397_1 (INTEGRASE)	4mda	MARINER MOS1 TRANSPOSASE (Drosophila mauritiana)	4 / 5	ASP A 156 ASP A 249 TYR A 276 PRO A 278	MN A 401 (-2.6A) MN A 401 ( 2.7A) RLT A 403 (-3.6A) RLT A 403 ( 4.9A)	0.75A	3l2wA-4mdaA: 9.6	3l2wA-4mdaA: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3M_A_DLUA398_1 (PFV INTEGRASE)	4mda	MARINER MOS1 TRANSPOSASE (Drosophila mauritiana)	4 / 8	ASP A 156 ASP A 249 TYR A 276 PRO A 278	MN A 401 (-2.6A) MN A 401 ( 2.7A) RLT A 403 (-3.6A) RLT A 403 ( 4.9A)	0.83A	3s3mA-4mdaA: 10.2	3s3mA-4mdaA: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3N_A_DLUA398_1 (PFV INTEGRASE)	4mda	MARINER MOS1 TRANSPOSASE (Drosophila mauritiana)	4 / 8	ASP A 156 ASP A 249 TYR A 276 PRO A 278	MN A 401 (-2.6A) MN A 401 ( 2.7A) RLT A 403 (-3.6A) RLT A 403 ( 4.9A)	0.92A	3s3nA-4mdaA: 10.4	3s3nA-4mdaA: 19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3O_A_DLUA399_1 (PFV INTEGRASE)	4mda	MARINER MOS1 TRANSPOSASE (Drosophila mauritiana)	4 / 7	ASP A 156 ASP A 249 TYR A 276 PRO A 278	MN A 401 (-2.6A) MN A 401 ( 2.7A) RLT A 403 (-3.6A) RLT A 403 ( 4.9A)	0.83A	3s3oA-4mdaA: 10.3	3s3oA-4mdaA: 19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4MDB_A_RLTA401_1 (MARINER MOS1 TRANSPOSASE)	4mda	MARINER MOS1 TRANSPOSASE (Drosophila mauritiana)	5 / 6	ASP A 156 ASP A 249 ASN A 250 ALA A 274 ASP A 284	MN A 401 (-2.6A) MN A 401 ( 2.7A) RLT A 403 (-3.4A) None MN A 402 ( 2.0A)	1.39A	4mdbA-4mdaA: 35.2	4mdbA-4mdaA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4MDB_A_RLTA401_1 (MARINER MOS1 TRANSPOSASE)	4mda	MARINER MOS1 TRANSPOSASE (Drosophila mauritiana)	6 / 6	ASP A 156 ASP A 249 ASN A 250 ALA A 275 TYR A 276 ASP A 284	MN A 401 (-2.6A) MN A 401 ( 2.7A) RLT A 403 (-3.4A) RLT A 403 (-2.9A) RLT A 403 (-3.6A) MN A 402 ( 2.0A)	0.57A	4mdbA-4mdaA: 35.2	4mdbA-4mdaA: 100.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3L2U_A_ELVA397_1","INTEGRASE","4mda","MARINER MOS1 TRANSPOSASE","Drosophila mauritiana",4,"ASP A 156;ASP A 249;TYR A 276;PRO A 278"," MN A 401 (-2.6A); MN A 401 ( 2.7A);RLT A 403 (-3.6A);RLT A 403 ( 4.9A)","0.73A","3l2uA-4mdaA:9.6",null],["3L2W_A_ELVA397_1","INTEGRASE","4mda","MARINER MOS1 TRANSPOSASE","Drosophila mauritiana",4,"ASP A 156;ASP A 249;TYR A 276;PRO A 278"," MN A 401 (-2.6A); MN A 401 ( 2.7A);RLT A 403 (-3.6A);RLT A 403 ( 4.9A)","0.75A","3l2wA-4mdaA:9.6","3l2uA-4mdaA:19.54"],["3S3M_A_DLUA398_1","PFV INTEGRASE","4mda","MARINER MOS1 TRANSPOSASE","Drosophila mauritiana",4,"ASP A 156;ASP A 249;TYR A 276;PRO A 278"," MN A 401 (-2.6A); MN A 401 ( 2.7A);RLT A 403 (-3.6A);RLT A 403 ( 4.9A)","0.83A","3s3mA-4mdaA:10.2","3l2wA-4mdaA:19.54"],["3S3N_A_DLUA398_1","PFV INTEGRASE","4mda","MARINER MOS1 TRANSPOSASE","Drosophila mauritiana",4,"ASP A 156;ASP A 249;TYR A 276;PRO A 278"," MN A 401 (-2.6A); MN A 401 ( 2.7A);RLT A 403 (-3.6A);RLT A 403 ( 4.9A)","0.92A","3s3nA-4mdaA:10.4","3s3mA-4mdaA:19.54"],["3S3O_A_DLUA399_1","PFV INTEGRASE","4mda","MARINER MOS1 TRANSPOSASE","Drosophila mauritiana",4,"ASP A 156;ASP A 249;TYR A 276;PRO A 278"," MN A 401 (-2.6A); MN A 401 ( 2.7A);RLT A 403 (-3.6A);RLT A 403 ( 4.9A)","0.83A","3s3oA-4mdaA:10.3","3s3nA-4mdaA:19.54"],["4MDB_A_RLTA401_1","MARINER MOS1 TRANSPOSASE","4mda","MARINER MOS1 TRANSPOSASE","Drosophila mauritiana",5,"ASP A 156;ASP A 249;ASN A 250;ALA A 274;ASP A 284"," MN A 401 (-2.6A); MN A 401 ( 2.7A);RLT A 403 (-3.4A);None; MN A 402 ( 2.0A)","1.39A","4mdbA-4mdaA:35.2","3s3oA-4mdaA:19.54"],["4MDB_A_RLTA401_1","MARINER MOS1 TRANSPOSASE","4mda","MARINER MOS1 TRANSPOSASE","Drosophila mauritiana",6,"ASP A 156;ASP A 249;ASN A 250;ALA A 275;TYR A 276;ASP A 284"," MN A 401 (-2.6A); MN A 401 ( 2.7A);RLT A 403 (-3.4A);RLT A 403 (-2.9A);RLT A 403 (-3.6A); MN A 402 ( 2.0A)","0.57A","4mdbA-4mdaA:35.2","4mdbA-4mdaA:100.00"]]