SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RIS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.40A 1rqjA-2o1oA:
25.8		 1rqjA-2o1oA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.41A 1rqjB-2o1oA:
25.8		 1rqjB-2o1oA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		4 / 7 MET A 110
ASP A 111
ASP A 106
LYS A 258
 None
MG  A 909 (-2.4A)
None
RIS  A 901 (-2.7A)
 1.27A 1t03A-1rqjA:
undetectable		 1t03A-1rqjA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 1yhlA-1rqjA:
31.1		 1yhlA-1rqjA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.42A 1yhlA-2o1oA:
36.8		 1yhlA-2o1oA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.34A 1yq7A-1rqjA:
29.4		 1yq7A-1rqjA:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.42A 1yq7A-2o1oA:
35.7		 1yq7A-2o1oA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 10 ASP A 111
ARG A 116
GLN A 241
ASP A 244
LYS A 258
 MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 1.15A 1yv5A-1rqjA:
29.6		 1yv5A-1rqjA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.30A 1yv5A-1rqjA:
29.6		 1yv5A-1rqjA:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.37A 1yv5A-2o1oA:
36.0		 1yv5A-2o1oA:
32.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.36A 1zw5A-1rqjA:
30.4		 1zw5A-1rqjA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.40A 1zw5A-2o1oA:
36.1		 1zw5A-2o1oA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
 0.45A 2e91A-1rqjA:
21.5		 2e91A-1rqjA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 9 ASP A 105
ASP A 111
GLN A 179
LYS A 202
THR A 203
LYS A 268
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
MG  A 909 ( 4.2A)
 1.35A 2e91A-1rqjA:
21.5		 2e91A-1rqjA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.44A 2e91A-2o1oA:
24.1		 2e91A-2o1oA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
LYS A 268
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
MG  A 909 ( 4.2A)
 1.48A 2e91B-1rqjA:
20.5		 2e91B-1rqjA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
 0.62A 2e91B-1rqjA:
20.5		 2e91B-1rqjA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.57A 2e91B-2o1oA:
23.2		 2e91B-2o1oA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 ASP A 105
ASP A 111
ARG A 116
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 2f89F-1rqjA:
31.4		 2f89F-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
LYS A 210
THR A 211
TYR A 214
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.44A 2f89F-2o1oA:
36.7		 2f89F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 2f8cF-1rqjA:
30.6		 2f8cF-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.41A 2f8cF-2o1oA:
36.1		 2f8cF-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 10 ASP A 111
ARG A 116
GLN A 241
ASP A 244
LYS A 258
 MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 1.10A 2f8zF-1rqjA:
31.6		 2f8zF-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.38A 2f8zF-1rqjA:
31.6		 2f8zF-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.46A 2f8zF-2o1oA:
36.3		 2f8zF-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 12 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.68A 2f94F-1rqjA:
30.1		 2f94F-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
LYS A 210
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.71A 2f94F-2o1oA:
36.0		 2f94F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.41A 2f94F-2o1oA:
36.0		 2f94F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.30A 2f9kF-1rqjA:
30.2		 2f9kF-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.38A 2f9kF-2o1oA:
36.3		 2f9kF-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
 0.40A 2o1oA-1rqjA:
25.8		 2o1oA-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
LYS A 268
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
MG  A 909 ( 4.2A)
 1.09A 2o1oB-1rqjA:
26.6		 2o1oB-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
 0.42A 2o1oB-1rqjA:
26.6		 2o1oB-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 10 LEU A 102
ASP A 105
ARG A 116
GLN A 179
LYS A 202
ASP A 263
 None
MG  A 907 (-2.5A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
MG  A 908 ( 3.9A)
 1.19A 2q58A-1rqjA:
11.1		 2q58A-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 245
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
None
 0.56A 2q58A-1rqjA:
11.1		 2q58A-1rqjA:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ARG A 124
GLN A 184
ASP A 268
 None
MG  A 503 (-2.5A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
MG  A 501 ( 4.8A)
 0.99A 2q58A-2o1oA:
50.1		 2q58A-2o1oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		10 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
ASN A 254
ASP A 255
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
RIS  A 400 ( 2.3A)
None
 0.46A 2q58A-2o1oA:
50.1		 2q58A-2o1oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
 0.42A 2q58B-1rqjA:
26.5		 2q58B-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 9 ASP A 105
ASP A 111
GLN A 179
LYS A 202
THR A 203
LYS A 268
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
MG  A 909 ( 4.2A)
 1.23A 2q58B-1rqjA:
26.5		 2q58B-1rqjA:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
ASN A 254
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
RIS  A 400 ( 2.3A)
 0.47A 2q58B-2o1oA:
45.3		 2q58B-2o1oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 9 ASP A 115
ASP A 119
GLN A 184
LYS A 210
LYS A 273
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
MG  A 502 ( 4.5A)
 1.49A 2q58B-2o1oA:
45.3		 2q58B-2o1oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.28A 2qisA-1rqjA:
30.0		 2qisA-1rqjA:
26.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.36A 2qisA-2o1oA:
36.2		 2qisA-2o1oA:
32.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.39A 3ez3A-1rqjA:
29.3		 3ez3A-1rqjA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.55A 3ez3A-2o1oA:
37.4		 3ez3A-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 3ez3B-1rqjA:
29.1		 3ez3B-1rqjA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.39A 3ez3B-2o1oA:
36.6		 3ez3B-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.37A 3ez3C-1rqjA:
29.3		 3ez3C-1rqjA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.52A 3ez3C-2o1oA:
37.4		 3ez3C-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.33A 3ez3D-1rqjA:
28.8		 3ez3D-1rqjA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.42A 3ez3D-2o1oA:
36.4		 3ez3D-2o1oA:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.23A 3ez3D-2o1oA:
36.4		 3ez3D-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 10 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.40A 3ibaA-1rqjA:
30.8		 3ibaA-1rqjA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.48A 3ibaA-2o1oA:
36.7		 3ibaA-2o1oA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.37A 3ldwA-1rqjA:
29.1		 3ldwA-1rqjA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.55A 3ldwA-2o1oA:
37.3		 3ldwA-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 3ldwB-1rqjA:
29.1		 3ldwB-1rqjA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.42A 3ldwB-2o1oA:
36.7		 3ldwB-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.36A 3ldwC-1rqjA:
29.1		 3ldwC-1rqjA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.52A 3ldwC-2o1oA:
37.3		 3ldwC-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.30A 3ldwD-1rqjA:
28.8		 3ldwD-1rqjA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.44A 3ldwD-2o1oA:
36.5		 3ldwD-2o1oA:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.28A 3n45F-1rqjA:
30.3		 3n45F-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.39A 3n45F-2o1oA:
36.5		 3n45F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 3n46F-1rqjA:
30.0		 3n46F-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.37A 3n46F-2o1oA:
36.1		 3n46F-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		3 / 3 LYS A 258
ARG A  69
LEU A 102
 RIS  A 901 (-2.7A)
IPE  A 900 (-3.2A)
None
 1.41A 3v4tE-1rqjA:
undetectable		 3v4tE-1rqjA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 4kfaA-1rqjA:
30.0		 4kfaA-1rqjA:
25.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.36A 4kfaA-2o1oA:
35.7		 4kfaA-2o1oA:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 4kpdA-1rqjA:
31.2		 4kpdA-1rqjA:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.37A 4kpdA-2o1oA:
35.8		 4kpdA-2o1oA:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 4kpjA-1rqjA:
29.9		 4kpjA-1rqjA:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.34A 4kpjA-2o1oA:
35.7		 4kpjA-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.23A 4kpjA-2o1oA:
35.7		 4kpjA-2o1oA:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 4kq5A-1rqjA:
29.9		 4kq5A-1rqjA:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.37A 4kq5A-2o1oA:
35.9		 4kq5A-2o1oA:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 4kqsA-1rqjA:
31.2		 4kqsA-1rqjA:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.34A 4kqsA-2o1oA:
35.8		 4kqsA-2o1oA:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 4n9uA-1rqjA:
30.0		 4n9uA-1rqjA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.35A 4n9uA-2o1oA:
35.7		 4n9uA-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 211
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-3.7A)
 1.25A 4n9uA-2o1oA:
35.7		 4n9uA-2o1oA:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 12 ASP A 105
ASP A 111
THR A 203
GLN A 179
ASP A 248
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
IPE  A 900 ( 3.3A)
RIS  A 901 (-3.2A)
MG  A 908 ( 4.7A)
 1.22A 4ng6A-1rqjA:
30.6		 4ng6A-1rqjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 12 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.60A 4ng6A-1rqjA:
30.6		 4ng6A-1rqjA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 112
ARG A 124
GLN A 251
THR A 215
TYR A 214
 None
RIS  A 400 (-2.9A)
RIS  A 400 (-3.1A)
None
None
 1.39A 4ng6A-2o1oA:
35.9		 4ng6A-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.63A 4ng6A-2o1oA:
35.9		 4ng6A-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.40A 4ng6A-2o1oA:
35.9		 4ng6A-2o1oA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 112
ASP A 115
ASP A 119
THR A 211
GLN A 184
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-3.7A)
RIS  A 400 ( 3.5A)
 1.38A 4ng6A-2o1oA:
35.9		 4ng6A-2o1oA:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.52A 4nkeA-1rqjA:
30.1		 4nkeA-1rqjA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.38A 4nkeA-2o1oA:
35.5		 4nkeA-2o1oA:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.24A 4nkeA-2o1oA:
35.5		 4nkeA-2o1oA:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.38A 4nkfA-1rqjA:
30.0		 4nkfA-1rqjA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.40A 4nkfA-2o1oA:
35.7		 4nkfA-2o1oA:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.56A 4nuaA-1rqjA:
30.3		 4nuaA-1rqjA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.36A 4nuaA-2o1oA:
35.7		 4nuaA-2o1oA:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.23A 4nuaA-2o1oA:
35.7		 4nuaA-2o1oA:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.35A 4oguA-1rqjA:
29.7		 4oguA-1rqjA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.39A 4oguA-2o1oA:
35.6		 4oguA-2o1oA:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 4p0vA-1rqjA:
31.2		 4p0vA-1rqjA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.39A 4p0vA-2o1oA:
36.3		 4p0vA-2o1oA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.37A 4p0wA-1rqjA:
31.0		 4p0wA-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 11 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.41A 4p0wA-2o1oA:
36.6		 4p0wA-2o1oA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.29A 4q23A-1rqjA:
29.7		 4q23A-1rqjA:
25.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
None
RIS  A 400 (-3.1A)
 0.41A 4q23A-2o1oA:
35.7		 4q23A-2o1oA:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.29A 4rxdA-1rqjA:
30.1		 4rxdA-1rqjA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.40A 4rxdA-2o1oA:
36.6		 4rxdA-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.18A 4rxdA-2o1oA:
36.6		 4rxdA-2o1oA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.28A 4rxdB-1rqjA:
30.3		 4rxdB-1rqjA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.41A 4rxdB-2o1oA:
36.7		 4rxdB-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.20A 4rxdB-2o1oA:
36.7		 4rxdB-2o1oA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.28A 4rxdC-1rqjA:
30.4		 4rxdC-1rqjA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		8 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.41A 4rxdC-2o1oA:
36.7		 4rxdC-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 10 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.19A 4rxdC-2o1oA:
36.7		 4rxdC-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 8 SER A 101
LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
 0.66A 4umjA-1rqjA:
35.7		 4umjA-1rqjA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 8 SER A 101
LEU A 102
ASP A 105
ASP A 111
ARG A 116
MET A 175
LYS A 202
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 ( 4.5A)
RIS  A 901 (-2.5A)
 0.73A 4umjA-1rqjA:
35.7		 4umjA-1rqjA:
52.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 8 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
 0.70A 4umjA-2o1oA:
22.4		 4umjA-2o1oA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 9 SER A 101
LEU A 102
ASP A 105
ARG A 116
MET A 175
LYS A 202
THR A 203
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
RIS  A 901 (-2.7A)
RIS  A 901 ( 4.5A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
 0.68A 4umjB-1rqjA:
35.8		 4umjB-1rqjA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 SER A 101
LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
 0.53A 4umjB-1rqjA:
35.8		 4umjB-1rqjA:
52.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
 0.58A 4umjB-2o1oA:
22.5		 4umjB-2o1oA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.19A 4umjB-2o1oA:
22.5		 4umjB-2o1oA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 12 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.35A 5cg5A-1rqjA:
29.2		 5cg5A-1rqjA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		10 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
LYS A 210
THR A 211
TYR A 214
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
None
RIS  A 400 (-3.1A)
 0.37A 5cg5A-2o1oA:
36.1		 5cg5A-2o1oA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 12 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.29A 5cg6A-1rqjA:
30.1		 5cg6A-1rqjA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.21A 5cg6A-2o1oA:
36.6		 5cg6A-2o1oA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		9 / 12 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
GLN A 184
LYS A 210
THR A 211
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
 0.33A 5cg6A-2o1oA:
36.6		 5cg6A-2o1oA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
LYS A 202
GLN A 241
ASP A 244
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
 0.62A 5eroA-1rqjA:
26.2		 5eroA-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 9 LEU A 112
ASP A 115
ASP A 119
ARG A 124
LYS A 210
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.66A 5eroA-2o1oA:
24.7		 5eroA-2o1oA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 9 ASP A 105
ARG A 116
LYS A 202
ASP A 245
LYS A 258
 MG  A 907 (-2.5A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
None
RIS  A 901 (-2.7A)
 1.43A 5eroB-1rqjA:
26.3		 5eroB-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 9 ASP A 105
ASP A 111
ARG A 116
LYS A 202
GLN A 241
ASP A 244
ASP A 245
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 0.64A 5eroB-1rqjA:
26.3		 5eroB-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 9 ASP A 111
ARG A 116
GLN A 241
ASP A 244
ASP A 245
 MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 1.26A 5eroB-1rqjA:
26.3		 5eroB-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 9 ASP A 115
ASP A 119
ARG A 124
LYS A 210
GLN A 251
ASP A 255
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
None
 0.57A 5eroB-2o1oA:
24.5		 5eroB-2o1oA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 10 ASP A 105
ASP A 106
ASP A 111
ARG A 116
LYS A 202
GLN A 241
ASP A 244
ASP A 245
 MG  A 907 (-2.5A)
None
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 0.69A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 10 ASP A 105
ASP A 111
ARG A 116
LYS A 202
GLN A 241
ASP A 245
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
None
RIS  A 901 (-2.7A)
 1.09A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 10 ASP A 111
ASP A 106
ARG A 116
GLN A 241
ASP A 244
ASP A 245
 MG  A 909 (-2.4A)
None
RIS  A 901 (-2.7A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 1.30A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 10 ASP A 111
ASP A 113
GLN A 241
ASP A 244
ASP A 245
 MG  A 909 (-2.4A)
MG  A 907 ( 4.9A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 1.08A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 10 ASP A 113
ASP A 111
LYS A 202
GLN A 241
ASP A 244
ASP A 245
 MG  A 907 ( 4.9A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
None
 1.46A 5eroC-1rqjA:
26.3		 5eroC-1rqjA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		7 / 10 ASP A 115
ASP A 116
ASP A 119
ARG A 124
LYS A 210
GLN A 251
ASP A 255
 MG  A 503 (-2.5A)
None
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
None
 0.63A 5eroC-2o1oA:
24.7		 5eroC-2o1oA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 7 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
 1.06A 6g31A-1rqjA:
24.3		 6g31A-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 7 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.99A 6g31A-2o1oA:
24.6		 6g31A-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 6 ASP A 105
ASP A 111
ARG A 116
GLN A 179
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 ( 3.6A)
 0.71A 6g31B-1rqjA:
24.5		 6g31B-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 6 ASP A 115
ASP A 119
ARG A 124
GLN A 184
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.83A 6g31B-2o1oA:
24.5		 6g31B-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 5 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
 1.20A 6g31C-1rqjA:
24.7		 6g31C-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 5 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
 1.02A 6g31C-2o1oA:
24.2		 6g31C-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 7 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
GLN A 241
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 ( 3.6A)
 0.58A 6g31D-1rqjA:
23.8		 6g31D-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 7 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.65A 6g31D-2o1oA:
24.0		 6g31D-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		4 / 4 LEU A 102
ASP A 105
ASP A 111
ARG A 116
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
 0.37A 6g31E-1rqjA:
18.7		 6g31E-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 4 LEU A 112
ASP A 115
ASP A 119
ARG A 124
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
 0.43A 6g31E-2o1oA:
15.8		 6g31E-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 5 ASP A 105
ASP A 111
ARG A 116
GLN A 179
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 ( 3.6A)
 0.63A 6g31F-1rqjA:
24.6		 6g31F-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 5 ASP A 115
ASP A 119
ARG A 124
GLN A 184
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.84A 6g31F-2o1oA:
24.3		 6g31F-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 7 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
 0.64A 6g31G-1rqjA:
23.2		 6g31G-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		6 / 7 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.65A 6g31G-2o1oA:
23.9		 6g31G-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		4 / 5 ASP A 105
ASP A 111
GLN A 179
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-3.2A)
RIS  A 901 ( 3.6A)
 0.51A 6g31H-1rqjA:
23.3		 6g31H-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		4 / 5 ASP A 105
ASP A 111
GLN A 179
LYS A 268
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-3.2A)
MG  A 909 ( 4.2A)
 1.42A 6g31H-1rqjA:
23.3		 6g31H-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 5 ASP A 115
ASP A 119
GLN A 184
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.62A 6g31H-2o1oA:
23.5		 6g31H-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		4 / 4 ASP A 105
ASP A 111
LYS A 202
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
 0.95A 6g31I-1rqjA:
23.8		 6g31I-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 4 ASP A 115
ASP A 119
LYS A 210
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.86A 6g31I-2o1oA:
23.6		 6g31I-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 6 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
 0.86A 6g31J-1rqjA:
24.7		 6g31J-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 6 LEU A 102
ASP A 105
ASP A 111
GLN A 179
GLN A 241
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-3.2A)
RIS  A 901 ( 3.6A)
 0.60A 6g31J-1rqjA:
24.7		 6g31J-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 6 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
 0.87A 6g31J-2o1oA:
24.7		 6g31J-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 6 LEU A 112
ASP A 115
ASP A 119
GLN A 184
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.64A 6g31J-2o1oA:
24.7		 6g31J-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		4 / 4 ASP A 105
ASP A 111
ARG A 116
GLN A 179
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
 0.51A 6g31K-1rqjA:
22.5		 6g31K-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 4 ASP A 115
ASP A 119
ARG A 124
GLN A 184
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
 0.46A 6g31K-2o1oA:
23.2		 6g31K-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 6 ASP A 105
ASP A 111
ARG A 116
GLN A 179
GLN A 241
LYS A 268
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 ( 3.6A)
MG  A 909 ( 4.2A)
 1.15A 6g31L-1rqjA:
24.2		 6g31L-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		4 / 6 ASP A 115
ASP A 119
ARG A 124
GLN A 184
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
 0.67A 6g31L-2o1oA:
24.3		 6g31L-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE
(Cryptosporidium
parvum) 		5 / 6 ASP A 115
ASP A 119
GLN A 184
GLN A 251
LYS A 273
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
MG  A 502 ( 4.5A)
 1.28A 6g31L-2o1oA:
24.3		 6g31L-2o1oA:
12.85