SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RIP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 129
ARG A 141
PHE A 145
GLY A 109
 None
RIP  A 272 ( 2.6A)
None
None
 1.00A 1fapB-1drkA:
undetectable		 1fapB-1drkA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 8 LEU A 129
ARG A 141
PHE A 145
GLY A 109
 None
RIP  A 401 (-3.0A)
None
None
 0.86A 1fapB-2ioyA:
undetectable		 1fapB-2ioyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 9 ASP A  67
ASP A 162
SER A 193
ASP A 243
THR A 220
 None
RIP  A 401 (-3.0A)
None
RIP  A 401 (-2.6A)
RIP  A 401 ( 4.8A)
 1.17A 1m4iB-4ry0A:
0.0		 1m4iB-4ry0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		5 / 10 ASP A 115
ASN A 132
ILE A 167
GLY A 166
GLY A  93
 RIP  A 401 (-2.8A)
None
None
None
CL  A 402 (-3.5A)
 1.00A 1mehA-4ry0A:
undetectable		 1mehA-4ry0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 THR A 239
ASP A 237
GLY A 235
ILE A 209
ALA A 223
 None
RIP  A 301 (-2.8A)
None
None
None
 1.38A 1oltA-4zjpA:
undetectable		 1oltA-4zjpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		4 / 6 THR A 158
PHE A 187
PHE A  39
ASN A  87
 None
RIP  A 301 (-3.4A)
RIP  A 301 (-4.6A)
None
 1.49A 1tt0C-4zjpA:
undetectable		 1tt0C-4zjpA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 172
GLY A 165
GLY A 132
ALA A 171
ALA A 160
 None
None
None
None
RIP  A 301 (-3.3A)
 1.07A 2yvlA-4zjpA:
4.9		 2yvlA-4zjpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 172
GLY A 165
GLY A 132
ALA A 171
ALA A 160
 None
None
None
None
RIP  A 301 (-3.3A)
 1.08A 2yvlD-4zjpA:
undetectable		 2yvlD-4zjpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		5 / 12 PHE A 165
ALA A 195
ALA A 163
ILE A 234
THR A 218
 RIP  A 401 (-3.4A)
None
None
None
None
 1.23A 3dl9B-2ioyA:
undetectable		 3dl9B-2ioyA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 PRO A 161
PHE A 164
ALA A 138
 None
RIP  A 272 ( 2.8A)
None
 0.65A 3itaD-1drkA:
0.0		 3itaD-1drkA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 8 ASN A  39
ASP A 115
SER A 130
ASP A  90
 RIP  A 401 (-3.2A)
RIP  A 401 (-2.8A)
None
None
 1.07A 3sg9B-4ry0A:
undetectable		 3sg9B-4ry0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 7 PHE A  16
PHE A  15
ALA A 137
LEU A 266
 RIP  A 401 (-4.5A)
RIP  A 401 (-3.6A)
RIP  A 401 (-3.2A)
None
 0.92A 4ejgC-2ioyA:
undetectable		 4ejgC-2ioyA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 8 ASP A 243
ASP A  67
ASN A 132
ASP A 115
 RIP  A 401 (-2.6A)
None
None
RIP  A 401 (-2.8A)
 1.11A 4feuD-4ry0A:
undetectable		 4feuD-4ry0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 GLN A  91
HIS A 100
GLU A 140
ARG A  90
 None
None
None
RIP  A 272 ( 3.9A)
 1.40A 4qyqC-1drkA:
undetectable		 4qyqC-1drkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 LEU A 236
ASP A 215
GLU A 221
PRO A  14
 None
RIP  A 272 ( 2.6A)
None
None
 1.09A 4xi3C-1drkA:
0.0		 4xi3C-1drkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y9T_A_PA1A401_1
(ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		6 / 12 PHE A  41
ASP A 115
ARG A 116
ASP A 162
TRP A 192
GLN A 263
 RIP  A 401 ( 4.0A)
RIP  A 401 (-2.8A)
RIP  A 401 (-3.9A)
RIP  A 401 (-3.0A)
RIP  A 401 (-3.5A)
RIP  A 401 (-3.2A)
 0.64A 4y9tA-4ry0A:
35.4		 4y9tA-4ry0A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BR1_A_X6XA401_1
(ABC TRANSPORTER,
BINDING PROTEIN)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		6 / 11 PHE A  41
ASP A 115
ARG A 116
ASP A 162
TRP A 192
GLN A 263
 RIP  A 401 ( 4.0A)
RIP  A 401 (-2.8A)
RIP  A 401 (-3.9A)
RIP  A 401 (-3.0A)
RIP  A 401 (-3.5A)
RIP  A 401 (-3.2A)
 0.62A 5br1A-4ry0A:
35.3		 5br1A-4ry0A:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		4 / 7 ALA A 135
ASP A 104
GLY A 109
GLU A 110
 RIP  A 401 ( 4.8A)
None
None
None
 0.93A 5btgA-2ioyA:
undetectable
5btgC-2ioyA:
undetectable
5btgD-2ioyA:
3.7		 5btgA-2ioyA:
21.19
5btgC-2ioyA:
21.19
5btgD-2ioyA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 GLN A  91
HIS A 100
GLU A 140
ARG A  90
 None
None
None
RIP  A 272 ( 3.9A)
 1.40A 5hpwC-1drkA:
undetectable		 5hpwC-1drkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 4 THR A 132
THR A 135
ALA A 138
ARG A  90
 None
None
None
RIP  A 272 ( 3.9A)
 1.35A 5wm7A-1drkA:
5.0		 5wm7A-1drkA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Caldanaerobacter
subterraneus) 		6 / 12 LEU A 196
PHE A 215
GLY A 217
GLN A 236
ILE A 225
MET A 230
 None
None
None
RIP  A 401 (-3.2A)
None
None
 1.32A 5y2tA-2ioyA:
undetectable		 5y2tA-2ioyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1drk D-RIBOSE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 THR A 135
PHE A  16
PHE A  15
ASN A  13
ASN A  64
 None
RIP  A 272 ( 3.6A)
RIP  A 272 ( 2.6A)
RIP  A 272 ( 2.8A)
None
 1.26A 6h7jB-1drkA:
undetectable		 6h7jB-1drkA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ry0 PROBABLE RIBOSE ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN
(Rhizobium
etli) 		4 / 8 GLN A 263
VAL A 157
ARG A 168
ASP A 115
 RIP  A 401 (-3.2A)
None
RIP  A 401 (-2.9A)
RIP  A 401 (-2.8A)
 1.07A 6hu9a-4ry0A:
undetectable
6hu9e-4ry0A:
undetectable		 6hu9a-4ry0A:
19.04
6hu9e-4ry0A:
19.44