SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RI2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.48A 1c9sA-3q88A:
undetectable
1c9sK-3q88A:
undetectable		 1c9sA-3q88A:
10.28
1c9sK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.47A 1c9sA-3q88A:
undetectable
1c9sB-3q88A:
undetectable		 1c9sA-3q88A:
10.28
1c9sB-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.50A 1c9sE-3q88A:
undetectable
1c9sF-3q88A:
undetectable		 1c9sE-3q88A:
10.28
1c9sF-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.49A 1gtfA-3q88A:
undetectable
1gtfK-3q88A:
undetectable		 1gtfA-3q88A:
10.28
1gtfK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 6 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.44A 1gtnD-3q88A:
undetectable
1gtnE-3q88A:
undetectable		 1gtnD-3q88A:
10.28
1gtnE-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.46A 1utdA-3q88A:
undetectable
1utdB-3q88A:
undetectable		 1utdA-3q88A:
10.28
1utdB-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 8 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.46A 1utdB-3q88A:
undetectable
1utdC-3q88A:
undetectable		 1utdB-3q88A:
10.28
1utdC-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.46A 1utdC-3q88A:
undetectable
1utdD-3q88A:
undetectable		 1utdC-3q88A:
10.28
1utdD-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 8 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 1utdF-3q88A:
undetectable
1utdG-3q88A:
undetectable		 1utdF-3q88A:
10.28
1utdG-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 8 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.48A 1utdJ-3q88A:
undetectable
1utdK-3q88A:
undetectable		 1utdJ-3q88A:
10.28
1utdK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.48A 1utdA-3q88A:
undetectable
1utdK-3q88A:
undetectable		 1utdA-3q88A:
10.28
1utdK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 5 ASN A  73
ALA A 203
GLY A  25
THR A  64
 None
None
RI2  A 401 (-3.5A)
None
 0.86A 3dl9A-5yg7A:
undetectable		 3dl9A-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		3 / 3 MET A  19
CYH A 135
PRO A 163
 RI2  A 401 (-4.5A)
RI2  A 401 (-3.6A)
None
 1.00A 3h52C-5yg7A:
undetectable		 3h52C-5yg7A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 4 PHE A 241
LYS A 240
ILE A 307
THR A 245
 None
RI2  A 401 (-2.8A)
None
None
 0.96A 3ia4B-5yg7A:
2.9		 3ia4B-5yg7A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 237
TYR A 239
SER A  70
 RI2  A 401 ( 4.3A)
None
None
 0.94A 4at0A-5yg7A:
undetectable		 4at0A-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eeuA-3q88A:
undetectable
5eeuK-3q88A:
undetectable		 5eeuA-3q88A:
10.28
5eeuK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eevA-3q88A:
undetectable
5eevK-3q88A:
undetectable		 5eevA-3q88A:
10.28
5eevK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eewA-3q88A:
undetectable
5eewK-3q88A:
undetectable		 5eewA-3q88A:
10.28
5eewK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 10 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eexA-3q88A:
undetectable
5eexK-3q88A:
undetectable		 5eexA-3q88A:
10.28
5eexK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eeyA-3q88A:
undetectable
5eeyK-3q88A:
undetectable		 5eeyA-3q88A:
10.28
5eeyK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.49A 5eezJ-3q88A:
undetectable
5eezK-3q88A:
undetectable		 5eezJ-3q88A:
10.28
5eezK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5eezA-3q88A:
undetectable
5eezK-3q88A:
undetectable		 5eezA-3q88A:
10.28
5eezK-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.48A 5ef0J-3q88A:
undetectable
5ef0K-3q88A:
undetectable		 5ef0J-3q88A:
10.28
5ef0K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 10 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5ef0A-3q88A:
undetectable
5ef0K-3q88A:
undetectable		 5ef0A-3q88A:
10.28
5ef0K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5ef1A-3q88A:
undetectable
5ef1K-3q88A:
undetectable		 5ef1A-3q88A:
10.28
5ef1K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.49A 5ef2J-3q88A:
undetectable
5ef2K-3q88A:
undetectable		 5ef2J-3q88A:
10.28
5ef2K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 GLY A 144
THR A 203
THR A 206
ILE A 196
SER A 200
 None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
RI2  A 601 (-2.6A)
 1.47A 5ef2A-3q88A:
undetectable
5ef2K-3q88A:
undetectable		 5ef2A-3q88A:
10.28
5ef2K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		5 / 9 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.48A 5ef3J-3q88A:
undetectable
5ef3K-3q88A:
undetectable		 5ef3J-3q88A:
10.28
5ef3K-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		6 / 12 ALA A  34
LEU A  61
TYR A 239
ILE A 206
GLY A 202
PHE A 106
 None
None
None
None
RI2  A 401 ( 3.9A)
None
 1.38A 5eshA-5yg7A:
undetectable		 5eshA-5yg7A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 GLY A 259
GLY A 260
GLN A 498
 None
RI2  A 601 ( 3.8A)
RI2  A 601 (-4.6A)
 0.36A 5imsA-3q88A:
4.5		 5imsA-3q88A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 260
ALA A  24
PHE A 281
ASN A 204
LYS A 215
 None
RI2  A 401 (-3.6A)
RI2  A 401 (-4.4A)
RI2  A 401 (-2.7A)
RI2  A 401 (-2.8A)
 1.34A 5kc4E-5yg7A:
undetectable		 5kc4E-5yg7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A  72
LYS A 240
THR A  67
TYR A  62
 None
RI2  A 401 (-2.8A)
None
None
 1.28A 5x2sI-5yg7A:
undetectable
5x2sJ-5yg7A:
undetectable
5x2sK-5yg7A:
undetectable		 5x2sI-5yg7A:
20.90
5x2sJ-5yg7A:
20.55
5x2sK-5yg7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A  25
ALA A  31
SER A  70
LEU A  71
ASN A  73
 RI2  A 401 (-3.5A)
None
None
None
None
 1.18A 5x6yB-5yg7A:
2.4		 5x6yB-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 LEU A 150
THR A 206
ASN A 209
 None
RI2  A 601 ( 4.6A)
None
 0.72A 6baaE-3q88A:
undetectable		 6baaE-3q88A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 LEU A 150
THR A 206
ASN A 209
 None
RI2  A 601 ( 4.6A)
None
 0.72A 6baaF-3q88A:
undetectable		 6baaF-3q88A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 LEU A 150
THR A 206
ASN A 209
 None
RI2  A 601 ( 4.6A)
None
 0.72A 6baaG-3q88A:
undetectable		 6baaG-3q88A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Francisella
tularensis) 		3 / 3 LEU A 150
THR A 206
ASN A 209
 None
RI2  A 601 ( 4.6A)
None
 0.72A 6baaH-3q88A:
undetectable		 6baaH-3q88A:
15.24