SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RFP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 2hw2 RIFAMPIN ADP-RIBOSYL
TRANSFERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 TRP A 115
GLY A  60
GLU A  62
HIS A 118
GLY A 117
 None
RFP  A1200 (-3.4A)
None
None
None
 1.19A 1acjA-2hw2A:
undetectable		 1acjA-2hw2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 12 SER A 247
THR A 248
ILE A 414
LEU A 412
LEU A 428
 RFP  A   1 (-3.1A)
None
RFP  A   1 ( 4.2A)
None
None
 1.19A 3lcvB-1skxA:
undetectable		 3lcvB-1skxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		3 / 3 LEU A 239
HIS A 242
MET A 243
 None
None
RFP  A   1 (-3.5A)
 0.61A 3thrD-1skxA:
undetectable		 3thrD-1skxA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 6brd RIFAMPIN
MONOOXYGENASE
(Streptomyces
venezuelae) 		5 / 12 HIS A  46
ASP A 296
LEU A 292
GLY A 293
VAL A 327
 RFP  A 502 (-3.9A)
None
None
None
None
 1.23A 4fqsB-6brdA:
undetectable		 4fqsB-6brdA:
15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		7 / 12 LEU A 240
SER A 247
PHE A 251
ARG A 410
LEU A 411
ILE A 414
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-3.1A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
RFP  A   1 ( 4.2A)
None
 0.72A 4x1fA-1skxA:
37.9		 4x1fA-1skxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		6 / 12 MET A 243
PHE A 251
ARG A 410
LEU A 411
ILE A 414
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
RFP  A   1 ( 4.2A)
None
 0.86A 4x1fA-1skxA:
37.9		 4x1fA-1skxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		7 / 12 LEU A 240
SER A 247
PHE A 251
ARG A 410
LEU A 411
ILE A 414
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-3.1A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
RFP  A   1 ( 4.2A)
None
 0.73A 4x1gA-1skxA:
37.7		 4x1gA-1skxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		5 / 12 MET A 243
PHE A 251
ARG A 410
LEU A 411
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
None
 1.01A 4x1gA-1skxA:
37.7		 4x1gA-1skxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 6brd RIFAMPIN
MONOOXYGENASE
(Streptomyces
venezuelae) 		8 / 12 GLY A  44
PHE A  74
ARG A 196
GLY A 203
PHE A 257
THR A 285
GLY A 286
GLY A 287
 RFP  A 502 ( 4.4A)
RFP  A 502 (-4.5A)
RFP  A 502 (-3.4A)
RFP  A 502 ( 4.7A)
FAD  A 501 (-4.3A)
RFP  A 502 (-4.1A)
RFP  A 502 (-3.5A)
FAD  A 501 (-3.3A)
 0.60A 5koxA-6brdA:
63.4		 5koxA-6brdA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens) 		3 / 3 ARG A 410
LYS A 210
ARG A 413
 RFP  A   1 ( 4.2A)
RFP  A   1 (-3.5A)
None
 1.29A 6az3C-1skxA:
0.0
6az3L-1skxA:
0.0
6az3M-1skxA:
undetectable		 6az3C-1skxA:
10.53
6az3L-1skxA:
13.85
6az3M-1skxA:
11.26