SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RFH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		3 / 3 GLN A 287
HIS A 281
PRO A 283
 None
None
RFH  A 502 ( 4.2A)
 0.90A 1d8cA-6c7sA:
undetectable		 1d8cA-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		4 / 6 ARG A 196
GLY A 203
PHE A 202
PRO A 217
 RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
None
None
 1.33A 2m2oB-6c7sA:
undetectable		 2m2oB-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 ALA A  76
GLN A 287
PRO A 283
LEU A 331
LEU A 341
 None
None
RFH  A 502 ( 4.2A)
None
RFH  A 502 (-4.4A)
 1.24A 2nv4A-6c7sA:
undetectable		 2nv4A-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 ALA A  76
GLN A 287
PRO A 283
LEU A 331
LEU A 341
 None
None
RFH  A 502 ( 4.2A)
None
RFH  A 502 (-4.4A)
 1.38A 2nv4B-6c7sA:
undetectable		 2nv4B-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 ALA A  76
MET A 338
LEU A 341
ARG A 196
HIS A 281
 None
RFH  A 502 ( 3.9A)
RFH  A 502 (-4.4A)
RFH  A 502 (-3.1A)
None
 1.27A 3olsB-6c7sA:
undetectable		 3olsB-6c7sA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 LEU A  58
LEU A 104
LEU A 105
GLY A  44
LEU A  94
 None
None
None
RFH  A 502 ( 4.7A)
None
 1.07A 5gtrA-6c7sA:
undetectable		 5gtrA-6c7sA:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		6 / 12 ARG A  43
GLY A  44
PHE A  69
PHE A  74
GLY A 203
VAL A 205
 RFH  A 502 ( 3.6A)
RFH  A 502 ( 4.7A)
RFH  A 502 ( 4.8A)
RFH  A 502 (-3.4A)
RFH  A 502 (-3.6A)
None
 1.39A 5koxA-6c7sA:
68.4		 5koxA-6c7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		11 / 12 GLY A  44
PHE A  69
PHE A  74
ARG A 196
GLY A 203
VAL A 205
ILE A 215
PHE A 256
THR A 284
GLY A 285
GLY A 286
 RFH  A 502 ( 4.7A)
RFH  A 502 ( 4.8A)
RFH  A 502 (-3.4A)
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
None
RFH  A 502 (-3.7A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
FAD  A 501 ( 3.3A)
 0.43A 5koxA-6c7sA:
68.4		 5koxA-6c7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		9 / 12 PHE A  69
PHE A  74
ARG A 196
GLY A 203
VAL A 205
ILE A 215
PHE A 256
THR A 284
GLY A 285
 RFH  A 502 ( 4.8A)
RFH  A 502 (-3.4A)
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
None
RFH  A 502 (-3.7A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
 1.09A 5koxA-6c7sA:
68.4		 5koxA-6c7sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		7 / 12 HIS A  46
PHE A  74
LEU A 176
ARG A 196
PHE A 256
THR A 284
GLY A 285
 None
RFH  A 502 (-3.4A)
FAD  A 501 ( 4.6A)
RFH  A 502 (-3.1A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
 0.73A 6brdA-6c7sA:
63.3		 6brdA-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		6 / 12 HIS A  46
PHE A  74
LEU A 176
PHE A 256
THR A 284
GLY A 286
 None
RFH  A 502 (-3.4A)
FAD  A 501 ( 4.6A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
FAD  A 501 ( 3.3A)
 1.29A 6brdA-6c7sA:
63.3		 6brdA-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 HIS A  46
VAL A  71
ARG A 351
THR A 284
GLY A 285
 None
None
None
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
 1.24A 6brdA-6c7sA:
63.3		 6brdA-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		5 / 12 HIS A  46
ARG A 351
THR A 284
GLY A 285
GLY A 286
 None
None
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
FAD  A 501 ( 3.3A)
 1.16A 6brdB-6c7sA:
63.3		 6brdB-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		8 / 12 HIS A  46
PHE A  74
ARG A 196
GLY A 203
PHE A 256
THR A 284
GLY A 285
GLY A 286
 None
RFH  A 502 (-3.4A)
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
FAD  A 501 ( 3.3A)
 0.50A 6brdB-6c7sA:
63.3		 6brdB-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		7 / 12 HIS A  46
PHE A  74
ARG A 196
GLY A 203
PHE A 256
THR A 284
GLY A 286
 None
RFH  A 502 (-3.4A)
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
FAD  A 501 ( 3.3A)
 1.17A 6brdB-6c7sA:
63.3		 6brdB-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		4 / 6 VAL A  93
LEU A 176
ARG A 201
PRO A 283
 None
FAD  A 501 ( 4.6A)
None
RFH  A 502 ( 4.2A)
 0.53A 6brdB-6c7sA:
63.3		 6brdB-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		7 / 12 VAL A  71
ARG A 196
GLY A 203
PHE A 256
PRO A 283
THR A 284
GLY A 285
 None
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 ( 4.2A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
 0.90A 6brdC-6c7sA:
58.2		 6brdC-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		6 / 12 VAL A  71
GLY A 203
PHE A 256
PRO A 283
THR A 284
GLY A 285
 None
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 ( 4.2A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
 1.23A 6brdC-6c7sA:
58.2		 6brdC-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE
(Nocardia
farcinica) 		6 / 12 VAL A  71
GLY A 203
PHE A 256
PRO A 283
THR A 284
GLY A 286
 None
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 ( 4.2A)
RFH  A 502 (-4.0A)
FAD  A 501 ( 3.3A)
 1.37A 6brdC-6c7sA:
58.2		 6brdC-6c7sA:
74.03