SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RET'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		3 / 3 ALA A  35
VAL A  33
TRP A  32
 None
None
RET  A 201 (-4.5A)
 0.85A 1av2A-4i9rA:
undetectable
1av2B-4i9rA:
undetectable		 1av2A-4i9rA:
10.48
1av2B-4i9rA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		3 / 3 TRP A  32
ALA A  35
VAL A  33
 RET  A 201 (-4.5A)
None
None
 0.98A 1av2C-4i9rA:
undetectable
1av2D-4i9rA:
undetectable		 1av2C-4i9rA:
10.48
1av2D-4i9rA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		3 / 3 ALA A  36
VAL A  33
TRP A  32
 None
None
RET  A 201 (-4.5A)
 0.89A 1bdwA-4i9rA:
undetectable
1bdwB-4i9rA:
undetectable		 1bdwA-4i9rA:
10.48
1bdwB-4i9rA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		3 / 3 ALA A  35
VAL A  33
TRP A  32
 None
None
RET  A 201 (-4.5A)
 0.93A 1c4dC-4i9rA:
undetectable
1c4dD-4i9rA:
undetectable		 1c4dC-4i9rA:
10.48
1c4dD-4i9rA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1
(Homo
sapiens) 		4 / 7 THR A 217
SER A 214
PHE A 173
LEU A 258
 None
None
RET  A 400 (-3.6A)
RET  A 400 ( 4.9A)
 1.08A 1qcaA-3hx3A:
undetectable		 1qcaA-3hx3A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 7 GLY A 118
GLN A 122
ILE A 116
VAL A 115
 RET  A 301 (-3.1A)
None
None
RET  A 301 ( 4.2A)
 1.06A 1rxcC-6eyuA:
undetectable		 1rxcC-6eyuA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3am6 RHODOPSIN-2
(Acetabularia
acetabulum) 		4 / 5 ALA A  12
TYR A  56
ILE A  15
ASP A 207
 None
None
None
RET  A 301 ( 4.1A)
 1.22A 1upfA-3am6A:
undetectable		 1upfA-3am6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		3 / 3 ALA A  35
VAL A  33
TRP A  32
 None
None
RET  A 201 (-4.5A)
 0.87A 1w5uA-4i9rA:
undetectable
1w5uB-4i9rA:
undetectable		 1w5uA-4i9rA:
10.48
1w5uB-4i9rA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		3 / 3 TRP A  32
ALA A  35
VAL A  33
 RET  A 201 (-4.5A)
None
None
 0.93A 1w5uA-4i9rA:
undetectable
1w5uB-4i9rA:
undetectable		 1w5uA-4i9rA:
10.48
1w5uB-4i9rA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		4 / 5 ALA A 206
TYR A 208
ALA A 202
TYR A 204
 None
None
None
RET  A 301 (-4.1A)
 1.07A 1xl6A-4klyA:
undetectable
1xl6B-4klyA:
2.8		 1xl6A-4klyA:
23.87
1xl6B-4klyA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5ax0 RHODOPSIN I
(Acetabularia
acetabulum) 		4 / 4 LEU A  98
PRO A 189
ILE A 182
LEU A 181
 None
RET  A 301 (-4.1A)
None
None
 0.92A 1ya4B-5ax0A:
undetectable		 1ya4B-5ax0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5ax0 RHODOPSIN I
(Acetabularia
acetabulum) 		4 / 4 LEU A  98
PRO A 189
ILE A 182
LEU A 181
 None
RET  A 301 (-4.1A)
None
None
 1.06A 1ya4C-5ax0A:
undetectable		 1ya4C-5ax0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 12 CYH A 105
PRO A 104
ILE A 103
SER A 234
TYR A 238
 None
None
None
RET  A1273 (-3.2A)
None
 1.07A 1z9hD-5g2cA:
undetectable		 1z9hD-5g2cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4jq6 PROTEORHODOPSIN
(uncultured
bacterium) 		5 / 12 ILE A 139
GLY A 137
LEU A 114
VAL A  84
ILE A  88
 None
RET  A 301 (-4.1A)
None
RET  A 301 (-4.3A)
None
 1.21A 1zq9A-4jq6A:
undetectable		 1zq9A-4jq6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 7 ALA A 118
ASP A 119
GLY A 150
ILE A 149
 LFA  A 306 ( 4.2A)
None
RET  A 301 (-3.7A)
LFA  A 311 ( 4.3A)
 0.83A 2fxdB-4hyjA:
undetectable		 2fxdB-4hyjA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		3 / 3 TRP A  32
ALA A  35
VAL A  33
 RET  A 201 (-4.5A)
None
None
 0.76A 2izqC-4i9rA:
undetectable
2izqD-4i9rA:
undetectable		 2izqC-4i9rA:
10.48
2izqD-4i9rA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 5 PHE A 188
PHE A 270
SER A  79
PHE A 205
 RET  A1000 (-4.5A)
None
None
RET  A1000 ( 3.8A)
 1.33A 2v0mD-3aynA:
undetectable		 2v0mD-3aynA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4ww3 RHODOPSIN
(Todarodes
pacificus) 		4 / 5 PHE A 188
PHE A 270
SER A  79
PHE A 205
 RET  A 401 (-4.7A)
None
None
RET  A 401 (-3.6A)
 1.26A 2v0mD-4ww3A:
undetectable		 2v0mD-4ww3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 7 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.89A 2v2gA-6eyuA:
undetectable
2v2gB-6eyuA:
undetectable		 2v2gA-6eyuA:
undetectable
2v2gB-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 7 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.88A 2v2gA-6eyuA:
undetectable
2v2gB-6eyuA:
undetectable		 2v2gA-6eyuA:
undetectable
2v2gB-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 7 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.89A 2v2gC-6eyuA:
undetectable
2v2gD-6eyuA:
undetectable		 2v2gC-6eyuA:
undetectable
2v2gD-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 7 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.87A 2v2gC-6eyuA:
undetectable
2v2gD-6eyuA:
undetectable		 2v2gC-6eyuA:
undetectable
2v2gD-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 8 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.88A 2v32C-6eyuA:
undetectable
2v32D-6eyuA:
undetectable		 2v32C-6eyuA:
undetectable
2v32D-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 8 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.89A 2v32C-6eyuA:
undetectable
2v32D-6eyuA:
undetectable		 2v32C-6eyuA:
undetectable
2v32D-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 8 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.86A 2v41C-6eyuA:
undetectable
2v41D-6eyuA:
undetectable		 2v41C-6eyuA:
undetectable
2v41D-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 8 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.88A 2v41C-6eyuA:
undetectable
2v41D-6eyuA:
undetectable		 2v41C-6eyuA:
undetectable
2v41D-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 7 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.90A 2v41E-6eyuA:
undetectable
2v41F-6eyuA:
undetectable		 2v41E-6eyuA:
undetectable
2v41F-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 7 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.85A 2v41E-6eyuA:
undetectable
2v41F-6eyuA:
undetectable		 2v41E-6eyuA:
undetectable
2v41F-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		4 / 8 THR A  81
PRO A  82
VAL A  79
SER A  80
 RET  A 301 (-4.4A)
None
MUN  A 310 ( 4.7A)
RET  A 301 ( 4.2A)
 0.86A 2v41G-6eyuA:
undetectable
2v41H-6eyuA:
undetectable		 2v41G-6eyuA:
undetectable
2v41H-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN
(gamma
proteobacterium
'Hot
75m4') 		4 / 4 ALA A 206
TYR A 208
ALA A 202
TYR A 204
 None
None
None
RET  A 301 (-4.1A)
 1.09A 2wlkA-4klyA:
undetectable
2wlkB-4klyA:
2.0		 2wlkA-4klyA:
23.87
2wlkB-4klyA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5ax0 RHODOPSIN I
(Acetabularia
acetabulum) 		4 / 7 MET A 122
ALA A 149
ALA A 152
LEU A 181
 RET  A 301 (-3.7A)
R16  A 308 ( 3.8A)
None
None
 0.95A 2wx2A-5ax0A:
undetectable		 2wx2A-5ax0A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		3 / 3 TRP A 193
VAL A 188
TRP A 142
 RET  A 301 (-4.2A)
None
RET  A 301 (-4.5A)
 1.32A 2xdcC-4l35A:
undetectable
2xdcD-4l35A:
undetectable		 2xdcC-4l35A:
6.06
2xdcD-4l35A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		3 / 3 TRP A 193
VAL A 188
TRP A 142
 RET  A 301 (-4.2A)
None
RET  A 301 (-4.5A)
 1.35A 2y6nE-4l35A:
undetectable
2y6nF-4l35A:
undetectable		 2y6nE-4l35A:
6.06
2y6nF-4l35A:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 9 THR A  88
PHE A 170
LEU A 147
VAL A 150
LEU A 151
 RET  A 301 ( 4.6A)
None
None
None
None
 1.44A 2zb8A-4fbzA:
undetectable		 2zb8A-4fbzA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 12 PHE A  15
LEU A  19
PRO A  39
VAL A  54
THR A  56
 RET  A 201 (-4.4A)
None
RET  A 201 (-4.0A)
RET  A 201 ( 4.8A)
None
 0.87A 3cwkA-4i9rA:
24.8		 3cwkA-4i9rA:
96.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		5 / 9 ARG A 183
ALA A 223
ILE A  56
GLY A 228
ILE A 230
 ACT  A 303 (-3.4A)
RET  A 301 (-3.6A)
None
None
None
 1.07A 3el4B-4qidA:
undetectable		 3el4B-4qidA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 8 ALA A 118
ASP A 119
GLY A 150
ILE A 149
 LFA  A 306 ( 4.2A)
None
RET  A 301 (-3.7A)
LFA  A 311 ( 4.3A)
 0.83A 3el9A-4hyjA:
undetectable		 3el9A-4hyjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		4 / 8 ASP A 218
TYR A 191
LEU A  98
PRO A  97
 RET  A 255 (-4.4A)
RET  A 255 (-3.7A)
None
None
 1.25A 3jq7B-1uazA:
undetectable		 3jq7B-1uazA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 8 TYR A  73
VAL A 182
LEU A 205
PRO A 206
 None
None
None
RET  A 301 ( 4.7A)
 1.03A 3jq7C-1xioA:
undetectable		 3jq7C-1xioA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		3 / 3 TRP A  32
ALA A  35
VAL A  33
 RET  A 201 (-4.5A)
None
None
 0.83A 3l8lA-4i9rA:
undetectable
3l8lB-4i9rA:
undetectable		 3l8lA-4i9rA:
10.48
3l8lB-4i9rA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		3 / 3 TRP A  32
ALA A  35
VAL A  33
 RET  A 201 (-4.5A)
None
None
 0.79A 3l8lC-4i9rA:
undetectable
3l8lD-4i9rA:
undetectable		 3l8lC-4i9rA:
10.48
3l8lD-4i9rA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.07A 3sudA-4yziA:
undetectable		 3sudA-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.02A 3sudD-4yziA:
undetectable		 3sudD-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2
(Chlamydomonas
reinhardtii) 		5 / 12 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.11A 3sueB-4yziA:
undetectable		 3sueB-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2l6x GREEN-LIGHT
ABSORBING
PROTEORHODOPSIN
(uncultured
marine
gamma
proteobacterium
EBAC31A08) 		4 / 5 TYR A 204
ILE A 232
LEU A 233
LYS A 231
 None
None
None
RET  A 301 (-1.3A)
 1.11A 3sueC-2l6xA:
undetectable		 3sueC-2l6xA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4jq6 PROTEORHODOPSIN
(uncultured
bacterium) 		4 / 8 PHE A  15
ALA A  18
ASN A 206
THR A  83
 None
None
None
RET  A 301 (-4.3A)
 0.96A 3t3sF-4jq6A:
undetectable		 3t3sF-4jq6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 4ww3 RHODOPSIN
(Todarodes
pacificus) 		4 / 5 LEU A 165
ALA A 167
PHE A 120
ASN A 200
 None
None
RET  A 401 (-4.0A)
None
 1.42A 3uq6A-4ww3A:
undetectable		 3uq6A-4ww3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4ww3 RHODOPSIN
(Todarodes
pacificus) 		4 / 4 LEU A 165
ALA A 167
PHE A 120
ASN A 200
 None
None
RET  A 401 (-4.0A)
None
 1.39A 3vaqA-4ww3A:
undetectable		 3vaqA-4ww3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4ww3 RHODOPSIN
(Todarodes
pacificus) 		4 / 4 LEU A 165
ALA A 167
PHE A 120
ASN A 200
 None
None
RET  A 401 (-4.0A)
None
 1.38A 3vasA-4ww3A:
undetectable		 3vasA-4ww3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		4 / 5 LEU A 148
LEU A 182
THR A 141
TRP A 137
 None
None
RET  A 301 (-3.9A)
RET  A 301 (-4.7A)
 1.35A 4do3A-4fbzA:
undetectable		 4do3A-4fbzA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4l35 CRUXRHODOPSIN-3
(Haloarcula
vallismortis) 		4 / 5 LEU A 153
LEU A 187
THR A 146
TRP A 142
 None
None
RET  A 301 (-4.0A)
RET  A 301 (-4.5A)
 1.41A 4do3A-4l35A:
undetectable		 4do3A-4l35A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ax0 RHODOPSIN I
(Acetabularia
acetabulum) 		3 / 3 ARG A  80
TRP A 192
GLY A 193
 None
RET  A 301 ( 4.1A)
D12  A 306 ( 3.9A)
 0.82A 4e7cA-5ax0A:
undetectable		 4e7cA-5ax0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1e12 HALORHODOPSIN
(Halobacterium
salinarum) 		4 / 6 ALA A  40
ASN A  36
VAL A  35
ASP A 238
 None
None
None
RET  A 999 (-4.4A)
 1.02A 4g24A-1e12A:
0.8		 4g24A-1e12A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 8 ILE A 216
ILE A 266
PHE A 270
GLY A 119
 None
None
None
RET  A1000 ( 3.8A)
 0.75A 4hdlA-3aynA:
undetectable		 4hdlA-3aynA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4ww3 RHODOPSIN
(Todarodes
pacificus) 		4 / 8 ILE A 216
ILE A 266
PHE A 270
GLY A 119
 None
None
None
RET  A 401 (-3.8A)
 0.76A 4hdlA-4ww3A:
undetectable		 4hdlA-4ww3A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 12 GLY A 139
GLY A 142
ILE A 137
ILE A 136
SER A 160
 RET  A1273 ( 3.7A)
None
OLA  A1276 ( 4.4A)
None
RET  A1273 (-3.3A)
 1.07A 4iv0B-5g2cA:
undetectable		 4iv0B-5g2cA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5g2c CHLORIDE PUMPING
RHODOPSIN
(Nonlabens
marinus) 		5 / 12 GLY A 139
GLY A 142
ILE A 137
ILE A 136
SER A 160
 RET  A1273 ( 3.7A)
None
OLA  A1276 ( 4.4A)
None
RET  A1273 (-3.3A)
 1.07A 4mwzA-5g2cA:
undetectable		 4mwzA-5g2cA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 12 GLY A  30
THR A  46
ILE A  48
THR A  88
GLY A 220
 22B  A 302 (-3.6A)
22B  A 302 (-3.9A)
None
RET  A 301 ( 4.6A)
None
 1.24A 4n48A-4fbzA:
undetectable		 4n48A-4fbzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3ddl XANTHORHODOPSIN
(Salinibacter
ruber) 		3 / 3 PRO A 210
MET A 211
TYR A 207
 None
SXN  A1401 (-3.8A)
RET  A1301 (-3.8A)
 0.83A 4qa2B-3ddlA:
undetectable		 4qa2B-3ddlA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4ww3 RHODOPSIN
(Todarodes
pacificus) 		4 / 7 PRO A 276
PHE A 303
TRP A 274
PHE A  83
 None
None
RET  A 401 ( 4.4A)
None
 1.29A 4v32A-4ww3A:
undetectable		 4v32A-4ww3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 8 PHE A 213
SER A 209
TRP A 176
TYR A 179
 None
RET  A 301 ( 4.3A)
RET  A 301 (-3.4A)
RET  A 301 (-3.5A)
 1.21A 5amiB-1xioA:
undetectable		 5amiB-1xioA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4tl3 ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 8 PHE A 213
SER A 209
TRP A 176
TYR A 179
 None
RET  A 301 ( 4.1A)
RET  A 301 (-3.8A)
RET  A 301 (-3.3A)
 1.29A 5amiB-4tl3A:
undetectable		 5amiB-4tl3A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3ddl XANTHORHODOPSIN
(Salinibacter
ruber) 		4 / 6 LEU A 196
TRP A 200
PRO A 204
GLU A 141
 None
RET  A1301 (-3.9A)
RET  A1301 ( 4.2A)
RET  A1301 ( 3.8A)
 1.21A 5b8iA-3ddlA:
undetectable		 5b8iA-3ddlA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		5 / 12 TYR A 185
TRP A 189
ILE A 148
GLY A 116
ILE A 117
 RET  A 999 (-3.5A)
RET  A 999 ( 4.3A)
None
ARC  A1002 ( 3.8A)
ARC  A1002 (-4.6A)
 0.99A 5d4uC-1brrA:
undetectable		 5d4uC-1brrA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		5 / 12 TYR A 185
TRP A 189
ILE A 148
GLY A 116
ILE A 117
 RET  A 999 (-3.5A)
RET  A 999 ( 4.3A)
None
ARC  A1002 ( 3.8A)
ARC  A1002 (-4.6A)
 0.95A 5d4uD-1brrA:
undetectable		 5d4uD-1brrA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3ddl XANTHORHODOPSIN
(Salinibacter
ruber) 		5 / 12 ASP A  96
THR A 100
PRO A 162
ILE A 161
TYR A  94
 None
RET  A1301 ( 4.8A)
None
UNL  A1409 ( 4.9A)
None
 1.23A 5dlvA-3ddlA:
undetectable		 5dlvA-3ddlA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4qid BACTERIORHODOPSIN-I
(Haloquadratum
walsbyi) 		4 / 4 VAL A 218
ALA A 223
ILE A 192
THR A 189
 None
RET  A 301 (-3.6A)
None
None
 1.01A 5e4dB-4qidA:
undetectable		 5e4dB-4qidA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5ax0 RHODOPSIN I
(Acetabularia
acetabulum) 		5 / 12 LYS A 137
PHE A 141
GLY A 126
ASP A  89
ALA A 196
 None
R16  A 308 (-4.8A)
RET  A 301 ( 3.8A)
RET  A 301 ( 4.9A)
None
 1.11A 5kpcB-5ax0A:
undetectable		 5kpcB-5ax0A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		4 / 8 LEU A  19
ILE A  63
TRP A 109
MET A 123
 None
RET  A 201 ( 4.7A)
RET  A 201 (-3.7A)
RET  A 201 (-4.6A)
 1.00A 5ljbA-4i9rA:
19.5		 5ljbA-4i9rA:
43.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		4 / 7 LEU A  19
ILE A  63
TRP A 109
MET A 123
 None
RET  A 201 ( 4.7A)
RET  A 201 (-3.7A)
RET  A 201 (-4.6A)
 1.02A 5ljcA-4i9rA:
19.6		 5ljcA-4i9rA:
43.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2
(Homo
sapiens) 		4 / 7 LEU A  22
ILE A  63
TRP A 109
MET A 123
 None
RET  A 201 ( 4.7A)
RET  A 201 (-3.7A)
RET  A 201 (-4.6A)
 1.45A 5ljcA-4i9rA:
19.6		 5ljcA-4i9rA:
43.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_B_ACTB302_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 5 GLU A 130
TYR A 198
TYR A  83
ARG A  82
 None
RET  A 301 (-4.3A)
None
None
 1.49A 5mthA-4hyjA:
undetectable
5mthB-4hyjA:
undetectable		 5mthA-4hyjA:
23.05
5mthB-4hyjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 4hyj RHODOPSIN
(Exiguobacterium
sibiricum) 		4 / 5 GLU A 130
TYR A 198
TYR A  83
ARG A  82
 None
RET  A 301 (-4.3A)
None
None
 1.47A 5mthH-4hyjA:
undetectable
5mthL-4hyjA:
undetectable		 5mthH-4hyjA:
23.05
5mthL-4hyjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 7 GLY A 191
TRP A 183
TYR A  73
ASP A 198
 None
RET  A 301 (-3.8A)
None
None
 1.20A 5vlmG-1xioA:
undetectable		 5vlmG-1xioA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3ddl XANTHORHODOPSIN
(Salinibacter
ruber) 		4 / 5 ALA A 146
SER A 143
GLY A 140
TYR A 207
 None
None
None
RET  A1301 (-3.8A)
 0.92A 5yodB-3ddlA:
undetectable		 5yodB-3ddlA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3ddl XANTHORHODOPSIN
(Salinibacter
ruber) 		4 / 5 ALA A 146
SER A 143
GLY A 140
TYR A 207
 None
None
None
RET  A1301 (-3.8A)
 1.10A 5yodD-3ddlA:
undetectable		 5yodD-3ddlA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5ax0 RHODOPSIN I
(Acetabularia
acetabulum) 		5 / 12 ALA A  50
MET A 122
ALA A 149
ALA A 152
LEU A 181
 D10  A 309 ( 3.8A)
RET  A 301 (-3.7A)
R16  A 308 ( 3.8A)
None
None
 1.35A 6aycA-5ax0A:
undetectable		 6aycA-5ax0A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 6 TRP A 274
MET A  92
GLY A  45
ALA A 306
 RET  A1000 (-4.2A)
None
None
None
 1.09A 6fosA-3aynA:
3.1		 6fosA-3aynA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4ww3 RHODOPSIN
(Todarodes
pacificus) 		4 / 6 TRP A 274
MET A  92
GLY A  45
ALA A 306
 RET  A 401 ( 4.4A)
None
None
None
 0.93A 6fosA-4ww3A:
2.5		 6fosA-4ww3A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_A_HSMA401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 9 TYR A 191
GLU A 210
GLU A 200
TYR A  89
ASP A 218
 RET  A 255 (-3.7A)
None
None
None
RET  A 255 (-4.4A)
 1.35A 6fu4A-1uazA:
0.0		 6fu4A-1uazA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_A_HSMA401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 9 TYR A 184
GLU A 204
GLU A 193
TYR A  82
ASP A 212
 RET  A 301 (-3.5A)
None
None
None
RET  A 301 (-4.5A)
 1.39A 6fu4A-4fbzA:
0.0		 6fu4A-4fbzA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_B_HSMB401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 9 TYR A 191
GLU A 210
GLU A 200
TYR A  89
ASP A 218
 RET  A 255 (-3.7A)
None
None
None
RET  A 255 (-4.4A)
 1.38A 6fu4B-1uazA:
0.0		 6fu4B-1uazA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_C_HSMC401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 9 TYR A 191
GLU A 210
GLU A 200
TYR A  89
ASP A 218
 RET  A 255 (-3.7A)
None
None
None
RET  A 255 (-4.4A)
 1.38A 6fu4C-1uazA:
0.0		 6fu4C-1uazA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_C_HSMC401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 9 TYR A 184
GLU A 204
GLU A 193
TYR A  82
ASP A 212
 RET  A 301 (-3.5A)
None
None
None
RET  A 301 (-4.5A)
 1.42A 6fu4C-4fbzA:
0.0		 6fu4C-4fbzA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_D_HSMD401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 1uaz ARCHAERHODOPSIN-1
(Halorubrum
chaoviator) 		5 / 9 TYR A 191
GLU A 210
GLU A 200
TYR A  89
ASP A 218
 RET  A 255 (-3.7A)
None
None
None
RET  A 255 (-4.4A)
 1.40A 6fu4D-1uazA:
0.0		 6fu4D-1uazA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_D_HSMD401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 4fbz DELTARHODOPSIN
(Haloterrigena
thermotolerans) 		5 / 9 TYR A 184
GLU A 204
GLU A 193
TYR A  82
ASP A 212
 RET  A 301 (-3.5A)
None
None
None
RET  A 301 (-4.5A)
 1.44A 6fu4D-4fbzA:
0.0		 6fu4D-4fbzA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 6eyu BACTERIORHODOPSIN
(Candidatus
Nanosalina
sp.
J07AB43) 		5 / 10 ALA A 110
LEU A 114
VAL A 140
ILE A 170
LEU A  85
 MUN  A 319 ( 4.2A)
RET  A 301 ( 4.5A)
None
None
None
 1.05A 6h1lA-6eyuA:
undetectable		 6h1lA-6eyuA:
undetectable