SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RES'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N49_B_RITB301_1 (PROTEASE)	3k8c	RIBOSE 5-PHOSPHATE ISOMERASE (Trypanosoma cruzi)	4 / 7	ASP A 45 GLY A 74 ILE A 77 ALA A 54	None RES A 160 (-3.4A) None None	0.72A	1n49A-3k8cA: undetectable	1n49A-3k8cA: 19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_C_W9TC1005_1 (HEMOLYTIC LECTIN CEL-III)	3k8c	RIBOSE 5-PHOSPHATE ISOMERASE (Trypanosoma cruzi)	3 / 3	ASP A 10 GLY A 70 TYR A 46	RES A 160 (-3.1A) RES A 160 (-3.3A) RES A 160 ( 4.3A)	0.73A	3w9tC-3k8cA: undetectable	3w9tC-3k8cA: 17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_G_W9TG503_1 (HEMOLYTIC LECTIN CEL-III)	3k8c	RIBOSE 5-PHOSPHATE ISOMERASE (Trypanosoma cruzi)	3 / 3	ASP A 10 GLY A 70 TYR A 46	RES A 160 (-3.1A) RES A 160 (-3.3A) RES A 160 ( 4.3A)	0.73A	3w9tG-3k8cA: undetectable	3w9tG-3k8cA: 17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M93_B_ACTB304_0 (S25-26 FAB (IGG1K) HEAVY CHAIN S25-26 FAB (IGG1K) LIGHT CHAIN)	3k8c	RIBOSE 5-PHOSPHATE ISOMERASE (Trypanosoma cruzi)	4 / 4	GLY A 70 SER A 71 ARG A 113 PRO A 12	RES A 160 (-3.3A) RES A 160 (-3.2A) RES A 160 (-3.1A) RES A 160 ( 4.7A)	1.09A	4m93B-3k8cA: undetectable 4m93C-3k8cA: 0.0	4m93B-3k8cA: 20.54 4m93C-3k8cA: 21.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1N49_B_RITB301_1","PROTEASE;PROTEASE","3k8c","RIBOSE 5-PHOSPHATE ISOMERASE","Trypanosoma cruzi",4,"ASP A  45;GLY A  74;ILE A  77;ALA A  54","None;RES A 160 (-3.4A);None;None","0.72A","1n49A-3k8cA:undetectable",null],["3W9T_C_W9TC1005_1","HEMOLYTIC LECTIN CEL-III","3k8c","RIBOSE 5-PHOSPHATE ISOMERASE","Trypanosoma cruzi",3,"ASP A  10;GLY A  70;TYR A  46","RES A 160 (-3.1A);RES A 160 (-3.3A);RES A 160 ( 4.3A)","0.73A","3w9tC-3k8cA:undetectable","1n49A-3k8cA:19.02"],["3W9T_G_W9TG503_1","HEMOLYTIC LECTIN CEL-III","3k8c","RIBOSE 5-PHOSPHATE ISOMERASE","Trypanosoma cruzi",3,"ASP A  10;GLY A  70;TYR A  46","RES A 160 (-3.1A);RES A 160 (-3.3A);RES A 160 ( 4.3A)","0.73A","3w9tG-3k8cA:undetectable","3w9tC-3k8cA:17.66"],["4M93_B_ACTB304_0","S25-26 FAB (IGG1K) HEAVY CHAIN;S25-26 FAB (IGG1K) LIGHT CHAIN","3k8c","RIBOSE 5-PHOSPHATE ISOMERASE","Trypanosoma cruzi",4,"GLY A  70;SER A  71;ARG A 113;PRO A  12","RES A 160 (-3.3A);RES A 160 (-3.2A);RES A 160 (-3.1A);RES A 160 ( 4.7A)","1.09A","4m93B-3k8cA:undetectable;4m93C-3k8cA:0.0","3w9tG-3k8cA:17.66"]]