SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'REA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4tns PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		4 / 8 PHE A 151
THR A 152
ILE A 156
HIS A  59
 None
None
None
REA  A 201 (-4.7A)
 0.80A 1ei6D-4tnsA:
undetectable		 1ei6D-4tnsA:
16.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		12 / 12 PHE B 221
ALA B 225
CYH B 228
LEU B 259
LEU B 262
ILE B 263
ILE B 266
ARG B 269
SER B 280
PHE B 295
LEU B 298
LEU B 407
 REA  B 503 ( 4.8A)
REA  B 503 (-3.8A)
REA  B 503 (-3.1A)
None
REA  B 503 (-3.9A)
REA  B 503 (-4.4A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
None
None
 0.44A 1xdkB-5uanB:
38.3		 1xdkB-5uanB:
98.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		3 / 3 LEU B 224
PHE B 279
ARG B 387
 REA  B 503 ( 4.0A)
REA  B 503 (-4.4A)
None
 0.50A 1xdkF-5uanB:
38.3		 1xdkF-5uanB:
98.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 12 PHE B 221
CYH B 228
LEU B 262
ARG B 265
ILE B 266
ARG B 269
PHE B 279
SER B 280
GLY B 384
LEU B 391
 REA  B 503 ( 4.8A)
REA  B 503 (-3.1A)
REA  B 503 (-3.9A)
None
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-4.4A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.4A)
None
 0.58A 2lbdA-5uanB:
38.0		 2lbdA-5uanB:
64.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		6 / 12 PHE B 221
LYS B 227
LEU B 262
PHE B 279
GLY B 384
LEU B 391
 REA  B 503 ( 4.8A)
None
REA  B 503 (-3.9A)
REA  B 503 (-4.4A)
REA  B 503 ( 4.4A)
None
 1.13A 2lbdA-5uanB:
38.0		 2lbdA-5uanB:
64.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.29A 2vdyA-2ve3A:
undetectable		 2vdyA-2ve3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.08A 2vdyB-2ve3A:
undetectable		 2vdyB-2ve3A:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 11 PHE B 221
CYH B 228
LEU B 262
ILE B 266
ARG B 269
PHE B 279
SER B 280
PHE B 295
VAL B 388
LEU B 391
 REA  B 503 ( 4.8A)
REA  B 503 (-3.1A)
REA  B 503 (-3.9A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-4.4A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
REA  B 503 ( 4.5A)
None
 0.36A 3a9eB-5uanB:
38.8		 3a9eB-5uanB:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 4tns PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		4 / 5 SER A 138
MET A 130
PHE A 125
ILE A 159
 None
REA  A 201 (-2.9A)
None
None
 1.49A 3g59A-4tnsA:
undetectable		 3g59A-4tnsA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 12 PHE B 221
ALA B 225
LEU B 259
LEU B 262
ILE B 266
ARG B 269
SER B 280
PHE B 295
GLY B 384
ILE B 403
 REA  B 503 ( 4.8A)
REA  B 503 (-3.8A)
None
REA  B 503 (-3.9A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
REA  B 503 ( 4.4A)
REA  B 503 ( 4.7A)
 0.60A 3lbdA-5uanB:
37.8		 3lbdA-5uanB:
64.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 8 PHE A 144
HIS A 101
GLY A 146
GLY A 136
 None
None
None
REA  A 602 (-3.4A)
 0.73A 3v3nB-5fhzA:
1.5		 3v3nB-5fhzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		4 / 8 PHE A 144
HIS A 101
GLY A 146
GLY A 136
 None
None
None
REA  A 602 (-3.4A)
 0.74A 3v3nC-5fhzA:
1.4		 3v3nC-5fhzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.29A 4c49B-2ve3A:
undetectable		 4c49B-2ve3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.35A 4c49C-2ve3A:
undetectable		 4c49C-2ve3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.27A 4c49D-2ve3A:
undetectable		 4c49D-2ve3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 323
THR A  95
TRP A  80
 HEM  A1444 (-2.7A)
None
REA  A1445 ( 3.9A)
 1.05A 4d7hA-2ve3A:
undetectable		 4d7hA-2ve3A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		11 / 11 PHE B 221
CYH B 228
LEU B 259
LEU B 262
ILE B 263
ARG B 269
PHE B 279
SER B 280
LEU B 298
LEU B 391
ILE B 403
 REA  B 503 ( 4.8A)
REA  B 503 (-3.1A)
None
REA  B 503 (-3.9A)
REA  B 503 (-4.4A)
REA  B 503 ( 4.8A)
REA  B 503 (-4.4A)
REA  B 503 (-2.1A)
None
None
REA  B 503 ( 4.7A)
 0.40A 4dm8A-5uanB:
38.5		 4dm8A-5uanB:
73.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A  69
PHE A 336
ILE A  46
GLY A 320
ALA A  64
 None
None
None
REA  A1445 (-4.5A)
None
 1.11A 4enhA-2ve3A:
41.4		 4enhA-2ve3A:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		5 / 11 ASN A 181
LEU A 185
MET A 186
TRP A 189
PHE A 477
 REA  A 602 (-3.9A)
None
REA  A 602 (-4.4A)
REA  A 602 ( 4.5A)
None
 1.41A 4fr8A-5fhzA:
62.7		 4fr8A-5fhzA:
63.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens) 		6 / 11 ASN A 181
PHE A 182
LEU A 185
MET A 186
TRP A 189
CYH A 314
 REA  A 602 (-3.9A)
REA  A 602 (-4.0A)
None
REA  A 602 (-4.4A)
REA  A 602 ( 4.5A)
REA  A 602 (-2.8A)
 0.82A 4fr8A-5fhzA:
62.7		 4fr8A-5fhzA:
63.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A  94
ALA A 254
GLU A 257
THR A 258
 REA  A1445 ( 3.7A)
HEM  A1444 (-3.3A)
None
HEM  A1444 ( 3.3A)
 0.79A 4r1zB-2ve3A:
36.4		 4r1zB-2ve3A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 323
THR A  95
TRP A  80
 HEM  A1444 (-2.7A)
None
REA  A1445 ( 3.9A)
 1.12A 4ug5A-2ve3A:
undetectable		 4ug5A-2ve3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 323
THR A  95
TRP A  80
 HEM  A1444 (-2.7A)
None
REA  A1445 ( 3.9A)
 1.05A 4uglA-2ve3A:
undetectable		 4uglA-2ve3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 323
THR A  95
TRP A  80
 HEM  A1444 (-2.7A)
None
REA  A1445 ( 3.9A)
 1.07A 5g6cA-2ve3A:
undetectable		 5g6cA-2ve3A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		11 / 12 TRP B 218
PHE B 221
ALA B 225
LEU B 262
ILE B 266
ARG B 269
SER B 280
PHE B 295
GLY B 384
LEU B 391
ILE B 403
 None
REA  B 503 ( 4.8A)
REA  B 503 (-3.8A)
REA  B 503 (-3.9A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
REA  B 503 ( 4.4A)
None
REA  B 503 ( 4.7A)
 0.55A 5m24A-5uanB:
37.8		 5m24A-5uanB:
62.43