SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RDF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 6 TRP A 604
ARG A 628
GLY A 563
ASP A 564
 None
RDF  A1665 (-2.6A)
None
None
 1.32A 1kf6M-3zukA:
undetectable
1kf6N-3zukA:
undetectable		 1kf6M-3zukA:
22.24
1kf6N-3zukA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 220
HIS A 223
GLY A 157
SER A 159
LEU A 153
 None
RDF  A2001 (-3.5A)
None
None
None
 1.43A 1kyvA-3dbkA:
undetectable
1kyvB-3dbkA:
undetectable		 1kyvA-3dbkA:
19.27
1kyvB-3dbkA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		4 / 4 ASP A 168
HIS A 140
ARG A 198
GLU A 164
 None
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.6A)
ZN  A 302 ( 2.2A)
 0.98A 1lqtA-3dbkA:
undetectable		 1lqtA-3dbkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 4 ASP A 671
HIS A 607
ARG A 738
GLU A 667
 None
ZN  A 771 ( 3.4A)
RDF  A 817 (-3.0A)
ZN  A 771 ( 2.1A)
 1.13A 1lqtA-3dwbA:
undetectable		 1lqtA-3dwbA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 4 ASP A 564
HIS A 493
ARG A 628
GLU A 560
 None
ZN  A1664 ( 3.4A)
RDF  A1665 (-2.6A)
ZN  A1664 ( 2.3A)
 0.97A 1lqtA-3zukA:
undetectable		 1lqtA-3zukA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		4 / 4 ASP A 163
HIS A 135
ARG A 191
GLU A 159
 None
ZN  A 401 ( 3.2A)
RDF  A 501 (-2.7A)
ZN  A 401 ( 1.9A)
 0.97A 1lqtA-4b52A:
undetectable		 1lqtA-4b52A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 4 ASP A 651
HIS A 584
ARG A 718
GLU A 647
 None
ZN  A 801 ( 3.3A)
RDF  A 802 (-2.7A)
ZN  A 801 ( 2.2A)
 1.07A 1lqtA-4zr5A:
undetectable		 1lqtA-4zr5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 8 GLU A 164
HIS A 140
HIS A 223
HIS A 144
GLU A 141
 ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-3.5A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.7A)
 1.23A 1v7zA-3dbkA:
undetectable		 1v7zA-3dbkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.75A 1v7zA-3dwbA:
undetectable		 1v7zA-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.83A 1v7zA-3zukA:
undetectable		 1v7zA-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.19A 1v7zA-4b52A:
undetectable		 1v7zA-4b52A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.79A 1v7zA-4zr5A:
undetectable		 1v7zA-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 8 GLU A 164
HIS A 140
HIS A 223
HIS A 144
GLU A 141
 ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-3.5A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.7A)
 1.23A 1v7zB-3dbkA:
undetectable		 1v7zB-3dbkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.75A 1v7zB-3dwbA:
undetectable		 1v7zB-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.84A 1v7zB-3zukA:
undetectable		 1v7zB-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.19A 1v7zB-4b52A:
undetectable		 1v7zB-4b52A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.80A 1v7zB-4zr5A:
undetectable		 1v7zB-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 8 GLU A 164
HIS A 140
HIS A 223
HIS A 144
GLU A 141
 ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-3.5A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.7A)
 1.23A 1v7zC-3dbkA:
undetectable		 1v7zC-3dbkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.76A 1v7zC-3dwbA:
undetectable		 1v7zC-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.84A 1v7zC-3zukA:
undetectable		 1v7zC-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.20A 1v7zC-4b52A:
undetectable		 1v7zC-4b52A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.80A 1v7zC-4zr5A:
undetectable		 1v7zC-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.78A 1v7zD-3dwbA:
undetectable		 1v7zD-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.86A 1v7zD-3zukA:
undetectable		 1v7zD-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.20A 1v7zD-4b52A:
undetectable		 1v7zD-4b52A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.81A 1v7zD-4zr5A:
undetectable		 1v7zD-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.78A 1v7zE-3dwbA:
undetectable		 1v7zE-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.87A 1v7zE-3zukA:
undetectable		 1v7zE-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.19A 1v7zE-4b52A:
undetectable		 1v7zE-4b52A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.82A 1v7zE-4zr5A:
undetectable		 1v7zE-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.77A 1v7zF-3dwbA:
undetectable		 1v7zF-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.85A 1v7zF-3zukA:
undetectable		 1v7zF-3zukA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.20A 1v7zF-4b52A:
undetectable		 1v7zF-4b52A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.81A 1v7zF-4zr5A:
undetectable		 1v7zF-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		4 / 7 ASN A 158
TYR A 150
ASN A 215
HIS A 219
 None
RDF  A 501 ( 4.7A)
None
RDF  A 501 (-3.6A)
 1.41A 1wu8A-4b52A:
undetectable
1wu8C-4b52A:
undetectable		 1wu8A-4b52A:
21.04
1wu8C-4b52A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 113
HIS A 140
GLU A 141
HIS A 144
GLU A 164
 RDF  A2001 (-4.3A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.7A)
ZN  A 302 ( 3.2A)
ZN  A 302 ( 2.2A)
 0.30A 2c6nA-3dbkA:
6.8		 2c6nA-3dbkA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 ALA A 567
HIS A 607
GLU A 608
HIS A 611
GLU A 667
 RDF  A 817 (-4.4A)
ZN  A 771 ( 3.4A)
RDF  A 817 (-2.4A)
ZN  A 771 ( 3.3A)
ZN  A 771 ( 2.1A)
 0.38A 2c6nA-3dwbA:
4.3		 2c6nA-3dwbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 453
HIS A 493
GLU A 494
HIS A 497
GLU A 560
 RDF  A1665 (-4.3A)
ZN  A1664 ( 3.4A)
RDF  A1665 (-2.5A)
ZN  A1664 (-3.1A)
ZN  A1664 ( 2.3A)
 0.37A 2c6nA-3zukA:
4.4		 2c6nA-3zukA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 12 ALA A 106
HIS A 135
GLU A 136
HIS A 139
GLU A 159
 RDF  A 501 (-4.7A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-2.5A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 1.9A)
 0.42A 2c6nA-4b52A:
5.4		 2c6nA-4b52A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 ALA A 544
HIS A 584
GLU A 585
HIS A 588
GLU A 647
 RDF  A 802 (-4.1A)
ZN  A 801 ( 3.3A)
RDF  A 802 (-2.7A)
ZN  A 801 ( 3.2A)
ZN  A 801 ( 2.2A)
 0.36A 2c6nA-4zr5A:
4.3		 2c6nA-4zr5A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 8 GLU A 164
HIS A 140
HIS A 223
HIS A 144
GLU A 141
 ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-3.5A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.7A)
 1.18A 3a6jA-3dbkA:
undetectable		 3a6jA-3dbkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.76A 3a6jA-3dwbA:
undetectable		 3a6jA-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.83A 3a6jA-3zukA:
undetectable		 3a6jA-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.16A 3a6jA-4b52A:
undetectable		 3a6jA-4b52A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.79A 3a6jA-4zr5A:
undetectable		 3a6jA-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 7 GLU A 164
HIS A 140
HIS A 223
HIS A 144
GLU A 141
 ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-3.5A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.7A)
 1.17A 3a6jB-3dbkA:
undetectable		 3a6jB-3dbkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.73A 3a6jB-3dwbA:
undetectable		 3a6jB-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.80A 3a6jB-3zukA:
undetectable		 3a6jB-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 7 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.14A 3a6jB-4b52A:
undetectable		 3a6jB-4b52A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 7 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.77A 3a6jB-4zr5A:
undetectable		 3a6jB-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 8 GLU A 164
HIS A 140
HIS A 223
HIS A 144
GLU A 141
 ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-3.5A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.7A)
 1.17A 3a6jC-3dbkA:
undetectable		 3a6jC-3dbkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.73A 3a6jC-3dwbA:
undetectable		 3a6jC-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.80A 3a6jC-3zukA:
undetectable		 3a6jC-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.15A 3a6jC-4b52A:
undetectable		 3a6jC-4b52A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.77A 3a6jC-4zr5A:
undetectable		 3a6jC-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 8 GLU A 164
HIS A 140
HIS A 223
HIS A 144
GLU A 141
 ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-3.5A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.7A)
 1.19A 3a6jE-3dbkA:
undetectable		 3a6jE-3dbkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.77A 3a6jE-3dwbA:
undetectable		 3a6jE-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.85A 3a6jE-3zukA:
undetectable		 3a6jE-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.16A 3a6jE-4b52A:
undetectable		 3a6jE-4b52A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.81A 3a6jE-4zr5A:
undetectable		 3a6jE-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		5 / 8 GLU A 164
HIS A 140
HIS A 223
HIS A 144
GLU A 141
 ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-3.5A)
ZN  A 302 ( 3.2A)
RDF  A2001 (-2.7A)
 1.18A 3a6jF-3dbkA:
undetectable		 3a6jF-3dbkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.73A 3a6jF-3dwbA:
undetectable		 3a6jF-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 560
HIS A 493
HIS A 497
GLU A 494
 ZN  A1664 ( 2.3A)
ZN  A1664 ( 3.4A)
ZN  A1664 (-3.1A)
RDF  A1665 (-2.5A)
 0.80A 3a6jF-3zukA:
undetectable		 3a6jF-3zukA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		5 / 8 GLU A 159
HIS A 135
HIS A 219
HIS A 139
GLU A 136
 ZN  A 401 ( 1.9A)
ZN  A 401 ( 3.2A)
RDF  A 501 (-3.6A)
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
 1.15A 3a6jF-4b52A:
undetectable		 3a6jF-4b52A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 647
HIS A 584
HIS A 588
GLU A 585
 ZN  A 801 ( 2.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 3.2A)
RDF  A 802 (-2.7A)
 0.76A 3a6jF-4zr5A:
undetectable		 3a6jF-4zr5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 ILE A 447
GLY A 583
ALA A 544
ALA A 650
ILE A 578
 None
None
RDF  A 802 (-4.1A)
ZN  A 801 ( 4.9A)
None
 0.96A 3jayA-4zr5A:
undetectable		 3jayA-4zr5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		3 / 3 HIS A 607
GLU A 608
HIS A 611
 ZN  A 771 ( 3.4A)
RDF  A 817 (-2.4A)
ZN  A 771 ( 3.3A)
 0.20A 3kecB-3dwbA:
4.2		 3kecB-3dwbA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 HIS A 732
ASP A 730
SER A 735
SER A 716
 RDF  A 817 (-3.6A)
RDF  A 817 ( 4.8A)
None
None
 1.11A 4kttC-3dwbA:
undetectable		 4kttC-3dwbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 137
ASP A 136
GLY A 187
ALA A 113
 RDF  A2001 ( 4.2A)
CA  A 303 (-3.7A)
None
RDF  A2001 (-4.3A)
 0.82A 4m48A-3dbkA:
undetectable		 4m48A-3dbkA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 HIS A 732
PRO A 731
ASP A 730
SER A 150
 RDF  A 817 (-3.6A)
RDF  A 817 (-4.7A)
RDF  A 817 ( 4.8A)
None
 1.25A 4ndnC-3dwbA:
undetectable		 4ndnC-3dwbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 HIS A 732
PRO A 731
ASP A 730
SER A 150
 RDF  A 817 (-3.6A)
RDF  A 817 (-4.7A)
RDF  A 817 ( 4.8A)
None
 1.30A 4odjA-3dwbA:
undetectable		 4odjA-3dwbA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4zr5 NEPRILYSIN
(Oryctolagus
cuniculus) 		5 / 12 PRO A  98
ILE A  97
TYR A 698
ASN A  72
ASP A 108
 None
None
None
None
RDF  A 802 (-3.7A)
 1.35A 4xe0A-4zr5A:
3.1		 4xe0A-4zr5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 HIS A 732
PRO A 731
ASP A 730
SER A 150
 RDF  A 817 (-3.6A)
RDF  A 817 (-4.7A)
RDF  A 817 ( 4.8A)
None
 1.26A 5a1iA-3dwbA:
undetectable		 5a1iA-3dwbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 5 SER A 127
ARG A 738
GLY A 741
THR A 664
 None
RDF  A 817 (-3.0A)
None
None
 1.06A 5btiA-3dwbA:
undetectable
5btiB-3dwbA:
undetectable		 5btiA-3dwbA:
19.82
5btiB-3dwbA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4b52 BACILLOLYSIN
(Paenibacillus
polymyxa) 		6 / 12 GLY A 128
GLY A 166
GLY A 134
HIS A 139
GLU A 136
ASP A 131
 None
None
None
ZN  A 401 ( 3.3A)
RDF  A 501 (-2.5A)
CA  A 402 (-2.9A)
 1.26A 5njvC-4b52A:
undetectable		 5njvC-4b52A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 568
GLY A 566
GLY A 563
VAL A 490
ALA A 571
 None
None
None
RDF  A1665 ( 4.3A)
None
 1.07A 5o96C-3zukA:
undetectable
5o96D-3zukA:
undetectable		 5o96C-3zukA:
19.17
5o96D-3zukA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 568
GLY A 566
GLY A 563
VAL A 490
ALA A 571
 None
None
None
RDF  A1665 ( 4.3A)
None
 1.05A 5o96E-3zukA:
undetectable
5o96F-3zukA:
undetectable		 5o96E-3zukA:
19.17
5o96F-3zukA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 568
GLY A 566
GLY A 563
VAL A 490
ALA A 571
 None
None
None
RDF  A1665 ( 4.3A)
None
 1.08A 5o96G-3zukA:
undetectable
5o96H-3zukA:
undetectable		 5o96G-3zukA:
19.17
5o96H-3zukA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 500
GLY A 496
GLU A 494
ASN A 452
HIS A 493
 PGE  A1684 ( 3.8A)
None
RDF  A1665 (-2.5A)
RDF  A1665 (-3.2A)
ZN  A1664 ( 3.4A)
 1.32A 5x7pB-3zukA:
0.7		 5x7pB-3zukA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 HIS A 732
ASP A 730
SER A 735
SER A 716
 RDF  A 817 (-3.6A)
RDF  A 817 ( 4.8A)
None
None
 1.11A 6fcbA-3dwbA:
undetectable		 6fcbA-3dwbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 HIS A 732
PRO A 731
ASP A 730
SER A 150
 RDF  A 817 (-3.6A)
RDF  A 817 (-4.7A)
RDF  A 817 ( 4.8A)
None
 1.26A 6g6rA-3dwbA:
undetectable		 6g6rA-3dwbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3dbk ELASTASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 221
ARG A 198
HIS A 224
ASP A 168
 RDF  A2001 ( 4.7A)
RDF  A2001 (-2.6A)
None
None
 0.98A 6mn4A-3dbkA:
undetectable		 6mn4A-3dbkA:
20.62