SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RC7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5exc GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		4 / 7 ARG I  91
SER I 105
ARG I  66
GLN I 116
 RC7  I  64 ( 2.7A)
RC7  I  64 ( 4.4A)
RC7  I  64 ( 4.3A)
NLW  A  61 ( 4.4A)
 1.06A 2c8aA-5excI:
undetectable		 2c8aA-5excI:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2gw4 KAEDE
(Trachyphyllia
geoffroyi) 		5 / 12 GLU B 212
ARG B  66
MET A  14
GLY A  27
LEU A  42
 RC7  B  63 ( 3.5A)
RC7  B  63 ( 3.0A)
NFA  A  61 ( 3.7A)
None
NFA  A  61 ( 4.3A)
 1.08A 2jfaB-2gw4B:
undetectable		 2jfaB-2gw4B:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2gw4 KAEDE
(Trachyphyllia
geoffroyi) 		3 / 3 PHE B 114
ASN B  65
PHE B  87
 None
RC7  B  63 ( 4.8A)
None
 0.85A 2zbuD-2gw4B:
undetectable		 2zbuD-2gw4B:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2gw4 KAEDE
(Trachyphyllia
geoffroyi) 		3 / 3 HIS B 213
GLU B 212
HIS B 194
 None
RC7  B  63 ( 3.5A)
RC7  B  63 ( 3.6A)
 0.78A 3ba0A-2gw4B:
undetectable		 3ba0A-2gw4B:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 5exc GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		3 / 3 HIS I 212
GLU I 211
HIS I 193
 None
RC7  I  64 ( 3.4A)
RC7  I  64 ( 3.6A)
 0.83A 3ba0A-5excI:
undetectable		 3ba0A-5excI:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2gw4 KAEDE
(Trachyphyllia
geoffroyi) 		4 / 6 PHE B  95
TYR B 169
LEU B 161
THR A  59
 None
None
None
RC7  B  63 ( 4.1A)
 1.27A 4paeA-2gw4B:
undetectable		 4paeA-2gw4B:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2gw4 KAEDE
(Trachyphyllia
geoffroyi) 		4 / 5 ARG B  66
GLY A  36
GLU B 212
SER A   2
 RC7  B  63 ( 3.0A)
None
RC7  B  63 ( 3.5A)
None
 1.25A 4z3oA-2gw4B:
undetectable
4z3oB-2gw4B:
undetectable		 4z3oA-2gw4B:
11.73
4z3oB-2gw4B:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2gw4 KAEDE
(Trachyphyllia
geoffroyi) 		4 / 5 SER A   2
ARG B  66
GLY A  36
GLU B 212
 None
RC7  B  63 ( 3.0A)
None
RC7  B  63 ( 3.5A)
 1.16A 5btiC-2gw4A:
undetectable
5btiD-2gw4A:
undetectable		 5btiC-2gw4A:
8.20
5btiD-2gw4A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2gw4 KAEDE
(Trachyphyllia
geoffroyi) 		5 / 10 TYR B 177
ARG B  91
VAL B  67
TYR B  71
ILE B 196
 None
RC7  B  63 ( 2.9A)
None
None
RC7  B  63 ( 3.6A)
 1.31A 5hw8C-2gw4B:
undetectable
5hw8H-2gw4B:
undetectable		 5hw8C-2gw4B:
24.31
5hw8H-2gw4B:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 5exc GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		5 / 10 TYR I 177
ARG I  91
VAL I  67
TYR I  71
ILE I 195
 None
RC7  I  64 ( 2.7A)
None
None
RC7  I  64 ( 4.2A)
 1.36A 5hw8C-5excI:
undetectable
5hw8H-5excI:
undetectable		 5hw8C-5excI:
19.14
5hw8H-5excI:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 2gw4 KAEDE
KAEDE
(Trachyphyllia
geoffroyi;
Trachyphyllia
geoffroyi) 		5 / 12 THR A  58
MET B 159
PHE B 173
ILE B 157
THR B 175
 None
RC7  B  63 ( 3.5A)
None
RC7  B  63 ( 4.7A)
None
 1.25A 5w8aA-2gw4A:
undetectable		 5w8aA-2gw4A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 5exc GREEN FLUORESCENT
PROTEIN
GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002;
Dendronephthya
sp.
SSAL-2002) 		5 / 12 THR A  58
MET I 159
PHE I 173
ILE I 157
THR I 175
 None
RC7  I  64 ( 3.3A)
None
RC7  I  64 ( 4.5A)
None
 1.28A 5w8aA-5excA:
undetectable		 5w8aA-5excA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5exc GREEN FLUORESCENT
PROTEIN
(Dendronephthya
sp.
SSAL-2002) 		5 / 11 TYR I  71
THR I 175
ARG I  66
THR I  69
VAL I 214
 None
None
RC7  I  64 ( 4.3A)
None
None
 1.45A 5whyA-5excI:
undetectable		 5whyA-5excI:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2gw4 KAEDE
KAEDE
(Trachyphyllia
geoffroyi;
Trachyphyllia
geoffroyi) 		5 / 12 TRP B  89
LEU B  93
HIS B 194
THR A  58
LEU A  57
 RC7  B  63 ( 4.1A)
None
RC7  B  63 ( 3.6A)
None
NFA  A  61 ( 4.4A)
 1.18A 6djzB-2gw4B:
undetectable		 6djzB-2gw4B:
21.18