SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RB0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 TRP A 316
VAL A  96
TYR A 106
GLY A 140
LEU A 139
 RB0  A 501 (-3.9A)
None
None
None
None
 1.22A 1i9jH-5iaiA:
undetectable
1i9jL-5iaiA:
undetectable		 1i9jH-5iaiA:
22.33
1i9jL-5iaiA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4q0s L-RIBOSE ISOMERASE
(Acinetobacter
sp.
DL-28) 		4 / 7 GLU A 204
HIS A 108
MET A  63
ILE A  65
 RB0  A 502 (-3.1A)
CO  A 501 ( 3.3A)
RB0  A 502 ( 4.4A)
None
 0.93A 1tuvA-4q0sA:
undetectable		 1tuvA-4q0sA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOT_A_2PMA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 10 PHE A  49
GLN A 208
TYR A 154
VAL A 101
TRP A 102
 None
RB0  A 501 (-3.1A)
None
None
None
 1.40A 2aotA-5iaiA:
1.6		 2aotA-5iaiA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_C_CU9C301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 TRP A 316
TYR A 111
TYR A 106
GLN A 399
TYR A  75
 RB0  A 501 (-3.9A)
None
None
None
None
 1.45A 3peoC-5iaiA:
0.0
3peoD-5iaiA:
0.0		 3peoC-5iaiA:
20.48
3peoD-5iaiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_H_CU9H301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 TRP A 316
TYR A 111
TYR A 106
GLN A 399
TYR A  75
 RB0  A 501 (-3.9A)
None
None
None
None
 1.46A 3peoH-5iaiA:
0.0
3peoI-5iaiA:
0.0		 3peoH-5iaiA:
20.48
3peoI-5iaiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 154
PRO A  48
TRP A 316
PHE A  49
 None
None
RB0  A 501 (-3.9A)
None
 1.45A 4grqA-5iaiA:
undetectable
4grqC-5iaiA:
undetectable		 4grqA-5iaiA:
12.84
4grqC-5iaiA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 TYR A 381
GLY A 315
GLY A 314
SER A 138
ALA A 152
 None
RB0  A 501 (-3.7A)
RB0  A 501 ( 4.0A)
None
None
 1.12A 4qtuD-5iaiA:
undetectable		 4qtuD-5iaiA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4q0s L-RIBOSE ISOMERASE
(Acinetobacter
sp.
DL-28) 		4 / 7 ALA A  49
ARG A 243
GLY A 242
THR A 213
 None
RB0  A 502 (-3.8A)
None
None
 0.81A 5bs8A-4q0sA:
undetectable
5bs8C-4q0sA:
undetectable
5bs8D-4q0sA:
undetectable		 5bs8A-4q0sA:
17.68
5bs8C-4q0sA:
17.68
5bs8D-4q0sA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4q0s L-RIBOSE ISOMERASE
(Acinetobacter
sp.
DL-28) 		4 / 6 ALA A  49
ARG A 243
GLY A 242
THR A 213
 None
RB0  A 502 (-3.8A)
None
None
 0.78A 5btgA-4q0sA:
undetectable
5btgB-4q0sA:
undetectable
5btgC-4q0sA:
undetectable		 5btgA-4q0sA:
17.68
5btgB-4q0sA:
21.40
5btgC-4q0sA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 9 SER A 278
GLN A  45
GLY A 317
ILE A 100
ALA A 103
 None
RB0  A 501 ( 4.9A)
None
RB0  A 501 (-4.6A)
None
 1.07A 5entC-5iaiA:
undetectable		 5entC-5iaiA:
22.52