SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RAR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
LEU A  28
PHE A  31
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 3.2A)
 0.86A 1ao8A-4m7vA:
22.4		 1ao8A-4m7vA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.74A 1ao8A-4m7vA:
22.4		 1ao8A-4m7vA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
 0.97A 1bzfA-4m7vA:
22.0		 1bzfA-4m7vA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.91A 1bzfA-4m7vA:
22.0		 1bzfA-4m7vA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  20
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.30A 1cd2A-4m7vA:
18.9		 1cd2A-4m7vA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.77A 1cd2A-4m7vA:
18.9		 1cd2A-4m7vA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.60A 1cd2A-4m7vA:
18.9		 1cd2A-4m7vA:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
LYS A  29
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 ( 4.2A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.69A 1d1gA-4m7vA:
19.1		 1d1gA-4m7vA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.51A 1d1gB-4m7vA:
19.1		 1d1gB-4m7vA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.72A 1ddrA-4m7vA:
23.0		 1ddrA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
THR A  46
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 3.2A)
 0.56A 1ddrA-4m7vA:
23.0		 1ddrA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
PHE A  31
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
None
RAR  A 200 (-4.4A)
 1.23A 1ddrB-4m7vA:
23.0		 1ddrB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.67A 1ddrB-4m7vA:
23.0		 1ddrB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 0.87A 1ddsA-4m7vA:
23.2		 1ddsA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.62A 1ddsA-4m7vA:
23.2		 1ddsA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.43A 1ddsA-4m7vA:
23.2		 1ddsA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.76A 1ddsB-4m7vA:
23.2		 1ddsB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.47A 1df7A-4m7vA:
22.2		 1df7A-4m7vA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
TRP A   6
ALA A   7
ASP A  27
PHE A  31
 RAR  A 200 (-4.0A)
None
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
 0.55A 1dg5A-4m7vA:
21.9		 1dg5A-4m7vA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.60A 1dhfA-4m7vA:
19.8		 1dhfA-4m7vA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.32A 1dhfA-4m7vA:
19.8		 1dhfA-4m7vA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.72A 1dhfB-4m7vA:
20.1		 1dhfB-4m7vA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.31A 1dhfB-4m7vA:
20.1		 1dhfB-4m7vA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.67A 1dhiA-4m7vA:
23.1		 1dhiA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.69A 1dhiB-4m7vA:
23.2		 1dhiB-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.68A 1dhjA-4m7vA:
23.1		 1dhjA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  55
PRO A  56
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 4.6A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.74A 1dhjB-4m7vA:
23.2		 1dhjB-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.70A 1draA-4m7vA:
23.2		 1draA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.69A 1draB-4m7vA:
23.2		 1draB-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.72A 1drbA-4m7vA:
23.0		 1drbA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.75A 1drbB-4m7vA:
23.2		 1drbB-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.67A 1dreA-4m7vA:
24.2		 1dreA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
LEU A  55
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
 0.76A 1drfA-4m7vA:
20.7		 1drfA-4m7vA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.22A 1dyiA-4m7vA:
23.2		 1dyiA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.65A 1dyiA-4m7vA:
23.2		 1dyiA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.43A 1dyiA-4m7vA:
23.2		 1dyiA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.25A 1dyiB-4m7vA:
23.2		 1dyiB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.59A 1dyiB-4m7vA:
23.2		 1dyiB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.41A 1dyiB-4m7vA:
23.2		 1dyiB-4m7vA:
37.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
ALA A   7
LEU A  20
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.34A 1dyrA-4m7vA:
18.6		 1dyrA-4m7vA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.23A 1j3jA-4m7vA:
20.5		 1j3jA-4m7vA:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.61A 1jolA-4m7vA:
23.2		 1jolA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
PRO A  56
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 4.6A)
RAR  A 200 (-4.4A)
 0.58A 1jolB-4m7vA:
23.2		 1jolB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 11 ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.63A 1jomA-4m7vA:
22.7		 1jomA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ALA A   7
ASP A  27
PHE A  31
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
None
RAR  A 200 (-4.4A)
 1.29A 1jomA-4m7vA:
22.7		 1jomA-4m7vA:
37.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.69A 1qzfA-4m7vA:
12.1		 1qzfA-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.70A 1qzfB-4m7vA:
20.5		 1qzfB-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.70A 1qzfC-4m7vA:
12.7		 1qzfC-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.70A 1qzfD-4m7vA:
12.1		 1qzfD-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.71A 1qzfE-4m7vA:
12.1		 1qzfE-4m7vA:
16.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.62A 1ra2A-4m7vA:
23.2		 1ra2A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.56A 1ra3A-4m7vA:
23.4		 1ra3A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.62A 1ra8A-4m7vA:
23.2		 1ra8A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.30A 1ra8A-4m7vA:
23.2		 1ra8A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.67A 1rb2A-4m7vA:
23.2		 1rb2A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.65A 1rb2B-4m7vA:
23.3		 1rb2B-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 10 ILE A   5
ALA A   7
ASP A  27
LEU A  28
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.49A 1rb3A-4m7vA:
23.4		 1rb3A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.63A 1rb3B-4m7vA:
23.5		 1rb3B-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.60A 1rd7A-4m7vA:
22.9		 1rd7A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.37A 1rd7A-4m7vA:
22.9		 1rd7A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 0.89A 1rd7B-4m7vA:
22.7		 1rd7B-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.56A 1rd7B-4m7vA:
22.7		 1rd7B-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.47A 1rd7B-4m7vA:
22.7		 1rd7B-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.48A 1re7A-4m7vA:
22.9		 1re7A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
PRO A  56
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 4.6A)
RAR  A 200 (-4.4A)
 0.59A 1re7B-4m7vA:
22.7		 1re7B-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.47A 1rg7A-4m7vA:
22.4		 1rg7A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.65A 1rh3A-4m7vA:
24.2		 1rh3A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.59A 1rx2A-4m7vA:
25.0		 1rx2A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.68A 1rx3A-4m7vA:
24.9		 1rx3A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
 0.68A 1rx3A-4m7vA:
24.9		 1rx3A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.26A 1rx7A-4m7vA:
22.9		 1rx7A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.69A 1rx7A-4m7vA:
22.9		 1rx7A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
PRO A  56
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 4.6A)
RAR  A 200 (-4.4A)
 0.68A 1rx8A-4m7vA:
24.7		 1rx8A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.72A 1tdrA-4m7vA:
23.2		 1tdrA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
 0.49A 1tdrA-4m7vA:
23.2		 1tdrA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 10 ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.66A 1tdrB-4m7vA:
23.2		 1tdrB-4m7vA:
37.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  20
ASP A  27
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.42A 2bl9A-4m7vA:
20.6		 2bl9A-4m7vA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.38A 2blaA-4m7vA:
19.9		 2blaA-4m7vA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
LEU A  20
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 0.99A 2cd2A-4m7vA:
19.0		 2cd2A-4m7vA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  20
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.77A 2cd2A-4m7vA:
19.0		 2cd2A-4m7vA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  20
THR A  46
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.75A 2cd2A-4m7vA:
19.0		 2cd2A-4m7vA:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
PRO A  56
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 4.6A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.78A 2d0kA-4m7vA:
22.6		 2d0kA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.71A 2d0kB-4m7vA:
22.5		 2d0kB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.44A 2d0kB-4m7vA:
22.5		 2d0kB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.63A 2drcA-4m7vA:
23.2		 2drcA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.62A 2drcB-4m7vA:
23.3		 2drcB-4m7vA:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.76A 2oipA-4m7vA:
21.1		 2oipA-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
PHE A  31
THR A  46
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.70A 2oipB-4m7vA:
19.4		 2oipB-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.70A 2oipB-4m7vA:
19.4		 2oipB-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 LEU A  20
ASP A  27
LYS A  29
PHE A  31
THR A  46
LEU A  40
 RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 ( 4.2A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
 1.48A 2oipB-4m7vA:
19.4		 2oipB-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.66A 2oipC-4m7vA:
21.0		 2oipC-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 LEU A  20
ASP A  27
LEU A  28
THR A  46
LEU A  40
 RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
 1.14A 2oipC-4m7vA:
21.0		 2oipC-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.72A 2oipD-4m7vA:
21.6		 2oipD-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
PHE A  31
THR A  46
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.74A 2oipE-4m7vA:
20.5		 2oipE-4m7vA:
16.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
LEU A  28
LEU A  55
PRO A  56
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 4.6A)
RAR  A 200 ( 3.2A)
 0.51A 2qk8A-4m7vA:
25.0		 2qk8A-4m7vA:
42.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
ALA A   7
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.28A 2w3aA-4m7vA:
20.0		 2w3aA-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 10 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.81A 2w3aB-4m7vA:
20.1		 2w3aB-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  20
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.20A 2w3bA-4m7vA:
19.9		 2w3bA-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
THR A  46
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.80A 2w3bA-4m7vA:
19.9		 2w3bA-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.67A 2w3bB-4m7vA:
20.0		 2w3bB-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.69A 2w3mA-4m7vA:
19.8		 2w3mA-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.69A 2w3mB-4m7vA:
20.0		 2w3mB-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 TRP A   6
ALA A   7
ASP A  27
LEU A  28
LEU A  55
THR A 116
 None
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 1.20A 2w3vA-4m7vA:
22.9		 2w3vA-4m7vA:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 TRP A   6
ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A 116
 None
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.35A 2w3vA-4m7vA:
22.9		 2w3vA-4m7vA:
35.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.24A 2w9gA-4m7vA:
25.4		 2w9gA-4m7vA:
43.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.32A 2w9hA-4m7vA:
25.4		 2w9hA-4m7vA:
43.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ILE A   5
ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.38A 2w9sA-4m7vA:
25.5		 2w9sA-4m7vA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ILE A   5
ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.41A 2w9sB-4m7vA:
25.6		 2w9sB-4m7vA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
LEU A  20
ASP A  27
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.4A)
 0.20A 2w9sC-4m7vA:
25.6		 2w9sC-4m7vA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
ASP A  27
LEU A  28
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.39A 2w9sD-4m7vA:
25.4		 2w9sD-4m7vA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
LEU A  20
ASP A  27
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.4A)
 0.40A 2w9sD-4m7vA:
25.4		 2w9sD-4m7vA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 8 ILE A   5
ALA A   7
LEU A  20
ASP A  27
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.4A)
 0.41A 2w9sE-4m7vA:
25.4		 2w9sE-4m7vA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
ASP A  27
LEU A  28
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.36A 2w9sF-4m7vA:
25.2		 2w9sF-4m7vA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
LEU A  20
ASP A  27
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.4A)
 0.40A 2w9sF-4m7vA:
25.2		 2w9sF-4m7vA:
42.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.54A 2zzaA-4m7vA:
24.9		 2zzaA-4m7vA:
38.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.53A 2zzaB-4m7vA:
24.9		 2zzaB-4m7vA:
38.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 VAL A 146
GLY A 144
ILE A 118
LEU A  24
THR A 116
 None
None
None
None
RAR  A 200 (-4.4A)
 1.28A 3bexC-4m7vA:
undetectable
3bexD-4m7vA:
undetectable		 3bexC-4m7vA:
20.16
3bexD-4m7vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 LEU A  24
THR A 116
VAL A 146
GLY A 144
ILE A 118
 None
RAR  A 200 (-4.4A)
None
None
None
 1.28A 3bexC-4m7vA:
undetectable
3bexD-4m7vA:
undetectable		 3bexC-4m7vA:
20.16
3bexD-4m7vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 VAL A 146
GLY A 144
ILE A 118
LEU A  24
THR A 116
 None
None
None
None
RAR  A 200 (-4.4A)
 1.28A 3bexE-4m7vA:
undetectable
3bexF-4m7vA:
undetectable		 3bexE-4m7vA:
20.16
3bexF-4m7vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 LEU A  24
THR A 116
VAL A 146
GLY A 144
ILE A 118
 None
RAR  A 200 (-4.4A)
None
None
None
 1.28A 3bexE-4m7vA:
undetectable
3bexF-4m7vA:
undetectable		 3bexE-4m7vA:
20.16
3bexF-4m7vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 VAL A 146
GLY A 144
ILE A 118
LEU A  24
THR A 116
 None
None
None
None
RAR  A 200 (-4.4A)
 1.28A 3bf1A-4m7vA:
undetectable
3bf1B-4m7vA:
undetectable		 3bf1A-4m7vA:
20.16
3bf1B-4m7vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 VAL A 146
GLY A 144
ILE A 118
LEU A  24
THR A 116
 None
None
None
None
RAR  A 200 (-4.4A)
 1.27A 3bf1C-4m7vA:
undetectable
3bf1D-4m7vA:
undetectable		 3bf1C-4m7vA:
20.16
3bf1D-4m7vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 LEU A  24
THR A 116
VAL A 146
GLY A 144
ILE A 118
 None
RAR  A 200 (-4.4A)
None
None
None
 1.26A 3bf1C-4m7vA:
undetectable
3bf1D-4m7vA:
undetectable		 3bf1C-4m7vA:
20.16
3bf1D-4m7vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 VAL A 146
GLY A 144
ILE A 118
LEU A  24
THR A 116
 None
None
None
None
RAR  A 200 (-4.4A)
 1.29A 3bf1E-4m7vA:
undetectable
3bf1F-4m7vA:
undetectable		 3bf1E-4m7vA:
20.16
3bf1F-4m7vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 LEU A  24
THR A 116
VAL A 146
GLY A 144
ILE A 118
 None
RAR  A 200 (-4.4A)
None
None
None
 1.24A 3bf1E-4m7vA:
undetectable
3bf1F-4m7vA:
undetectable		 3bf1E-4m7vA:
20.16
3bf1F-4m7vA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
LEU A  55
PRO A  56
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 4.6A)
RAR  A 200 ( 3.2A)
 0.70A 3cl9A-4m7vA:
18.0		 3cl9A-4m7vA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
THR A  46
PRO A  56
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 4.6A)
RAR  A 200 ( 3.2A)
 0.66A 3cl9A-4m7vA:
18.0		 3cl9A-4m7vA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 0.86A 3clbC-4m7vA:
18.7		 3clbC-4m7vA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.71A 3clbC-4m7vA:
18.7		 3clbC-4m7vA:
16.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
LEU A  20
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.67A 3datA-4m7vA:
25.2		 3datA-4m7vA:
42.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.56A 3dauA-4m7vA:
24.7		 3dauA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.48A 3dfrA-4m7vA:
24.3		 3dfrA-4m7vA:
37.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.65A 3drcA-4m7vA:
23.2		 3drcA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.63A 3drcB-4m7vA:
23.3		 3drcB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  20
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.68A 3eigA-4m7vA:
20.0		 3eigA-4m7vA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
LEU A  20
LEU A  28
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.51A 3fl9B-4m7vA:
24.8		 3fl9B-4m7vA:
43.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ALA A   7
LEU A  20
LEU A  28
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.48A 3fl9E-4m7vA:
24.6		 3fl9E-4m7vA:
43.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
LEU A  20
LEU A  28
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.44A 3fl9G-4m7vA:
24.8		 3fl9G-4m7vA:
43.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.22A 3frbX-4m7vA:
25.5		 3frbX-4m7vA:
42.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 9 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.29A 3freX-4m7vA:
25.4		 3freX-4m7vA:
43.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.64A 3hj3A-4m7vA:
21.8		 3hj3A-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.67A 3hj3A-4m7vA:
21.8		 3hj3A-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
PHE A  31
THR A  46
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 3.2A)
 0.68A 3hj3B-4m7vA:
21.9		 3hj3B-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.73A 3hj3B-4m7vA:
21.9		 3hj3B-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		9 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.63A 3hj3C-4m7vA:
20.2		 3hj3C-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.72A 3hj3D-4m7vA:
17.5		 3hj3D-4m7vA:
16.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.55A 3ia4B-4m7vA:
24.8		 3ia4B-4m7vA:
39.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
LEU A  28
PHE A  31
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.53A 3ia4C-4m7vA:
24.7		 3ia4C-4m7vA:
39.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.55A 3ia4D-4m7vA:
24.8		 3ia4D-4m7vA:
39.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
TRP A   6
ALA A   7
LEU A  20
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
None
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.56A 3ix9A-4m7vA:
26.5		 3ix9A-4m7vA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  20
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.53A 3ix9B-4m7vA:
26.9		 3ix9B-4m7vA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ALA A   7
LEU A  20
LEU A  28
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.54A 3jw5B-4m7vA:
25.8		 3jw5B-4m7vA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
THR A  46
LEU A  55
ARG A  58
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.63A 3k2hA-4m7vA:
21.1		 3k2hA-4m7vA:
14.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
ALA A   7
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.85A 3n0hA-4m7vA:
20.5		 3n0hA-4m7vA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
ALA A   7
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.32A 3n0hA-4m7vA:
20.5		 3n0hA-4m7vA:
31.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
HIS A  23
ASP A  27
THR A  46
THR A 116
 RAR  A 200 ( 3.6A)
None
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.78A 3nrrB-4m7vA:
21.0		 3nrrB-4m7vA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.27A 3qfxA-4m7vA:
18.8		 3qfxA-4m7vA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.28A 3qfxB-4m7vA:
18.8		 3qfxB-4m7vA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.24A 3qg2A-4m7vA:
20.5		 3qg2A-4m7vA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.23A 3qg2B-4m7vA:
20.2		 3qg2B-4m7vA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.25A 3qgtA-4m7vA:
20.3		 3qgtA-4m7vA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.26A 3qgtB-4m7vA:
19.9		 3qgtB-4m7vA:
13.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.67A 3ql0A-4m7vA:
24.8		 3ql0A-4m7vA:
38.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.51A 3ql3A-4m7vA:
25.0		 3ql3A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.88A 3s3vA-4m7vA:
20.2		 3s3vA-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.30A 3s3vA-4m7vA:
20.2		 3s3vA-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 9 ILE A   5
ALA A   7
LEU A  20
ASP A  27
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.23A 3tq8A-4m7vA:
24.8		 3tq8A-4m7vA:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
None
RAR  A 200 (-4.4A)
 0.91A 3tq9A-4m7vA:
24.4		 3tq9A-4m7vA:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.51A 3tq9A-4m7vA:
24.4		 3tq9A-4m7vA:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 11 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.17A 3tqbA-4m7vA:
24.1		 3tqbA-4m7vA:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 11 ALA A   7
LEU A  20
ASP A  27
LEU A  28
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.73A 3tqbA-4m7vA:
24.1		 3tqbA-4m7vA:
33.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ALA A   7
LEU A  20
ASP A  27
LEU A  42
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
None
RAR  A 200 (-4.4A)
 1.09A 3tqbA-4m7vA:
24.1		 3tqbA-4m7vA:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ASP A  27
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.23A 3um5A-4m7vA:
20.3		 3um5A-4m7vA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ASP A  27
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.29A 3um5B-4m7vA:
19.8		 3um5B-4m7vA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.25A 4cd2A-4m7vA:
17.5		 4cd2A-4m7vA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.72A 4cd2A-4m7vA:
17.5		 4cd2A-4m7vA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.37A 4cd2A-4m7vA:
17.5		 4cd2A-4m7vA:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.63A 4dfrA-4m7vA:
23.2		 4dfrA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
THR A  46
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
 0.48A 4dfrA-4m7vA:
23.2		 4dfrA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.61A 4dfrB-4m7vA:
23.3		 4dfrB-4m7vA:
37.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  20
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 1.20A 4eckA-4m7vA:
18.7		 4eckA-4m7vA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
LEU A  20
PHE A  31
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
None
RAR  A 200 (-4.4A)
 1.16A 4eckA-4m7vA:
18.7		 4eckA-4m7vA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  20
PHE A  31
MET A  50
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 1.24A 4eckA-4m7vA:
18.7		 4eckA-4m7vA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  20
ASP A  27
PHE A  31
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
None
RAR  A 200 (-4.4A)
 0.98A 4eckB-4m7vA:
18.5		 4eckB-4m7vA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 1.08A 4eckB-4m7vA:
18.5		 4eckB-4m7vA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
PHE A  31
MET A  50
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.0A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 1.10A 4eckB-4m7vA:
18.5		 4eckB-4m7vA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.85A 4eilA-4m7vA:
19.9		 4eilA-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ALA A   7
ASP A  27
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.66A 4eilB-4m7vA:
20.2		 4eilB-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.83A 4eilC-4m7vA:
19.9		 4eilC-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ALA A   7
ASP A  27
MET A  50
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.69A 4eilD-4m7vA:
19.4		 4eilD-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.86A 4eilE-4m7vA:
20.5		 4eilE-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 9 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.95A 4eilF-4m7vA:
19.5		 4eilF-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 10 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.84A 4eilG-4m7vA:
20.0		 4eilG-4m7vA:
15.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
 0.75A 4ej1A-4m7vA:
22.8		 4ej1A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
 0.29A 4ej1A-4m7vA:
22.8		 4ej1A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  28
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.31A 4ej1B-4m7vA:
22.7		 4ej1B-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.49A 4ej1B-4m7vA:
22.7		 4ej1B-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.54A 4ej1B-4m7vA:
22.7		 4ej1B-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.70A 4fhbA-4m7vA:
23.4		 4fhbA-4m7vA:
37.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 ILE A   5
ALA A   7
LEU A  20
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.25A 4g8zX-4m7vA:
19.2		 4g8zX-4m7vA:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.69A 4gh8A-4m7vA:
24.0		 4gh8A-4m7vA:
36.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 3.2A)
 0.49A 4gh8B-4m7vA:
23.8		 4gh8B-4m7vA:
36.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
 0.71A 4i13A-4m7vA:
23.0		 4i13A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
 0.37A 4i13A-4m7vA:
23.0		 4i13A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		3 / 3 ASP A  27
ARG A  58
THR A 116
 RAR  A 200 (-2.6A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.52A 4i13A-4m7vA:
23.0		 4i13A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ALA A   7
ASP A  27
PHE A  31
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
None
RAR  A 200 (-4.4A)
 1.26A 4i1nA-4m7vA:
23.1		 4i1nA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.67A 4i1nA-4m7vA:
23.1		 4i1nA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  42
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
None
RAR  A 200 (-4.4A)
 1.32A 4i1nA-4m7vA:
23.1		 4i1nA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
THR A  46
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.82A 4kebB-4m7vA:
20.1		 4kebB-4m7vA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.69A 4kfjB-4m7vA:
20.2		 4kfjB-4m7vA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  55
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
 0.73A 4kjjA-4m7vA:
23.9		 4kjjA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		4 / 4 ASP A  27
LEU A  28
ARG A  58
THR A 116
 RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.51A 4kjjA-4m7vA:
23.9		 4kjjA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		4 / 4 ASP A  27
LEU A  28
ARG A  58
THR A 116
 RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.47A 4kjkA-4m7vA:
24.8		 4kjkA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.61A 4kjlA-4m7vA:
24.3		 4kjlA-4m7vA:
38.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 10 ILE A   5
ALA A   7
ASP A  27
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.60A 4km0A-4m7vA:
20.7		 4km0A-4m7vA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 10 ILE A   5
TRP A   6
ALA A   7
ASP A  27
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
None
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.31A 4km0A-4m7vA:
20.7		 4km0A-4m7vA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 10 TRP A   6
ALA A   7
ASP A  27
LEU A  55
THR A 116
 None
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 1.07A 4km0A-4m7vA:
20.7		 4km0A-4m7vA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
TRP A   6
ALA A   7
ASP A  27
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
None
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.55A 4km0B-4m7vA:
21.3		 4km0B-4m7vA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 TRP A   6
ALA A   7
ASP A  27
LEU A  55
THR A 116
 None
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 1.08A 4km0B-4m7vA:
21.3		 4km0B-4m7vA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.74A 4km2A-4m7vA:
21.0		 4km2A-4m7vA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.56A 4km2B-4m7vA:
20.6		 4km2B-4m7vA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.74A 4ky8A-4m7vA:
14.5		 4ky8A-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.69A 4ky8B-4m7vA:
15.5		 4ky8B-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.67A 4ky8B-4m7vA:
15.5		 4ky8B-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.76A 4ky8C-4m7vA:
21.5		 4ky8C-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.74A 4ky8D-4m7vA:
18.0		 4ky8D-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.74A 4ky8E-4m7vA:
21.3		 4ky8E-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.82A 4kyaA-4m7vA:
20.0		 4kyaA-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 0.82A 4kyaA-4m7vA:
20.0		 4kyaA-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ASP A  27
THR A  46
MET A  50
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.77A 4kyaA-4m7vA:
20.0		 4kyaA-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.95A 4kyaB-4m7vA:
20.1		 4kyaB-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 10 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.81A 4kyaC-4m7vA:
14.6		 4kyaC-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.99A 4kyaD-4m7vA:
13.1		 4kyaD-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.83A 4kyaE-4m7vA:
20.0		 4kyaE-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 0.82A 4kyaE-4m7vA:
20.0		 4kyaE-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ASP A  27
THR A  46
MET A  50
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.76A 4kyaE-4m7vA:
20.0		 4kyaE-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.99A 4kyaF-4m7vA:
13.0		 4kyaF-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.84A 4kyaG-4m7vA:
19.9		 4kyaG-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ALA A   7
ASP A  27
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 0.82A 4kyaG-4m7vA:
19.9		 4kyaG-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ALA A   7
ASP A  27
THR A  46
MET A  50
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.78A 4kyaG-4m7vA:
19.9		 4kyaG-4m7vA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
MET A  50
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.98A 4kyaH-4m7vA:
19.3		 4kyaH-4m7vA:
15.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
ASP A  27
PHE A  31
LEU A  55
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
 0.49A 4m2xA-4m7vA:
21.9		 4m2xA-4m7vA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
LEU A  42
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
None
None
RAR  A 200 (-4.4A)
 0.95A 4m2xC-4m7vA:
22.0		 4m2xC-4m7vA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.39A 4m2xC-4m7vA:
22.0		 4m2xC-4m7vA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  20
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.22A 4m6kA-4m7vA:
20.8		 4m6kA-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  20
PHE A  31
THR A  46
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.77A 4m6kA-4m7vA:
20.8		 4m6kA-4m7vA:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
LEU A  28
PHE A  31
THR A  46
LEU A  55
 RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
 0.70A 4nx6A-4m7vA:
25.1		 4nx6A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		4 / 4 ILE A   5
ASP A  27
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 (-2.6A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.51A 4nx6A-4m7vA:
25.1		 4nx6A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		4 / 4 ILE A   5
ASP A  27
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 (-2.6A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.56A 4nx7A-4m7vA:
25.2		 4nx7A-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
LEU A  55
PRO A  56
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 4.6A)
 0.69A 4p3qA-4m7vA:
24.8		 4p3qA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
PRO A  56
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 4.6A)
 0.52A 4p3qA-4m7vA:
24.8		 4p3qA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
 0.58A 4p3rA-4m7vA:
11.4		 4p3rA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
 0.20A 4p3rA-4m7vA:
11.4		 4p3rA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		3 / 3 ASP A  27
ARG A  58
THR A 116
 RAR  A 200 (-2.6A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.52A 4p3rA-4m7vA:
11.4		 4p3rA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.61A 4p66A-4m7vA:
25.1		 4p66A-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
ASP A  27
PHE A  31
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.49A 4p68A-4m7vA:
24.4		 4p68A-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
 0.57A 4pssA-4m7vA:
undetectable		 4pssA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
 0.27A 4pssA-4m7vA:
undetectable		 4pssA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  28
PHE A  31
THR A  46
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.64A 4pstA-4m7vA:
undetectable		 4pstA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		3 / 3 ILE A   5
ASP A  27
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 (-2.6A)
RAR  A 200 ( 3.2A)
 0.56A 4pstA-4m7vA:
undetectable		 4pstA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.60A 4psyA-4m7vA:
25.2		 4psyA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.75A 4pthA-4m7vA:
11.8		 4pthA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		3 / 3 ASP A  27
LEU A  28
PHE A  31
 RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
 0.35A 4pthA-4m7vA:
11.8		 4pthA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.51A 4ptjA-4m7vA:
24.9		 4ptjA-4m7vA:
37.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.68A 4q0dA-4m7vA:
21.6		 4q0dA-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.73A 4q0dA-4m7vA:
21.6		 4q0dA-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.68A 4q0dB-4m7vA:
21.5		 4q0dB-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.73A 4q0dB-4m7vA:
21.5		 4q0dB-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.68A 4q0dC-4m7vA:
21.5		 4q0dC-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.73A 4q0dC-4m7vA:
21.5		 4q0dC-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.68A 4q0dD-4m7vA:
21.5		 4q0dD-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.73A 4q0dD-4m7vA:
21.5		 4q0dD-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.68A 4q0dE-4m7vA:
21.6		 4q0dE-4m7vA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ALA A   7
LEU A  20
ASP A  27
LEU A  28
LYS A  29
ARG A  58
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 ( 3.7A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.73A 4q0dE-4m7vA:
21.6		 4q0dE-4m7vA:
16.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ALA A   7
ASP A  27
LEU A  28
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
None
RAR  A 200 (-4.4A)
 1.09A 4qi9A-4m7vA:
21.9		 4qi9A-4m7vA:
38.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.59A 4qi9A-4m7vA:
21.9		 4qi9A-4m7vA:
38.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.64A 4qi9B-4m7vA:
22.6		 4qi9B-4m7vA:
38.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.60A 4qi9C-4m7vA:
21.8		 4qi9C-4m7vA:
38.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.23A 4qleA-4m7vA:
23.5		 4qleA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.63A 4qleA-4m7vA:
23.5		 4qleA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.36A 4qleA-4m7vA:
23.5		 4qleA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.62A 4qleB-4m7vA:
23.5		 4qleB-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 11 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.63A 4qlfA-4m7vA:
20.8		 4qlfA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.67A 4qlgA-4m7vA:
23.5		 4qlgA-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.31A 4qlgB-4m7vA:
23.2		 4qlgB-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		9 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.68A 4qlgB-4m7vA:
23.2		 4qlgB-4m7vA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.65A 4rgcA-4m7vA:
25.1		 4rgcA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.70A 4x5fA-4m7vA:
23.1		 4x5fA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		8 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.70A 4x5fB-4m7vA:
23.5		 4x5fB-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
ASP A  27
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.24A 4x5gA-4m7vA:
23.3		 4x5gA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.59A 4x5gA-4m7vA:
23.3		 4x5gA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.33A 4x5gA-4m7vA:
23.3		 4x5gA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.62A 4x5gB-4m7vA:
23.8		 4x5gB-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 12 ILE A   5
ALA A   7
LEU A  28
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.29A 4x5gB-4m7vA:
23.8		 4x5gB-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.74A 4x5hA-4m7vA:
23.4		 4x5hA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.34A 4x5hA-4m7vA:
23.4		 4x5hA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ALA A   7
LEU A  28
PHE A  31
THR A  46
LEU A  40
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
None
RAR  A 200 (-4.4A)
 1.21A 4x5iA-4m7vA:
23.2		 4x5iA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.85A 4x5iA-4m7vA:
23.2		 4x5iA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.37A 4x5iA-4m7vA:
23.2		 4x5iA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.40A 4x5jA-4m7vA:
23.2		 4x5jA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.37A 5e8qA-4m7vA:
23.2		 5e8qA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		3 / 3 ASP A  27
LEU A  55
ARG A  58
 RAR  A 200 (-2.6A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
 0.58A 5e8qA-4m7vA:
23.2		 5e8qA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.58A 5e8qB-4m7vA:
12.8		 5e8qB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.34A 5e8qB-4m7vA:
12.8		 5e8qB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.60A 5eajA-4m7vA:
23.2		 5eajA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.44A 5eajA-4m7vA:
23.2		 5eajA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
PRO A  56
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 4.6A)
RAR  A 200 (-4.4A)
 0.68A 5eajB-4m7vA:
23.3		 5eajB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
PRO A  56
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 4.6A)
RAR  A 200 (-4.4A)
 0.57A 5eajB-4m7vA:
23.3		 5eajB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.63A 5hi6A-4m7vA:
23.3		 5hi6A-4m7vA:
39.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
ASP A  27
LEU A  28
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.65A 5hi6B-4m7vA:
23.2		 5hi6B-4m7vA:
39.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 8 ILE A   5
ALA A   7
ASP A  27
LEU A  28
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.46A 5uihA-4m7vA:
23.3		 5uihA-4m7vA:
26.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.57A 5ujxA-4m7vA:
23.2		 5ujxA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.47A 5ujxA-4m7vA:
23.2		 5ujxA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.68A 5ujxB-4m7vA:
10.1		 5ujxB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.33A 5ujxB-4m7vA:
10.1		 5ujxB-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
ARG A  58
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 ( 3.2A)
RAR  A 200 (-4.4A)
 0.49A 5z6fA-4m7vA:
25.1		 5z6fA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		7 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.67A 5z6jA-4m7vA:
25.4		 5z6jA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.59A 5z6kA-4m7vA:
25.4		 5z6kA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A  46
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.4A)
 0.33A 5z6kA-4m7vA:
25.4		 5z6kA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 9 ILE A   5
ALA A   7
ASP A  27
LEU A  28
PRO A  56
ARG A  58
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 4.6A)
RAR  A 200 ( 3.2A)
 0.58A 5z6lA-4m7vA:
24.7		 5z6lA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ALA A   7
ASP A  27
LEU A  28
PHE A  31
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.81A 5z6mA-4m7vA:
23.9		 5z6mA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ALA A   7
LEU A  28
PHE A  31
LEU A  55
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.93A 5z6mA-4m7vA:
23.9		 5z6mA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		5 / 11 ILE A   5
ALA A   7
LEU A  28
PHE A  31
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
RAR  A 200 (-3.8A)
RAR  A 200 (-4.4A)
 0.51A 5z6mA-4m7vA:
23.9		 5z6mA-4m7vA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 10 ALA A   7
ASP A  27
PHE A  31
THR A  46
MET A  50
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.4A)
 0.51A 6aogA-4m7vA:
20.0		 6aogA-4m7vA:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 10 ALA A   7
ASP A  27
PHE A  31
THR A  46
MET A  50
THR A 116
 RAR  A 200 ( 3.6A)
RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.0A)
RAR  A 200 (-4.4A)
 0.56A 6aogB-4m7vA:
19.8		 6aogB-4m7vA:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		6 / 12 ILE A   5
ALA A   7
PHE A  31
THR A  46
LEU A  55
THR A 116
 RAR  A 200 (-4.0A)
RAR  A 200 ( 3.6A)
RAR  A 200 (-3.8A)
NAP  A 201 (-3.0A)
RAR  A 200 (-4.2A)
RAR  A 200 (-4.4A)
 0.63A 7dfrA-4m7vA:
24.4		 7dfrA-4m7vA:
37.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4m7v DIHYDROFOLATE
REDUCTASE
(Enterococcus
faecalis) 		3 / 3 ASP A  27
LEU A  28
ARG A  58
 RAR  A 200 (-2.6A)
RAR  A 200 (-3.8A)
RAR  A 200 ( 3.2A)
 0.43A 7dfrA-4m7vA:
24.4		 7dfrA-4m7vA:
37.71