SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'RAM'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GMK_C_DVAC8_0 (GRAMICIDIN A)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	3 / 4	VAL A 627 TRP A 640 TRP A 347	None RAM A1202 (-3.7A) None	1.37A	1gmkC-3w5nA: undetectable 1gmkD-3w5nA: undetectable	1gmkC-3w5nA: 2.27 1gmkD-3w5nA: 2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_B_SAMB1293_0 (GLYCINE N-METHYLTRANSFERASE)	2gh4	PUTATIVE GLYCOSYL HYDROLASE YTER (Bacillus subtilis)	5 / 12	TYR A 41 ALA A 92 MET A 147 GLY A 353 HIS A 42	GAD A1002 ( 4.1A) None GAD A1002 ( 4.3A) None RAM A1001 (-3.9A)	1.17A	1kiaB-2gh4A: undetectable	1kiaB-2gh4A: 22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_A_TFPA204_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	4 / 7	LEU A 625 PHE A 598 MET A 655 SER A 657	None RAM A1204 (-3.6A) None None	0.89A	1wrlA-3w5nA: undetectable 1wrlB-3w5nA: undetectable	1wrlA-3w5nA: 7.09 1wrlB-3w5nA: 7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_B_TFPB203_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	4 / 6	LEU A 625 PHE A 598 MET A 655 SER A 657	None RAM A1204 (-3.6A) None None	0.84A	1wrlB-3w5nA: undetectable	1wrlB-3w5nA: 7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_C_TFPC208_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	4 / 5	LEU A 625 PHE A 598 MET A 655 SER A 657	None RAM A1204 (-3.6A) None None	1.07A	1wrlC-3w5nA: undetectable	1wrlC-3w5nA: 7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_E_TFPE212_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	4 / 7	LEU A 625 PHE A 598 MET A 655 SER A 657	None RAM A1204 (-3.6A) None None	0.87A	1wrlE-3w5nA: undetectable	1wrlE-3w5nA: 7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3A_A_TEPA1434_1 (CHITINASE)	4wzz	PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Lachnoclostridiu m phytofermentans)	3 / 3	TRP A 192 THR A 245 TYR A 64	None RAM A 401 (-3.1A) RAM A 401 (-3.1A)	1.20A	2a3aA-4wzzA: undetectable	2a3aA-4wzzA: 23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3A_B_TEPB2434_1 (CHITINASE)	4wzz	PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Lachnoclostridiu m phytofermentans)	3 / 3	TRP A 192 THR A 245 TYR A 64	None RAM A 401 (-3.1A) RAM A 401 (-3.1A)	1.22A	2a3aB-4wzzA: 2.2	2a3aB-4wzzA: 23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3B_A_CFFA1434_1 (CHITINASE)	4wzz	PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Lachnoclostridiu m phytofermentans)	3 / 3	TRP A 192 THR A 245 TYR A 64	None RAM A 401 (-3.1A) RAM A 401 (-3.1A)	1.21A	2a3bA-4wzzA: undetectable	2a3bA-4wzzA: 23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E5D_A_NCAA1501_0 (NICOTINAMIDE PHOSPHORIBOSYLTRANSF ERASE)	2zux	YESW PROTEIN (Bacillus subtilis)	4 / 7	ALA A 594 ARG A 304 ASP A 401 TYR A 595	None None CA A 629 (-2.5A) RAM A 639 (-4.7A)	1.07A	2e5dA-2zuxA: undetectable 2e5dB-2zuxA: undetectable	2e5dA-2zuxA: 22.91 2e5dB-2zuxA: 22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E5D_B_NCAB1502_0 (NICOTINAMIDE PHOSPHORIBOSYLTRANSF ERASE)	2zux	YESW PROTEIN (Bacillus subtilis)	4 / 7	ASP A 401 TYR A 595 ALA A 594 ARG A 304	CA A 629 (-2.5A) RAM A 639 (-4.7A) None None	1.07A	2e5dA-2zuxA: undetectable 2e5dB-2zuxA: undetectable	2e5dA-2zuxA: 22.91 2e5dB-2zuxA: 22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_A_SAMA2001_1 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	4 / 6	TYR A 393 GLY A 383 TYR A 350 ASP A 432	RAM A1206 (-3.8A) None None None	1.12A	2g72A-3w5nA: undetectable	2g72A-3w5nA: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	5ols	RHAMNOGALACTURONAN LYASE (Bacteroides thetaiotaomicron)	3 / 3	ARG A 319 ASP A 215 ASN A 324	GTR A 608 (-3.0A) CA A 601 (-2.1A) RAM A 607 (-2.8A)	0.78A	2zzmA-5olsA: undetectable	2zzmA-5olsA: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BSZ_E_RTLE177_0 (PLASMA RETINOL-BINDING PROTEIN)	4wzz	PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Lachnoclostridiu m phytofermentans)	5 / 11	ALA A 183 ALA A 182 LEU A 269 GLN A 153 GLN A 96	None RAM A 401 ( 3.7A) RAM A 401 ( 3.9A) RAM A 401 (-4.1A) None	1.25A	3bszE-4wzzA: undetectable	3bszE-4wzzA: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EMB_A_SAMA4633_0 (METHYLTRANSFERASE)	4xhc	ALPHA-L-RHAMNOSIDASE (Klebsiella oxytoca)	5 / 12	GLY A 218 LEU A 235 ASN A 294 VAL A 291 ASP A 229	None None None None RAM A 900 (-2.7A)	0.93A	3embA-4xhcA: undetectable	3embA-4xhcA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HII_A_PNTA901_0 (AMILORIDE-SENSITIVE AMINE OXIDASE)	5ols	RHAMNOGALACTURONAN LYASE (Bacteroides thetaiotaomicron)	5 / 12	ASP A 246 GLY A 269 TYR A 270 TYR A 322 ASN A 324	CA A 602 (-2.5A) None None GTR A 608 (-4.9A) RAM A 607 (-2.8A)	1.43A	3hiiA-5olsA: undetectable	3hiiA-5olsA: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_A_THHA642_1 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	5ols	RHAMNOGALACTURONAN LYASE (Bacteroides thetaiotaomicron)	3 / 3	ASN A 324 ASP A 280 ARG A 125	RAM A 607 (-2.8A) CA A 602 ( 3.2A) ADA A 604 ( 3.0A)	0.87A	3k13A-5olsA: undetectable	3k13A-5olsA: 23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_C_THHC643_1 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	2fv0	UNSATURATED GLUCURONYL HYDROLASE (Bacillus sp. GL1)	3 / 3	ASN A 88 ASP A 41 ARG A 341	GAD A 404 (-2.1A) RAM A 402 ( 4.6A) None	0.87A	3k13C-2fv0A: undetectable	3k13C-2fv0A: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WQV_A_GCSA501_1 (CHITINASE)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	5 / 11	GLY A 639 ASP A 349 TYR A 393 ARG A 351 TRP A 347	None None RAM A1206 (-3.8A) RAM A1206 (-3.0A) None	1.36A	3wqvA-3w5nA: undetectable	3wqvA-3w5nA: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WQW_A_GCSA501_1 (CHITINASE)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	5 / 11	GLY A 639 ASP A 349 TYR A 393 ARG A 351 TRP A 347	None None RAM A1206 (-3.8A) RAM A1206 (-3.0A) None	1.39A	3wqwA-3w5nA: undetectable	3wqwA-3w5nA: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7T_A_5FWA1002_1 (SUPEROXIDE DISMUTASE [CU-ZN])	4xhc	ALPHA-L-RHAMNOSIDASE (Klebsiella oxytoca)	3 / 3	ASN A 267 TRP A 226 ASP A 278	None RAM A 900 (-3.8A) None	1.09A	4a7tA-4xhcA: undetectable 4a7tF-4xhcA: undetectable	4a7tA-4xhcA: 16.56 4a7tF-4xhcA: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K0B_B_SAMB504_0 (S-ADENOSYLMETHIONINE SYNTHASE)	5xqo	PCRGLX PROTEIN (Penicillium chrysogenum)	4 / 8	HIS A 565 ASN A 902 ASP A 642 ILE A 649	None RAM A1003 ( 4.1A) None None	0.89A	4k0bA-5xqoA: undetectable	4k0bA-5xqoA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L7I_B_SAMB501_0 (S-ADENOSYLMETHIONINE SYNTHASE)	5xqo	PCRGLX PROTEIN (Penicillium chrysogenum)	4 / 8	HIS A 565 ASN A 902 ASP A 642 ILE A 649	None RAM A1003 ( 4.1A) None None	0.83A	4l7iA-5xqoA: undetectable	4l7iA-5xqoA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L8F_D_MTXD301_1 (GAMMA-GLUTAMYL HYDROLASE)	5ols	RHAMNOGALACTURONAN LYASE (Bacteroides thetaiotaomicron)	5 / 11	GLY A 209 GLY A 211 GLY A 212 GLU A 207 GLN A 155	None None CA A 602 (-4.1A) None RAM A 605 ( 3.3A)	1.12A	4l8fD-5olsA: undetectable	4l8fD-5olsA: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA8_C_Z80C301_1 (MAJOR PRION PROTEIN)	4wzz	PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Lachnoclostridiu m phytofermentans)	4 / 5	LEU A 292 GLY A 270 ILE A 159 GLN A 153	RAM A 401 ( 4.6A) None None RAM A 401 (-4.1A)	0.99A	4ma8C-4wzzA: undetectable	4ma8C-4wzzA: 11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N49_A_SAMA601_1 (CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-M ETHYLTRANSFERASE 1)	2zux	YESW PROTEIN (Bacillus subtilis)	4 / 4	ASN A 208 GLY A 238 ASP A 153 ASP A 187	None RAM A 642 (-3.5A) CA A 630 (-2.8A) RAM A 641 (-2.7A)	1.42A	4n49A-2zuxA: undetectable	4n49A-2zuxA: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_H_377H401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	2zux	YESW PROTEIN (Bacillus subtilis)	4 / 6	TYR A 595 ASN A 364 GLU A 422 TYR A 326	RAM A 639 (-4.7A) None CA A 629 (-2.6A) None	1.32A	4twdG-2zuxA: undetectable 4twdH-2zuxA: undetectable	4twdG-2zuxA: 18.07 4twdH-2zuxA: 18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U8Y_B_MIYB1102_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	5xqo	PCRGLX PROTEIN (Penicillium chrysogenum)	5 / 12	GLU A 587 ASN A 902 ASP A 903 ILE A 904 PHE A 544	ADA A1004 ( 3.7A) RAM A1003 ( 4.1A) None None None	1.09A	4u8yB-5xqoA: undetectable	4u8yB-5xqoA: 5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_A_SAMA301_0 (PANTOTHENATE SYNTHETASE)	5ols	RHAMNOGALACTURONAN LYASE (Bacteroides thetaiotaomicron)	5 / 12	GLY A 269 GLN A 155 GLY A 248 ASP A 250 THR A 282	None RAM A 605 ( 3.3A) None AQA A 606 ( 3.1A) None	1.26A	5hg0A-5olsA: undetectable	5hg0A-5olsA: 19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVS_B_ADNB401_1 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	4 / 8	ALA A 682 ASP A 630 ASN A 687 PHE A 388	None RAM A1202 (-3.4A) RAM A1206 (-3.1A) None	0.99A	5mvsB-3w5nA: 2.6	5mvsB-3w5nA: 17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N0X_B_SAMB501_0 (PEPTIDE N-METHYLTRANSFERASE)	4xn3	TAIL SPIKE PROTEIN (Salmonella virus HK620)	5 / 12	ILE A 215 TYR A 204 GLY A 214 HIS A 212 GLN A 281	None None None RAM A1001 (-3.7A) None	1.16A	5n0xB-4xn3A: undetectable	5n0xB-4xn3A: 20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NEK_D_AZMD302_1 (PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	4 / 8	ASP A 630 ASP A 643 ARG A 896 HIS A 916	RAM A1202 (-3.4A) RAM A1202 (-2.8A) None RAM A1202 (-4.0A)	0.67A	5nekD-3w5nA: undetectable	5nekD-3w5nA: 5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NO9_D_95ZD302_1 (25 KDA PROTEIN ELICITOR)	5ols	RHAMNOGALACTURONAN LYASE (Bacteroides thetaiotaomicron)	5 / 7	ASP A 247 GLY A 248 ASP A 246 HIS A 220 ASP A 250	CA A 601 ( 3.3A) None CA A 602 (-2.5A) RAM A 605 ( 3.6A) AQA A 606 ( 3.1A)	1.45A	5no9D-5olsA: undetectable	5no9D-5olsA: 10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODI_G_ACTG702_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	2zux	YESW PROTEIN (Bacillus subtilis)	3 / 3	GLY A 186 THR A 141 ASN A 175	RAM A 641 ( 4.4A) None None	0.68A	5odiG-2zuxA: undetectable	5odiG-2zuxA: 24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OV9_A_CVIA609_0 (ACETYLCHOLINESTERASE)	2zux	YESW PROTEIN (Bacillus subtilis)	4 / 6	TYR A 325 ASP A 423 HIS A 421 TYR A 595	None None None RAM A 639 (-4.7A)	1.34A	5ov9A-2zuxA: undetectable	5ov9A-2zuxA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OV9_B_CVIB603_0 (ACETYLCHOLINESTERASE)	2zux	YESW PROTEIN (Bacillus subtilis)	4 / 7	TYR A 325 ASP A 423 HIS A 421 TYR A 595	None None None RAM A 639 (-4.7A)	1.34A	5ov9B-2zuxA: undetectable	5ov9B-2zuxA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGZ_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	4wzz	PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Lachnoclostridiu m phytofermentans)	3 / 3	VAL A 213 VAL A 179 GLN A 189	None None RAM A 401 (-3.1A)	0.68A	5qgzA-4wzzA: undetectable	5qgzA-4wzzA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QH6_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	4wzz	PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Lachnoclostridiu m phytofermentans)	3 / 3	VAL A 213 VAL A 179 GLN A 189	None None RAM A 401 (-3.1A)	0.67A	5qh6A-4wzzA: undetectable	5qh6A-4wzzA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QHA_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	4wzz	PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN (Lachnoclostridiu m phytofermentans)	3 / 3	VAL A 213 VAL A 179 GLN A 189	None None RAM A 401 (-3.1A)	0.64A	5qhaA-4wzzA: undetectable	5qhaA-4wzzA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUO_B_MTLB805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	4 / 8	ASN A 150 ASN A 228 ASP A 179 TRP A 292	None CA A1201 (-3.2A) RAM A1203 ( 2.5A) None	1.29A	5vuoB-3w5nA: undetectable	5vuoB-3w5nA: 17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2T_B_8LXB501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3w5n	PUTATIVE RHAMNOSIDASE (Streptomyces avermitilis)	4 / 8	GLU A 636 HIS A 916 SER A 921 LEU A 847	RAM A1202 (-3.1A) RAM A1202 (-4.0A) None None	1.07A	5y2tB-3w5nA: undetectable	5y2tB-3w5nA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GMK_C_DVAC8_0","GRAMICIDIN A","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",3,"VAL A 627;TRP A 640;TRP A 347","None;RAM A1202 (-3.7A);None","1.37A","1gmkC-3w5nA:undetectable;1gmkD-3w5nA:undetectable",null],["1KIA_B_SAMB1293_0","GLYCINE N-METHYLTRANSFERASE","2gh4","PUTATIVE GLYCOSYL HYDROLASE YTER","Bacillus subtilis",5,"TYR A  41;ALA A  92;MET A 147;GLY A 353;HIS A  42","GAD A1002 ( 4.1A);None;GAD A1002 ( 4.3A);None;RAM A1001 (-3.9A)","1.17A","1kiaB-2gh4A:undetectable","1gmkC-3w5nA:2.27;1gmkD-3w5nA:2.27"],["1WRL_A_TFPA204_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES;TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",4,"LEU A 625;PHE A 598;MET A 655;SER A 657","None;RAM A1204 (-3.6A);None;None","0.89A","1wrlA-3w5nA:undetectable;1wrlB-3w5nA:undetectable","1kiaB-2gh4A:22.79"],["1WRL_B_TFPB203_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",4,"LEU A 625;PHE A 598;MET A 655;SER A 657","None;RAM A1204 (-3.6A);None;None","0.84A","1wrlB-3w5nA:undetectable","1wrlA-3w5nA:7.09;1wrlB-3w5nA:7.09"],["1WRL_C_TFPC208_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",4,"LEU A 625;PHE A 598;MET A 655;SER A 657","None;RAM A1204 (-3.6A);None;None","1.07A","1wrlC-3w5nA:undetectable","1wrlB-3w5nA:7.09"],["1WRL_E_TFPE212_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",4,"LEU A 625;PHE A 598;MET A 655;SER A 657","None;RAM A1204 (-3.6A);None;None","0.87A","1wrlE-3w5nA:undetectable","1wrlC-3w5nA:7.09"],["2A3A_A_TEPA1434_1","CHITINASE","4wzz","PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Lachnoclostridium phytofermentans",3,"TRP A 192;THR A 245;TYR A  64","None;RAM A 401 (-3.1A);RAM A 401 (-3.1A)","1.20A","2a3aA-4wzzA:undetectable","1wrlE-3w5nA:7.09"],["2A3A_B_TEPB2434_1","CHITINASE","4wzz","PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Lachnoclostridium phytofermentans",3,"TRP A 192;THR A 245;TYR A  64","None;RAM A 401 (-3.1A);RAM A 401 (-3.1A)","1.22A","2a3aB-4wzzA:2.2","2a3aA-4wzzA:23.79"],["2A3B_A_CFFA1434_1","CHITINASE","4wzz","PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Lachnoclostridium phytofermentans",3,"TRP A 192;THR A 245;TYR A  64","None;RAM A 401 (-3.1A);RAM A 401 (-3.1A)","1.21A","2a3bA-4wzzA:undetectable","2a3aB-4wzzA:23.79"],["2E5D_A_NCAA1501_0","NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE","2zux","YESW PROTEIN","Bacillus subtilis",4,"ALA A 594;ARG A 304;ASP A 401;TYR A 595","None;None; CA A 629 (-2.5A);RAM A 639 (-4.7A)","1.07A","2e5dA-2zuxA:undetectable;2e5dB-2zuxA:undetectable","2a3bA-4wzzA:23.79"],["2E5D_B_NCAB1502_0","NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE","2zux","YESW PROTEIN","Bacillus subtilis",4,"ASP A 401;TYR A 595;ALA A 594;ARG A 304"," CA A 629 (-2.5A);RAM A 639 (-4.7A);None;None","1.07A","2e5dA-2zuxA:undetectable;2e5dB-2zuxA:undetectable","2e5dA-2zuxA:22.91;2e5dB-2zuxA:22.91"],["2G72_A_SAMA2001_1","PHENYLETHANOLAMINE N-METHYLTRANSFERASE","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",4,"TYR A 393;GLY A 383;TYR A 350;ASP A 432","RAM A1206 (-3.8A);None;None;None","1.12A","2g72A-3w5nA:undetectable","2e5dA-2zuxA:22.91;2e5dB-2zuxA:22.91"],["2ZZM_A_SAMA401_1","UNCHARACTERIZED PROTEIN MJ0883","5ols","RHAMNOGALACTURONAN LYASE","Bacteroides thetaiotaomicron",3,"ARG A 319;ASP A 215;ASN A 324","GTR A 608 (-3.0A); CA A 601 (-2.1A);RAM A 607 (-2.8A)","0.78A","2zzmA-5olsA:undetectable","2g72A-3w5nA:15.05"],["3BSZ_E_RTLE177_0","PLASMA RETINOL-BINDING PROTEIN","4wzz","PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Lachnoclostridium phytofermentans",5,"ALA A 183;ALA A 182;LEU A 269;GLN A 153;GLN A  96","None;RAM A 401 ( 3.7A);RAM A 401 ( 3.9A);RAM A 401 (-4.1A);None","1.25A","3bszE-4wzzA:undetectable","2zzmA-5olsA:21.27"],["3EMB_A_SAMA4633_0","METHYLTRANSFERASE","4xhc","ALPHA-L-RHAMNOSIDASE","Klebsiella oxytoca",5,"GLY A 218;LEU A 235;ASN A 294;VAL A 291;ASP A 229","None;None;None;None;RAM A 900 (-2.7A)","0.93A","3embA-4xhcA:undetectable","3bszE-4wzzA:19.60"],["3HII_A_PNTA901_0","AMILORIDE-SENSITIVE AMINE OXIDASE","5ols","RHAMNOGALACTURONAN LYASE","Bacteroides thetaiotaomicron",5,"ASP A 246;GLY A 269;TYR A 270;TYR A 322;ASN A 324"," CA A 602 (-2.5A);None;None;GTR A 608 (-4.9A);RAM A 607 (-2.8A)","1.43A","3hiiA-5olsA:undetectable","3embA-4xhcA:undetectable"],["3K13_A_THHA642_1","5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE","5ols","RHAMNOGALACTURONAN LYASE","Bacteroides thetaiotaomicron",3,"ASN A 324;ASP A 280;ARG A 125","RAM A 607 (-2.8A); CA A 602 ( 3.2A);ADA A 604 ( 3.0A)","0.87A","3k13A-5olsA:undetectable","3hiiA-5olsA:20.93"],["3K13_C_THHC643_1","5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE","2fv0","UNSATURATED GLUCURONYL HYDROLASE","Bacillus sp. GL1",3,"ASN A  88;ASP A  41;ARG A 341","GAD A 404 (-2.1A);RAM A 402 ( 4.6A);None","0.87A","3k13C-2fv0A:undetectable","3k13A-5olsA:23.02"],["3WQV_A_GCSA501_1","CHITINASE","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",5,"GLY A 639;ASP A 349;TYR A 393;ARG A 351;TRP A 347","None;None;RAM A1206 (-3.8A);RAM A1206 (-3.0A);None","1.36A","3wqvA-3w5nA:undetectable","3k13C-2fv0A:22.37"],["3WQW_A_GCSA501_1","CHITINASE","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",5,"GLY A 639;ASP A 349;TYR A 393;ARG A 351;TRP A 347","None;None;RAM A1206 (-3.8A);RAM A1206 (-3.0A);None","1.39A","3wqwA-3w5nA:undetectable","3wqvA-3w5nA:17.80"],["4A7T_A_5FWA1002_1","SUPEROXIDE DISMUTASE [CU-ZN];SUPEROXIDE DISMUTASE [CU-ZN]","4xhc","ALPHA-L-RHAMNOSIDASE","Klebsiella oxytoca",3,"ASN A 267;TRP A 226;ASP A 278","None;RAM A 900 (-3.8A);None","1.09A","4a7tA-4xhcA:undetectable;4a7tF-4xhcA:undetectable","3wqwA-3w5nA:17.80"],["4K0B_B_SAMB504_0","S-ADENOSYLMETHIONINE SYNTHASE","5xqo","PCRGLX PROTEIN","Penicillium chrysogenum",4,"HIS A 565;ASN A 902;ASP A 642;ILE A 649","None;RAM A1003 ( 4.1A);None;None","0.89A","4k0bA-5xqoA:undetectable","4a7tA-4xhcA:16.56;4a7tF-4xhcA:16.56"],["4L7I_B_SAMB501_0","S-ADENOSYLMETHIONINE SYNTHASE","5xqo","PCRGLX PROTEIN","Penicillium chrysogenum",4,"HIS A 565;ASN A 902;ASP A 642;ILE A 649","None;RAM A1003 ( 4.1A);None;None","0.83A","4l7iA-5xqoA:undetectable","4k0bA-5xqoA:undetectable"],["4L8F_D_MTXD301_1","GAMMA-GLUTAMYL HYDROLASE","5ols","RHAMNOGALACTURONAN LYASE","Bacteroides thetaiotaomicron",5,"GLY A 209;GLY A 211;GLY A 212;GLU A 207;GLN A 155","None;None; CA A 602 (-4.1A);None;RAM A 605 ( 3.3A)","1.12A","4l8fD-5olsA:undetectable","4l7iA-5xqoA:undetectable"],["4MA8_C_Z80C301_1","MAJOR PRION PROTEIN","4wzz","PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Lachnoclostridium phytofermentans",4,"LEU A 292;GLY A 270;ILE A 159;GLN A 153","RAM A 401 ( 4.6A);None;None;RAM A 401 (-4.1A)","0.99A","4ma8C-4wzzA:undetectable","4l8fD-5olsA:21.09"],["4N49_A_SAMA601_1","CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1","2zux","YESW PROTEIN","Bacillus subtilis",4,"ASN A 208;GLY A 238;ASP A 153;ASP A 187","None;RAM A 642 (-3.5A); CA A 630 (-2.8A);RAM A 641 (-2.7A)","1.42A","4n49A-2zuxA:undetectable","4ma8C-4wzzA:11.86"],["4TWD_H_377H401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","2zux","YESW PROTEIN","Bacillus subtilis",4,"TYR A 595;ASN A 364;GLU A 422;TYR A 326","RAM A 639 (-4.7A);None; CA A 629 (-2.6A);None","1.32A","4twdG-2zuxA:undetectable;4twdH-2zuxA:undetectable","4n49A-2zuxA:22.85"],["4U8Y_B_MIYB1102_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","5xqo","PCRGLX PROTEIN","Penicillium chrysogenum",5,"GLU A 587;ASN A 902;ASP A 903;ILE A 904;PHE A 544","ADA A1004 ( 3.7A);RAM A1003 ( 4.1A);None;None;None","1.09A","4u8yB-5xqoA:undetectable","4twdG-2zuxA:18.07;4twdH-2zuxA:18.07"],["5HG0_A_SAMA301_0","PANTOTHENATE SYNTHETASE","5ols","RHAMNOGALACTURONAN LYASE","Bacteroides thetaiotaomicron",5,"GLY A 269;GLN A 155;GLY A 248;ASP A 250;THR A 282","None;RAM A 605 ( 3.3A);None;AQA A 606 ( 3.1A);None","1.26A","5hg0A-5olsA:undetectable","4u8yB-5xqoA:5.85"],["5MVS_B_ADNB401_1","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",4,"ALA A 682;ASP A 630;ASN A 687;PHE A 388","None;RAM A1202 (-3.4A);RAM A1206 (-3.1A);None","0.99A","5mvsB-3w5nA:2.6","5hg0A-5olsA:19.65"],["5N0X_B_SAMB501_0","PEPTIDE N-METHYLTRANSFERASE","4xn3","TAIL SPIKE PROTEIN","Salmonella virus HK620",5,"ILE A 215;TYR A 204;GLY A 214;HIS A 212;GLN A 281","None;None;None;RAM A1001 (-3.7A);None","1.16A","5n0xB-4xn3A:undetectable","5mvsB-3w5nA:17.31"],["5NEK_D_AZMD302_1","PEPTIDOGLYCAN N-ACETYLGLUCOSAMINE DEACETYLASE","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",4,"ASP A 630;ASP A 643;ARG A 896;HIS A 916","RAM A1202 (-3.4A);RAM A1202 (-2.8A);None;RAM A1202 (-4.0A)","0.67A","5nekD-3w5nA:undetectable","5n0xB-4xn3A:20.16"],["5NO9_D_95ZD302_1","25 KDA PROTEIN ELICITOR","5ols","RHAMNOGALACTURONAN LYASE","Bacteroides thetaiotaomicron",5,"ASP A 247;GLY A 248;ASP A 246;HIS A 220;ASP A 250"," CA A 601 ( 3.3A);None; CA A 602 (-2.5A);RAM A 605 ( 3.6A);AQA A 606 ( 3.1A)","1.45A","5no9D-5olsA:undetectable","5nekD-3w5nA:5.34"],["5ODI_G_ACTG702_0","HETERODISULFIDE REDUCTASE, SUBUNIT A","2zux","YESW PROTEIN","Bacillus subtilis",3,"GLY A 186;THR A 141;ASN A 175","RAM A 641 ( 4.4A);None;None","0.68A","5odiG-2zuxA:undetectable","5no9D-5olsA:10.44"],["5OV9_A_CVIA609_0","ACETYLCHOLINESTERASE","2zux","YESW PROTEIN","Bacillus subtilis",4,"TYR A 325;ASP A 423;HIS A 421;TYR A 595","None;None;None;RAM A 639 (-4.7A)","1.34A","5ov9A-2zuxA:undetectable","5odiG-2zuxA:24.04"],["5OV9_B_CVIB603_0","ACETYLCHOLINESTERASE","2zux","YESW PROTEIN","Bacillus subtilis",4,"TYR A 325;ASP A 423;HIS A 421;TYR A 595","None;None;None;RAM A 639 (-4.7A)","1.34A","5ov9B-2zuxA:undetectable","5ov9A-2zuxA:25.00"],["5QGZ_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","4wzz","PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Lachnoclostridium phytofermentans",3,"VAL A 213;VAL A 179;GLN A 189","None;None;RAM A 401 (-3.1A)","0.68A","5qgzA-4wzzA:undetectable","5ov9B-2zuxA:25.00"],["5QH6_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","4wzz","PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Lachnoclostridium phytofermentans",3,"VAL A 213;VAL A 179;GLN A 189","None;None;RAM A 401 (-3.1A)","0.67A","5qh6A-4wzzA:undetectable","5qgzA-4wzzA:19.57"],["5QHA_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","4wzz","PUTATIVE SUGAR ABC TRANSPORTER, SUBSTRATE-BINDING PROTEIN","Lachnoclostridium phytofermentans",3,"VAL A 213;VAL A 179;GLN A 189","None;None;RAM A 401 (-3.1A)","0.64A","5qhaA-4wzzA:undetectable","5qh6A-4wzzA:19.57"],["5VUO_B_MTLB805_0","NITRIC OXIDE SYNTHASE, BRAIN","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",4,"ASN A 150;ASN A 228;ASP A 179;TRP A 292","None; CA A1201 (-3.2A);RAM A1203 ( 2.5A);None","1.29A","5vuoB-3w5nA:undetectable","5qhaA-4wzzA:19.57"],["5Y2T_B_8LXB501_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","3w5n","PUTATIVE RHAMNOSIDASE","Streptomyces avermitilis",4,"GLU A 636;HIS A 916;SER A 921;LEU A 847","RAM A1202 (-3.1A);RAM A1202 (-4.0A);None;None","1.07A","5y2tB-3w5nA:undetectable","5vuoB-3w5nA:17.20"]]