SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'R78'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6cw0 CGD2_2690 PROTEIN
(Cryptosporidium
parvum) 		4 / 8 VAL A  30
LEU A  35
LEU A  37
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 (-3.3A)
 0.54A 3u5kA-6cw0A:
16.7		 3u5kA-6cw0A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6cw0 CGD2_2690 PROTEIN
(Cryptosporidium
parvum) 		4 / 7 VAL A  30
LEU A  35
LEU A  37
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 (-3.3A)
 0.49A 3u5kB-6cw0A:
16.7		 3u5kB-6cw0A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6cw0 CGD2_2690 PROTEIN
(Cryptosporidium
parvum) 		4 / 8 VAL A  30
LEU A  35
LEU A  37
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 (-3.3A)
 0.53A 3u5kC-6cw0A:
16.9		 3u5kC-6cw0A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 6cw0 CGD2_2690 PROTEIN
(Cryptosporidium
parvum) 		4 / 5 VAL A  30
LEU A  35
LEU A  37
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 (-3.3A)
 0.64A 4a9jA-6cw0A:
17.5		 4a9jA-6cw0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 6cw0 CGD2_2690 PROTEIN
(Cryptosporidium
parvum) 		4 / 5 VAL A  30
LEU A  35
LEU A  37
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 (-3.3A)
 0.66A 4a9jB-6cw0A:
17.8		 4a9jB-6cw0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 6cw0 CGD2_2690 PROTEIN
(Cryptosporidium
parvum) 		4 / 5 VAL A  30
LEU A  35
LEU A  37
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 (-3.3A)
 0.65A 4a9jC-6cw0A:
17.9		 4a9jC-6cw0A:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 6cw0 CGD2_2690 PROTEIN
(Cryptosporidium
parvum) 		5 / 6 VAL A  30
LEU A  35
TYR A  82
ASN A  83
VAL A  89
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
UNX  A 203 ( 4.1A)
R78  A 201 (-3.3A)
UNX  A 205 ( 4.1A)
 0.47A 4a9kA-6cw0A:
17.9		 4a9kA-6cw0A:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 6cw0 CGD2_2690 PROTEIN
(Cryptosporidium
parvum) 		4 / 5 VAL A  30
LEU A  35
ASN A  83
VAL A  89
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
R78  A 201 (-3.3A)
UNX  A 205 ( 4.1A)
 0.53A 4a9kB-6cw0A:
18.1		 4a9kB-6cw0A:
38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4py6 BROMODOMAIN PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 6 VAL A1221
TYR A1235
ASN A1278
ILE A1287
 R78  A1401 ( 4.6A)
R78  A1401 ( 4.9A)
R78  A1401 (-3.2A)
R78  A1401 (-4.1A)
 0.73A 5pbeA-4py6A:
15.2		 5pbeA-4py6A:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4py6 BROMODOMAIN PROTEIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 VAL A1221
CYH A1274
ASN A1278
ILE A1287
 R78  A1401 ( 4.6A)
R78  A1401 ( 4.1A)
R78  A1401 (-3.2A)
R78  A1401 (-4.1A)
 0.60A 5y1yA-4py6A:
14.5		 5y1yA-4py6A:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5tcm UNCHARACTERIZED
PROTEIN
(Leishmania
donovani) 		5 / 8 VAL A  30
LEU A  37
CYH A  83
TYR A  86
ASN A  87
 R78  A 201 (-4.4A)
None
R78  A 201 ( 3.9A)
R78  A 201 (-4.5A)
R78  A 201 (-3.4A)
 0.78A 5y1yA-5tcmA:
11.5		 5y1yA-5tcmA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 6cw0 CGD2_2690 PROTEIN
(Cryptosporidium
parvum) 		6 / 8 VAL A  30
LEU A  35
LEU A  37
CYH A  79
TYR A  82
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 ( 3.8A)
UNX  A 203 ( 4.1A)
R78  A 201 (-3.3A)
 0.35A 5y1yA-6cw0A:
16.9		 5y1yA-6cw0A:
28.00