SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'R71'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		4 / 6 TRP A 230
TYR A 530
PHE A 696
SER A 699
 None
None
R71  A1733 (-3.6A)
None
 1.39A 2a3cB-1w6jA:
undetectable		 2a3cB-1w6jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
 R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
 1.15A 5nnaA-1w6jA:
undetectable		 5nnaA-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
 R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
 1.14A 5nnaB-1w6jA:
undetectable		 5nnaB-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
 R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
 1.14A 5nnaC-1w6jA:
undetectable		 5nnaC-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
 R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
 1.15A 5nnaD-1w6jA:
undetectable		 5nnaD-1w6jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1w6j LANOSTEROL SYNTHASE
(Homo
sapiens) 		5 / 12 HIS A 232
VAL A 346
ILE A 323
ASP A 326
ASP A 327
 R71  A1733 (-3.5A)
None
None
None
None
 1.45A 6bxnA-1w6jA:
undetectable		 6bxnA-1w6jA:
18.21