SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'R5P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASP A  41
GLY A  70
ILE A  73
ALA A  50
 None
R5P  A 651 (-3.3A)
None
None
 0.65A 1n49A-3heeA:
undetectable		 1n49A-3heeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A   8
GLY A  66
TYR A  42
 R5P  A 651 (-2.7A)
R5P  A 651 (-3.5A)
R5P  A 651 (-3.9A)
 0.78A 3w9tC-3heeA:
undetectable		 3w9tC-3heeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A   8
GLY A  66
TYR A  42
 R5P  A 651 (-2.7A)
R5P  A 651 (-3.5A)
R5P  A 651 (-3.9A)
 0.78A 3w9tG-3heeA:
undetectable		 3w9tG-3heeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 THR A  34
GLY A   6
ARG A 109
ILE A  71
 None
None
R5P  A 651 (-3.3A)
None
 1.11A 4acaC-3heeA:
2.5		 4acaC-3heeA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Pyrococcus
horikoshii) 		5 / 10 ALA A  45
ILE A  28
VAL A  23
GLY A  25
VAL A 277
 None
None
None
None
R5P  A 401 ( 4.4A)
 1.00A 4j5jB-4firA:
undetectable		 4j5jB-4firA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3hee RIBOSE-5-PHOSPHATE
ISOMERASE
(Ruminiclostridiu
m
thermocellum) 		6 / 12 GLY A 107
GLY A  66
LEU A  69
VAL A  85
ALA A 105
LEU A 106
 None
R5P  A 651 (-3.5A)
None
None
None
None
 1.30A 5kpcA-3heeA:
undetectable		 5kpcA-3heeA:
18.14