SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'R4C'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.28A 1os2A-4gr8A:
29.4		 1os2A-4gr8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.23A 1os2D-4gr8A:
29.4		 1os2D-4gr8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		5 / 10 THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.43A 1r55A-4gr8A:
10.5		 1r55A-4gr8A:
25.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.18A 1uttA-4gr8A:
29.5		 1uttA-4gr8A:
99.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.24A 1utzA-4gr8A:
30.0		 1utzA-4gr8A:
99.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.20A 1utzB-4gr8A:
30.2		 1utzB-4gr8A:
99.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.75A 1v55A-4gr8A:
undetectable		 1v55A-4gr8A:
13.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		6 / 6 ILE A 180
HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-4.3A)
ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.30A 1y93A-4gr8A:
30.0		 1y93A-4gr8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.73A 2eijA-4gr8A:
undetectable		 2eijA-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.75A 2eijN-4gr8A:
undetectable		 2eijN-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.77A 2eikN-4gr8A:
undetectable		 2eikN-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.76A 2eilN-4gr8A:
undetectable		 2eilN-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.75A 2eimA-4gr8A:
undetectable		 2eimA-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.74A 2eimN-4gr8A:
undetectable		 2eimN-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.72A 2einN-4gr8A:
undetectable		 2einN-4gr8A:
13.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.20A 2hu6A-4gr8A:
30.1		 2hu6A-4gr8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		6 / 9 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.48A 2jihA-4gr8A:
10.6		 2jihA-4gr8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		6 / 8 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.49A 2jihB-4gr8A:
10.8		 2jihB-4gr8A:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.49A 2ow9A-4gr8A:
27.2		 2ow9A-4gr8A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.29A 2ow9B-4gr8A:
27.6		 2ow9B-4gr8A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.32A 2ozrC-4gr8A:
27.8		 2ozrC-4gr8A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.40A 2ozrD-4gr8A:
28.0		 2ozrD-4gr8A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.38A 2ozrE-4gr8A:
27.1		 2ozrE-4gr8A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 218
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.26A 2ozrF-4gr8A:
26.9		 2ozrF-4gr8A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 183
GLU A 219
HIS A 222
 ZN  A 302 (-3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
 0.55A 3ba0A-4gr8A:
26.7		 3ba0A-4gr8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.77A 3bvdA-4gr8A:
undetectable		 3bvdA-4gr8A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.75A 3dtuA-4gr8A:
undetectable		 3dtuA-4gr8A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		6 / 9 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.45A 3hy7A-4gr8A:
11.2		 3hy7A-4gr8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		6 / 9 LEU A 181
THR A 215
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-3.6A)
R4C  A 306 (-3.6A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.43A 3hy7B-4gr8A:
11.0		 3hy7B-4gr8A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 5 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.28A 3kecA-4gr8A:
26.9		 3kecA-4gr8A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 218
GLU A 219
HIS A 222
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
 0.13A 3kecB-4gr8A:
27.3		 3kecB-4gr8A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.40A 3likA-4gr8A:
30.3		 3likA-4gr8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.19A 3lilA-4gr8A:
30.2		 3lilA-4gr8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		5 / 5 ILE A 180
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-4.3A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.44A 3ljgA-4gr8A:
30.3		 3ljgA-4gr8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.40A 3lkaA-4gr8A:
29.9		 3lkaA-4gr8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.74A 3wg7A-4gr8A:
undetectable		 3wg7A-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.72A 3x2qN-4gr8A:
undetectable		 3x2qN-4gr8A:
13.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.50A 4a7bA-4gr8A:
27.6		 4a7bA-4gr8A:
58.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
 0.18A 4a7bB-4gr8A:
27.6		 4a7bB-4gr8A:
58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.73A 5b1bA-4gr8A:
undetectable		 5b1bA-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.75A 5b1bN-4gr8A:
undetectable		 5b1bN-4gr8A:
13.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.21A 5n5jA-4gr8A:
30.1		 5n5jA-4gr8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		5 / 5 ILE A 180
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-4.3A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.27A 5n5kA-4gr8A:
30.2		 5n5kA-4gr8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.72A 5w97a-4gr8A:
undetectable		 5w97a-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.72A 5x19N-4gr8A:
undetectable		 5x19N-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.72A 5x1bA-4gr8A:
undetectable		 5x1bA-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.69A 5x1bN-4gr8A:
undetectable		 5x1bN-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.73A 5x1fA-4gr8A:
undetectable		 5x1fA-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.67A 5x1fN-4gr8A:
undetectable		 5x1fN-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.74A 5xdxN-4gr8A:
undetectable		 5xdxN-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.77A 5z85N-4gr8A:
undetectable		 5z85N-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.74A 5zcoN-4gr8A:
undetectable		 5zcoN-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.72A 6nmfA-4gr8A:
undetectable		 6nmfA-4gr8A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens) 		3 / 3 HIS A 228
HIS A 222
HIS A 218
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
R4C  A 306 ( 3.2A)
 0.73A 6nmfN-4gr8A:
undetectable		 6nmfN-4gr8A:
13.44