SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'R20'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 R20  A 906 ( 3.8A)
CO  A 502 ( 3.8A)
CO  A 502 ( 3.2A)
R20  A 906 (-4.0A)
CO  A 501 ( 1.9A)
 1.24A 1a4lA-2aduA:
undetectable		 1a4lA-2aduA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 R20  A 906 ( 3.8A)
CO  A 502 ( 3.8A)
CO  A 502 ( 3.2A)
R20  A 906 (-4.0A)
CO  A 501 ( 1.9A)
 1.21A 1a4lC-2aduA:
undetectable		 1a4lC-2aduA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ASP A 251
HIS A 331
HIS A 339
TYR A 444
PRO A 220
 CO  A 501 ( 1.9A)
CO  A 502 ( 3.2A)
R20  A 906 (-4.0A)
R20  A 906 (-3.5A)
None
 1.44A 1ituA-2aduA:
undetectable		 1ituA-2aduA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ASP A 251
HIS A 331
HIS A 339
TYR A 444
PRO A 220
 CO  A 501 ( 1.9A)
CO  A 502 ( 3.2A)
R20  A 906 (-4.0A)
R20  A 906 (-3.5A)
None
 1.42A 1ituB-2aduA:
undetectable		 1ituB-2aduA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 TYR A 444
GLU A 364
HIS A 331
GLY A 330
 R20  A 906 (-3.5A)
CO  A 502 ( 2.6A)
CO  A 502 ( 3.2A)
None
 0.87A 2ha4A-2aduA:
undetectable		 2ha4A-2aduA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 TYR A 444
GLU A 364
HIS A 331
GLY A 330
 R20  A 906 (-3.5A)
CO  A 502 ( 2.6A)
CO  A 502 ( 3.2A)
None
 0.85A 2ha4B-2aduA:
undetectable		 2ha4B-2aduA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 LEU A 447
PRO A 220
ASP A 262
ILE A 338
HIS A 331
 None
None
CO  A 501 (-2.2A)
R20  A 906 ( 4.5A)
CO  A 502 ( 3.2A)
 1.39A 5dv4A-2aduA:
undetectable		 5dv4A-2aduA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 GLY A 330
HIS A 331
ASP A 262
HIS A 231
 None
CO  A 502 ( 3.2A)
CO  A 501 (-2.2A)
R20  A 906 (-4.4A)
 0.77A 5nnwD-2aduA:
undetectable		 5nnwD-2aduA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 GLY A 330
HIS A 331
ASP A 262
HIS A 231
 None
CO  A 502 ( 3.2A)
CO  A 501 (-2.2A)
R20  A 906 (-4.4A)
 0.79A 5no9D-2aduA:
undetectable		 5no9D-2aduA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 SER A 473
THR A 461
PHE A 219
ALA A 362
TYR A 478
 None
None
R20  A 906 ( 3.8A)
CO  A 502 ( 3.8A)
None
 1.46A 6drxA-2aduA:
undetectable		 6drxA-2aduA:
21.61