SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'R1P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ARG A 137
THR A 140
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.29A 1jdvA-3bjeA:
28.4
1jdvD-3bjeA:
28.4		 1jdvA-3bjeA:
23.68
1jdvD-3bjeA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
THR A  97
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1jdvA-3qpbA:
31.6
1jdvD-3qpbA:
31.6		 1jdvA-3qpbA:
31.29
1jdvD-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ARG A 137
THR A 140
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.30A 1jdvB-3bjeA:
28.4
1jdvC-3bjeA:
28.9		 1jdvB-3bjeA:
23.68
1jdvC-3bjeA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
THR A  97
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.32A 1jdvB-3qpbA:
31.6
1jdvC-3qpbA:
31.3		 1jdvB-3qpbA:
31.29
1jdvC-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 ARG A 137
THR A 140
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.27A 1jdvA-3bjeA:
28.4
1jdvD-3bjeA:
28.4		 1jdvA-3bjeA:
23.68
1jdvD-3bjeA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
THR A  97
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 1jdvA-3qpbA:
31.6
1jdvD-3qpbA:
31.6		 1jdvA-3qpbA:
31.29
1jdvD-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.08A 1jdvE-3bjeA:
28.4
1jdvF-3bjeA:
28.9		 1jdvE-3bjeA:
23.68
1jdvF-3bjeA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.42A 1jdvE-3bjeA:
28.4
1jdvF-3bjeA:
28.9		 1jdvE-3bjeA:
23.68
1jdvF-3bjeA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 12 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.31A 1jdvE-3qpbA:
31.7
1jdvF-3qpbA:
31.3		 1jdvE-3qpbA:
31.29
1jdvF-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.45A 1odiA-3bjeA:
21.3		 1odiA-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.33A 1odiA-3bjeA:
21.3		 1odiA-3bjeA:
25.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.49A 1odiA-3qpbA:
26.3		 1odiA-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1odiA-3qpbA:
26.3		 1odiA-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.49A 1odiB-3bjeA:
30.2		 1odiB-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.29A 1odiB-3bjeA:
30.2		 1odiB-3bjeA:
25.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.45A 1odiB-3qpbA:
33.9		 1odiB-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.35A 1odiB-3qpbA:
33.9		 1odiB-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.45A 1odiC-3bjeA:
30.2		 1odiC-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.24A 1odiC-3bjeA:
30.2		 1odiC-3bjeA:
25.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.46A 1odiC-3qpbA:
33.8		 1odiC-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.37A 1odiC-3qpbA:
33.8		 1odiC-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.48A 1odiD-3bjeA:
30.3		 1odiD-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.25A 1odiD-3bjeA:
30.3		 1odiD-3bjeA:
25.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.47A 1odiD-3qpbA:
33.8		 1odiD-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1odiD-3qpbA:
33.8		 1odiD-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.44A 1odiE-3bjeA:
30.3		 1odiE-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.27A 1odiE-3bjeA:
30.3		 1odiE-3bjeA:
25.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.48A 1odiE-3qpbA:
33.8		 1odiE-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.35A 1odiE-3qpbA:
33.8		 1odiE-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.45A 1odiF-3bjeA:
30.1		 1odiF-3bjeA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.26A 1odiF-3bjeA:
30.1		 1odiF-3bjeA:
25.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
GLU A 198
ILE A 101
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-2.6A)
None
 1.50A 1odiF-3qpbA:
33.5		 1odiF-3qpbA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1odiF-3qpbA:
33.5		 1odiF-3qpbA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 9 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.02A 1pk7A-3bjeA:
28.6		 1pk7A-3bjeA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 9 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.29A 1pk7A-3qpbA:
31.9		 1pk7A-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 8 ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.06A 1pk7B-3bjeA:
28.6		 1pk7B-3bjeA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 8 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.28A 1pk7B-3qpbA:
32.1		 1pk7B-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.42A 1pk7C-3bjeA:
29.0		 1pk7C-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.19A 1pk7C-3bjeA:
29.0		 1pk7C-3bjeA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.36A 1pk7C-3qpbA:
32.1		 1pk7C-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.35A 1pk9A-3bjeA:
28.7		 1pk9A-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.10A 1pk9A-3bjeA:
28.7		 1pk9A-3bjeA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 1pk9A-3qpbA:
31.8		 1pk9A-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.31A 1pk9B-3bjeA:
28.6		 1pk9B-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.03A 1pk9B-3bjeA:
28.6		 1pk9B-3bjeA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 9 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 1pk9B-3qpbA:
32.0		 1pk9B-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.40A 1pk9C-3bjeA:
28.0		 1pk9C-3bjeA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.32A 1pk9C-3qpbA:
32.3		 1pk9C-3qpbA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.35A 1pw7A-3bjeA:
28.8		 1pw7A-3bjeA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.06A 1pw7A-3bjeA:
28.8		 1pw7A-3bjeA:
26.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.33A 1pw7A-3qpbA:
31.8		 1pw7A-3qpbA:
31.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.36A 1pw7B-3bjeA:
29.2		 1pw7B-3bjeA:
26.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 9 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.36A 1pw7B-3qpbA:
32.2		 1pw7B-3qpbA:
31.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 MET A  87
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 0.78A 1pw7C-3bjeA:
29.1		 1pw7C-3bjeA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.22A 1rxcB-3bjeA:
31.0		 1rxcB-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.33A 1rxcC-3bjeA:
5.7		 1rxcC-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.18A 1rxcD-3bjeA:
30.7		 1rxcD-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.22A 1rxcE-3bjeA:
30.9		 1rxcE-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.22A 1rxcF-3bjeA:
31.1		 1rxcF-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 1rxcI-3bjeA:
30.9		 1rxcI-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.27A 1rxcK-3bjeA:
29.7		 1rxcK-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.21A 1rxcL-3bjeA:
30.9		 1rxcL-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ILE A  83
GLY A  42
ILE A  92
VAL A  47
ASN A  91
 None
R1P  A 401 (-3.2A)
None
None
None
 1.23A 1sg9A-3bjeA:
undetectable		 1sg9A-3bjeA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.34A 1vhwA-3bjeA:
29.5
1vhwD-3bjeA:
29.5		 1vhwA-3bjeA:
24.44
1vhwD-3bjeA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 1vhwA-3qpbA:
32.8
1vhwD-3qpbA:
32.8		 1vhwA-3qpbA:
30.54
1vhwD-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 MET A  87
ARG A 137
GLY A 142
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.32A 1vhwB-3bjeA:
29.8
1vhwF-3bjeA:
29.3		 1vhwB-3bjeA:
24.44
1vhwF-3bjeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.33A 1vhwC-3bjeA:
29.6
1vhwE-3bjeA:
29.4		 1vhwC-3bjeA:
24.44
1vhwE-3bjeA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.42A 1vhwC-3qpbA:
32.8
1vhwE-3qpbA:
32.6		 1vhwC-3qpbA:
30.54
1vhwE-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.33A 1vhwA-3bjeA:
29.5
1vhwD-3bjeA:
29.5		 1vhwA-3bjeA:
24.44
1vhwD-3bjeA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.42A 1vhwA-3qpbA:
32.8
1vhwD-3qpbA:
32.8		 1vhwA-3qpbA:
30.54
1vhwD-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.34A 1vhwC-3bjeA:
29.6
1vhwE-3bjeA:
29.4		 1vhwC-3bjeA:
24.44
1vhwE-3bjeA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 1vhwC-3qpbA:
32.8
1vhwE-3qpbA:
32.6		 1vhwC-3qpbA:
30.54
1vhwE-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.36A 1vhwB-3bjeA:
29.8
1vhwF-3bjeA:
29.3		 1vhwB-3bjeA:
24.44
1vhwF-3bjeA:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.44A 1vhwB-3qpbA:
32.8
1vhwF-3qpbA:
33.4		 1vhwB-3qpbA:
30.54
1vhwF-3qpbA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.02A 1z35A-3bjeA:
16.6		 1z35A-3bjeA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.47A 1z35A-3bjeA:
16.6		 1z35A-3bjeA:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 10 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.51A 1z35A-3qpbA:
32.7		 1z35A-3qpbA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 9 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.03A 1z37A-3bjeA:
29.0		 1z37A-3bjeA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 9 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.45A 1z37A-3bjeA:
29.0		 1z37A-3bjeA:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 9 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 1z37A-3qpbA:
32.8		 1z37A-3qpbA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.43A 2ac7A-3bjeA:
27.6
2ac7B-3bjeA:
27.7		 2ac7A-3bjeA:
26.00
2ac7B-3bjeA:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.30A 2ac7A-3qpbA:
30.7
2ac7B-3qpbA:
30.7		 2ac7A-3qpbA:
31.10
2ac7B-3qpbA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.43A 2ac7A-3bjeA:
27.6
2ac7B-3bjeA:
27.7		 2ac7A-3bjeA:
26.00
2ac7B-3bjeA:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.31A 2ac7A-3qpbA:
30.7
2ac7B-3qpbA:
30.7		 2ac7A-3qpbA:
31.10
2ac7B-3qpbA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 THR A 140
GLY A 142
PHE A 242
GLN A 246
ARG A 248
GLU A 284
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-4.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
 0.29A 3kvrA-3bjeA:
23.9		 3kvrA-3bjeA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 THR A  97
GLY A  99
PHE A 165
GLU A 196
MET A 197
 R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.5A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
 0.42A 3kvrA-3qpbA:
24.6		 3kvrA-3qpbA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 THR A 140
GLY A 142
PHE A 242
GLN A 246
ARG A 248
GLU A 284
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-4.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
 0.21A 3kvrB-3bjeA:
23.9		 3kvrB-3bjeA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 THR A  97
GLY A  99
PHE A 165
GLU A 196
MET A 197
 R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.5A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
 0.46A 3kvrB-3qpbA:
24.5		 3kvrB-3qpbA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 3kvvA-3bjeA:
30.5		 3kvvA-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.21A 3kvvB-3bjeA:
30.4		 3kvvB-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.21A 3kvvC-3bjeA:
30.0		 3kvvC-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.28A 3kvvD-3bjeA:
29.9		 3kvvD-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.24A 3kvvE-3bjeA:
30.9		 3kvvE-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.25A 3kvvF-3bjeA:
13.6		 3kvvF-3bjeA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 THR A 140
GLY A 142
GLN A 246
ARG A 248
GLU A 284
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
 0.31A 3nbqA-3bjeA:
23.3		 3nbqA-3bjeA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.26A 3nbqB-3bjeA:
23.4		 3nbqB-3bjeA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.24A 3nbqC-3bjeA:
23.4		 3nbqC-3bjeA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
ARG A 311
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
None
 0.37A 3nbqD-3bjeA:
23.5		 3nbqD-3bjeA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 MET A  87
ARG A 137
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.46A 3u40A-3bjeA:
28.9
3u40F-3bjeA:
27.3		 3u40A-3bjeA:
23.61
3u40F-3bjeA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 MET A  87
ARG A 137
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.46A 3u40B-3bjeA:
28.5
3u40C-3bjeA:
15.2		 3u40B-3bjeA:
23.61
3u40C-3bjeA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.46A 3u40B-3bjeA:
28.6
3u40C-3bjeA:
15.2		 3u40B-3bjeA:
23.61
3u40C-3bjeA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.44A 3u40B-3qpbA:
31.0
3u40C-3qpbA:
30.9		 3u40B-3qpbA:
29.79
3u40C-3qpbA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.43A 3u40D-3bjeA:
29.1
3u40E-3bjeA:
27.9		 3u40D-3bjeA:
23.61
3u40E-3bjeA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.39A 3u40D-3qpbA:
31.2
3u40E-3qpbA:
31.3		 3u40D-3qpbA:
29.79
3u40E-3qpbA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 12 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.51A 3u40D-3bjeA:
29.1
3u40E-3bjeA:
27.9		 3u40D-3bjeA:
23.61
3u40E-3bjeA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.47A 3u40D-3qpbA:
31.2
3u40E-3qpbA:
31.3		 3u40D-3qpbA:
29.79
3u40E-3qpbA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 10 MET A  87
ARG A 137
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.40A 3u40A-3bjeA:
28.9
3u40F-3bjeA:
27.3		 3u40A-3bjeA:
23.61
3u40F-3bjeA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.43A 3uawA-3bjeA:
17.2		 3uawA-3bjeA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.27A 3uawA-3bjeA:
17.2		 3uawA-3bjeA:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 11 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.34A 3uawA-3qpbA:
31.5		 3uawA-3qpbA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 10 MET A  87
ARG A 137
THR A 140
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.42A 3uayA-3bjeA:
29.5		 3uayA-3bjeA:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		6 / 10 ARG A  94
THR A  97
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
R1P  A1254 (-3.0A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.32A 3uayA-3qpbA:
31.2		 3uayA-3qpbA:
31.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.34A 4d9hA-3bjeA:
28.2		 4d9hA-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.06A 4d9hA-3bjeA:
28.2		 4d9hA-3bjeA:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.37A 4d9hA-3qpbA:
30.4		 4d9hA-3qpbA:
34.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 MET A  87
GLY A 142
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.09A 4da6A-3bjeA:
27.8		 4da6A-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		8 / 10 MET A  87
ARG A 137
GLY A 142
ALA A 239
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
None
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 0.96A 4da7A-3bjeA:
28.1		 4da7A-3bjeA:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 10 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.37A 4da7A-3qpbA:
30.3		 4da7A-3qpbA:
34.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 11 MET A  87
ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.30A 4danA-3bjeA:
27.8		 4danA-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 11 MET A  87
GLY A 142
GLU A 284
MET A 285
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
URA  A 501 (-3.2A)
 1.09A 4danA-3bjeA:
27.8		 4danA-3bjeA:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 11 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.38A 4danA-3qpbA:
29.9		 4danA-3qpbA:
34.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ARG A 137
GLY A 142
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.32A 4danA-3bjeA:
27.8
4danB-3bjeA:
28.0		 4danA-3bjeA:
27.25
4danB-3bjeA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY A 142
GLU A 284
MET A 285
GLU A 286
SER A 309
 URA  A 501 (-3.4A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.15A 4danA-3bjeA:
27.8
4danB-3bjeA:
28.0		 4danA-3bjeA:
27.25
4danB-3bjeA:
27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 ARG A  94
GLY A  99
GLU A 196
MET A 197
GLU A 198
 R1P  A1254 (-3.1A)
URA  A1255 (-3.2A)
R1P  A1254 ( 4.4A)
R1P  A1254 (-3.9A)
R1P  A1254 (-2.6A)
 0.43A 4danA-3qpbA:
29.9
4danB-3qpbA:
30.2		 4danA-3qpbA:
34.58
4danB-3qpbA:
34.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vA-3bjeA:
17.2		 4e1vA-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.25A 4e1vB-3bjeA:
29.6		 4e1vB-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vC-3bjeA:
29.6		 4e1vC-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vD-3bjeA:
29.9		 4e1vD-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vE-3bjeA:
30.0		 4e1vE-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY A 142
GLN A 246
ARG A 248
MET A 285
 URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.26A 4e1vF-3bjeA:
29.6		 4e1vF-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.38A 4e1vG-3bjeA:
28.8		 4e1vG-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 8 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4e1vH-3bjeA:
29.7		 4e1vH-3bjeA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 7 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 4txnA-3bjeA:
23.2		 4txnA-3bjeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 7 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.23A 4txnB-3bjeA:
23.1		 4txnB-3bjeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 7 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 4txnC-3bjeA:
23.0		 4txnC-3bjeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 7 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 4txnD-3bjeA:
22.9		 4txnD-3bjeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3qpb URIDINE
PHOSPHORYLASE
(Streptococcus
pyogenes) 		5 / 12 THR A  97
GLY A  73
PRO A  75
SER A  76
ALA A  77
 R1P  A1254 (-3.0A)
None
None
None
None
 1.03A 4ypmA-3qpbA:
undetectable		 4ypmA-3qpbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 9 MET A  87
ARG A 137
GLY A 142
ALA A 239
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
None
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.30A 5i3cA-3bjeA:
28.9		 5i3cA-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		6 / 10 MET A  87
GLY A 142
ALA A 239
GLU A 284
MET A 285
GLU A 286
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
None
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
 0.37A 5i3cB-3bjeA:
29.0		 5i3cB-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		7 / 11 MET A  87
GLY A 142
ALA A 239
GLU A 284
MET A 285
GLU A 286
SER A 309
 R1P  A 401 ( 3.9A)
URA  A 501 (-3.4A)
None
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
R1P  A 401 (-2.6A)
URA  A 501 (-3.2A)
 1.10A 5i3cC-3bjeA:
29.3		 5i3cC-3bjeA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 LEU A  96
ARG A 137
ILE A 135
PHE A  40
 None
R1P  A 401 (-3.0A)
None
None
 1.34A 5kirB-3bjeA:
undetectable		 5kirB-3bjeA:
20.29