SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'R16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WX2_A_TPFA1460_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	4 / 7	MET A 122 ALA A 149 ALA A 152 LEU A 181	RET A 301 (-3.7A) R16 A 308 ( 3.8A) None None	0.95A	2wx2A-5ax0A: undetectable	2wx2A-5ax0A: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPC_B_SAMB401_0 (PAVINE N-METHYLTRANSFERASE)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	5 / 12	LYS A 137 PHE A 141 GLY A 126 ASP A 89 ALA A 196	None R16 A 308 (-4.8A) RET A 301 ( 3.8A) RET A 301 ( 4.9A) None	1.11A	5kpcB-5ax0A: undetectable	5kpcB-5ax0A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1801_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5vkp	POTASSIUM CHANNEL SUBFAMILY K MEMBER 2 (Mus musculus)	4 / 9	LYS A 156 ILE A 157 ILE A 161 LEU A 164	None None R16 A 407 ( 4.5A) R16 A 407 (-4.8A)	0.74A	5vkqB-5vkpA: 5.2 5vkqC-5vkpA: 5.2	5vkqB-5vkpA: 10.58 5vkqC-5vkpA: 10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_1 (PROTEIN CYP51)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	5 / 12	ALA A 50 MET A 122 ALA A 149 ALA A 152 LEU A 181	D10 A 309 ( 3.8A) RET A 301 (-3.7A) R16 A 308 ( 3.8A) None None	1.35A	6aycA-5ax0A: undetectable	6aycA-5ax0A: 13.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2WX2_A_TPFA1460_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","5ax0","RHODOPSIN I","Acetabularia acetabulum",4,"MET A 122;ALA A 149;ALA A 152;LEU A 181","RET A 301 (-3.7A);R16 A 308 ( 3.8A);None;None","0.95A","2wx2A-5ax0A:undetectable",null],["5KPC_B_SAMB401_0","PAVINE N-METHYLTRANSFERASE","5ax0","RHODOPSIN I","Acetabularia acetabulum",5,"LYS A 137;PHE A 141;GLY A 126;ASP A  89;ALA A 196","None;R16 A 308 (-4.8A);RET A 301 ( 3.8A);RET A 301 ( 4.9A);None","1.11A","5kpcB-5ax0A:undetectable","2wx2A-5ax0A:20.17"],["5VKQ_C_PCFC1801_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","5vkp","POTASSIUM CHANNEL SUBFAMILY K MEMBER 2","Mus musculus",4,"LYS A 156;ILE A 157;ILE A 161;LEU A 164","None;None;R16 A 407 ( 4.5A);R16 A 407 (-4.8A)","0.74A","5vkqB-5vkpA:5.2;5vkqC-5vkpA:5.2","5kpcB-5ax0A:20.00"],["6AYC_A_1YNA502_1","PROTEIN CYP51","5ax0","RHODOPSIN I","Acetabularia acetabulum",5,"ALA A  50;MET A 122;ALA A 149;ALA A 152;LEU A 181","D10 A 309 ( 3.8A);RET A 301 (-3.7A);R16 A 308 ( 3.8A);None;None","1.35A","6aycA-5ax0A:undetectable","5vkqB-5vkpA:10.58;5vkqC-5vkpA:10.58"]]