SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'QUN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 PHE A  22
GLU A  28
GLN A 143
VAL A 173
TRP A 179
TRP A 183
ASN A 283
 None
None
None
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
None
 0.38A 1jqdA-1jqeA:
42.3		 1jqdA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 PHE A 243
GLN A 143
VAL A 173
TRP A 179
 QUN  A 500 (-4.1A)
None
None
QUN  A 500 (-3.6A)
 1.20A 1jqdA-1jqeA:
42.3		 1jqdA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JQD_B_HSMB601_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		10 / 10 PHE A  22
GLU A  28
GLN A 143
TYR A 146
VAL A 173
TRP A 179
TRP A 183
PHE A 243
ASN A 283
LEU A 285
 None
None
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-4.1A)
None
None
 0.37A 1jqdB-1jqeA:
42.8		 1jqdB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOT_A_2PMA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 10 GLN A 143
TYR A 146
TYR A 147
VAL A 173
TRP A 179
TRP A 183
TYR A 198
PHE A 243
 None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
None
QUN  A 500 (-4.1A)
 0.48A 2aotA-1jqeA:
42.6		 2aotA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOT_A_2PMA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 TYR A 146
TYR A 147
VAL A 173
TRP A 179
PHE A  22
 QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
None
 1.29A 2aotA-1jqeA:
42.6		 2aotA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOT_B_2PMB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 12 PHE A  22
GLN A 143
TYR A 146
TYR A 147
TRP A 179
TRP A 183
CYH A 196
TYR A 198
PHE A 243
 None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
None
QUN  A 500 (-4.1A)
 0.60A 2aotB-1jqeA:
42.5		 2aotB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOT_B_2PMB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 12 PHE A  22
TYR A 146
TYR A 147
TRP A 183
CYH A 196
TYR A 198
PHE A 243
GLU A 246
 None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
None
QUN  A 500 (-4.1A)
QUN  A 500 (-3.9A)
 0.84A 2aotB-1jqeA:
42.5		 2aotB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 12 GLU A  28
GLN A  94
GLN A 143
TYR A 146
TYR A 147
VAL A 173
TRP A 179
TRP A 183
CYH A 196
 None
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
 0.51A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 12 GLU A  28
GLN A  94
GLN A 143
TYR A 146
VAL A 173
TRP A 179
TRP A 183
CYH A 196
GLU A 246
 None
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
 0.86A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 12 PHE A  19
GLN A  94
TYR A 146
TYR A 147
VAL A 173
TRP A 179
TRP A 183
CYH A 196
 SAH  A 400 (-3.9A)
SAH  A 400 (-3.8A)
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
 0.78A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 12 PHE A  19
GLN A  94
TYR A 146
VAL A 173
TRP A 179
TRP A 183
CYH A 196
GLU A 246
 SAH  A 400 (-3.9A)
SAH  A 400 (-3.8A)
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
 1.07A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A  22
GLN A 143
TYR A 146
CYH A 196
GLU A 246
 None
None
QUN  A 500 (-3.3A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
 1.37A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A  22
GLN A 143
TYR A 146
TYR A 147
CYH A 196
 None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
 1.43A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A  22
GLN A 143
TYR A 146
VAL A 172
CYH A 196
 None
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
 1.45A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 8 ASP A 180
TRP A 183
LYS A 184
GLY A 187
PHE A 190
THR A 247
 None
QUN  A 500 (-4.9A)
None
None
None
None
 1.07A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 8 ASP A 180
TRP A 183
LYS A 184
PHE A 190
TYR A 198
THR A 247
 None
QUN  A 500 (-4.9A)
None
None
None
None
 1.09A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 8 TRP A 183
LYS A 181
PHE A 190
TYR A 198
THR A 247
 QUN  A 500 (-4.9A)
None
None
None
None
 1.25A 2aouA-1jqeA:
42.2		 2aouA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLN A  94
TYR A 146
VAL A 173
TRP A 183
PHE A  22
 SAH  A 400 (-3.8A)
QUN  A 500 (-3.3A)
None
QUN  A 500 (-4.9A)
None
 1.42A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 12 GLU A  28
GLN A  94
GLN A 143
TYR A 146
VAL A 173
TRP A 183
CYH A 196
PHE A 243
GLU A 246
 None
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.1A)
QUN  A 500 (-3.9A)
 0.87A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		10 / 12 GLU A  28
SER A  91
GLN A  94
GLN A 143
TYR A 146
TYR A 147
VAL A 173
TRP A 183
CYH A 196
PHE A 243
 None
SAH  A 400 (-4.7A)
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.1A)
 0.64A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TRP A 183
GLY A 187
PHE A 190
THR A 247
 QUN  A 500 (-4.9A)
None
None
None
 1.04A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TRP A 183
PHE A 190
TYR A 198
THR A 247
 QUN  A 500 (-4.9A)
None
None
None
 1.03A 2aouB-1jqeA:
42.9		 2aouB-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 PHE A  22
GLU A  28
GLN A 143
TYR A 147
TRP A 179
TRP A 183
GLU A 246
 None
None
None
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.9A)
 0.74A 2aowA-1jqeA:
40.2		 2aowA-1jqeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOW_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 9 PHE A  22
GLU A  28
GLN A 143
TYR A 146
TYR A 147
TRP A 179
TRP A 183
CYH A 196
GLU A 246
 None
None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
 0.76A 2aowB-1jqeA:
40.2		 2aowB-1jqeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 8 PHE A  19
PHE A  22
GLU A  28
TYR A 146
TYR A 147
TRP A 179
TRP A 183
 SAH  A 400 (-3.9A)
None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
 0.76A 2aoxA-1jqeA:
39.8		 2aoxA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 8 PHE A  22
GLU A  28
GLN A 143
TYR A 146
TYR A 147
TRP A 179
TRP A 183
 None
None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
 0.51A 2aoxA-1jqeA:
39.8		 2aoxA-1jqeA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 PHE A  19
PHE A  22
GLU A  28
GLN A 143
TYR A 147
TRP A 179
TRP A 183
 SAH  A 400 (-3.9A)
None
None
None
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
 0.80A 2aoxB-1jqeA:
39.8		 2aoxB-1jqeA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 146
PRO A 152
ALA A 153
MET A 141
MET A 207
 QUN  A 500 (-3.3A)
None
None
None
None
 0.98A 2x2nB-1jqeA:
undetectable		 2x2nB-1jqeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  60
GLY A  62
VAL A  88
TYR A 147
VAL A 148
 SAH  A 400 (-3.3A)
SAH  A 400 (-3.2A)
None
QUN  A 500 ( 3.6A)
SAH  A 400 ( 4.8A)
 0.67A 4f84A-1jqeA:
13.6		 4f84A-1jqeA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A 243
CYH A 229
ASN A 251
ALA A 254
LEU A 258
 QUN  A 500 (-4.1A)
None
None
None
None
 1.49A 4oadA-1jqeA:
2.5		 4oadA-1jqeA:
20.85