SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'QUE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 12 HIS A 115
PHE A 141
PHE A  56
HIS A  71
HIS A  69
 NI  A 300 (-3.2A)
QUE  A 301 (-4.8A)
None
NI  A 300 ( 3.3A)
QUE  A 301 ( 3.0A)
 1.05A 1a4lA-5fljA:
undetectable		 1a4lA-5fljA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 12 HIS A 115
PHE A 141
PHE A  56
HIS A  71
HIS A  69
 NI  A 300 (-3.2A)
QUE  A 301 (-4.8A)
None
NI  A 300 ( 3.3A)
QUE  A 301 ( 3.0A)
 1.03A 1a4lC-5fljA:
undetectable		 1a4lC-5fljA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.87A 1iepA-2hckA:
29.9		 1iepA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.94A 1iepA-2hckA:
29.9		 1iepA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.5A)
 0.94A 1iepB-2hckA:
29.9		 1iepB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 ( 4.5A)
 0.91A 1iepB-2hckA:
29.9		 1iepB-2hckA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 7 PHE A 141
PHE A  56
VAL A 174
HIS A 115
 QUE  A 301 (-4.8A)
None
None
NI  A 300 (-3.2A)
 0.91A 1lh6A-5fljA:
undetectable		 1lh6A-5fljA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.70A 1m17A-2hckA:
28.3		 1m17A-2hckA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
 0.93A 1m17A-3lm5A:
24.8		 1m17A-3lm5A:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 9 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
ALA A 113
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.71A 1muoA-3lm5A:
15.1		 1muoA-3lm5A:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
PHE A 340
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
 0.67A 1opjA-2hckA:
29.4		 1opjA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
VAL A 323
THR A 338
PHE A 340
GLY A 344
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.5A)
 0.83A 1opjB-2hckA:
29.2		 1opjB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.85A 1opjB-2hckA:
29.2		 1opjB-2hckA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 11 TYR A 117
PHE A  78
PHE A 165
PHE A 137
VAL A 174
 QUE  A 301 (-4.8A)
QUE  A 301 (-3.9A)
None
QUE  A 301 ( 4.9A)
None
 1.29A 1q23J-5fljA:
undetectable		 1q23J-5fljA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
ALA A 293
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.56A 1xbbA-2hckA:
30.2		 1xbbA-2hckA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 9 LEU A  39
VAL A  47
ALA A  60
ALA A 113
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.9A)
None
None
 0.73A 1xbbA-3lm5A:
26.9		 1xbbA-3lm5A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 293
THR A 338
GLY A 344
LEU A 347
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.76A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 MET A 314
THR A 338
GLY A 344
LEU A 347
ASP A 348
ASP A 404
 None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.1A)
None
 0.97A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
LYS A 295
LEU A 325
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
 0.62A 1xkkA-2hckA:
31.3		 1xkkA-2hckA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 9 LEU A  39
VAL A  47
LYS A  62
LEU A  96
LEU A 108
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
None
None
 0.78A 1xkkA-3lm5A:
23.3		 1xkkA-3lm5A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 10 LEU A  39
ALA A  60
ILE A  94
LEU A 110
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.1A)
None
 0.63A 1yi4A-3lm5A:
26.7		 1yi4A-3lm5A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 8 PHE A  36
GLU A  59
GLY A  60
THR A  41
 QUE  A 301 (-4.5A)
None
None
None
 0.90A 1ykiA-5fljA:
undetectable
1ykiB-5fljA:
undetectable		 1ykiA-5fljA:
25.32
1ykiB-5fljA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 8 THR A  41
PHE A  36
GLU A  59
GLY A  60
 None
QUE  A 301 (-4.5A)
None
None
 0.88A 1ykiA-5fljA:
undetectable
1ykiB-5fljA:
undetectable		 1ykiA-5fljA:
25.32
1ykiB-5fljA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 8 PHE A  36
GLU A  59
GLY A  60
THR A  41
 QUE  A 301 (-4.5A)
None
None
None
 0.89A 1ykiC-5fljA:
undetectable
1ykiD-5fljA:
undetectable		 1ykiC-5fljA:
25.32
1ykiD-5fljA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		4 / 8 THR A  41
PHE A  36
GLU A  59
GLY A  60
 None
QUE  A 301 (-4.5A)
None
None
 0.88A 1ykiC-5fljA:
undetectable
1ykiD-5fljA:
undetectable		 1ykiC-5fljA:
25.32
1ykiD-5fljA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 11 PHE A 117
PHE A 118
GLY A  97
ILE A 172
LEU A 174
 None
HIU  A 502 (-4.8A)
HIU  A 502 ( 3.5A)
QUE  A 501 (-3.9A)
HIU  A 502 (-4.9A)
 1.05A 1z11A-3bptA:
undetectable		 1z11A-3bptA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 11 PHE A 117
PHE A 118
GLY A  97
ILE A 172
LEU A 174
 None
HIU  A 502 (-4.8A)
HIU  A 502 ( 3.5A)
QUE  A 501 (-3.9A)
HIU  A 502 (-4.9A)
 1.05A 1z11B-3bptA:
undetectable		 1z11B-3bptA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 11 GLY A  40
VAL A  47
ALA A  60
TYR A 112
ALA A 113
LEU A 165
ASP A 179
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
QUE  A   1 (-2.9A)
 0.66A 2evaA-3lm5A:
24.6		 2evaA-3lm5A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
ASP A 158
LYS A 160
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
None
QUE  A   1 (-2.9A)
 0.75A 2fumA-3lm5A:
27.6		 2fumA-3lm5A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
LYS A 160
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
QUE  A   1 (-2.9A)
 0.81A 2fumB-3lm5A:
27.6		 2fumB-3lm5A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
QUE  A   1 (-2.9A)
 0.67A 2fumC-3lm5A:
25.8		 2fumC-3lm5A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A 160
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
QUE  A   1 (-2.9A)
 0.65A 2fumD-3lm5A:
26.1		 2fumD-3lm5A:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.76A 2gqgA-2hckA:
30.7		 2gqgA-2hckA:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 2gqgB-2hckA:
31.0		 2gqgB-2hckA:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.65A 2gqgB-2hckA:
31.0		 2gqgB-2hckA:
30.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.61A 2hyyA-2hckA:
30.1		 2hyyA-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 QUE  A   1 (-3.9A)
None
None
None
 0.90A 2hyyA-2hckA:
30.1		 2hyyA-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.56A 2hyyB-2hckA:
30.3		 2hyyB-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
None
 0.92A 2hyyB-2hckA:
30.3		 2hyyB-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 293
VAL A 323
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.63A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.83A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.91A 2hyyC-2hckA:
30.4		 2hyyC-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.91A 2hyyD-2hckA:
30.2		 2hyyD-2hckA:
30.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 4 LEU A 273
LYS A 295
VAL A 323
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.87A 2hyyD-2hckA:
30.2		 2hyyD-2hckA:
30.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LYS A 295
THR A 338
GLY A 344
ASP A 348
LEU A 393
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
 0.71A 2itoA-2hckA:
28.4		 2itoA-2hckA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
LYS A 295
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.70A 2itoA-2hckA:
28.4		 2itoA-2hckA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
LEU A  84
LEU A 108
TYR A 112
ALA A 113
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
QUE  A   1 (-2.9A)
 0.56A 2ivuA-3lm5A:
25.8		 2ivuA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
LEU A 108
TYR A 112
ALA A 113
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
QUE  A   1 (-2.9A)
 0.67A 2ivuA-3lm5A:
25.8		 2ivuA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 ILE A  81
ILE A  77
LEU A 108
ARG A  68
ILE A  94
 None
None
None
None
QUE  A   1 (-4.6A)
 0.98A 2nnhA-3lm5A:
undetectable		 2nnhA-3lm5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 10 ILE A  81
ILE A  77
LEU A 108
ARG A  68
ILE A  94
 None
None
None
None
QUE  A   1 (-4.6A)
 0.97A 2nnhB-3lm5A:
undetectable		 2nnhB-3lm5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 11 ALA A  33
PHE A 140
PHE A 141
ILE A  66
PRO A  67
 None
QUE  A 301 (-4.3A)
QUE  A 301 (-4.8A)
QUE  A 301 ( 4.0A)
None
 1.17A 2w3aA-5fljA:
undetectable		 2w3aA-5fljA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 GLY A  40
VAL A  47
ALA A  60
LEU A 110
TYR A 112
GLY A 116
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
 0.72A 2wgjA-3lm5A:
8.4		 2wgjA-3lm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 2xp2A-2hckA:
29.4		 2xp2A-2hckA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 VAL A  47
ALA A  60
ILE A  94
GLY A 116
GLU A 117
LEU A 165
ASP A 179
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
None
None
None
QUE  A   1 (-2.9A)
 0.74A 2y7jA-3lm5A:
31.9		 2y7jA-3lm5A:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 10 VAL A  47
ALA A  60
ILE A  94
GLY A 116
LEU A 165
ASP A 179
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
None
None
QUE  A   1 (-2.9A)
 0.79A 2y7jB-3lm5A:
31.9		 2y7jB-3lm5A:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASP A 348
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
 0.51A 2y7jD-2hckA:
24.2		 2y7jD-2hckA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 8 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.53A 2yfxA-2hckA:
28.8		 2yfxA-2hckA:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.81A 2zvaA-2hckA:
33.8		 2zvaA-2hckA:
60.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 273
ALA A 293
VAL A 323
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.62A 3aoxA-2hckA:
28.2		 3aoxA-2hckA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 VAL A 281
ALA A 293
MET A 314
LEU A 325
THR A 338
GLY A 344
LEU A 393
ASP A 404
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
 0.83A 3bbtB-2hckA:
31.7		 3bbtB-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
PHE A 405
LEU A 407
 QUE  A   1 ( 4.8A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
None
 1.09A 3bbtB-2hckA:
31.7		 3bbtB-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
LEU A 393
ASP A 404
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
 0.82A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.70A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
LYS A 295
MET A 314
GLY A 344
LEU A 393
ASP A 404
PHE A 405
LEU A 407
 QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
None
 1.13A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
LYS A 295
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
LEU A 407
 QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
 0.99A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
ASP A 179
PHE A 180
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
None
 0.97A 3bbtD-3lm5A:
12.6		 3bbtD-3lm5A:
24.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
ALA A 293
LYS A 295
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.94A 3c7qA-2hckA:
27.5		 3c7qA-2hckA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.76A 3c7qA-2hckA:
27.5		 3c7qA-2hckA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
PHE A 340
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
QUE  A   1 (-4.2A)
 0.71A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
GLY A 344
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.45A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.58A 3cs9A-2hckA:
30.2		 3cs9A-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 ALA A 293
LEU A 322
GLY A 344
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.5A)
 0.42A 3cs9B-2hckA:
30.5		 3cs9B-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
 0.68A 3cs9B-2hckA:
30.5		 3cs9B-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
VAL A 281
VAL A 323
ILE A 336
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-4.4A)
 0.82A 3cs9B-2hckA:
30.5		 3cs9B-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
THR A 338
PHE A 340
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 ( 4.5A)
 0.74A 3cs9C-2hckA:
30.1		 3cs9C-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
None
None
 0.79A 3cs9C-2hckA:
30.1		 3cs9C-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
PHE A 340
GLY A 344
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.5A)
 0.38A 3cs9D-2hckA:
29.0		 3cs9D-2hckA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
THR A 338
PHE A 340
GLY A 344
HIS A 384
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
None
 0.51A 3cs9D-2hckA:
29.0		 3cs9D-2hckA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 6 LEU A  39
VAL A  47
LYS A  62
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
None
 0.72A 3cs9D-3lm5A:
22.4		 3cs9D-3lm5A:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
GLY A 274
GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
SER A 345
ASN A 391
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 ( 4.7A)
None
QUE  A   1 (-4.4A)
 0.90A 3eygA-2hckA:
28.1		 3eygA-2hckA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
 0.76A 3fupA-2hckA:
28.7		 3fupA-2hckA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
GLY A 276
GLY A 279
VAL A 281
ALA A 293
SER A 345
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 ( 4.7A)
QUE  A   1 (-4.4A)
 0.73A 3fupA-2hckA:
28.7		 3fupA-2hckA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 11 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
 0.41A 3g0eA-3lm5A:
22.4		 3g0eA-3lm5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 11 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
 0.45A 3g0fA-3lm5A:
23.4		 3g0fA-3lm5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 10 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
 0.47A 3g0fB-3lm5A:
23.5		 3g0fB-3lm5A:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.56A 3g5dA-2hckA:
32.4		 3g5dA-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.64A 3g5dA-2hckA:
32.4		 3g5dA-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.78A 3g5dB-2hckA:
32.6		 3g5dB-2hckA:
50.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 LYS A  62
VAL A  93
LEU A 108
ILE A 177
 QUE  A   1 (-4.1A)
None
None
None
 0.49A 3gp0A-3lm5A:
24.0		 3gp0A-3lm5A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		4 / 7 TYR A 122
VAL A 178
ILE A 100
GLY A 146
 None
HIU  A 502 (-4.6A)
QUE  A 501 ( 3.8A)
HIU  A 502 (-2.7A)
 1.00A 3gssA-3bptA:
undetectable		 3gssA-3bptA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		4 / 7 TYR A 122
VAL A 178
ILE A 100
GLY A 146
 None
HIU  A 502 (-4.6A)
QUE  A 501 ( 3.8A)
HIU  A 502 (-2.7A)
 1.00A 3gssB-3bptA:
undetectable		 3gssB-3bptA:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.82A 3gvuA-2hckA:
30.5		 3gvuA-2hckA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.57A 3ik3A-2hckA:
30.0		 3ik3A-2hckA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.64A 3ik3B-2hckA:
29.8		 3ik3B-2hckA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 7 LEU A 273
LYS A 295
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.85A 3ik3B-2hckA:
29.8		 3ik3B-2hckA:
31.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.78A 3k54A-2hckA:
30.3		 3k54A-2hckA:
28.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.63A 3k5vA-2hckA:
29.4		 3k5vA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
None
 0.86A 3k5vA-2hckA:
29.4		 3k5vA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.59A 3k5vB-2hckA:
29.5		 3k5vB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
LYS A 295
VAL A 323
ILE A 336
 QUE  A   1 (-3.9A)
None
None
None
 0.86A 3k5vB-2hckA:
29.5		 3k5vB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 (-3.9A)
None
None
None
 0.69A 3k5vB-2hckA:
29.5		 3k5vB-2hckA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		4 / 5 ILE A 100
PHE A 342
ASP A 341
GLU A 344
 QUE  A 501 ( 3.8A)
None
None
None
 1.03A 3kp6A-3bptA:
undetectable
3kp6B-3bptA:
undetectable		 3kp6A-3bptA:
20.33
3kp6B-3bptA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
TYR A 112
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
 0.78A 3lxkA-3lm5A:
25.6		 3lxkA-3lm5A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
SER A 345
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 ( 4.7A)
QUE  A   1 (-4.4A)
 0.69A 3lxnA-2hckA:
27.9		 3lxnA-2hckA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
ILE A  94
TYR A 112
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
 0.70A 3lxnA-3lm5A:
25.5		 3lxnA-3lm5A:
28.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 ALA A 293
VAL A 323
PHE A 340
MET A 341
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.55A 3miyA-2hckA:
31.4		 3miyA-2hckA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 ALA A 293
PHE A 340
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.35A 3miyB-2hckA:
31.4		 3miyB-2hckA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.88A 3ms9A-2hckA:
29.7		 3ms9A-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.83A 3ms9B-2hckA:
29.9		 3ms9B-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.90A 3ms9B-2hckA:
29.9		 3ms9B-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.92A 3mssA-2hckA:
29.9		 3mssA-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.59A 3mssB-2hckA:
30.1		 3mssB-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.91A 3mssC-2hckA:
29.8		 3mssC-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.87A 3mssD-2hckA:
30.1		 3mssD-2hckA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 6 VAL A 281
LYS A 295
VAL A 323
ILE A 336
MET A 341
 QUE  A   1 ( 4.8A)
None
None
None
None
 0.90A 3mssD-2hckA:
30.1		 3mssD-2hckA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		5 / 12 PHE A  78
PHE A 176
VAL A 174
ALA A 130
PHE A 137
 QUE  A 301 (-3.9A)
QUE  A 301 (-4.4A)
None
QUE  A 301 ( 4.6A)
QUE  A 301 ( 4.9A)
 1.39A 3nhxA-5fljA:
undetectable		 3nhxA-5fljA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.74A 3octA-2hckA:
29.8		 3octA-2hckA:
26.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.74A 3oezB-2hckA:
32.7		 3oezB-2hckA:
50.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 VAL A  47
ALA A  60
LYS A  62
GLU A  80
VAL A  83
TYR A 112
LEU A 165
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-3.1A)
None
QUE  A   1 (-4.9A)
None
 0.80A 3oezB-3lm5A:
24.4		 3oezB-3lm5A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 GLY A  40
VAL A  47
ALA A  60
LEU A  84
ILE A  94
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
 0.51A 3ohtB-3lm5A:
6.9		 3ohtB-3lm5A:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 293
LEU A 322
VAL A 323
THR A 338
GLY A 344
HIS A 384
ALA A 403
 QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
QUE  A   1 ( 4.5A)
 0.65A 3oxzA-2hckA:
30.2		 3oxzA-2hckA:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 9 LEU A 273
LYS A 295
ILE A 336
MET A 341
LEU A 393
 QUE  A   1 (-3.9A)
None
None
None
QUE  A   1 (-4.4A)
 0.76A 3oxzA-2hckA:
30.1		 3oxzA-2hckA:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.89A 3pyyB-2hckA:
30.1		 3pyyB-2hckA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.87A 3qlgA-2hckA:
32.8		 3qlgA-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
None
 0.74A 3qlgB-2hckA:
32.6		 3qlgB-2hckA:
50.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		9 / 12 VAL A  47
ALA A  60
GLU A  80
LEU A  84
ILE A  94
TYR A 112
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
None
 0.90A 3rgfA-3lm5A:
18.4		 3rgfA-3lm5A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 LEU A  64
PHE A 180
ILE A 118
VAL A  47
ILE A  94
 None
None
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
 1.12A 3sp9A-3lm5A:
undetectable		 3sp9A-3lm5A:
25.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.61A 3sxrA-2hckA:
30.6		 3sxrA-2hckA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.64A 3sxrB-2hckA:
30.2		 3sxrB-2hckA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 3ue4A-2hckA:
31.1		 3ue4A-2hckA:
33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.62A 3ue4B-2hckA:
30.7		 3ue4B-2hckA:
33.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.82A 3ug2A-2hckA:
27.9		 3ug2A-2hckA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
 0.86A 3ug2A-3lm5A:
24.1		 3ug2A-3lm5A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
LEU A 393
ASP A 404
 None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
None
 1.02A 3v5wA-2hckA:
8.6		 3v5wA-2hckA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 LEU A  39
VAL A  47
ALA A  60
LEU A  84
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
None
 0.51A 3wzdA-3lm5A:
23.3		 3wzdA-3lm5A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
VAL A  47
ALA A  60
LEU A  84
GLY A 116
LEU A 149
HIS A 156
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
None
None
None
 0.55A 3wzeA-3lm5A:
23.8		 3wzeA-3lm5A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 273
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.51A 3zbfA-2hckA:
29.1		 3zbfA-2hckA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.76A 4ag8A-2hckA:
28.7		 4ag8A-2hckA:
28.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 11 LEU A 273
ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.58A 4agdA-2hckA:
27.8		 4agdA-2hckA:
30.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  84
ASP A 158
LYS A 160
ASN A 163
ASP A 179
GLY A 197
 QUE  A   1 ( 4.6A)
None
None
None
QUE  A   1 (-2.9A)
None
 1.09A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A 108
LEU A  84
ASP A 158
LYS A 160
ASN A 163
ASP A 179
 None
QUE  A   1 ( 4.6A)
None
None
None
QUE  A   1 (-2.9A)
 1.47A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A 108
LEU A  84
LYS A 160
ASN A 163
ASP A 179
GLY A 181
 None
QUE  A   1 ( 4.6A)
None
None
QUE  A   1 (-2.9A)
None
 1.42A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A 108
LEU A 110
ASP A 158
LYS A 160
ASN A 163
ASP A 179
 None
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
 1.45A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.78A 4anqA-2hckA:
29.0		 4anqA-2hckA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.79A 4ansA-2hckA:
28.9		 4ansA-2hckA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
VAL A  47
ALA A  60
GLU A  80
LEU A  84
GLY A 116
LEU A 149
HIS A 156
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 ( 4.6A)
None
None
None
 0.77A 4asdA-3lm5A:
23.6		 4asdA-3lm5A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 ALA A 293
LYS A 295
ILE A 336
THR A 338
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.91A 4c8bA-2hckA:
25.6		 4c8bA-2hckA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
GLY A 344
SER A 345
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.7A)
 0.73A 4ckiA-2hckA:
30.1		 4ckiA-2hckA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
GLY A 274
VAL A 281
ALA A 293
GLY A 344
SER A 345
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.7A)
QUE  A   1 (-4.4A)
 0.46A 4ckiA-2hckA:
30.1		 4ckiA-2hckA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 11 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
ALA A 113
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
None
 0.79A 4ckiA-3lm5A:
25.5		 4ckiA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 10 LEU A  39
GLY A  40
GLY A  42
VAL A  47
ALA A  60
TYR A 112
ALA A 113
LEU A 165
 QUE  A   1 ( 3.8A)
None
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.64A 4ckjA-3lm5A:
26.2		 4ckjA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.60A 4hjoA-2hckA:
32.7		 4hjoA-2hckA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.69A 4i22A-2hckA:
30.8		 4i22A-2hckA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
GLY A 344
ASP A 348
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
 0.52A 4i22A-2hckA:
30.8		 4i22A-2hckA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
 0.85A 4i22A-3lm5A:
12.6		 4i22A-3lm5A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 VAL A  47
ALA A  60
ILE A  94
ASP A 158
LYS A 160
ASN A 163
LEU A 165
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
None
None
None
None
 0.67A 4i41A-3lm5A:
26.8		 4i41A-3lm5A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 GLY A  40
VAL A  47
ALA A  60
LEU A  96
LEU A 108
GLY A 116
GLU A 117
LEU A 165
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
None
None
None
 0.55A 4ifgA-3lm5A:
26.1		 4ifgA-3lm5A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 ALA A 293
VAL A 323
PHE A 340
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.68A 4ks8A-2hckA:
19.7		 4ks8A-2hckA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 VAL A  47
ALA A  60
LEU A  64
LEU A 165
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
 0.69A 4l9iA-3lm5A:
9.2		 4l9iA-3lm5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 8 GLY A 276
VAL A 281
ALA A 293
MET A 341
LEU A 393
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
 0.85A 4l9iB-2hckA:
20.7		 4l9iB-2hckA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  84
ASN A 163
ASP A 179
PHE A 180
GLY A 181
LEU A  64
 QUE  A   1 ( 4.6A)
None
QUE  A   1 (-2.9A)
None
None
None
 1.27A 4lmnA-3lm5A:
23.5		 4lmnA-3lm5A:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
 0.66A 4mxoA-2hckA:
32.5		 4mxoA-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.63A 4mxoB-2hckA:
32.5		 4mxoB-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.64A 4mxxA-2hckA:
32.5		 4mxxA-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.60A 4mxxB-2hckA:
32.5		 4mxxB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.76A 4mxyB-2hckA:
32.8		 4mxyB-2hckA:
50.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.76A 4mxzB-2hckA:
32.8		 4mxzB-2hckA:
50.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ASN A 391
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
None
 0.95A 4o0sA-2hckA:
25.2		 4o0sA-2hckA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 11 LEU A  39
GLY A  40
VAL A  47
ALA A  60
ASN A 163
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
QUE  A   1 (-2.9A)
 0.47A 4o0sA-3lm5A:
30.4		 4o0sA-3lm5A:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 11 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
QUE  A   1 (-2.9A)
 0.88A 4o0sA-3lm5A:
30.4		 4o0sA-3lm5A:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 6 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
 0.32A 4o0wA-3lm5A:
29.5		 4o0wA-3lm5A:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 7 GLY A  40
ALA A  60
ASN A 163
LEU A 165
ASP A 179
 None
QUE  A   1 (-3.2A)
None
None
QUE  A   1 (-2.9A)
 1.00A 4ogrE-3lm5A:
27.2		 4ogrE-3lm5A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
ALA A 403
ASP A 404
 QUE  A   1 (-3.9A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 ( 4.5A)
None
 0.84A 4otiA-2hckA:
20.2		 4otiA-2hckA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.82A 4otiA-2hckA:
20.2		 4otiA-2hckA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
LYS A 295
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.71A 4otwA-2hckA:
31.0		 4otwA-2hckA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 8 LEU A 273
VAL A 281
HIS A 384
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
QUE  A   1 (-4.4A)
 0.61A 4qrcA-2hckA:
29.6		 4qrcA-2hckA:
30.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 12 GLY A 199
ILE A 142
ALA A  96
MET A 144
GLY A 145
 None
None
QUE  A 501 ( 4.0A)
None
HIU  A 502 ( 3.7A)
 1.04A 4r29D-3bptA:
undetectable		 4r29D-3bptA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 ALA A 293
ILE A 336
THR A 338
SER A 345
PHE A 405
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.7A)
None
 0.75A 4rzvA-2hckA:
11.3		 4rzvA-2hckA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 VAL A 281
ALA A 293
THR A 338
SER A 345
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.7A)
None
 0.78A 4rzvB-2hckA:
28.1		 4rzvB-2hckA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
ALA A 293
PHE A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.63A 4twpA-2hckA:
30.7		 4twpA-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
PHE A 340
MET A 341
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.77A 4twpA-2hckA:
30.7		 4twpA-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
PHE A 340
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.97A 4twpB-2hckA:
30.8		 4twpB-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
VAL A 281
ALA A 293
PHE A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.75A 4twpB-2hckA:
30.8		 4twpB-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 11 LEU A 273
GLY A 276
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.64A 4u5jA-2hckA:
33.6		 4u5jA-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 11 LEU A 273
GLY A 279
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 1.16A 4u5jA-2hckA:
33.6		 4u5jA-2hckA:
51.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 11 LEU A  39
GLY A  42
VAL A  47
ALA A  60
TYR A 112
GLY A 116
ASN A 163
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
None
 0.74A 4u5jA-3lm5A:
26.8		 4u5jA-3lm5A:
27.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.52A 4u5jB-2hckA:
33.1		 4u5jB-2hckA:
51.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 9 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
 0.75A 4u5jB-3lm5A:
14.0		 4u5jB-3lm5A:
27.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 273
ALA A 293
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.50A 4uxqA-2hckA:
29.7		 4uxqA-2hckA:
35.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 7 VAL A  47
LYS A  62
ILE A  94
ALA A 113
ILE A 177
 QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-3.9A)
None
 0.59A 4uxqA-3lm5A:
23.8		 4uxqA-3lm5A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.85A 4v01A-3lm5A:
23.3		 4v01A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 9 LEU A  39
VAL A  47
LYS A  62
ILE A  94
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.79A 4v01A-3lm5A:
23.3		 4v01A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.78A 4v01B-3lm5A:
24.1		 4v01B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 9 LEU A  39
VAL A  47
ILE A  94
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.70A 4v01B-3lm5A:
24.1		 4v01B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 9 LEU A  39
VAL A  47
LYS A  62
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
None
 0.88A 4v01B-3lm5A:
24.1		 4v01B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 VAL A  47
ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.86A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 8 LYS A  62
ILE A  94
TYR A 112
ILE A 177
 QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
 0.75A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 8 LYS A  62
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
None
 0.71A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 273
VAL A 281
LYS A 295
LEU A 393
ILE A 402
LEU A 407
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
QUE  A   1 (-4.4A)
None
None
 1.05A 4v04B-2hckA:
29.1		 4v04B-2hckA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 10 LEU A  39
VAL A  47
LYS A  62
ILE A  94
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.71A 4v04B-3lm5A:
24.1		 4v04B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.86A 4v04B-3lm5A:
24.1		 4v04B-3lm5A:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.51A 4wa9A-2hckA:
28.2		 4wa9A-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.71A 4wa9A-2hckA:
28.2		 4wa9A-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 11 LEU A 273
ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
 0.65A 4wa9A-2hckA:
28.2		 4wa9A-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 ALA A 293
THR A 338
PHE A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.58A 4wa9B-2hckA:
30.4		 4wa9B-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
THR A 338
PHE A 340
MET A 341
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 1.17A 4wa9B-2hckA:
30.4		 4wa9B-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
THR A 338
PHE A 340
MET A 341
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.85A 4wa9B-2hckA:
30.4		 4wa9B-2hckA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
ALA A 293
MET A 341
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
 0.71A 4wboC-2hckA:
20.6		 4wboC-2hckA:
25.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		11 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.69A 4xeyA-2hckA:
30.9		 4xeyA-2hckA:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.67A 4xeyB-2hckA:
30.5		 4xeyB-2hckA:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		10 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.57A 4xeyB-2hckA:
30.5		 4xeyB-2hckA:
40.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
THR A 338
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.73A 4xliA-2hckA:
30.7		 4xliA-2hckA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		9 / 12 LEU A 273
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.83A 4xliB-2hckA:
30.6		 4xliB-2hckA:
33.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 8 LEU A 273
GLY A 274
VAL A 281
ALA A 293
MET A 341
GLY A 344
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
 0.64A 4zauA-2hckA:
28.6		 4zauA-2hckA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.58A 5aaaA-2hckA:
29.5		 5aaaA-2hckA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.64A 5aabA-2hckA:
29.2		 5aabA-2hckA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 10 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 110
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.1A)
None
None
 0.86A 5aabA-3lm5A:
25.1		 5aabA-3lm5A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.61A 5aacA-2hckA:
29.0		 5aacA-2hckA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 10 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 110
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.1A)
None
None
 0.85A 5aacA-3lm5A:
25.0		 5aacA-3lm5A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
ALA A 293
LYS A 295
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.85A 5ajqA-2hckA:
24.3		 5ajqA-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
GLY A 274
ALA A 293
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.85A 5ajqA-2hckA:
24.3		 5ajqA-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 10 ALA A 293
PHE A 340
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.40A 5ajqB-2hckA:
23.6		 5ajqB-2hckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
VAL A  47
ALA A  60
GLU A  80
ILE A  94
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.87A 5bvwA-3lm5A:
23.2		 5bvwA-3lm5A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
VAL A  47
ALA A  60
LYS A  62
ILE A  94
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.84A 5bvwA-3lm5A:
23.2		 5bvwA-3lm5A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.57A 5h2uA-2hckA:
33.8		 5h2uA-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
VAL A 281
ALA A 293
ILE A 336
THR A 338
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.71A 5h2uB-2hckA:
33.7		 5h2uB-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
ILE A 336
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.69A 5h2uC-2hckA:
28.3		 5h2uC-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
ALA A 293
THR A 338
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.67A 5h2uC-2hckA:
28.3		 5h2uC-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
ILE A 336
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.53A 5h2uD-2hckA:
33.8		 5h2uD-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.59A 5h2uD-2hckA:
33.8		 5h2uD-2hckA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
ASP A 348
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.1A)
None
 0.84A 5hesA-2hckA:
10.7		 5hesA-2hckA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 VAL A  47
ALA A  60
ILE A  94
TYR A 112
ALA A 113
PHE A 180
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.91A 5hesA-3lm5A:
10.4		 5hesA-3lm5A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 276
VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
 0.91A 5hieA-2hckA:
27.0		 5hieA-2hckA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 276
VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
 0.90A 5hieB-2hckA:
27.0		 5hieB-2hckA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 274
GLY A 276
VAL A 281
ALA A 293
LYS A 295
THR A 338
 QUE  A   1 ( 4.2A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
 0.94A 5hieC-2hckA:
26.8		 5hieC-2hckA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 GLY A 276
VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
 None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
 0.90A 5hieD-2hckA:
26.6		 5hieD-2hckA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A 178
VAL A 148
LEU A 184
LEU A 350
MET A 302
 HIU  A 502 (-4.6A)
None
None
QUE  A 501 (-4.6A)
None
 1.18A 5hv1A-3bptA:
undetectable		 5hv1A-3bptA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 ALA A  60
LYS A  62
ILE A  94
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.71A 5i9xA-3lm5A:
24.6		 5i9xA-3lm5A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		3 / 3 LYS A  62
GLN A 162
ASN A 163
 QUE  A   1 (-4.1A)
None
None
 0.81A 5l2tA-3lm5A:
11.1		 5l2tA-3lm5A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		9 / 11 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LEU A 110
TYR A 112
ALA A 113
GLU A 117
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
None
 0.44A 5lvnA-3lm5A:
29.3		 5lvnA-3lm5A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 GLY A  40
VAL A  47
ALA A  60
GLU A  80
LEU A 110
TYR A 112
GLY A 116
GLU A 117
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
None
 0.74A 5mafA-3lm5A:
29.4		 5mafA-3lm5A:
15.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 10 LEU A 273
VAL A 281
LYS A 295
ILE A 336
PHE A 340
MET A 341
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-4.2A)
None
 0.84A 5mo4A-2hckA:
37.5		 5mo4A-2hckA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LEU A 322
VAL A 323
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.53A 5mo4A-2hckA:
37.5		 5mo4A-2hckA:
38.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
ILE A 336
THR A 338
GLY A 344
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
None
 0.90A 5p9iA-2hckA:
33.4		 5p9iA-2hckA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 VAL A 281
ALA A 293
MET A 314
ILE A 336
THR A 338
GLY A 344
LEU A 393
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.74A 5p9iA-2hckA:
33.4		 5p9iA-2hckA:
26.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 115
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
 0.96A 5vcyA-3lm5A:
26.2		 5vcyA-3lm5A:
31.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 ( 4.5A)
 0.63A 5xv7A-2hckA:
20.3		 5xv7A-2hckA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		5 / 12 LEU A 273
GLY A 274
VAL A 281
GLY A 344
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.5A)
 0.76A 5xv7A-2hckA:
20.3		 5xv7A-2hckA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-4.4A)
None
 0.86A 5yu9A-2hckA:
30.9		 5yu9A-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		8 / 12 GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.92A 5yu9B-2hckA:
30.9		 5yu9B-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
ASP A 404
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
None
 0.98A 5yu9C-2hckA:
30.2		 5yu9C-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
ASP A 404
 QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
None
 1.07A 5yu9D-2hckA:
30.6		 5yu9D-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 ALA A 293
MET A 314
GLY A 344
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.81A 5yu9D-2hckA:
30.6		 5yu9D-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 404
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
None
 0.98A 5yu9D-2hckA:
30.6		 5yu9D-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		6 / 12 VAL A 281
ALA A 293
MET A 314
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.74A 5yu9D-2hckA:
30.6		 5yu9D-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5flj QUERCETINASE QUED
(Streptomyces
sp.
FLA) 		3 / 3 HIS A  69
HIS A 115
HIS A  71
 QUE  A 301 ( 3.0A)
NI  A 300 (-3.2A)
NI  A 300 ( 3.3A)
 0.51A 5zrdA-5fljA:
undetectable		 5zrdA-5fljA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
VAL A  47
ALA A  60
GLU A  80
TYR A 112
ALA A 113
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.67A 5zv2A-3lm5A:
23.5		 5zv2A-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		3 / 3 LYS A  62
LEU A 165
ASP A 179
 QUE  A   1 (-4.1A)
None
QUE  A   1 (-2.9A)
 0.82A 5zv2A-3lm5A:
23.5		 5zv2A-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  39
VAL A  47
ALA A  60
GLU A  80
ALA A 113
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
 0.63A 5zv2B-3lm5A:
23.9		 5zv2B-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  39
VAL A  47
ALA A  60
LYS A  62
ALA A 113
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-3.9A)
None
 0.58A 5zv2B-3lm5A:
23.9		 5zv2B-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		3 / 3 TYR A 112
LEU A 165
ASP A 179
 QUE  A   1 (-4.9A)
None
QUE  A   1 (-2.9A)
 0.71A 5zv2B-3lm5A:
23.8		 5zv2B-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.51A 6fnmA-2hckA:
30.4		 6fnmA-2hckA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.76A 6fnmA-2hckA:
30.4		 6fnmA-2hckA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.5A)
 0.95A 6hd4A-2hckA:
29.2		 6hd4A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.95A 6hd4A-2hckA:
29.2		 6hd4A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.93A 6hd4B-2hckA:
29.4		 6hd4B-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		4 / 6 LEU A 273
PHE A 340
MET A 341
GLY A 344
 QUE  A   1 (-3.9A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
 0.75A 6hd4B-2hckA:
29.4		 6hd4B-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
PHE A 340
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
 0.67A 6hd6A-2hckA:
29.3		 6hd6A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
PHE A 340
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 ( 4.5A)
 0.92A 6hd6A-2hckA:
29.3		 6hd6A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
PHE A 340
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
 0.81A 6hd6A-2hckA:
29.3		 6hd6A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 VAL A 281
ALA A 293
VAL A 323
THR A 338
PHE A 340
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.90A 6hd6A-2hckA:
29.3		 6hd6A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens) 		7 / 12 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
PHE A 340
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
 0.76A 6hd6B-2hckA:
29.4		 6hd6B-2hckA:
13.06