SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'QQV'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2I_B_QPSB1060_1 (ALPHA-1,4-GLUCAN LYASE ISOZYME 1)	4bsq	CATHEPSIN S (Mus musculus)	5 / 10	PHE A 150 ASN A 186 GLY A 191 ALA A 146 GLN A 141	None None QQV A1341 (-3.1A) None QQV A1341 (-3.3A)	1.33A	2x2iB-4bsqA: undetectable	2x2iB-4bsqA: 12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2I_B_QPSB1060_1 (ALPHA-1,4-GLUCAN LYASE ISOZYME 1)	4bsq	CATHEPSIN S (Mus musculus)	5 / 10	SER A 151 SER A 258 GLY A 191 ALA A 146 GLN A 141	None None QQV A1341 (-3.1A) None QQV A1341 (-3.3A)	1.46A	2x2iB-4bsqA: undetectable	2x2iB-4bsqA: 12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGL_A_RZXA257_1 (CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 1)	4bsq	CATHEPSIN S (Mus musculus)	4 / 7	VAL A 285 ILE A 261 SER A 336 TYR A 334	QQV A1341 (-4.2A) None None QQV A1341 (-3.5A)	0.94A	3pglA-4bsqA: undetectable	3pglA-4bsqA: 20.41