SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'QPP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		6 / 9 LEU A  29
VAL A  37
LYS A  52
LEU A  84
LEU A  96
LEU A 100
 QPP  A1314 (-3.7A)
QPP  A1314 ( 4.6A)
None
None
None
QPP  A1314 (-4.5A)
 0.61A 1xkkA-2jc6A:
20.4		 1xkkA-2jc6A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		6 / 12 LEU A  29
GLY A  30
GLY A  32
VAL A  37
ALA A  50
MET A  98
 QPP  A1314 (-3.7A)
QPP  A1314 ( 3.7A)
None
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.1A)
 0.50A 2fumD-2jc6A:
23.1		 2fumD-2jc6A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 6 LEU A  29
VAL A  37
LYS A  52
LEU A 151
 QPP  A1314 (-3.7A)
QPP  A1314 ( 4.6A)
None
None
 0.75A 3cs9D-2jc6A:
15.7		 3cs9D-2jc6A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 7 LYS A  52
LEU A  96
LEU A 100
ILE A  81
 None
None
QPP  A1314 (-4.5A)
None
 0.91A 3gp0A-2jc6A:
20.2		 3gp0A-2jc6A:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 7 LYS A  52
LEU A  96
LEU A 100
ILE A 163
 None
None
QPP  A1314 (-4.5A)
None
 0.60A 3gp0A-2jc6A:
20.2		 3gp0A-2jc6A:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		5 / 8 GLY A  32
VAL A  37
ALA A  50
LYS A  52
MET A  98
 None
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
None
QPP  A1314 ( 4.1A)
 0.31A 4l9iB-2jc6A:
17.2		 4l9iB-2jc6A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		5 / 10 ALA A  50
LYS A  52
LEU A 100
VAL A 101
LEU A 151
 QPP  A1314 ( 3.7A)
None
QPP  A1314 (-4.5A)
QPP  A1314 (-4.0A)
None
 0.66A 4rz7A-2jc6A:
23.7		 4rz7A-2jc6A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		5 / 6 LEU A  29
VAL A  37
LYS A  52
ILE A  81
ILE A 163
 QPP  A1314 (-3.7A)
QPP  A1314 ( 4.6A)
None
None
None
 0.69A 4tyjA-2jc6A:
20.6		 4tyjA-2jc6A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		6 / 9 LEU A  29
VAL A  37
LYS A  52
ILE A  76
ARG A 143
ILE A 163
 QPP  A1314 (-3.7A)
QPP  A1314 ( 4.6A)
None
None
None
None
 0.94A 4v01B-2jc6A:
21.4		 4v01B-2jc6A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 8 LEU A  29
ALA A  50
LEU A 151
SER A 164
 QPP  A1314 (-3.7A)
QPP  A1314 ( 3.7A)
None
None
 0.66A 4wboB-2jc6A:
21.4		 4wboB-2jc6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 8 LEU A  29
ALA A  50
MET A  98
SER A 164
 QPP  A1314 (-3.7A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.1A)
None
 0.38A 4wboB-2jc6A:
21.4		 4wboB-2jc6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 6 LEU A  29
ALA A  50
MET A  98
LEU A 151
 QPP  A1314 (-3.7A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.1A)
None
 0.75A 4wboC-2jc6A:
21.0		 4wboC-2jc6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		5 / 8 LEU A  29
GLY A  30
VAL A  37
ALA A  50
LEU A 100
 QPP  A1314 (-3.7A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
QPP  A1314 (-4.5A)
 0.39A 4zauA-2jc6A:
20.9		 4zauA-2jc6A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 8 VAL A  37
ILE A  81
ILE A 140
ILE A 163
 QPP  A1314 ( 4.6A)
None
None
None
 0.61A 5hi2A-2jc6A:
22.9		 5hi2A-2jc6A:
27.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 7 GLY A  30
GLY A  32
VAL A  37
LYS A  52
 QPP  A1314 ( 3.7A)
None
QPP  A1314 ( 4.6A)
None
 0.20A 5izjA-2jc6A:
17.7		 5izjA-2jc6A:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 7 GLY A  30
GLY A  32
VAL A  37
LYS A  52
 QPP  A1314 ( 3.7A)
None
QPP  A1314 ( 4.6A)
None
 0.30A 5j5xA-2jc6A:
22.9		 5j5xA-2jc6A:
31.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		5 / 10 GLY A  30
VAL A  37
ALA A  50
MET A  98
LEU A 100
 QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.1A)
QPP  A1314 (-4.5A)
 0.67A 5lw1E-2jc6A:
19.3		 5lw1E-2jc6A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		5 / 9 GLY A  30
VAL A  37
ALA A  50
MET A  98
LEU A 100
 QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.1A)
QPP  A1314 (-4.5A)
 0.70A 5lw1H-2jc6A:
19.7		 5lw1H-2jc6A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		4 / 4 VAL A  37
LYS A  52
VAL A  82
ASN A 149
 QPP  A1314 ( 4.6A)
None
None
None
 0.91A 5vc3A-2jc6A:
21.2		 5vc3A-2jc6A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens) 		6 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
LYS A  52
LEU A  96
 QPP  A1314 (-3.7A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
None
None
 0.57A 5yu9A-2jc6A:
20.3		 5yu9A-2jc6A:
14.07