SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PZW'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
GLY A 464
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.83A 1iepA-4q9zA:
15.5		 1iepA-4q9zA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
GLY A 464
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 ( 4.6A)
 0.80A 1iepB-4q9zA:
20.4		 1iepB-4q9zA:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 9 LEU A 386
GLY A 387
VAL A 394
ALA A 407
TYR A 460
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
 0.70A 1muoA-4q9zA:
9.4		 1muoA-4q9zA:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.73A 1opjA-4q9zA:
15.0		 1opjA-4q9zA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 11 SER A 433
ILE A 518
ALA A 521
LEU A 432
MET A 458
 None
None
PZW  A 801 ( 4.6A)
None
PZW  A 801 (-4.4A)
 1.13A 1uduA-4q9zA:
undetectable		 1uduA-4q9zA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 10 LEU A 386
PHE A 391
ALA A 407
ASP A 465
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 (-3.7A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
 0.46A 1yi4A-4q9zA:
28.2		 1yi4A-4q9zA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 VAL A 394
ALA A 407
GLU A 428
GLY A 464
LEU A 511
ALA A 521
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.85A 2hyyA-4q9zA:
20.3		 2hyyA-4q9zA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
GLY A 387
VAL A 394
ALA A 407
LYS A 409
GLU A 428
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.67A 2ityA-4q9zA:
22.2		 2ityA-4q9zA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 LEU A 386
VAL A 394
ALA A 407
LYS A 409
GLU A 428
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.60A 2itzA-4q9zA:
22.2		 2itzA-4q9zA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 LEU A 386
GLY A 387
LYS A 409
GLU A 428
LEU A 432
TYR A 460
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
None
None
None
None
PZW  A 801 (-3.2A)
 0.70A 2ivuA-4q9zA:
24.5		 2ivuA-4q9zA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
GLY A 387
VAL A 394
LYS A 409
LEU A 432
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.61A 2ivuA-4q9zA:
24.5		 2ivuA-4q9zA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
GLY A 387
GLY A 389
VAL A 394
ALA A 407
TYR A 460
LEU A 461
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
None
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.3A)
PZW  A 801 (-4.8A)
 0.60A 3fupB-4q9zA:
23.6		 3fupB-4q9zA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 11 LEU A 386
VAL A 394
ALA A 407
TYR A 460
GLY A 464
ASP A 465
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 (-4.8A)
 0.75A 3g0fA-4q9zA:
20.4		 3g0fA-4q9zA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 10 LEU A 386
VAL A 394
ALA A 407
TYR A 460
GLY A 464
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
 0.69A 3g0fB-4q9zA:
20.5		 3g0fB-4q9zA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
TYR A 460
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.52A 3g5dA-4q9zA:
16.8		 3g5dA-4q9zA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
ALA A 407
LYS A 409
GLU A 428
TYR A 460
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.58A 3g5dB-4q9zA:
16.7		 3g5dB-4q9zA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.71A 3gvuA-4q9zA:
20.6		 3gvuA-4q9zA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 VAL A 394
ALA A 407
GLU A 428
GLY A 464
LEU A 511
ALA A 521
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.78A 3k5vB-4q9zA:
19.8		 3k5vB-4q9zA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.83A 3ms9A-4q9zA:
20.0		 3ms9A-4q9zA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
GLY A 464
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.82A 3ms9B-4q9zA:
20.0		 3ms9B-4q9zA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.87A 3mssA-4q9zA:
20.1		 3mssA-4q9zA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.88A 3mssC-4q9zA:
20.1		 3mssC-4q9zA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
ALA A 407
GLU A 428
GLY A 464
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.87A 3mssD-4q9zA:
15.6		 3mssD-4q9zA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 VAL A 394
ALA A 407
GLU A 428
VAL A 431
TYR A 460
LEU A 511
ALA A 521
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.83A 3oezB-4q9zA:
15.6		 3oezB-4q9zA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 VAL A 394
ALA A 407
LYS A 409
VAL A 431
TYR A 460
LEU A 511
ALA A 521
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.88A 3oezB-4q9zA:
15.6		 3oezB-4q9zA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.70A 3pyyB-4q9zA:
15.5		 3pyyB-4q9zA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
TYR A 460
LEU A 511
ALA A 521
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
PZW  A 801 (-3.2A)
 0.49A 3qlgB-4q9zA:
21.8		 3qlgB-4q9zA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 VAL A 394
ALA A 407
GLU A 428
LEU A 432
TYR A 460
LEU A 495
ALA A 521
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
None
PZW  A 801 ( 4.6A)
 0.75A 3rgfA-4q9zA:
3.7		 3rgfA-4q9zA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 GLY A 392
VAL A 394
ALA A 407
LYS A 409
LEU A 411
LEU A 511
ASP A 522
 None
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.83A 3v5wA-4q9zA:
37.4		 3v5wA-4q9zA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
VAL A 394
ALA A 407
LYS A 409
LEU A 432
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
 0.57A 4agcA-4q9zA:
19.6		 4agcA-4q9zA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 12 LEU A 432
ASP A 504
LYS A 506
ASN A 509
ASP A 522
 None
None
None
PZW  A 801 (-4.4A)
PZW  A 801 (-3.2A)
 0.74A 4an2A-4q9zA:
23.6		 4an2A-4q9zA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 12 ALA A 521
ASN A 509
ARG A 503
ILE A 500
VAL A 431
 PZW  A 801 ( 4.6A)
PZW  A 801 (-4.4A)
None
None
None
 1.17A 4azwA-4q9zA:
8.6		 4azwA-4q9zA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 10 LEU A 386
GLY A 387
GLY A 389
VAL A 394
ALA A 407
TYR A 460
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
None
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
 0.48A 4ckjA-4q9zA:
24.6		 4ckjA-4q9zA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 12 ASP A 508
LEU A 569
ILE A 518
ASN A 509
LEU A 492
 None
None
None
PZW  A 801 (-4.4A)
None
 1.14A 4fr0A-4q9zA:
undetectable		 4fr0A-4q9zA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 PHE A 391
VAL A 394
ALA A 407
ASP A 465
ASP A 504
LYS A 506
ASN A 509
LEU A 511
 PZW  A 801 (-3.7A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 (-4.4A)
PZW  A 801 (-4.8A)
 0.72A 4i41A-4q9zA:
28.0		 4i41A-4q9zA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 11 PHE A 391
VAL A 394
ALA A 407
LYS A 409
ASP A 465
LEU A 511
 PZW  A 801 (-3.7A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
 0.74A 4iaaA-4q9zA:
28.0		 4iaaA-4q9zA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.86A 4mxyA-4q9zA:
22.6		 4mxyA-4q9zA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
ALA A 407
LYS A 409
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.91A 4mxyA-4q9zA:
22.6		 4mxyA-4q9zA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
ALA A 407
MET A 458
TYR A 460
LEU A 511
ALA A 521
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
PZW  A 801 (-3.2A)
 0.70A 4mxyB-4q9zA:
18.4		 4mxyB-4q9zA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.86A 4mxzA-4q9zA:
22.6		 4mxzA-4q9zA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
ALA A 407
LYS A 409
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.91A 4mxzA-4q9zA:
22.6		 4mxzA-4q9zA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
ALA A 407
MET A 458
TYR A 460
LEU A 511
ALA A 521
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
PZW  A 801 (-3.2A)
 0.70A 4mxzB-4q9zA:
18.4		 4mxzB-4q9zA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 11 LEU A 386
GLY A 387
VAL A 394
ALA A 407
LYS A 409
ASN A 509
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.69A 4o0sA-4q9zA:
30.8		 4o0sA-4q9zA:
31.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 6 LEU A 386
GLY A 387
VAL A 394
ALA A 407
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 (-4.8A)
 0.65A 4o0wA-4q9zA:
29.5		 4o0wA-4q9zA:
32.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
LYS A 409
TYR A 460
GLY A 464
LEU A 511
ALA A 521
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
PZW  A 801 (-3.2A)
 0.96A 4otwA-4q9zA:
19.9		 4otwA-4q9zA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 ALA A 407
GLU A 428
THR A 442
MET A 458
TYR A 460
LEU A 511
ALA A 521
 PZW  A 801 (-3.5A)
None
PZW  A 801 ( 4.0A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.57A 4qmnA-4q9zA:
29.2		 4qmnA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 ALA A 407
GLU A 428
THR A 442
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.5A)
None
PZW  A 801 ( 4.0A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.74A 4qmnA-4q9zA:
29.2		 4qmnA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 11 ALA A 407
GLU A 428
MET A 458
TYR A 460
LEU A 461
LEU A 511
 PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.3A)
PZW  A 801 (-4.8A)
 0.61A 4qmsA-4q9zA:
29.4		 4qmsA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 11 ALA A 407
GLU A 428
MET A 458
TYR A 460
LEU A 511
ASP A 522
 PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.74A 4qmsA-4q9zA:
29.4		 4qmsA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 11 ALA A 407
LYS A 409
MET A 458
TYR A 460
LEU A 461
LEU A 511
 PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.3A)
PZW  A 801 (-4.8A)
 0.82A 4qmsA-4q9zA:
29.4		 4qmsA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 GLY A 387
VAL A 394
ALA A 407
THR A 442
MET A 458
TYR A 460
LEU A 461
LEU A 511
 PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 ( 4.0A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.3A)
PZW  A 801 (-4.8A)
 0.64A 4qmzA-4q9zA:
29.5		 4qmzA-4q9zA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
VAL A 394
ALA A 407
LYS A 409
GLY A 464
ASN A 509
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.4A)
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.79A 4twpA-4q9zA:
22.8		 4twpA-4q9zA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 11 LEU A 386
GLY A 389
VAL A 394
ALA A 407
TYR A 460
ASN A 509
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
None
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.4A)
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.54A 4u5jA-4q9zA:
23.0		 4u5jA-4q9zA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 9 LEU A 386
VAL A 394
LYS A 409
TYR A 460
LEU A 511
ILE A 520
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
None
None
PZW  A 801 (-4.8A)
None
 0.72A 4v01B-4q9zA:
20.4		 4v01B-4q9zA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 10 LEU A 386
VAL A 394
LYS A 409
TYR A 460
LEU A 511
ILE A 520
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
None
None
PZW  A 801 (-4.8A)
None
 0.92A 4v04B-4q9zA:
20.3		 4v04B-4q9zA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		8 / 12 LEU A 386
ALA A 407
LYS A 409
GLU A 428
TYR A 460
GLY A 464
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-3.5A)
None
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.81A 4xliB-4q9zA:
20.0		 4xliB-4q9zA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		9 / 12 LEU A 386
VAL A 394
ALA A 407
LYS A 409
GLU A 428
TYR A 460
GLY A 464
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.84A 5bvwA-4q9zA:
16.4		 5bvwA-4q9zA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 12 VAL A 394
ALA A 407
LYS A 409
LEU A 432
PHE A 523
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
 0.79A 5cswA-4q9zA:
20.9		 5cswA-4q9zA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 12 VAL A 394
ALA A 407
LYS A 409
LEU A 432
PHE A 523
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
 0.83A 5cswB-4q9zA:
20.7		 5cswB-4q9zA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 7 GLY A 387
GLY A 389
GLY A 392
VAL A 394
LEU A 411
 PZW  A 801 ( 3.8A)
None
None
PZW  A 801 (-4.6A)
None
 0.77A 5izjB-4q9zA:
35.2		 5izjB-4q9zA:
37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 7 GLY A 387
GLY A 389
SER A 390
GLY A 392
LEU A 411
 PZW  A 801 ( 3.8A)
None
None
None
None
 1.06A 5izjB-4q9zA:
35.2		 5izjB-4q9zA:
37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 7 GLY A 387
GLY A 389
SER A 390
LYS A 409
LEU A 411
 PZW  A 801 ( 3.8A)
None
None
None
None
 1.10A 5izjA-4q9zA:
28.5		 5izjA-4q9zA:
37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 7 GLY A 387
GLY A 389
VAL A 394
LYS A 409
LEU A 411
 PZW  A 801 ( 3.8A)
None
PZW  A 801 (-4.6A)
None
None
 0.54A 5izjA-4q9zA:
28.5		 5izjA-4q9zA:
37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 7 GLY A 387
GLY A 389
SER A 390
VAL A 394
LYS A 409
 PZW  A 801 ( 3.8A)
None
None
PZW  A 801 (-4.6A)
None
 0.82A 5j5xA-4q9zA:
39.0		 5j5xA-4q9zA:
37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 GLY A 387
VAL A 394
ALA A 407
ASP A 465
LEU A 511
ALA A 521
 PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.72A 5l2iA-4q9zA:
7.4		 5l2iA-4q9zA:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 11 LEU A 386
GLY A 387
VAL A 394
ALA A 407
TYR A 460
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
 0.50A 5lvnA-4q9zA:
28.7		 5lvnA-4q9zA:
34.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 10 LEU A 386
VAL A 394
ALA A 407
MET A 458
TYR A 460
LEU A 511
PHE A 664
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 (-4.4A)
None
PZW  A 801 (-4.8A)
PZW  A 801 (-4.3A)
 0.68A 5n3hA-4q9zA:
39.7		 5n3hA-4q9zA:
37.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		5 / 12 LEU A 386
GLY A 387
VAL A 394
ALA A 407
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 ( 4.6A)
 0.21A 5xv7A-4q9zA:
24.3		 5xv7A-4q9zA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		6 / 12 LEU A 386
GLY A 387
VAL A 394
ALA A 407
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.49A 5yu9A-4q9zA:
20.2		 5yu9A-4q9zA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 LEU A 386
VAL A 394
ALA A 407
GLU A 428
TYR A 460
GLY A 464
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 ( 4.6A)
 0.76A 5zv2A-4q9zA:
12.0		 5zv2A-4q9zA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		7 / 12 LEU A 386
VAL A 394
ALA A 407
LYS A 409
GLU A 428
GLY A 464
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 ( 4.6A)
 0.71A 5zv2B-4q9zA:
17.6		 5zv2B-4q9zA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens) 		3 / 3 TYR A 460
LEU A 511
ASP A 522
 None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.60A 5zv2B-4q9zA:
17.6		 5zv2B-4q9zA:
11.59