SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PYI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2f17 THIAMIN
PYROPHOSPHOKINASE 1
(Mus
musculus) 		4 / 4 ARG A 131
ASP A  46
ASP A  73
ASP A  71
 PYI  A 902 ( 3.4A)
MG  A 901 ( 3.4A)
MG  A 901 (-2.9A)
MG  A 901 (-2.6A)
 1.34A 3naiB-2f17A:
undetectable		 3naiB-2f17A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2f17 THIAMIN
PYROPHOSPHOKINASE 1
(Mus
musculus) 		5 / 12 GLY A 126
GLY A 127
PHE A 101
ALA A 137
GLN A 134
 None
AMP  A 301 (-3.1A)
AMP  A 301 (-4.8A)
None
PYI  A 902 ( 3.0A)
 1.14A 4ubeA-2f17A:
undetectable		 4ubeA-2f17A:
22.13