SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PYC'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HO5_A_ADNA1604_1 (5'-NUCLEOTIDASE)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	5 / 11	ILE B 139 SER B 92 GLY B 91 PHE B 78 ASN B 64	None PYC B 904 (-3.0A) PYC B 904 (-3.5A) None None	1.42A	1ho5A-4k7gB: 2.4	1ho5A-4k7gB: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ICU_B_NIOB219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	4 / 6	GLY A 131 SER A 305 THR A 304 PHE A 333	PYC A 700 (-3.7A) None None None	1.06A	1icuA-1w61A: undetectable 1icuB-1w61A: undetectable	1icuA-1w61A: 20.54 1icuB-1w61A: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_A_BEZA524_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	4 / 6	SER A 305 THR A 304 PHE A 333 GLY A 131	None None None PYC A 700 (-3.7A)	1.00A	1kqbA-1w61A: undetectable 1kqbB-1w61A: undetectable	1kqbA-1w61A: 19.86 1kqbB-1w61A: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_B_BEZB525_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	4 / 5	GLY A 131 SER A 305 THR A 304 PHE A 333	PYC A 700 (-3.7A) None None None	1.10A	1kqbA-1w61A: undetectable 1kqbB-1w61A: undetectable	1kqbA-1w61A: 19.86 1kqbB-1w61A: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KQB_C_BEZC522_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	4 / 6	SER A 305 THR A 304 PHE A 333 GLY A 131	None None None PYC A 700 (-3.7A)	1.03A	1kqbC-1w61A: undetectable 1kqbD-1w61A: undetectable	1kqbC-1w61A: 19.86 1kqbD-1w61A: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW5_A_SAMA401_0 (MODIFICATION METHYLASE RSRI)	4q60	PROLINE RACEMASE (Burkholderia multivorans)	5 / 12	ASP A 9 THR A 239 GLY A 13 SER A 268 ALA A 289	GOL A 401 ( 4.6A) PYC A 402 (-3.4A) None None None	1.32A	1nw5A-4q60A: undetectable	1nw5A-4q60A: 24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1O86_A_LPRA702_2 (ANGIOTENSIN CONVERTING ENZYME)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	4 / 4	SER B 90 VAL B 144 PHE B 224 VAL B 244	PYC B 904 (-3.1A) None PYC B 904 ( 4.8A) None	1.17A	1o86A-4k7gB: undetectable	1o86A-4k7gB: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P93_C_DEXC3999_1 (GLUCOCORTICOID RECEPTOR)	4q60	PROLINE RACEMASE (Burkholderia multivorans)	5 / 12	ASN A 134 GLY A 161 LEU A 86 CYH A 89 THR A 93	PYC A 402 (-4.2A) None None None None	1.50A	1p93C-4q60A: undetectable	1p93C-4q60A: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QX4_A_ML1A233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	4 / 8	ILE B 309 PHE B 224 GLY B 170 GLY B 171	None PYC B 904 ( 4.8A) None None	0.76A	2qx4A-4k7gB: undetectable 2qx4B-4k7gB: undetectable	2qx4A-4k7gB: 20.71 2qx4B-4k7gB: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WA2_A_SAMA1248_0 (NON-STRUCTURAL PROTEIN 5)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	5 / 12	GLY A 301 GLY A 335 SER A 305 THR A 322 GLU A 364	PYC A 700 (-3.7A) None None None None	1.21A	2wa2A-1w61A: undetectable	2wa2A-1w61A: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E4E_B_4PZB501_1 (CYTOCHROME P450 2E1)	4j9w	PROLINE RACEMASE FAMILY PROTEIN (Pseudomonas protegens)	3 / 3	ALA A 62 THR A 16 CYH A 88	None None PYC A 402 (-3.7A)	0.72A	3e4eB-4j9wA: undetectable	3e4eB-4j9wA: 22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB200_0 (ILEAL BILE ACID-BINDING PROTEIN)	4q60	PROLINE RACEMASE (Burkholderia multivorans)	4 / 5	PRO A 16 VAL A 61 THR A 241 GLY A 240	None None PYC A 402 (-3.6A) PYC A 402 (-4.0A)	1.21A	3elzB-4q60A: undetectable	3elzB-4q60A: 17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GN8_A_DEXA247_1 (GLUCOCORTICOID RECEPTOR 2)	4q60	PROLINE RACEMASE (Burkholderia multivorans)	5 / 12	ASN A 134 GLY A 161 CYH A 89 THR A 93 VAL A 132	PYC A 402 (-4.2A) None None None None	1.29A	3gn8A-4q60A: undetectable	3gn8A-4q60A: 18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GN8_B_DEXB247_1 (GLUCOCORTICOID RECEPTOR 2)	4q60	PROLINE RACEMASE (Burkholderia multivorans)	5 / 12	ASN A 134 GLY A 161 CYH A 89 THR A 93 VAL A 132	PYC A 402 (-4.2A) None None None None	1.31A	3gn8B-4q60A: undetectable	3gn8B-4q60A: 18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_C_THHC643_0 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	5 / 12	ARG A 88 ASN A 218 PHE A 290 ARG A 248 ILE A 265	None None PYC A 700 (-3.7A) None None	1.21A	3k13C-1w61A: undetectable	3k13C-1w61A: 22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MTE_A_SAMA220_0 (16S RRNA METHYLASE)	4j9w	PROLINE RACEMASE FAMILY PROTEIN (Pseudomonas protegens)	5 / 12	GLY A 91 VAL A 96 ALA A 74 LEU A 85 THR A 118	None None None PYC A 402 ( 4.8A) None	1.11A	3mteA-4j9wA: undetectable	3mteA-4j9wA: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXC_A_ROCA401_3 (PROTEASE)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	5 / 12	LEU A 106 GLY A 103 GLY A 131 ILE A 135 ILE A 118	None None PYC A 700 (-3.7A) None None	0.94A	3oxcB-1w61A: undetectable	3oxcB-1w61A: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_C_SAMC6735_1 (16S RRNA METHYLASE)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	4 / 5	ASN B 93 ASP B 172 THR B 202 SER B 92	None ACT B 902 (-3.5A) None PYC B 904 (-3.0A)	1.44A	3p2kC-4k7gB: undetectable	3p2kC-4k7gB: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWW_A_ROCA1001_2 (ENDOTHIAPEPSIN)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	4 / 8	GLY A 216 SER A 305 ASP A 296 SER A 298	None None PYC A 700 (-3.3A) PYC A 700 ( 4.3A)	0.84A	3pwwA-1w61A: undetectable	3pwwA-1w61A: 21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWW_A_ROCA1001_2 (ENDOTHIAPEPSIN)	4j9w	PROLINE RACEMASE FAMILY PROTEIN (Pseudomonas protegens)	4 / 8	GLY A 160 SER A 241 ASP A 232 SER A 234	None None PYC A 402 (-3.6A) PYC A 402 ( 4.4A)	0.83A	3pwwA-4j9wA: undetectable	3pwwA-4j9wA: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWW_A_ROCA1001_2 (ENDOTHIAPEPSIN)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	4 / 8	GLY B 170 SER B 261 ASP B 252 SER B 254	None None PYC B 904 (-3.2A) PYC B 904 ( 3.9A)	0.82A	3pwwA-4k7gB: undetectable	3pwwA-4k7gB: 24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A99_A_MIYA391_1 (TETX2 PROTEIN)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	5 / 10	MET A 129 ASN A 133 GLY A 301 SER A 305 GLY A 169	None None PYC A 700 (-3.7A) None None	1.05A	4a99A-1w61A: undetectable	4a99A-1w61A: 22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JEC_B_478B401_2 (HIV-1 PROTEASE)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	5 / 12	LEU A 106 GLY A 103 GLY A 131 ILE A 135 ILE A 118	None None PYC A 700 (-3.7A) None None	0.99A	4jecB-1w61A: undetectable	4jecB-1w61A: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA2)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	4 / 6	SER B 242 GLY B 171 ASP B 172 GLY B 91	None None ACT B 902 (-3.5A) PYC B 904 (-3.5A)	0.98A	4koeA-4k7gB: undetectable 4koeB-4k7gB: undetectable 4koeC-4k7gB: undetectable	4koeA-4k7gB: 21.63 4koeB-4k7gB: 21.63 4koeC-4k7gB: 22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4LB0_A_ACTA401_0 (UNCHARACTERIZED PROTEIN)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	6 / 9	GLY A 131 ASP A 296 SER A 298 CYH A 300 GLY A 301 THR A 302	PYC A 700 (-3.7A) PYC A 700 (-3.3A) PYC A 700 ( 4.3A) PYC A 700 (-3.4A) PYC A 700 (-3.7A) PYC A 700 (-2.6A)	0.27A	4lb0A-1w61A: 46.7	4lb0A-1w61A: 30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LB0_A_ACTA401_0 (UNCHARACTERIZED PROTEIN)	4j9w	PROLINE RACEMASE FAMILY PROTEIN (Pseudomonas protegens)	6 / 9	GLY A 89 ASP A 232 SER A 234 CYH A 236 GLY A 237 THR A 238	PYC A 402 (-3.6A) PYC A 402 (-3.6A) PYC A 402 ( 4.4A) PYC A 402 (-3.6A) PYC A 402 (-3.6A) PYC A 402 (-2.7A)	0.25A	4lb0A-4j9wA: 41.0	4lb0A-4j9wA: 28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4LB0_A_ACTA401_0 (UNCHARACTERIZED PROTEIN)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	7 / 9	SER B 90 GLY B 91 SER B 92 ASP B 252 SER B 254 GLY B 257 THR B 258	PYC B 904 (-3.1A) PYC B 904 (-3.5A) PYC B 904 (-3.0A) PYC B 904 (-3.2A) PYC B 904 ( 3.9A) PYC B 904 (-3.7A) PYC B 904 (-2.8A)	0.15A	4lb0A-4k7gB: 50.0	4lb0A-4k7gB: 40.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QOI_B_ML1B303_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	5 / 11	GLY A 301 GLY A 303 GLY A 367 GLN A 334 PHE A 323	PYC A 700 (-3.7A) None None None None	1.14A	4qoiA-1w61A: undetectable 4qoiB-1w61A: undetectable	4qoiA-1w61A: 20.43 4qoiB-1w61A: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2D_F_LFXF102_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	3 / 4	ARG B 253 GLY B 16 GLU B 17	None None PYC B 904 (-4.5A)	0.67A	4z2dB-4k7gB: undetectable 4z2dC-4k7gB: undetectable	4z2dB-4k7gB: 22.52 4z2dC-4k7gB: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z53_F_TR6F101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A E-SITE DNA)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	4 / 6	GLY B 171 ASP B 172 GLY B 91 SER B 242	None ACT B 902 (-3.5A) PYC B 904 (-3.5A) None	1.01A	4z53A-4k7gB: undetectable 4z53B-4k7gB: undetectable	4z53A-4k7gB: 18.59 4z53B-4k7gB: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBQ_A_DIFA601_1 (SERUM ALBUMIN)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	5 / 11	LEU B 142 VAL B 141 LEU B 264 GLY B 257 ARG B 306	None None None PYC B 904 (-3.7A) None	1.12A	4zbqA-4k7gB: undetectable	4zbqA-4k7gB: 19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0Y_A_FOLA201_0 (CONSERVED HYPOTHETICAL MEMBRANE PROTEIN)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	5 / 12	ASN B 93 THR B 256 ASN B 143 VAL B 141 HIS B 213	None PYC B 904 (-4.3A) None None None	1.34A	5d0yA-4k7gB: undetectable	5d0yA-4k7gB: 23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0Y_B_FOLB201_0 (CONSERVED HYPOTHETICAL MEMBRANE PROTEIN)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	5 / 12	ASN B 93 THR B 256 ASN B 143 VAL B 141 HIS B 213	None PYC B 904 (-4.3A) None None None	1.33A	5d0yB-4k7gB: undetectable	5d0yB-4k7gB: 23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5J4N_B_AG2B501_1 (ARGININE/AGMATINE ANTIPORTER)	4q60	PROLINE RACEMASE (Burkholderia multivorans)	4 / 6	ILE A 94 GLY A 161 ASN A 163 ILE A 285	None None None PYC A 402 (-3.8A)	0.90A	5j4nB-4q60A: undetectable	5j4nB-4q60A: 24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JGL_B_SAMB301_0 (UBIE/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	5 / 12	GLY A 131 ALA A 164 LEU A 262 GLY A 216 SER A 191	PYC A 700 (-3.7A) None None None None	1.41A	5jglB-1w61A: undetectable	5jglB-1w61A: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5K4P_A_SORA611_0 (PROBABLE PHOSPHATIDYLETHANOLA MINE TRANSFERASE MCR-1)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	4 / 6	GLY B 171 THR B 258 SER B 261 GLY B 257	None PYC B 904 (-2.8A) None PYC B 904 (-3.7A)	0.81A	5k4pA-4k7gB: undetectable	5k4pA-4k7gB: 23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPC_B_SAMB401_0 (PAVINE N-METHYLTRANSFERASE)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	5 / 12	SER B 146 GLY B 257 GLY B 259 SER B 242 GLN B 226	None PYC B 904 (-3.7A) None None None	1.16A	5kpcB-4k7gB: undetectable	5kpcB-4k7gB: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M66_B_ADNB502_1 (ADENOSYLHOMOCYSTEINA SE)	4j9w	PROLINE RACEMASE FAMILY PROTEIN (Pseudomonas protegens)	5 / 12	HIS A 90 THR A 11 ASP A 232 GLY A 94 PHE A 269	PYC A 402 (-4.1A) None PYC A 402 (-3.6A) None GOL A 404 (-4.7A)	1.48A	5m66B-4j9wA: undetectable	5m66B-4j9wA: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MWY_A_YNUA1101_1 (MINERALOCORTICOID RECEPTOR)	1w61	B-CELL MITOGEN (Trypanosoma cruzi)	4 / 6	GLN A 241 CYH A 300 THR A 302 PHE A 220	None PYC A 700 (-3.4A) PYC A 700 (-2.6A) None	1.22A	5mwyA-1w61A: undetectable	5mwyA-1w61A: 19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE0_A_XINA401_2 (AP2-ASSOCIATED PROTEIN KINASE 1)	4j9w	PROLINE RACEMASE FAMILY PROTEIN (Pseudomonas protegens)	4 / 5	LEU A 284 VAL A 131 MET A 87 CYH A 236	None None None PYC A 402 (-3.6A)	1.42A	5te0A-4j9wA: undetectable	5te0A-4j9wA: 23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BRD_C_RFPC502_1 (RIFAMPIN MONOOXYGENASE)	4k7g	3-HYDROXYPROLINE DEHYDRATSE (Agrobacterium vitis)	5 / 12	VAL B 127 GLY B 19 PRO B 255 THR B 256 GLY B 257	None None None PYC B 904 (-4.3A) PYC B 904 (-3.7A)	1.12A	6brdC-4k7gB: undetectable	6brdC-4k7gB: 16.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HO5_A_ADNA1604_1","5'-NUCLEOTIDASE","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",5,"ILE B 139;SER B  92;GLY B  91;PHE B  78;ASN B  64","None;PYC B 904 (-3.0A);PYC B 904 (-3.5A);None;None","1.42A","1ho5A-4k7gB:2.4",null],["1ICU_B_NIOB219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","1w61","B-CELL MITOGEN","Trypanosoma cruzi",4,"GLY A 131;SER A 305;THR A 304;PHE A 333","PYC A 700 (-3.7A);None;None;None","1.06A","1icuA-1w61A:undetectable;1icuB-1w61A:undetectable","1ho5A-4k7gB:21.56"],["1KQB_A_BEZA524_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","1w61","B-CELL MITOGEN","Trypanosoma cruzi",4,"SER A 305;THR A 304;PHE A 333;GLY A 131","None;None;None;PYC A 700 (-3.7A)","1.00A","1kqbA-1w61A:undetectable;1kqbB-1w61A:undetectable","1icuA-1w61A:20.54;1icuB-1w61A:20.54"],["1KQB_B_BEZB525_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","1w61","B-CELL MITOGEN","Trypanosoma cruzi",4,"GLY A 131;SER A 305;THR A 304;PHE A 333","PYC A 700 (-3.7A);None;None;None","1.10A","1kqbA-1w61A:undetectable;1kqbB-1w61A:undetectable","1kqbA-1w61A:19.86;1kqbB-1w61A:19.86"],["1KQB_C_BEZC522_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","1w61","B-CELL MITOGEN","Trypanosoma cruzi",4,"SER A 305;THR A 304;PHE A 333;GLY A 131","None;None;None;PYC A 700 (-3.7A)","1.03A","1kqbC-1w61A:undetectable;1kqbD-1w61A:undetectable","1kqbA-1w61A:19.86;1kqbB-1w61A:19.86"],["1NW5_A_SAMA401_0","MODIFICATION METHYLASE RSRI","4q60","PROLINE RACEMASE","Burkholderia multivorans",5,"ASP A   9;THR A 239;GLY A  13;SER A 268;ALA A 289","GOL A 401 ( 4.6A);PYC A 402 (-3.4A);None;None;None","1.32A","1nw5A-4q60A:undetectable","1kqbC-1w61A:19.86;1kqbD-1w61A:19.86"],["1O86_A_LPRA702_2","ANGIOTENSIN CONVERTING ENZYME","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",4,"SER B  90;VAL B 144;PHE B 224;VAL B 244","PYC B 904 (-3.1A);None;PYC B 904 ( 4.8A);None","1.17A","1o86A-4k7gB:undetectable","1nw5A-4q60A:24.15"],["1P93_C_DEXC3999_1","GLUCOCORTICOID RECEPTOR","4q60","PROLINE RACEMASE","Burkholderia multivorans",5,"ASN A 134;GLY A 161;LEU A  86;CYH A  89;THR A  93","PYC A 402 (-4.2A);None;None;None;None","1.50A","1p93C-4q60A:undetectable","1o86A-4k7gB:20.26"],["2QX4_A_ML1A233_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE];RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",4,"ILE B 309;PHE B 224;GLY B 170;GLY B 171","None;PYC B 904 ( 4.8A);None;None","0.76A","2qx4A-4k7gB:undetectable;2qx4B-4k7gB:undetectable","1p93C-4q60A:19.37"],["2WA2_A_SAMA1248_0","NON-STRUCTURAL PROTEIN 5","1w61","B-CELL MITOGEN","Trypanosoma cruzi",5,"GLY A 301;GLY A 335;SER A 305;THR A 322;GLU A 364","PYC A 700 (-3.7A);None;None;None;None","1.21A","2wa2A-1w61A:undetectable","2qx4A-4k7gB:20.71;2qx4B-4k7gB:20.71"],["3E4E_B_4PZB501_1","CYTOCHROME P450 2E1","4j9w","PROLINE RACEMASE FAMILY PROTEIN","Pseudomonas protegens",3,"ALA A  62;THR A  16;CYH A  88","None;None;PYC A 402 (-3.7A)","0.72A","3e4eB-4j9wA:undetectable","2wa2A-1w61A:22.30"],["3ELZ_B_CHDB200_0","ILEAL BILE ACID-BINDING PROTEIN","4q60","PROLINE RACEMASE","Burkholderia multivorans",4,"PRO A  16;VAL A  61;THR A 241;GLY A 240","None;None;PYC A 402 (-3.6A);PYC A 402 (-4.0A)","1.21A","3elzB-4q60A:undetectable","3e4eB-4j9wA:22.24"],["3GN8_A_DEXA247_1","GLUCOCORTICOID RECEPTOR 2","4q60","PROLINE RACEMASE","Burkholderia multivorans",5,"ASN A 134;GLY A 161;CYH A  89;THR A  93;VAL A 132","PYC A 402 (-4.2A);None;None;None;None","1.29A","3gn8A-4q60A:undetectable","3elzB-4q60A:17.74"],["3GN8_B_DEXB247_1","GLUCOCORTICOID RECEPTOR 2","4q60","PROLINE RACEMASE","Burkholderia multivorans",5,"ASN A 134;GLY A 161;CYH A  89;THR A  93;VAL A 132","PYC A 402 (-4.2A);None;None;None;None","1.31A","3gn8B-4q60A:undetectable","3gn8A-4q60A:18.90"],["3K13_C_THHC643_0","5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE","1w61","B-CELL MITOGEN","Trypanosoma cruzi",5,"ARG A  88;ASN A 218;PHE A 290;ARG A 248;ILE A 265","None;None;PYC A 700 (-3.7A);None;None","1.21A","3k13C-1w61A:undetectable","3gn8B-4q60A:18.90"],["3MTE_A_SAMA220_0","16S RRNA METHYLASE","4j9w","PROLINE RACEMASE FAMILY PROTEIN","Pseudomonas protegens",5,"GLY A  91;VAL A  96;ALA A  74;LEU A  85;THR A 118","None;None;None;PYC A 402 ( 4.8A);None","1.11A","3mteA-4j9wA:undetectable","3k13C-1w61A:22.41"],["3OXC_A_ROCA401_3","PROTEASE;PROTEASE","1w61","B-CELL MITOGEN","Trypanosoma cruzi",5,"LEU A 106;GLY A 103;GLY A 131;ILE A 135;ILE A 118","None;None;PYC A 700 (-3.7A);None;None","0.94A","3oxcB-1w61A:undetectable","3mteA-4j9wA:20.54"],["3P2K_C_SAMC6735_1","16S RRNA METHYLASE","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",4,"ASN B  93;ASP B 172;THR B 202;SER B  92","None;ACT B 902 (-3.5A);None;PYC B 904 (-3.0A)","1.44A","3p2kC-4k7gB:undetectable","3oxcB-1w61A:12.62"],["3PWW_A_ROCA1001_2","ENDOTHIAPEPSIN","1w61","B-CELL MITOGEN","Trypanosoma cruzi",4,"GLY A 216;SER A 305;ASP A 296;SER A 298","None;None;PYC A 700 (-3.3A);PYC A 700 ( 4.3A)","0.84A","3pwwA-1w61A:undetectable","3p2kC-4k7gB:19.95"],["3PWW_A_ROCA1001_2","ENDOTHIAPEPSIN","4j9w","PROLINE RACEMASE FAMILY PROTEIN","Pseudomonas protegens",4,"GLY A 160;SER A 241;ASP A 232;SER A 234","None;None;PYC A 402 (-3.6A);PYC A 402 ( 4.4A)","0.83A","3pwwA-4j9wA:undetectable","3pwwA-1w61A:21.08"],["3PWW_A_ROCA1001_2","ENDOTHIAPEPSIN","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",4,"GLY B 170;SER B 261;ASP B 252;SER B 254","None;None;PYC B 904 (-3.2A);PYC B 904 ( 3.9A)","0.82A","3pwwA-4k7gB:undetectable","3pwwA-4j9wA:22.07"],["4A99_A_MIYA391_1","TETX2 PROTEIN","1w61","B-CELL MITOGEN","Trypanosoma cruzi",5,"MET A 129;ASN A 133;GLY A 301;SER A 305;GLY A 169","None;None;PYC A 700 (-3.7A);None;None","1.05A","4a99A-1w61A:undetectable","3pwwA-4k7gB:24.48"],["4JEC_B_478B401_2","HIV-1 PROTEASE","1w61","B-CELL MITOGEN","Trypanosoma cruzi",5,"LEU A 106;GLY A 103;GLY A 131;ILE A 135;ILE A 118","None;None;PYC A 700 (-3.7A);None;None","0.99A","4jecB-1w61A:undetectable","4a99A-1w61A:22.56"],["4KOE_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B;E-SITE DNA2","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",4,"SER B 242;GLY B 171;ASP B 172;GLY B  91","None;None;ACT B 902 (-3.5A);PYC B 904 (-3.5A)","0.98A","4koeA-4k7gB:undetectable;4koeB-4k7gB:undetectable;4koeC-4k7gB:undetectable","4jecB-1w61A:12.62"],["4LB0_A_ACTA401_0","UNCHARACTERIZED PROTEIN","1w61","B-CELL MITOGEN","Trypanosoma cruzi",6,"GLY A 131;ASP A 296;SER A 298;CYH A 300;GLY A 301;THR A 302","PYC A 700 (-3.7A);PYC A 700 (-3.3A);PYC A 700 ( 4.3A);PYC A 700 (-3.4A);PYC A 700 (-3.7A);PYC A 700 (-2.6A)","0.27A","4lb0A-1w61A:46.7","4koeA-4k7gB:21.63;4koeB-4k7gB:21.63;4koeC-4k7gB:22.22"],["4LB0_A_ACTA401_0","UNCHARACTERIZED PROTEIN","4j9w","PROLINE RACEMASE FAMILY PROTEIN","Pseudomonas protegens",6,"GLY A  89;ASP A 232;SER A 234;CYH A 236;GLY A 237;THR A 238","PYC A 402 (-3.6A);PYC A 402 (-3.6A);PYC A 402 ( 4.4A);PYC A 402 (-3.6A);PYC A 402 (-3.6A);PYC A 402 (-2.7A)","0.25A","4lb0A-4j9wA:41.0","4lb0A-1w61A:30.77"],["4LB0_A_ACTA401_0","UNCHARACTERIZED PROTEIN","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",7,"SER B  90;GLY B  91;SER B  92;ASP B 252;SER B 254;GLY B 257;THR B 258","PYC B 904 (-3.1A);PYC B 904 (-3.5A);PYC B 904 (-3.0A);PYC B 904 (-3.2A);PYC B 904 ( 3.9A);PYC B 904 (-3.7A);PYC B 904 (-2.8A)","0.15A","4lb0A-4k7gB:50.0","4lb0A-4j9wA:28.65"],["4QOI_B_ML1B303_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE];RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","1w61","B-CELL MITOGEN","Trypanosoma cruzi",5,"GLY A 301;GLY A 303;GLY A 367;GLN A 334;PHE A 323","PYC A 700 (-3.7A);None;None;None;None","1.14A","4qoiA-1w61A:undetectable;4qoiB-1w61A:undetectable","4lb0A-4k7gB:40.79"],["4Z2D_F_LFXF102_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B;SYMMETRIZED E-SITE DNA","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",3,"ARG B 253;GLY B  16;GLU B  17","None;None;PYC B 904 (-4.5A)","0.67A","4z2dB-4k7gB:undetectable;4z2dC-4k7gB:undetectable","4qoiA-1w61A:20.43;4qoiB-1w61A:20.43"],["4Z53_F_TR6F101_1","DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;DNA TOPOISOMERASE 4 SUBUNIT B,DNA TOPOISOMERASE 4 SUBUNIT A;E-SITE DNA","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",4,"GLY B 171;ASP B 172;GLY B  91;SER B 242","None;ACT B 902 (-3.5A);PYC B 904 (-3.5A);None","1.01A","4z53A-4k7gB:undetectable;4z53B-4k7gB:undetectable","4z2dB-4k7gB:22.52;4z2dC-4k7gB:22.48"],["4ZBQ_A_DIFA601_1","SERUM ALBUMIN","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",5,"LEU B 142;VAL B 141;LEU B 264;GLY B 257;ARG B 306","None;None;None;PYC B 904 (-3.7A);None","1.12A","4zbqA-4k7gB:undetectable","4z53A-4k7gB:18.59;4z53B-4k7gB:18.59"],["5D0Y_A_FOLA201_0","CONSERVED HYPOTHETICAL MEMBRANE PROTEIN","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",5,"ASN B  93;THR B 256;ASN B 143;VAL B 141;HIS B 213","None;PYC B 904 (-4.3A);None;None;None","1.34A","5d0yA-4k7gB:undetectable","4zbqA-4k7gB:19.15"],["5D0Y_B_FOLB201_0","CONSERVED HYPOTHETICAL MEMBRANE PROTEIN","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",5,"ASN B  93;THR B 256;ASN B 143;VAL B 141;HIS B 213","None;PYC B 904 (-4.3A);None;None;None","1.33A","5d0yB-4k7gB:undetectable","5d0yA-4k7gB:23.46"],["5J4N_B_AG2B501_1","ARGININE\/AGMATINE ANTIPORTER","4q60","PROLINE RACEMASE","Burkholderia multivorans",4,"ILE A  94;GLY A 161;ASN A 163;ILE A 285","None;None;None;PYC A 402 (-3.8A)","0.90A","5j4nB-4q60A:undetectable","5d0yB-4k7gB:23.46"],["5JGL_B_SAMB301_0","UBIE\/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE","1w61","B-CELL MITOGEN","Trypanosoma cruzi",5,"GLY A 131;ALA A 164;LEU A 262;GLY A 216;SER A 191","PYC A 700 (-3.7A);None;None;None;None","1.41A","5jglB-1w61A:undetectable","5j4nB-4q60A:24.41"],["5K4P_A_SORA611_0","PROBABLE PHOSPHATIDYLETHANOLAMINE TRANSFERASE MCR-1","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",4,"GLY B 171;THR B 258;SER B 261;GLY B 257","None;PYC B 904 (-2.8A);None;PYC B 904 (-3.7A)","0.81A","5k4pA-4k7gB:undetectable","5jglB-1w61A:22.06"],["5KPC_B_SAMB401_0","PAVINE N-METHYLTRANSFERASE","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",5,"SER B 146;GLY B 257;GLY B 259;SER B 242;GLN B 226","None;PYC B 904 (-3.7A);None;None;None","1.16A","5kpcB-4k7gB:undetectable","5k4pA-4k7gB:23.47"],["5M66_B_ADNB502_1","ADENOSYLHOMOCYSTEINASE","4j9w","PROLINE RACEMASE FAMILY PROTEIN","Pseudomonas protegens",5,"HIS A  90;THR A  11;ASP A 232;GLY A  94;PHE A 269","PYC A 402 (-4.1A);None;PYC A 402 (-3.6A);None;GOL A 404 (-4.7A)","1.48A","5m66B-4j9wA:undetectable","5kpcB-4k7gB:21.97"],["5MWY_A_YNUA1101_1","MINERALOCORTICOID RECEPTOR","1w61","B-CELL MITOGEN","Trypanosoma cruzi",4,"GLN A 241;CYH A 300;THR A 302;PHE A 220","None;PYC A 700 (-3.4A);PYC A 700 (-2.6A);None","1.22A","5mwyA-1w61A:undetectable","5m66B-4j9wA:24.10"],["5TE0_A_XINA401_2","AP2-ASSOCIATED PROTEIN KINASE 1","4j9w","PROLINE RACEMASE FAMILY PROTEIN","Pseudomonas protegens",4,"LEU A 284;VAL A 131;MET A  87;CYH A 236","None;None;None;PYC A 402 (-3.6A)","1.42A","5te0A-4j9wA:undetectable","5mwyA-1w61A:19.15"],["6BRD_C_RFPC502_1","RIFAMPIN MONOOXYGENASE","4k7g","3-HYDROXYPROLINE DEHYDRATSE","Agrobacterium vitis",5,"VAL B 127;GLY B  19;PRO B 255;THR B 256;GLY B 257","None;None;None;PYC B 904 (-4.3A);PYC B 904 (-3.7A)","1.12A","6brdC-4k7gB:undetectable","5te0A-4j9wA:23.22"]]