SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PY1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 ALA A 230
LYS A 232
GLU A 245
LEU A 278
GLY A 286
LEU A 340
ASP A 351
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.45A 1m17A-1py5A:
22.9		 1m17A-1py5A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 9 GLY A 212
VAL A 219
ALA A 230
LEU A 260
TYR A 282
LEU A 340
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.2A)
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
 0.81A 1muoA-1py5A:
16.7		 1muoA-1py5A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ALA A 230
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.59A 1uwhA-1py5A:
25.6		 1uwhA-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		4 / 6 ILE A 211
VAL A 219
ILE A 259
ILE A 329
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
None
None
 0.64A 1uwhA-1py5A:
25.6		 1uwhA-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 ALA A 230
LYS A 232
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.56A 1uwhB-1py5A:
25.5		 1uwhB-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		4 / 6 ILE A 211
VAL A 219
ILE A 259
ILE A 329
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
None
None
 0.64A 1uwhB-1py5A:
25.5		 1uwhB-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 VAL A 219
ALA A 230
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.51A 1uwjA-1py5A:
6.5		 1uwjA-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		4 / 7 ILE A 211
LYS A 232
ILE A 259
ILE A 329
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.9A)
None
None
 0.60A 1uwjA-1py5A:
6.5		 1uwjA-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 ILE A 211
VAL A 219
ALA A 230
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.68A 1uwjB-1py5A:
24.7		 1uwjB-1py5A:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 11 GLY A 212
GLY A 214
VAL A 219
ALA A 230
TYR A 282
SER A 287
LEU A 340
 None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
None
PY1  A 700 (-4.4A)
 0.66A 2evaA-1py5A:
27.1		 2evaA-1py5A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 11 GLY A 212
VAL A 219
ALA A 230
TYR A 282
SER A 287
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
None
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.75A 2evaA-1py5A:
27.1		 2evaA-1py5A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 GLY A 212
GLY A 214
VAL A 219
ALA A 230
LYS A 335
ASN A 338
ASP A 351
 None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
None
None
PY1  A 700 (-2.7A)
 0.97A 2fumD-1py5A:
16.0		 2fumD-1py5A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 ALA A 230
LYS A 232
GLU A 245
LEU A 278
GLY A 286
ASP A 290
LEU A 340
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-4.4A)
 0.74A 2itoA-1py5A:
26.8		 2itoA-1py5A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 GLY A 212
VAL A 219
ALA A 230
LYS A 232
GLU A 245
LEU A 278
GLY A 286
LEU A 340
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.77A 2ityA-1py5A:
26.7		 2ityA-1py5A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 VAL A 219
ALA A 230
LYS A 232
GLU A 245
LEU A 278
GLY A 286
LEU A 340
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.71A 2ityA-1py5A:
26.7		 2ityA-1py5A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 VAL A 219
ALA A 230
LYS A 232
GLU A 245
GLY A 286
ASP A 290
LEU A 340
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.74A 2itzA-1py5A:
26.6		 2itzA-1py5A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 GLY A 212
VAL A 219
LYS A 232
GLU A 245
TYR A 282
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.58A 2ivuA-1py5A:
28.4		 2ivuA-1py5A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 GLY A 212
VAL A 219
ALA A 230
LEU A 260
TYR A 282
GLY A 286
ALA A 350
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.2A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 ( 4.2A)
 0.74A 2wgjA-1py5A:
25.2		 2wgjA-1py5A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 ILE A 211
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.70A 2y6oA-1py5A:
26.1		 2y6oA-1py5A:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 ILE A 211
VAL A 219
ALA A 230
GLY A 286
LEU A 340
ASP A 351
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.54A 2y7jA-1py5A:
19.4		 2y7jA-1py5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 10 ILE A 211
VAL A 219
ALA A 230
GLY A 286
LEU A 340
ASP A 351
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.53A 2y7jB-1py5A:
18.8		 2y7jB-1py5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 10 ILE A 211
VAL A 219
ALA A 230
GLY A 286
ASP A 290
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-4.4A)
 0.66A 2y7jC-1py5A:
19.5		 2y7jC-1py5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 10 ILE A 211
VAL A 219
ALA A 230
GLY A 286
ASP A 290
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-4.4A)
 0.57A 2y7jD-1py5A:
18.7		 2y7jD-1py5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ALA A 230
GLY A 286
HIS A 331
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.39A 3cs9A-1py5A:
26.0		 3cs9A-1py5A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		9 / 12 GLY A 212
GLY A 214
GLY A 217
VAL A 219
ALA A 230
LYS A 232
SER A 287
ASN A 338
LEU A 340
 None
None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
None
None
PY1  A 700 (-4.4A)
 0.70A 3eygA-1py5A:
28.0		 3eygA-1py5A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		9 / 12 GLY A 212
GLY A 214
GLY A 217
VAL A 219
ALA A 230
LYS A 232
TYR A 282
SER A 287
LEU A 340
 None
None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.6A)
None
PY1  A 700 (-4.4A)
 0.84A 3fupA-1py5A:
28.0		 3fupA-1py5A:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 VAL A 219
ALA A 230
GLU A 245
TYR A 282
GLY A 286
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.44A 3g5dA-1py5A:
20.6		 3g5dA-1py5A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 VAL A 219
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.48A 3g5dB-1py5A:
20.6		 3g5dB-1py5A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 GLY A 212
GLY A 214
VAL A 219
ALA A 230
LYS A 232
TYR A 282
SER A 287
LEU A 340
 None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.6A)
None
PY1  A 700 (-4.4A)
 0.71A 3lxnA-1py5A:
27.8		 3lxnA-1py5A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 9 ILE A 211
ALA A 230
LYS A 232
GLY A 286
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.71A 3miyB-1py5A:
26.3		 3miyB-1py5A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 VAL A 219
ALA A 230
GLU A 245
TYR A 282
GLY A 286
LEU A 340
ALA A 350
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
PY1  A 700 (-2.7A)
 0.50A 3qlgB-1py5A:
20.3		 3qlgB-1py5A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 VAL A 219
ALA A 230
GLU A 245
TYR A 282
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
None
None
PY1  A 700 ( 4.2A)
 0.85A 3rgfA-1py5A:
16.2		 3rgfA-1py5A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 ILE A 211
GLY A 214
GLY A 217
VAL A 219
ALA A 230
LYS A 232
LEU A 340
ASP A 351
 PY1  A 700 (-3.6A)
None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.95A 3v5wA-1py5A:
6.8		 3v5wA-1py5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 VAL A 219
ALA A 230
LYS A 232
GLU A 245
GLY A 286
LEU A 316
HIS A 331
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.6A)
None
None
 0.64A 3wzeA-1py5A:
25.7		 3wzeA-1py5A:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 ALA A 230
LYS A 232
GLU A 245
LEU A 316
HIS A 331
ARG A 332
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
None
None
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.78A 3zosA-1py5A:
24.1		 3zosA-1py5A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 ALA A 230
LYS A 232
GLU A 245
LEU A 316
HIS A 331
ARG A 332
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
None
None
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.79A 3zosB-1py5A:
24.2		 3zosB-1py5A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 VAL A 219
ALA A 230
GLU A 245
ILE A 248
TYR A 282
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 1.04A 4bkjA-1py5A:
24.3		 4bkjA-1py5A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 VAL A 219
ALA A 230
GLU A 245
ILE A 248
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.96A 4bkjB-1py5A:
24.4		 4bkjB-1py5A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 ALA A 230
LYS A 232
GLU A 245
LEU A 260
HIS A 331
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.48A 4c8bA-1py5A:
18.5		 4c8bA-1py5A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		4 / 5 VAL A 219
ILE A 259
TYR A 282
ILE A 349
 PY1  A 700 ( 4.7A)
None
PY1  A 700 (-4.6A)
None
 0.70A 4c8bA-1py5A:
18.5		 4c8bA-1py5A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 ALA A 230
LYS A 232
GLU A 245
ILE A 259
LEU A 260
HIS A 331
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.2A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.66A 4c8bB-1py5A:
18.7		 4c8bB-1py5A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 11 GLY A 212
GLY A 214
VAL A 219
ALA A 230
TYR A 282
GLY A 286
SER A 287
LEU A 340
 None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-4.4A)
 0.71A 4ckiA-1py5A:
28.3		 4ckiA-1py5A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 10 GLY A 212
VAL A 219
ALA A 230
TYR A 282
SER A 287
LEU A 340
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
None
PY1  A 700 (-4.4A)
 0.60A 4ckjA-1py5A:
28.1		 4ckjA-1py5A:
26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 VAL A 219
ALA A 230
GLU A 245
ILE A 248
TYR A 282
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.79A 4csvA-1py5A:
20.2		 4csvA-1py5A:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 8 GLY A 214
VAL A 219
ALA A 230
LYS A 232
LEU A 340
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.4A)
 0.69A 4l9iB-1py5A:
17.2		 4l9iB-1py5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 VAL A 219
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.87A 4mxoB-1py5A:
20.6		 4mxoB-1py5A:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 11 GLY A 212
VAL A 219
ALA A 230
LYS A 232
LEU A 260
ASN A 338
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.2A)
None
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.62A 4o0sA-1py5A:
18.4		 4o0sA-1py5A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		4 / 6 VAL A 219
ALA A 230
LEU A 260
LEU A 340
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.2A)
PY1  A 700 (-4.4A)
 0.48A 4o0uA-1py5A:
17.1		 4o0uA-1py5A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 8 ILE A 211
VAL A 219
ALA A 230
ASN A 338
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
None
PY1  A 700 (-4.4A)
 0.56A 4ogrA-1py5A:
25.4		 4ogrA-1py5A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 9 ILE A 211
GLY A 214
VAL A 219
ALA A 230
ASN A 338
LEU A 340
 PY1  A 700 (-3.6A)
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
None
PY1  A 700 (-4.4A)
 0.91A 4ogrI-1py5A:
25.7		 4ogrI-1py5A:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 ILE A 211
GLY A 212
VAL A 219
ALA A 230
TYR A 282
LEU A 340
 PY1  A 700 (-3.6A)
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
 0.68A 4qmzA-1py5A:
25.9		 4qmzA-1py5A:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ALA A 230
GLU A 245
LEU A 316
ARG A 332
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 ( 4.2A)
 0.59A 4qrcA-1py5A:
26.1		 4qrcA-1py5A:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 VAL A 219
ALA A 230
LYS A 232
LEU A 260
SER A 287
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.2A)
None
 0.70A 4rzvB-1py5A:
25.2		 4rzvB-1py5A:
30.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ALA A 230
GLU A 245
HIS A 331
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.50A 4tyjA-1py5A:
25.8		 4tyjA-1py5A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 10 VAL A 219
GLU A 245
LEU A 254
ILE A 259
TYR A 282
ARG A 332
ILE A 349
 PY1  A 700 ( 4.7A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 (-4.6A)
None
None
 1.01A 4u0iA-1py5A:
25.7		 4u0iA-1py5A:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ALA A 230
LEU A 316
HIS A 331
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
None
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.38A 4uxqA-1py5A:
26.2		 4uxqA-1py5A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ALA A 230
GLU A 245
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 ( 4.2A)
 0.62A 4v01A-1py5A:
24.9		 4v01A-1py5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ALA A 230
GLU A 245
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 ( 4.2A)
 0.57A 4v01B-1py5A:
25.1		 4v01B-1py5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 VAL A 219
ALA A 230
GLU A 245
HIS A 331
ALA A 350
GLY A 353
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 ( 4.2A)
None
 0.91A 4v04A-1py5A:
20.7		 4v04A-1py5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 VAL A 219
ALA A 230
GLU A 245
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 ( 4.2A)
 0.63A 4v04A-1py5A:
20.7		 4v04A-1py5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ALA A 230
GLU A 245
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 ( 4.2A)
 0.62A 4v04B-1py5A:
25.1		 4v04B-1py5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 ALA A 230
LYS A 232
GLU A 245
LEU A 278
GLY A 286
LEU A 340
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.55A 4wkqA-1py5A:
27.4		 4wkqA-1py5A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ASP A 351
LEU A 352
LEU A 316
LEU A 334
ILE A 349
 PY1  A 700 (-2.7A)
None
None
None
None
 1.10A 4x1fA-1py5A:
0.0		 4x1fA-1py5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 ASP A 351
LEU A 352
LEU A 316
LEU A 334
ILE A 349
 PY1  A 700 (-2.7A)
None
None
None
None
 1.12A 4x1gA-1py5A:
0.0		 4x1gA-1py5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.52A 4xliB-1py5A:
28.1		 4xliB-1py5A:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 VAL A 219
ALA A 230
LYS A 232
LEU A 260
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.2A)
PY1  A 700 (-2.7A)
 0.73A 4xv2A-1py5A:
25.1		 4xv2A-1py5A:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 VAL A 219
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.68A 5bvwA-1py5A:
24.6		 5bvwA-1py5A:
25.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 ALA A 230
LYS A 232
GLU A 245
LEU A 260
LEU A 316
HIS A 331
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
None
 0.59A 5hi2A-1py5A:
25.6		 5hi2A-1py5A:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 GLY A 212
VAL A 219
ALA A 230
LYS A 232
LEU A 260
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.2A)
PY1  A 700 (-2.7A)
 0.92A 5hieC-1py5A:
25.6		 5hieC-1py5A:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 ILE A 211
ALA A 230
GLU A 245
TYR A 282
GLY A 286
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.67A 5i9xA-1py5A:
26.2		 5i9xA-1py5A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 ILE A 211
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
 PY1  A 700 (-3.6A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.65A 5i9yA-1py5A:
26.1		 5i9yA-1py5A:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 GLU A 209
ILE A 211
GLY A 212
VAL A 219
ALA A 230
LYS A 232
GLU A 245
GLY A 286
 None
PY1  A 700 (-3.6A)
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.6A)
 0.85A 5mafA-1py5A:
18.3		 5mafA-1py5A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		8 / 12 ILE A 211
GLY A 212
VAL A 219
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
 PY1  A 700 (-3.6A)
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
 0.77A 5mafA-1py5A:
18.3		 5mafA-1py5A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 GLU A 209
ILE A 211
GLY A 212
ALA A 230
TYR A 282
GLY A 286
ASP A 290
 None
PY1  A 700 (-3.6A)
None
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
None
 0.74A 5vc3A-1py5A:
18.6		 5vc3A-1py5A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 GLY A 212
VAL A 219
ALA A 230
LYS A 232
LEU A 278
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.95A 5yu9A-1py5A:
24.4		 5yu9A-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 GLY A 212
VAL A 219
ALA A 230
LEU A 278
ASP A 290
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.8A)
None
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.82A 5yu9B-1py5A:
24.6		 5yu9B-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 GLY A 212
VAL A 219
ALA A 230
LYS A 232
ASP A 290
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
None
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.97A 5yu9B-1py5A:
24.6		 5yu9B-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 VAL A 219
ALA A 230
LEU A 278
GLY A 286
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-2.7A)
 0.68A 5yu9C-1py5A:
24.3		 5yu9C-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		6 / 12 VAL A 219
ALA A 230
LYS A 232
GLY A 286
ASP A 290
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-2.7A)
 1.00A 5yu9C-1py5A:
24.3		 5yu9C-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		5 / 12 VAL A 219
ALA A 230
GLY A 286
LEU A 340
ASP A 351
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.47A 5yu9D-1py5A:
24.7		 5yu9D-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens) 		7 / 12 VAL A 219
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.68A 6bsdA-1py5A:
24.5		 6bsdA-1py5A:
12.97