SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PXP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDU_A_ESTA351_1 (17-BETA-HYDROXYSTERO ID DEHYDROGENASE)	3f4n	PYRIDOXINE 5'-PHOSPHATE SYNTHASE (Yersinia pestis)	5 / 12	VAL A 8 GLY A 7 LEU A 6 GLY A 215 LEU A 237	None None None PXP A 501 (-3.6A) None	1.01A	1fduA-3f4nA: undetectable	1fduA-3f4nA: 20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A2Q_A_ACAA602_1 (6-AMINOHEXANOATE-CYC LIC-DIMER HYDROLASE)	3f4n	PYRIDOXINE 5'-PHOSPHATE SYNTHASE (Yersinia pestis)	4 / 7	ASN A 9 ALA A 31 ALA A 30 ALA A 34	PXP A 501 (-4.3A) None None None	0.63A	3a2qA-3f4nA: undetectable	3a2qA-3f4nA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_D_ADND500_1 (ADENOSYLHOMOCYSTEINA SE)	3f4n	PYRIDOXINE 5'-PHOSPHATE SYNTHASE (Yersinia pestis)	5 / 12	THR A 156 GLU A 72 THR A 43 GLY A 194 PHE A 133	None PXP A 501 (-3.0A) None PXP A 501 (-3.5A) PXP A 501 (-3.3A)	1.48A	3ce6D-3f4nA: undetectable	3ce6D-3f4nA: 20.00