SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PXM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 MET A 109
PRO A 504
ALA A 176
ALA A 172
GLN A 328
 PXM  A 609 ( 4.8A)
FAD  A 601 (-4.3A)
None
None
PXM  A 609 ( 3.9A)
 1.29A 2jjpA-4ha6A:
undetectable		 2jjpA-4ha6A:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		10 / 11 GLU A  68
PRO A  69
LEU A  73
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
ASN A 196
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
None
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
None
 0.38A 2z9wA-2z9vA:
70.8		 2z9wA-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		6 / 11 TYR A  95
CYH A 142
THR A 146
SER A 174
ASN A 196
LYS A 197
 PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 ( 3.7A)
None
SO4  A1601 (-2.7A)
 0.77A 2z9wA-2z9vA:
70.8		 2z9wA-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		10 / 11 GLU A  68
PRO A  69
LEU A  73
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
ASN A 196
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
None
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
None
 0.38A 2z9wB-2z9vA:
69.7		 2z9wB-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		8 / 11 GLU A  68
PRO A  69
TYR A  95
CYH A 142
THR A 146
SER A 174
ASN A 196
LYS A 197
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 ( 3.7A)
None
SO4  A1601 (-2.7A)
 0.71A 2z9wB-2z9vA:
69.7		 2z9wB-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9X_A_PXLA1503_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		9 / 10 GLU A  68
PRO A  69
VAL A  70
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
PXM  A1501 (-4.1A)
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
 0.24A 2z9xA-2z9vA:
70.2		 2z9xA-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9X_A_PXLA1503_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		5 / 10 TYR A  95
CYH A 142
ASP A 171
SER A 174
LYS A 197
 PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 3.7A)
SO4  A1601 (-2.7A)
 1.01A 2z9xA-2z9vA:
70.2		 2z9xA-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		10 / 11 GLU A  68
PRO A  69
VAL A  70
LEU A  73
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
PXM  A1501 (-4.1A)
None
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
 0.31A 2z9xB-2z9vA:
69.1		 2z9xB-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		5 / 11 TYR A  95
CYH A 142
ASP A 171
SER A 174
LYS A 197
 PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 3.7A)
SO4  A1601 (-2.7A)
 1.02A 2z9xB-2z9vA:
69.1		 2z9xB-2z9vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		3 / 3 TYR A 335
ASP A 115
HIS A 462
 None
None
PXM  A 609 (-3.8A)
 0.87A 3e23A-4ha6A:
2.1		 3e23A-4ha6A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		4 / 6 GLY A 200
PRO A 202
GLY A 204
GLU A  68
 None
None
None
PXM  A1501 (-3.2A)
 0.86A 4dxuA-2z9vA:
undetectable		 4dxuA-2z9vA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		3 / 3 MET A 333
HIS A 460
GLY A 107
 None
PXM  A 609 (-3.8A)
FAD  A 601 (-3.4A)
 0.84A 5gwzB-4ha6A:
undetectable		 5gwzB-4ha6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		4 / 8 GLN A 328
ILE A 174
ALA A 334
VAL A 351
 PXM  A 609 ( 3.9A)
None
None
None
 1.05A 6hu9a-4ha6A:
undetectable
6hu9e-4ha6A:
undetectable		 6hu9a-4ha6A:
23.57
6hu9e-4ha6A:
14.14