SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PXL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 10 SER A  12
VAL A  14
HIS A  46
THR A  47
VAL A 231
 PXL  A 313 (-3.3A)
None
PXL  A 313 (-4.9A)
PXL  A 313 (-2.7A)
SO4  A 314 ( 4.0A)
 0.68A 1td2A-3fhxA:
37.6		 1td2A-3fhxA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 10 HIS A  48
THR A  49
GLN A  50
TYR A  84
ASP A 224
 None
PXL  A 400 (-2.9A)
PXL  A 400 (-4.0A)
PXL  A 400 (-3.7A)
PXL  A 400 (-2.4A)
 0.30A 1td2A-3mbhA:
34.0		 1td2A-3mbhA:
27.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 9 HIS A  46
THR A  47
TYR A  84
VAL A 115
VAL A 231
 PXL  A 313 (-4.9A)
PXL  A 313 (-2.7A)
PXL  A 313 ( 4.6A)
ATP  A 407 ( 4.5A)
SO4  A 314 ( 4.0A)
 0.87A 1td2B-3fhxA:
37.8		 1td2B-3fhxA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		5 / 9 SER A  12
HIS A  46
THR A  47
VAL A 115
VAL A 231
 PXL  A 313 (-3.3A)
PXL  A 313 (-4.9A)
PXL  A 313 (-2.7A)
ATP  A 407 ( 4.5A)
SO4  A 314 ( 4.0A)
 0.91A 1td2B-3fhxA:
37.8		 1td2B-3fhxA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		5 / 9 HIS A  48
THR A  49
TYR A  84
VAL A 113
ASP A 224
 None
PXL  A 400 (-2.9A)
PXL  A 400 (-3.7A)
PXL  A 400 (-4.4A)
PXL  A 400 (-2.4A)
 0.40A 1td2B-3mbhA:
34.3		 1td2B-3mbhA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		4 / 8 SER A  10
VAL A  12
TYR A  83
ASP A 224
 PXL  A 288 (-2.4A)
None
PXL  A 288 (-3.8A)
PXL  A 288 (-2.5A)
 0.47A 2ddwA-1td2A:
31.5		 2ddwA-1td2A:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 121
GLU A 148
THR A 227
 PXL  A 400 (-3.8A)
None
None
 0.97A 2y7hB-3mbhA:
2.6		 2y7hB-3mbhA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHX_A_PXLA313_1
(PYRIDOXAL KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		4 / 4 SER A  10
HIS A  44
THR A  45
VAL A 220
 PXL  A 288 (-2.4A)
PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-4.5A)
 0.73A 3fhxA-1td2A:
37.6		 3fhxA-1td2A:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 8 VAL A  39
PHE A  41
HIS A  44
THR A  45
VAL A 220
 None
None
PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-4.5A)
 0.51A 3fhxB-1td2A:
37.3		 3fhxB-1td2A:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 9 VAL A 220
GLN A  46
VAL A  39
ASN A  19
GLY A  18
 PXL  A 288 (-4.5A)
PXL  A 288 (-3.9A)
None
None
PXL  A 288 ( 4.1A)
 1.41A 3km6B-1td2A:
0.5		 3km6B-1td2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		6 / 11 HIS A  44
THR A  45
GLN A  46
TYR A  83
VAL A 114
ASP A 224
 PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
PXL  A 288 (-3.8A)
None
PXL  A 288 (-2.5A)
 0.40A 3mbhA-1td2A:
33.9		 3mbhA-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		6 / 12 HIS A  44
THR A  45
GLN A  46
TYR A  83
VAL A 114
ASP A 224
 PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
PXL  A 288 (-3.8A)
None
PXL  A 288 (-2.5A)
 0.36A 3mbhB-1td2A:
33.9		 3mbhB-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 12 SER A  10
HIS A  44
THR A  45
GLN A  46
VAL A 114
 PXL  A 288 (-2.4A)
PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
None
 1.28A 3mbhB-1td2A:
33.9		 3mbhB-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		6 / 12 HIS A  44
THR A  45
GLN A  46
TYR A  83
VAL A 114
ASP A 224
 PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
PXL  A 288 (-3.8A)
None
PXL  A 288 (-2.5A)
 0.33A 3mbhC-1td2A:
34.0		 3mbhC-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 12 SER A  10
HIS A  44
THR A  45
GLN A  46
VAL A 114
 PXL  A 288 (-2.4A)
PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
None
 1.26A 3mbhC-1td2A:
34.0		 3mbhC-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 2ddw PYRIDOXINE KINASE
(Escherichia
coli) 		5 / 12 VAL A  30
LEU A  54
TYR A  96
VAL A 127
ASP A 233
 PXL  A1003 ( 4.3A)
PXL  A1003 ( 4.9A)
PXL  A1003 ( 3.9A)
None
PXL  A1003 (-3.7A)
 0.84A 3mbhC-2ddwA:
29.5		 3mbhC-2ddwA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		6 / 12 HIS A  44
THR A  45
GLN A  46
TYR A  83
VAL A 114
ASP A 224
 PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
PXL  A 288 (-3.8A)
None
PXL  A 288 (-2.5A)
 0.38A 3mbhD-1td2A:
33.8		 3mbhD-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 12 SER A  10
HIS A  44
THR A  45
GLN A  46
VAL A 114
 PXL  A 288 (-2.4A)
PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
None
 1.28A 3mbhD-1td2A:
33.8		 3mbhD-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		6 / 12 HIS A  44
THR A  45
GLN A  46
TYR A  83
VAL A 114
ASP A 224
 PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
PXL  A 288 (-3.8A)
None
PXL  A 288 (-2.5A)
 0.33A 3mbhE-1td2A:
33.8		 3mbhE-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 12 SER A  10
HIS A  44
THR A  45
GLN A  46
VAL A 114
 PXL  A 288 (-2.4A)
PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
None
 1.25A 3mbhE-1td2A:
33.8		 3mbhE-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		6 / 11 HIS A  44
THR A  45
GLN A  46
TYR A  83
VAL A 114
ASP A 224
 PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-3.9A)
PXL  A 288 (-3.8A)
None
PXL  A 288 (-2.5A)
 0.35A 3mbhF-1td2A:
33.8		 3mbhF-1td2A:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		4 / 6 CYH A 214
THR A 215
GLY A  19
ASP A  23
 PXL  A 300 ( 2.9A)
None
PXL  A 300 (-3.6A)
None
 1.20A 3w9tE-4c5nA:
undetectable		 3w9tE-4c5nA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 11 GLY A 223
ALA A  17
GLY A 221
VAL A 114
CYH A 122
 None
PXL  A 288 ( 3.9A)
PXL  A 288 ( 4.2A)
None
PXL  A 288 (-2.0A)
 1.34A 4c5lA-1td2A:
27.9		 4c5lA-1td2A:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		9 / 11 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 210
CYH A 214
 PXL  A 300 (-3.9A)
PXL  A 300 (-4.3A)
PXL  A 300 ( 4.0A)
PXL  A 300 (-3.6A)
PXL  A 300 ( 4.5A)
PXL  A 300 ( 4.2A)
None
ACP  A 500 (-4.3A)
PXL  A 300 ( 2.9A)
 0.26A 4c5lA-4c5nA:
46.2		 4c5lA-4c5nA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 9 GLY A  11
ALA A  22
GLY A  19
HIS A 260
CYH A 214
 PXL  A 300 (-3.9A)
None
PXL  A 300 (-3.6A)
None
PXL  A 300 ( 2.9A)
 1.38A 4c5lB-4c5nA:
48.2		 4c5lB-4c5nA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		9 / 9 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 210
CYH A 214
 PXL  A 300 (-3.9A)
PXL  A 300 (-4.3A)
PXL  A 300 ( 4.0A)
PXL  A 300 (-3.6A)
PXL  A 300 ( 4.5A)
PXL  A 300 ( 4.2A)
None
ACP  A 500 (-4.3A)
PXL  A 300 ( 2.9A)
 0.17A 4c5lB-4c5nA:
48.2		 4c5lB-4c5nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 10 GLY A 223
ALA A  17
GLY A 221
VAL A 114
CYH A 122
 None
PXL  A 288 ( 3.9A)
PXL  A 288 ( 4.2A)
None
PXL  A 288 (-2.0A)
 1.36A 4c5lC-1td2A:
28.8		 4c5lC-1td2A:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 210
CYH A 214
 PXL  A 300 (-3.9A)
PXL  A 300 (-4.3A)
PXL  A 300 ( 4.0A)
PXL  A 300 (-3.6A)
PXL  A 300 ( 4.5A)
PXL  A 300 ( 4.2A)
None
ACP  A 500 (-4.3A)
PXL  A 300 ( 2.9A)
 0.26A 4c5lC-4c5nA:
48.1		 4c5lC-4c5nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 10 GLY A 223
ALA A  17
GLY A 221
VAL A 114
CYH A 122
 None
PXL  A 288 ( 3.9A)
PXL  A 288 ( 4.2A)
None
PXL  A 288 (-2.0A)
 1.33A 4c5lD-1td2A:
28.6		 4c5lD-1td2A:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		9 / 10 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 210
CYH A 214
 PXL  A 300 (-3.9A)
PXL  A 300 (-4.3A)
PXL  A 300 ( 4.0A)
PXL  A 300 (-3.6A)
PXL  A 300 ( 4.5A)
PXL  A 300 ( 4.2A)
None
ACP  A 500 (-4.3A)
PXL  A 300 ( 2.9A)
 0.21A 4c5lD-4c5nA:
47.8		 4c5lD-4c5nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 10 GLY A 223
ALA A  17
GLY A 221
VAL A 114
CYH A 122
 None
PXL  A 288 ( 3.9A)
PXL  A 288 ( 4.2A)
None
PXL  A 288 (-2.0A)
 1.33A 4c5nD-1td2A:
28.9		 4c5nD-1td2A:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		4 / 5 GLY A  18
THR A  45
VAL A 220
ASP A 224
 PXL  A 288 ( 4.1A)
PXL  A 288 (-2.7A)
PXL  A 288 (-4.5A)
PXL  A 288 (-2.5A)
 0.44A 4eohA-1td2A:
36.8		 4eohA-1td2A:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		4 / 5 SER A  10
THR A  45
VAL A 220
ASP A 224
 PXL  A 288 (-2.4A)
PXL  A 288 (-2.7A)
PXL  A 288 (-4.5A)
PXL  A 288 (-2.5A)
 0.78A 4eohA-1td2A:
36.8		 4eohA-1td2A:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 5 SER A  12
GLY A  20
THR A  47
VAL A 231
 PXL  A 313 (-3.3A)
None
PXL  A 313 (-2.7A)
SO4  A 314 ( 4.0A)
 0.18A 4eohA-3fhxA:
51.8		 4eohA-3fhxA:
99.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 5 SER A  10
HIS A  44
TYR A  83
VAL A 220
ASP A 224
 PXL  A 288 (-2.4A)
PXL  A 288 (-4.9A)
PXL  A 288 (-3.8A)
PXL  A 288 (-4.5A)
PXL  A 288 (-2.5A)
 0.89A 4eohB-1td2A:
36.8		 4eohB-1td2A:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 3fhx PYRIDOXAL KINASE
(Homo
sapiens) 		4 / 5 SER A  12
HIS A  46
TYR A  84
VAL A 231
 PXL  A 313 (-3.3A)
PXL  A 313 (-4.9A)
PXL  A 313 ( 4.6A)
SO4  A 314 ( 4.0A)
 0.24A 4eohB-3fhxA:
51.4		 4eohB-3fhxA:
99.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 146
VAL A 136
PRO A 106
THR A  39
GLY A  11
 None
None
None
None
PXL  A 300 (-3.9A)
 1.31A 4hvcB-4c5nA:
3.1		 4hvcB-4c5nA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 224
VAL A 103
GLY A  19
ASP A  23
PHE A  27
 None
None
PXL  A 300 (-3.6A)
None
None
 1.42A 4mubA-4c5nA:
1.8		 4mubA-4c5nA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		4 / 5 ASP A  13
VAL A 107
ASP A 105
GLY A 213
 PXL  A 300 (-4.3A)
None
None
ACP  A 500 (-3.3A)
 0.86A 4xp6A-4c5nA:
undetectable		 4xp6A-4c5nA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 12 GLY A 223
ILE A 254
ALA A  21
GLY A  18
ALA A  22
 None
None
None
PXL  A 288 ( 4.1A)
None
 0.86A 5kb6A-1td2A:
18.3		 5kb6A-1td2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1td2 PYRIDOXAMINE KINASE
(Escherichia
coli) 		5 / 12 GLY A 223
ILE A 254
ALA A  21
GLY A  18
ALA A  22
 None
None
None
PXL  A 288 ( 4.1A)
None
 0.84A 5kb6B-1td2A:
18.2		 5kb6B-1td2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 226
ASP A 224
LEU A 270
 None
PXL  A 400 (-2.4A)
None
 0.73A 5uhcC-3mbhA:
undetectable		 5uhcC-3mbhA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		3 / 3 ASP A 105
ASP A  13
ASN A 252
 None
PXL  A 300 (-4.3A)
None
 0.86A 6gngB-4c5nA:
undetectable		 6gngB-4c5nA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4c5n PHOSPHOMETHYLPYRIMID
INE KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 146
VAL A 136
PRO A 106
THR A  39
GLY A  11
 None
None
None
None
PXL  A 300 (-3.9A)
 1.29A 6mn8A-4c5nA:
undetectable		 6mn8A-4c5nA:
19.14