SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PXG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  57
VAL A 261
ARG A 267
 None
PXG  A 470 (-4.0A)
None
 0.88A 3b0wB-4b98A:
undetectable		 3b0wB-4b98A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 THR A 238
SER A 241
VAL A 245
ALA A   2
HIS A 309
 PXG  A 401 (-3.5A)
None
None
None
FMT  A 403 (-3.8A)
 1.46A 3u9fD-4uugA:
undetectable
3u9fE-4uugA:
undetectable		 3u9fD-4uugA:
18.79
3u9fE-4uugA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 THR A 238
SER A 241
VAL A 245
ALA A   2
HIS A 309
 PXG  A 401 (-3.5A)
None
None
None
FMT  A 403 (-3.8A)
 1.42A 3u9fG-4uugA:
undetectable
3u9fH-4uugA:
undetectable		 3u9fG-4uugA:
18.79
3u9fH-4uugA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4uug AMINE TRANSAMINASE
(Aspergillus
fumigatus) 		5 / 12 GLY A 213
GLY A 215
LEU A 210
ILE A 269
LEU A 284
 None
PXG  A 401 (-3.3A)
None
None
None
 0.98A 4n49A-4uugA:
undetectable		 4n49A-4uugA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 226
ARG A 378
GLY A 233
GLY A 230
 PXG  A 470 (-3.9A)
None
None
None
 0.91A 4rdxA-4b98A:
undetectable		 4rdxA-4b98A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 152
HIS A 154
GLY A 148
GLU A 226
 None
None
None
PXG  A 470 (-3.9A)
 1.11A 4v20A-4b98A:
undetectable		 4v20A-4b98A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 285
GLY A 160
GLY A 155
GLU A 122
ILE A 128
 None
None
PXG  A 470 (-3.5A)
None
None
 0.97A 6ectA-4b98A:
undetectable		 6ectA-4b98A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 285
GLY A 160
GLY A 155
ILE A 224
GLU A 122
 None
None
PXG  A 470 (-3.5A)
None
None
 1.05A 6ectA-4b98A:
undetectable		 6ectA-4b98A:
23.64