SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'PX8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 8 PHE A 267
ASN A 296
SER A 174
ALA A 265
 PX8  A 610 (-3.1A)
None
MYR  A 611 ( 4.6A)
None
 1.01A 1rqpC-5w7dA:
undetectable		 1rqpC-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 8 PHE A 267
ASN A 296
SER A 174
ALA A 265
 PX8  A 610 (-3.1A)
None
MYR  A 611 ( 4.6A)
None
 1.01A 1rqpA-5w7dA:
undetectable		 1rqpA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 5 PHE A 446
LEU A  41
PHE A 447
SER A 377
 PX8  A 610 ( 4.2A)
PX8  A 610 ( 4.5A)
None
None
 1.33A 1wrkB-5w7dA:
undetectable		 1wrkB-5w7dA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 7 PHE A 528
PHE A 446
LEU A  41
SER A 377
 PX8  A 610 (-4.9A)
PX8  A 610 ( 4.2A)
PX8  A 610 ( 4.5A)
None
 1.15A 1wrlE-5w7dA:
undetectable		 1wrlE-5w7dA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 11 HIS A 529
HIS A 266
ALA A 265
SER A 335
GLY A 260
 PX8  A 610 (-3.7A)
None
None
None
None
 1.24A 2uxpB-5w7dA:
2.2		 2uxpB-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		4 / 8 PHE A 267
ASN A 296
SER A 174
ALA A 265
 PX8  A 610 (-3.1A)
None
MYR  A 611 ( 4.6A)
None
 0.98A 2v7uA-5w7dA:
undetectable		 2v7uA-5w7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5w7d ACYLOXYACYL
HYDROLASE
(Mus
musculus) 		5 / 9 GLY A 260
ALA A 263
GLY A 264
MET A 369
HIS A 529
 None
None
None
None
PX8  A 610 (-3.7A)
 1.16A 4c5lB-5w7dA:
undetectable		 4c5lB-5w7dA:
16.27